LOCUS       NP_031892                585 aa            linear   ROD 24-DEC-2024
DEFINITION  delta-like protein 3 precursor [Mus musculus].
ACCESSION   NP_031892
VERSION     NP_031892.2
DBSOURCE    REFSEQ: accession NM_007866.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 585)
  AUTHORS   El Azhar,Y., Schulthess,P., van Oostrom,M.J., Weterings,S.D.C.,
            Meijer,W.H.M., Tsuchida-Straeten,N., Thomas,W.M., Bauer,M. and
            Sonnen,K.F.
  TITLE     Unravelling differential Hes1 dynamics during axis elongation of
            mouse embryos through single-cell tracking
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39315665
REFERENCE   2  (residues 1 to 585)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   3  (residues 1 to 585)
  AUTHORS   Feng,X., Ye,Y., Zhang,J., Zhang,Y., Zhao,S., Mak,J.C.W., Otomo,N.,
            Zhao,Z., Niu,Y., Yonezawa,Y., Li,G., Lin,M., Li,X., Cheung,P.W.H.,
            Xu,K., Takeda,K., Wang,S., Xie,J., Kotani,T., Choi,V.N.T.,
            Song,Y.Q., Yang,Y., Luk,K.D.K., Lee,K.S., Li,Z., Li,P.S.,
            Leung,C.Y.H., Lin,X., Wang,X., Qiu,G., Watanabe,K., Wu,Z.,
            Posey,J.E., Ikegawa,S., Lupski,J.R., Cheung,J.P.Y., Zhang,T.J.,
            Gao,B. and Wu,N.
  CONSRTM   DISCO (Deciphering disorders Involving Scoliosis and COmorbidities)
            study group; Japanese Early Onset Scoliosis Research Group
  TITLE     Core planar cell polarity genes VANGL1 and VANGL2 in predisposition
            to congenital vertebral malformations
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2310283121 (2024)
   PUBMED   38669183
REFERENCE   4  (residues 1 to 585)
  AUTHORS   Shapiro,F., Wang,J., Flynn,E. and Wu,J.Y.
  TITLE     Pudgy mouse rib deformities emanate from abnormal paravertebral
            longitudinal cartilage/bone accumulations
  JOURNAL   Biol Open 13 (1) (2024)
   PUBMED   38252118
  REMARK    GeneRIF: Pudgy mouse rib deformities emanate from abnormal
            paravertebral longitudinal cartilage/bone accumulations.
REFERENCE   5  (residues 1 to 585)
  AUTHORS   Zhao,F., He,J., Tang,J., Cui,N., Shi,Y., Li,Z., Liu,S., Wang,Y.,
            Ma,M., Zhao,C., Luo,L. and Li,L.
  TITLE     Brain milieu induces early microglial maturation through the
            BAX-Notch axis
  JOURNAL   Nat Commun 13 (1), 6117 (2022)
   PUBMED   36253375
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 585)
  AUTHORS   Casarosa,S., Fode,C. and Guillemot,F.
  TITLE     Mash1 regulates neurogenesis in the ventral telencephalon
  JOURNAL   Development 126 (3), 525-534 (1999)
   PUBMED   9876181
REFERENCE   7  (residues 1 to 585)
  AUTHORS   Evrard,Y.A., Lun,Y., Aulehla,A., Gan,L. and Johnson,R.L.
  TITLE     lunatic fringe is an essential mediator of somite segmentation and
            patterning
  JOURNAL   Nature 394 (6691), 377-381 (1998)
   PUBMED   9690473
REFERENCE   8  (residues 1 to 585)
  AUTHORS   Zhang,N. and Gridley,T.
  TITLE     Defects in somite formation in lunatic fringe-deficient mice
  JOURNAL   Nature 394 (6691), 374-377 (1998)
   PUBMED   9690472
REFERENCE   9  (residues 1 to 585)
  AUTHORS   Kusumi,K., Sun,E.S., Kerrebrock,A.W., Bronson,R.T., Chi,D.C.,
            Bulotsky,M.S., Spencer,J.B., Birren,B.W., Frankel,W.N. and
            Lander,E.S.
  TITLE     The mouse pudgy mutation disrupts Delta homologue Dll3 and
            initiation of early somite boundaries
  JOURNAL   Nat Genet 19 (3), 274-278 (1998)
   PUBMED   9662403
REFERENCE   10 (residues 1 to 585)
  AUTHORS   Dunwoodie,S.L., Henrique,D., Harrison,S.M. and Beddington,R.S.
  TITLE     Mouse Dll3: a novel divergent Delta gene which may complement the
            function of other Delta homologues during early pattern formation
            in the mouse embryo
  JOURNAL   Development 124 (16), 3065-3076 (1997)
   PUBMED   9272948
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB868475.1 and BC052002.1.
            
            On Oct 20, 2006 this sequence version replaced NP_031892.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052002.1, AK144282.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..585
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.67 cM"
     Protein         1..585
                     /product="delta-like protein 3 precursor"
                     /note="delta-like protein 3; delta3; M-Delta-3; drosophila
                     Delta homolog 3; delta-like 3"
                     /calculated_mol_wt=58564
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2580
     Region          25..173
                     /region_name="MNNL"
                     /note="N terminus of Notch ligand C2-like domain;
                     pfam07657"
                     /db_xref="CDD:462222"
     Region          277..308
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          314..347
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          352..387
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          389..424
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(389,392,406)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          429..463
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            491..511
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88516.1)"
     Region          548..567
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88516.1)"
     CDS             1..585
                     /gene="Dll3"
                     /gene_synonym="pu; pudgy"
                     /coded_by="NM_007866.2:40..1797"
                     /db_xref="CCDS:CCDS39856.1"
                     /db_xref="GeneID:13389"
                     /db_xref="MGI:MGI:1096877"
ORIGIN      
        1 mvslqvspls qtlilafllp qalpagvfel qihsfgpgpg lgtprspcna rgpcrlffrv
       61 clkpgvsqea teslcalgaa lstsvpvyte hpgesaaalp lpdglvrvpf rdawpgtfsl
      121 vietwreqlg ehaggpawnl larvvgrrrl aaggpwardv qrtgtwelhf syrarceppa
      181 vgaacarlcr srsapsrcgp glrpctpfpd eceapsvcrp gcspehgyce epdecrcleg
      241 wtgplctvpv stssclnsrv pgpastgcll pgpgpcdgnp canggscset sgsfecacpr
      301 gfyglrcevs gvtcadgpcf ngglcvgged pdsayvchcp pgfqgsncek rvdrcslqpc
      361 qngglcldlg halrcrcrag fagprcehdl ddcagracan ggtcvegggs rrcscalgfg
      421 grdcreradp casrpcahgg rcyahfsglv cacapgymgv rcefavrpdg adavpaaprg
      481 lrqadpqrfl lppalgllva aglagaallv ihvrrrgpgq dtgtrllsgt repsvhtlpd
      541 alnnlrlqdg agdgpsssad wnhpedgdsr siyvipapsi yarea
//
