LOCUS       NM_019454               3451 bp    mRNA    linear   ROD 02-MAY-2023
DEFINITION  Mus musculus delta like canonical Notch ligand 4 (Dll4), mRNA.
ACCESSION   NM_019454
VERSION     NM_019454.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3451)
  AUTHORS   Sargis T, Youn SW, Thakkar K, Naiche LA, Paik NY, Pajcini KV and
            Kitajewski JK.
  TITLE     Notch1 and Notch4 core binding domain peptibodies exhibit distinct
            ligand-binding and anti-angiogenic properties
  JOURNAL   Angiogenesis 26 (2), 249-263 (2023)
   PUBMED   36376768
  REMARK    GeneRIF: Notch1 and Notch4 core binding domain peptibodies exhibit
            distinct ligand-binding and anti-angiogenic properties.
REFERENCE   2  (bases 1 to 3451)
  AUTHORS   Rusidze M, Faure MC, Sicard P, Raymond-Letron I, Giton F, Vessieres
            E, Prevot V, Henrion D, Arnal JF, Cornil CA and Lenfant F.
  TITLE     Loss of function of the maternal membrane oestrogen receptor
            ERalpha alters expansion of trophoblast cells and impacts mouse
            fertility
  JOURNAL   Development 149 (19) (2022)
   PUBMED   36239412
REFERENCE   3  (bases 1 to 3451)
  AUTHORS   De Zoysa P, Toubat O, Harvey DC, Yi C, Liu J, Cavallero S, Hong YK,
            Sucov HM and Kumar SR.
  TITLE     Delta-like ligand-4 regulates Notch-mediated maturation of second
            heart field progenitor-derived pharyngeal arterial endothelial
            cells
  JOURNAL   J Cell Mol Med 26 (20), 5181-5194 (2022)
   PUBMED   36082581
  REMARK    GeneRIF: Delta-like ligand-4 regulates Notch-mediated maturation of
            second heart field progenitor-derived pharyngeal arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 3451)
  AUTHORS   Nagakubo D, Hirakawa M, Iwanami N and Boehm T.
  TITLE     Limits to in vivo fate changes of epithelia in thymus and
            parathyroid by ectopic expression of transcription factors Gcm2 and
            Foxn1
  JOURNAL   Sci Rep 12 (1), 13554 (2022)
   PUBMED   35941210
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3451)
  AUTHORS   Lee CK, Park BY, Jo T, Park CH, Kim JH, Chung KJ, Kim YH, Park DY
            and Kim IK.
  TITLE     Dll4 Inhibition Promotes Graft Retention in Fat Grafting Enriched
            with Adipose-Derived Stem Cells
  JOURNAL   Stem Cells Transl Med 11 (7), 742-752 (2022)
   PUBMED   35579982
  REMARK    GeneRIF: Dll4 Inhibition Promotes Graft Retention in Fat Grafting
            Enriched with Adipose-Derived Stem Cells.
REFERENCE   6  (bases 1 to 3451)
  AUTHORS   Villa N, Walker L, Lindsell CE, Gasson J, Iruela-Arispe ML and
            Weinmaster G.
  TITLE     Vascular expression of Notch pathway receptors and ligands is
            restricted to arterial vessels
  JOURNAL   Mech Dev 108 (1-2), 161-164 (2001)
   PUBMED   11578869
REFERENCE   7  (bases 1 to 3451)
  AUTHORS   Yoneya T, Tahara T, Nagao K, Yamada Y, Yamamoto T, Osawa M,
            Miyatani S and Nishikawa M.
  TITLE     Molecular cloning of delta-4, a new mouse and human Notch ligand
  JOURNAL   J Biochem 129 (1), 27-34 (2001)
   PUBMED   11134954
REFERENCE   8  (bases 1 to 3451)
  AUTHORS   Rao PK, Dorsch M, Chickering T, Zheng G, Jiang C, Goodearl A,
            Kadesch T and McCarthy S.
  TITLE     Isolation and characterization of the notch ligand delta4
  JOURNAL   Exp Cell Res 260 (2), 379-386 (2000)
   PUBMED   11035934
REFERENCE   9  (bases 1 to 3451)
  AUTHORS   Krebs LT, Xue Y, Norton CR, Shutter JR, Maguire M, Sundberg JP,
            Gallahan D, Closson V, Kitajewski J, Callahan R, Smith GH, Stark KL
            and Gridley T.
  TITLE     Notch signaling is essential for vascular morphogenesis in mice
  JOURNAL   Genes Dev 14 (11), 1343-1352 (2000)
   PUBMED   10837027
REFERENCE   10 (bases 1 to 3451)
  AUTHORS   Shutter JR, Scully S, Fan W, Richards WG, Kitajewski J, Deblandre
            GA, Kintner CR and Stark KL.
  TITLE     Dll4, a novel Notch ligand expressed in arterial endothelium
  JOURNAL   Genes Dev 14 (11), 1313-1318 (2000)
   PUBMED   10837024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052322.1, BC049130.1 and AL929318.11.
            
            [WARNING] On May 18, 2023 this sequence was replaced by
            NM_019454.4.
            
            On Jul 2, 2009 this sequence version replaced NM_019454.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052322.1, BC049130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AK052322.1         2-41
            41-3445             BC049130.1         1-3405
            3446-3451           AL929318.11        123477-123482
FEATURES             Location/Qualifiers
     source          1..3451
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..3451
                     /gene="Dll4"
                     /gene_synonym="Delta4"
                     /note="delta like canonical Notch ligand 4"
                     /db_xref="GeneID:54485"
                     /db_xref="MGI:MGI:1859388"
     exon            1..423
                     /gene="Dll4"
                     /gene_synonym="Delta4"
                     /inference="alignment:Splign:2.1.0"
     exon            424..696
                     /gene="Dll4"
                     /gene_synonym="Delta4"
                     /inference="alignment:Splign:2.1.0"
     exon            697..754
                     /gene="Dll4"
                     /gene_synonym="Delta4"
                     /inference="alignment:Splign:2.1.0"
     exon            755..1018
                     /gene="Dll4"
                     /gene_synonym="Delta4"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1079
                     /gene="Dll4"
                     /gene_synonym="Delta4"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1210
                     /gene="Dll4"
                     /gene_synonym="Delta4"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1380
                     /gene="Dll4"
                     /gene_synonym="Delta4"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1600
                     /gene="Dll4"
                     /gene_synonym="Delta4"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..2303
                     /gene="Dll4"
                     /gene_synonym="Delta4"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2412
                     /gene="Dll4"
                     /gene_synonym="Delta4"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..3451
                     /gene="Dll4"
                     /gene_synonym="Delta4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atataagaaa ggctctggag caagcaggtt tcagtagcgg cgctgctcgc aggctaggaa
       61 cccgaggcca agagctgcag ccaaagtcac ttgggtgcag tgtactccct cactagcccg
      121 ctcgagaccc taggatttgc tccaggacac gtacttagag cagccaccgc ccagtcgccc
      181 tcacctggat tacctaccga ggcatcgagc agcggagttt ttgagaaggc gacaagggag
      241 cagcgtcccg aggggaatca gcttttcagg aactcggctg gcagacggga cttgcgggag
      301 agcgacatcc ctaacaagca gattcggagt cccggagtgg agaggacacc ccaagggatg
      361 acgcctgcgt cccggagcgc ctgtcgctgg gcgctactgc tgctggcggt actgtggccg
      421 cagcagcgcg ctgcgggctc cggcatcttc cagctgcggc tgcaggagtt cgtcaaccag
      481 cgcggtatgc tggccaatgg gcagtcctgc gaaccgggct gccggacttt cttccgcatc
      541 tgccttaagc acttccaggc aaccttctcc gagggaccct gcacctttgg caatgtctcc
      601 acgccggtat tgggcaccaa ctccttcgtc gtcagggaca agaatagcgg cagtggtcgc
      661 aaccctctgc agttgccctt caatttcacc tggccgggaa ccttctcact caacatccaa
      721 gcttggcaca caccgggaga cgacctgcgg ccagagactt cgccaggaaa ctctctcatc
      781 agccaaatca tcatccaagg ctctcttgct gtgggtaaga tttggcgaac agacgagcaa
      841 aatgacaccc tcaccagact gagctactct taccgggtca tctgcagtga caactactat
      901 ggagagagct gttctcgcct atgcaagaag cgcgatgacc acttcggaca ttatgagtgc
      961 cagccagatg gcagcctgtc ctgcctgccg ggctggactg ggaagtactg tgaccagcct
     1021 atatgtcttt ctggctgtca tgagcagaat ggttactgca gcaagccaga tgagtgcatc
     1081 tgccgtccag gttggcaggg tcgcctgtgc aatgaatgta tcccccacaa tggctgtcgt
     1141 catggcacct gcagcatccc ctggcagtgt gcctgcgatg agggatgggg aggtctgttt
     1201 tgtgaccaag atctcaacta ctgtactcac cactctccgt gcaagaatgg atcaacgtgt
     1261 tccaacagtg ggccaaaggg ttatacctgc acctgtctcc caggctacac tggtgagcac
     1321 tgtgagctgg gactcagcaa gtgtgccagc aacccctgtc gaaatggtgg cagctgtaag
     1381 gaccaggaga atagctacca ctgcctgtgt cccccaggct actatggcca gcactgtgag
     1441 catagtacct tgacctgcgc ggactcaccc tgcttcaatg ggggctcttg ccgggagcgc
     1501 aaccaggggt ccagttatgc ctgcgaatgc ccccccaact ttaccggctc taactgtgag
     1561 aagaaagtag acaggtgtac cagcaacccg tgtgccaatg gaggccagtg ccagaacaga
     1621 ggtccaagcc gaacctgccg ctgccggcct ggattcacag gcacccactg tgaactgcac
     1681 atcagcgatt gtgcccgaag tccctgtgcc cacgggggca cttgccacga tctggagaat
     1741 gggcctgtgt gcacctgccc cgctggcttc tctggaaggc gctgcgaggt gcggataacc
     1801 cacgatgcct gtgcctccgg accctgcttc aatggggcca cctgctacac tggcctctcc
     1861 ccaaacaact tcgtctgcaa ctgtccttat ggctttgtgg gcagccgctg cgagtttccc
     1921 gtgggcttgc cacccagctt cccctgggta gctgtctcgc tgggcgtggg gctagtggta
     1981 ctgctggtgc tcctggtcat ggtggtagtg gctgtgcggc agctgcggct tcggaggccc
     2041 gatgacgaga gcagggaagc catgaacaat ctgtcagact tccagaagga caacctaatc
     2101 cctgccgccc agctcaaaaa cacaaaccag aagaaggagc tggaagtgga ctgtggtctg
     2161 gacaagtcca attgtggcaa actgcagaac cacacattgg actacaatct agccccggga
     2221 ctcctaggac ggggcggcat gcctgggaag tatcctcaca gtgacaagag cttaggagag
     2281 aaggtgccac ttcggttaca cagtgagaag ccagagtgtc gaatatcagc catttgctct
     2341 cccagggact ctatgtacca atcagtgtgt ttgatatcag aagagaggaa cgagtgtgtg
     2401 attgccacag aggtataagg caggagccta ctcagacacc cagctccggc ccagcagctg
     2461 ggccttcctt ctgcattgtt tacattgcat cctgtatggg acatctttag tatgcacagt
     2521 gctgctctgc ggaggaggag gaaatggcat gaactgaaca gactgtgaac ccgccaagag
     2581 tcgcaccggc tctgcacacc tccaggagtc tgcctggctt cagatgggca gccccgccaa
     2641 gggaacagag ttgaggagtt agaggagcat cagttgagct gatatctaag gtgcctctcg
     2701 aacttggact tgctctgcca acagtggtca tcatggagct cttgactgtt ctccagagag
     2761 tggcagtggc cctagtgggt cttggcgctg ctgtagctcc tgtgggcatc tgtatttcca
     2821 aagtgccttt gcccagactc catcctcaca gctgggccca aatgagaaag cagagaggag
     2881 gcttgcaaag gataggcctc ccgcaggcag aacagccttg gagtttggca ttaagcagga
     2941 gctactctgc aggtgaggaa agcccgagga ggggacacgt gtgactcctg cctccaaccc
     3001 cagtaggtgg agtgccacct gtagcctcta ggcaagagtt ggtccttccc ctggtcctgg
     3061 tgcctctggg ctcatgtgaa cagatgggct tagggcacgc cccttttgcc agccaggggt
     3121 acaggcctca ctggggagct cagggccttc atgctaaact cccaataagg gagatggggg
     3181 gaagggggct gtggcctagg cccttccctc cctcacaccc atttctgggc ccttgagcct
     3241 gggctccacc agtgcccact gctgccccga gaccaacctt gaagccgatc ttcaaaaatc
     3301 aataatatga ggttttgttt tgtagtttat tttggaatct agtattttga taatttaaga
     3361 atcagaagca ctggcctttc tacattttat aacattattt tgtatataat gtgtatttat
     3421 aatatgaaac agatgtgtac aggaatttat t
//
