LOCUS       NM_007866               2163 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus delta like canonical Notch ligand 3 (Dll3), mRNA.
ACCESSION   NM_007866
VERSION     NM_007866.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2163)
  AUTHORS   El Azhar,Y., Schulthess,P., van Oostrom,M.J., Weterings,S.D.C.,
            Meijer,W.H.M., Tsuchida-Straeten,N., Thomas,W.M., Bauer,M. and
            Sonnen,K.F.
  TITLE     Unravelling differential Hes1 dynamics during axis elongation of
            mouse embryos through single-cell tracking
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39315665
REFERENCE   2  (bases 1 to 2163)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   3  (bases 1 to 2163)
  AUTHORS   Feng,X., Ye,Y., Zhang,J., Zhang,Y., Zhao,S., Mak,J.C.W., Otomo,N.,
            Zhao,Z., Niu,Y., Yonezawa,Y., Li,G., Lin,M., Li,X., Cheung,P.W.H.,
            Xu,K., Takeda,K., Wang,S., Xie,J., Kotani,T., Choi,V.N.T.,
            Song,Y.Q., Yang,Y., Luk,K.D.K., Lee,K.S., Li,Z., Li,P.S.,
            Leung,C.Y.H., Lin,X., Wang,X., Qiu,G., Watanabe,K., Wu,Z.,
            Posey,J.E., Ikegawa,S., Lupski,J.R., Cheung,J.P.Y., Zhang,T.J.,
            Gao,B. and Wu,N.
  CONSRTM   DISCO (Deciphering disorders Involving Scoliosis and COmorbidities)
            study group; Japanese Early Onset Scoliosis Research Group
  TITLE     Core planar cell polarity genes VANGL1 and VANGL2 in predisposition
            to congenital vertebral malformations
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2310283121 (2024)
   PUBMED   38669183
REFERENCE   4  (bases 1 to 2163)
  AUTHORS   Shapiro,F., Wang,J., Flynn,E. and Wu,J.Y.
  TITLE     Pudgy mouse rib deformities emanate from abnormal paravertebral
            longitudinal cartilage/bone accumulations
  JOURNAL   Biol Open 13 (1) (2024)
   PUBMED   38252118
  REMARK    GeneRIF: Pudgy mouse rib deformities emanate from abnormal
            paravertebral longitudinal cartilage/bone accumulations.
REFERENCE   5  (bases 1 to 2163)
  AUTHORS   Zhao,F., He,J., Tang,J., Cui,N., Shi,Y., Li,Z., Liu,S., Wang,Y.,
            Ma,M., Zhao,C., Luo,L. and Li,L.
  TITLE     Brain milieu induces early microglial maturation through the
            BAX-Notch axis
  JOURNAL   Nat Commun 13 (1), 6117 (2022)
   PUBMED   36253375
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2163)
  AUTHORS   Casarosa,S., Fode,C. and Guillemot,F.
  TITLE     Mash1 regulates neurogenesis in the ventral telencephalon
  JOURNAL   Development 126 (3), 525-534 (1999)
   PUBMED   9876181
REFERENCE   7  (bases 1 to 2163)
  AUTHORS   Evrard,Y.A., Lun,Y., Aulehla,A., Gan,L. and Johnson,R.L.
  TITLE     lunatic fringe is an essential mediator of somite segmentation and
            patterning
  JOURNAL   Nature 394 (6691), 377-381 (1998)
   PUBMED   9690473
REFERENCE   8  (bases 1 to 2163)
  AUTHORS   Zhang,N. and Gridley,T.
  TITLE     Defects in somite formation in lunatic fringe-deficient mice
  JOURNAL   Nature 394 (6691), 374-377 (1998)
   PUBMED   9690472
REFERENCE   9  (bases 1 to 2163)
  AUTHORS   Kusumi,K., Sun,E.S., Kerrebrock,A.W., Bronson,R.T., Chi,D.C.,
            Bulotsky,M.S., Spencer,J.B., Birren,B.W., Frankel,W.N. and
            Lander,E.S.
  TITLE     The mouse pudgy mutation disrupts Delta homologue Dll3 and
            initiation of early somite boundaries
  JOURNAL   Nat Genet 19 (3), 274-278 (1998)
   PUBMED   9662403
REFERENCE   10 (bases 1 to 2163)
  AUTHORS   Dunwoodie,S.L., Henrique,D., Harrison,S.M. and Beddington,R.S.
  TITLE     Mouse Dll3: a novel divergent Delta gene which may complement the
            function of other Delta homologues during early pattern formation
            in the mouse embryo
  JOURNAL   Development 124 (16), 3065-3076 (1997)
   PUBMED   9272948
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB868475.1 and BC052002.1.
            
            On Oct 20, 2006 this sequence version replaced NM_007866.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052002.1, AK144282.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BB868475.1         1-23
            24-2163             BC052002.1         1-2140
FEATURES             Location/Qualifiers
     source          1..2163
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.67 cM"
     gene            1..2163
                     /gene="Dll3"
                     /gene_synonym="pu; pudgy"
                     /note="delta like canonical Notch ligand 3"
                     /db_xref="GeneID:13389"
                     /db_xref="MGI:MGI:1096877"
     exon            1..102
                     /gene="Dll3"
                     /gene_synonym="pu; pudgy"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1797
                     /gene="Dll3"
                     /gene_synonym="pu; pudgy"
                     /note="delta-like protein 3; delta3; M-Delta-3; drosophila
                     Delta homolog 3; delta-like 3"
                     /codon_start=1
                     /product="delta-like protein 3 precursor"
                     /protein_id="NP_031892.2"
                     /db_xref="CCDS:CCDS39856.1"
                     /db_xref="GeneID:13389"
                     /db_xref="MGI:MGI:1096877"
                     /translation="MVSLQVSPLSQTLILAFLLPQALPAGVFELQIHSFGPGPGLGTP
                     RSPCNARGPCRLFFRVCLKPGVSQEATESLCALGAALSTSVPVYTEHPGESAAALPLP
                     DGLVRVPFRDAWPGTFSLVIETWREQLGEHAGGPAWNLLARVVGRRRLAAGGPWARDV
                     QRTGTWELHFSYRARCEPPAVGAACARLCRSRSAPSRCGPGLRPCTPFPDECEAPSVC
                     RPGCSPEHGYCEEPDECRCLEGWTGPLCTVPVSTSSCLNSRVPGPASTGCLLPGPGPC
                     DGNPCANGGSCSETSGSFECACPRGFYGLRCEVSGVTCADGPCFNGGLCVGGEDPDSA
                     YVCHCPPGFQGSNCEKRVDRCSLQPCQNGGLCLDLGHALRCRCRAGFAGPRCEHDLDD
                     CAGRACANGGTCVEGGGSRRCSCALGFGGRDCRERADPCASRPCAHGGRCYAHFSGLV
                     CACAPGYMGVRCEFAVRPDGADAVPAAPRGLRQADPQRFLLPPALGLLVAAGLAGAAL
                     LVIHVRRRGPGQDTGTRLLSGTREPSVHTLPDALNNLRLQDGAGDGPSSSADWNHPED
                     GDSRSIYVIPAPSIYAREA"
     exon            103..384
                     /gene="Dll3"
                     /gene_synonym="pu; pudgy"
                     /inference="alignment:Splign:2.1.0"
     exon            385..442
                     /gene="Dll3"
                     /gene_synonym="pu; pudgy"
                     /inference="alignment:Splign:2.1.0"
     exon            443..685
                     /gene="Dll3"
                     /gene_synonym="pu; pudgy"
                     /inference="alignment:Splign:2.1.0"
     exon            686..903
                     /gene="Dll3"
                     /gene_synonym="pu; pudgy"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1126
                     /gene="Dll3"
                     /gene_synonym="pu; pudgy"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1706
                     /gene="Dll3"
                     /gene_synonym="pu; pudgy"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1791
                     /gene="Dll3"
                     /gene_synonym="pu; pudgy"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..2163
                     /gene="Dll3"
                     /gene_synonym="pu; pudgy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1980..1985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dll3"
                     /gene_synonym="pu; pudgy"
                     /note="hexamer: TATAAA"
     polyA_site      2006
                     /gene="Dll3"
                     /gene_synonym="pu; pudgy"
                     /note="major polyA site"
ORIGIN      
        1 gactcctgag actatttccc catcctgtcc cccaaagcaa tggtctctct gcaggtgtct
       61 ccgctttccc agacgctgat cctggctttt cttcttcctc aggcactgcc agctggtgtc
      121 ttcgagctac aaattcattc tttcgggcca ggcccaggcc tcgggacccc acgctccccc
      181 tgcaacgccc gaggcccttg ccgcctcttc ttcagggtct gcctgaagcc cggagtctcc
      241 caggaggcca ccgagtccct gtgcgccctg ggcgcagcac tgagcacgag cgtcccggtc
      301 tatacggagc accccggaga gtcagcggct gccctgccgc tgcctgatgg cctcgtacgt
      361 gtgcccttcc gcgatgcttg gccgggcacc ttctccctcg tcattgaaac ctggagagag
      421 cagctgggag agcatgctgg agggcccgcc tggaacctgc tagcacgtgt ggtcggccgt
      481 agacgcctgg cggctggggg cccgtgggcc cgcgatgtgc agcgcacagg cacatgggag
      541 ttgcacttct cctaccgcgc gcggtgcgag ccgcccgccg tcggggccgc ctgcgcgcgc
      601 ctgtgccgct cacgcagtgc cccctcgcgg tgtggcccgg gactgcgacc ctgcacgcca
      661 ttcccagacg agtgcgaagc cccgtctgtg tgtcgaccag gctgcagccc cgagcacggc
      721 tactgtgaag agcctgatga atgccgttgc ctggagggct ggactggacc cctctgcacg
      781 gtccctgtct ccaccagtag ctgcctgaac tccagggttc ctggtcctgc cagcactgga
      841 tgccttttac ctgggcctgg accttgtgat gggaacccat gtgccaatgg gggcagctgt
      901 agtgaaacct ctggctcctt tgaatgtgcc tgtccccggg gattctacgg gcttcgatgt
      961 gaggtgagcg gggtcacgtg cgcagatgga ccctgcttca atggcggctt gtgtgttggc
     1021 ggtgaagatc ctgactctgc ctatgtctgt cattgcccac ctggtttcca aggctctaac
     1081 tgtgagaaga gggtggaccg ctgtagcctg cagccatgtc agaatggcgg cctctgcctg
     1141 gacctgggcc acgcgttgcg ctgccgctgt cgcgcgggat tcgccgggcc gcgctgcgag
     1201 cacgacctgg acgactgcgc cggccgcgcc tgtgccaacg gcggcacgtg cgtggagggc
     1261 ggcggctcgc gccgctgctc ctgtgcgctg ggcttcggcg ggcgcgactg ccgagaacgc
     1321 gccgacccct gcgcctcccg cccctgcgcg catggaggcc gttgctacgc ccacttctct
     1381 ggcctggtct gcgcctgcgc gcccggctac atgggcgtga gatgcgagtt cgctgtgcgc
     1441 ccggacggcg cggacgcggt gcccgccgcc ccgcggggcc tgaggcaggc ggatccacag
     1501 cgctttcttc tgcctcccgc cttggggctg ctggtggccg ccggtttggc tggcgccgca
     1561 ctcttggtca tccacgttcg ccgccgaggt cctggccagg ataccgggac tcgcctgctt
     1621 tctgggaccc gggagccttc ggtccacacg ctcccggatg cactcaacaa cctgaggtta
     1681 caagacggtg ctggggatgg ccccagttcg tcggctgact ggaatcatcc tgaagatgga
     1741 gactctagat ccatttatgt cataccagcc ccttccattt atgcacgaga ggcctgatcc
     1801 tgccccttct ctatcttgtc ccttctctat catcgcctgg agatggagcc tgaatgattt
     1861 tatttacttt gtggtgtcca atctctacct ccccctaccg actggagact ctttgaaagg
     1921 gctttattgt acatattgct tatttataac ctagtttttc tcatctcccc agagacatct
     1981 ataaaggttc ttattttgct caaccacatc aggctgagaa ctttttattt tcccaggata
     2041 gagtttcctc tctgtaaaag ccctggccag cctagaactc tgtagaccag gctggcctcg
     2101 aactcacaga gatccacctg cttctgcccc ctaagtgctg gcattaaagg cgtgcaccac
     2161 tcc
//
