LOCUS       NM_007865               3444 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus delta like canonical Notch ligand 1 (Dll1), transcript
            variant 1, mRNA.
ACCESSION   NM_007865
VERSION     NM_007865.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3444)
  AUTHORS   Matsuoka,R., Kitajima,K., Nii,T., Zou,Z., Tanaka,K., Joo,K.,
            Ohkawa,Y., Ohga,S. and Meno,C.
  TITLE     Hyperglycaemia induces diet-dependent defects of the left-right
            axis by lowering intracellular pH
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167550 (2025)
   PUBMED   39442590
REFERENCE   2  (bases 1 to 3444)
  AUTHORS   El Azhar,Y., Schulthess,P., van Oostrom,M.J., Weterings,S.D.C.,
            Meijer,W.H.M., Tsuchida-Straeten,N., Thomas,W.M., Bauer,M. and
            Sonnen,K.F.
  TITLE     Unravelling differential Hes1 dynamics during axis elongation of
            mouse embryos through single-cell tracking
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39315665
REFERENCE   3  (bases 1 to 3444)
  AUTHORS   Barao,S., Xu,Y., Llongueras,J.P., Vistein,R., Goff,L.,
            Nielsen,K.J., Bae,B.I., Smith,R.S., Walsh,C.A., Stein-O'Brien,G.
            and Muller,U.
  TITLE     Conserved transcriptional regulation by BRN1 and BRN2 in
            neocortical progenitors drives mammalian neural specification and
            neocortical expansion
  JOURNAL   Nat Commun 15 (1), 8043 (2024)
   PUBMED   39271675
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3444)
  AUTHORS   Feng,X., Ye,Y., Zhang,J., Zhang,Y., Zhao,S., Mak,J.C.W., Otomo,N.,
            Zhao,Z., Niu,Y., Yonezawa,Y., Li,G., Lin,M., Li,X., Cheung,P.W.H.,
            Xu,K., Takeda,K., Wang,S., Xie,J., Kotani,T., Choi,V.N.T.,
            Song,Y.Q., Yang,Y., Luk,K.D.K., Lee,K.S., Li,Z., Li,P.S.,
            Leung,C.Y.H., Lin,X., Wang,X., Qiu,G., Watanabe,K., Wu,Z.,
            Posey,J.E., Ikegawa,S., Lupski,J.R., Cheung,J.P.Y., Zhang,T.J.,
            Gao,B. and Wu,N.
  CONSRTM   DISCO (Deciphering disorders Involving Scoliosis and COmorbidities)
            study group; Japanese Early Onset Scoliosis Research Group
  TITLE     Core planar cell polarity genes VANGL1 and VANGL2 in predisposition
            to congenital vertebral malformations
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2310283121 (2024)
   PUBMED   38669183
REFERENCE   5  (bases 1 to 3444)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 3444)
  AUTHORS   Hrabe de Angelis,M., McIntyre,J. 2nd and Gossler,A.
  TITLE     Maintenance of somite borders in mice requires the Delta homologue
            DII1
  JOURNAL   Nature 386 (6626), 717-721 (1997)
   PUBMED   9109488
REFERENCE   7  (bases 1 to 3444)
  AUTHORS   de la Pompa,J.L., Wakeham,A., Correia,K.M., Samper,E., Brown,S.,
            Aguilera,R.J., Nakano,T., Honjo,T., Mak,T.W., Rossant,J. and
            Conlon,R.A.
  TITLE     Conservation of the Notch signalling pathway in mammalian
            neurogenesis
  JOURNAL   Development 124 (6), 1139-1148 (1997)
   PUBMED   9102301
REFERENCE   8  (bases 1 to 3444)
  AUTHORS   Lindsell,C.E., Boulter,J., diSibio,G., Gossler,A. and Weinmaster,G.
  TITLE     Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3
            genes identify ligand-receptor pairs that may function in neural
            development
  JOURNAL   Mol Cell Neurosci 8 (1), 14-27 (1996)
   PUBMED   8923452
REFERENCE   9  (bases 1 to 3444)
  AUTHORS   Bettenhausen,B., Hrabe de Angelis,M., Simon,D., Guenet,J.L. and
            Gossler,A.
  TITLE     Transient and restricted expression during mouse embryogenesis of
            Dll1, a murine gene closely related to Drosophila Delta
  JOURNAL   Development 121 (8), 2407-2418 (1995)
   PUBMED   7671806
REFERENCE   10 (bases 1 to 3444)
  AUTHORS   Beermann,F., Bartels,I., Franke,U. and Hansmann,I.
  TITLE     Chromosome segregation at meiosis I in female T(2;4)1Go/+ mice: no
            evidence for a decreased crossover frequency with maternal age
  JOURNAL   Chromosoma 95 (1), 1-7 (1987)
   PUBMED   3581995
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ768900.1 and BC065063.1.
            
            On Jan 10, 2008 this sequence version replaced NM_007865.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065063.1, X80903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               BQ768900.1         1-236
            237-3148            BC065063.1         1-2912
            3149-3444           BC065063.1         2914-3209
FEATURES             Location/Qualifiers
     source          1..3444
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.95 cM"
     gene            1..3444
                     /gene="Dll1"
                     /gene_synonym="Delta1"
                     /note="delta like canonical Notch ligand 1"
                     /db_xref="GeneID:13388"
                     /db_xref="MGI:MGI:104659"
     exon            1..637
                     /gene="Dll1"
                     /gene_synonym="Delta1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..931
                     /gene="Dll1"
                     /gene_synonym="Delta1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..992
                     /gene="Dll1"
                     /gene_synonym="Delta1"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1250
                     /gene="Dll1"
                     /gene_synonym="Delta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1311
                     /gene="Dll1"
                     /gene_synonym="Delta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1442
                     /gene="Dll1"
                     /gene_synonym="Delta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1612
                     /gene="Dll1"
                     /gene_synonym="Delta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1829
                     /gene="Dll1"
                     /gene_synonym="Delta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..2628
                     /gene="Dll1"
                     /gene_synonym="Delta1"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2746
                     /gene="Dll1"
                     /gene_synonym="Delta1"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..3428
                     /gene="Dll1"
                     /gene_synonym="Delta1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3408..3413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dll1"
                     /gene_synonym="Delta1"
                     /note="hexamer: AATAAA"
     regulatory      3412..3417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dll1"
                     /gene_synonym="Delta1"
                     /note="hexamer: AATATA"
     polyA_site      3425
                     /gene="Dll1"
                     /gene_synonym="Delta1"
     polyA_site      3428
                     /gene="Dll1"
                     /gene_synonym="Delta1"
                     /note="major polyA site"
ORIGIN      
        1 cttggcgata gtgcaagaga taccggtcta gaacactctg ggagcggcag cggctgccga
       61 gtgacgccgg gccgggaaac cagggcgcgc gccgcagtcc ttgccaccac cgttcccacc
      121 gcgcccctcg gggccccgga ttatcgcctc accggtggga tttccagacc gccgcttcct
      181 aataggcctg cgaaggaagc cactgcaagc tctcttggga attaagctga acatctgggc
      241 tctcttccct ctgtgtctta tctcctttct cctctttccc tccgcgaaga agcttaagac
      301 aaaaccagaa agcaggagac actcacctct ccgtggactg aaagccagac gaagaggaaa
      361 ccgaaagttg tcctttctca gtgcctcgta gagctcttgc cggggaccta gctgaaggca
      421 ccgcaccctc ctgaagcgac ctggccctga tagcacacct ggagccgaga gacgcctttc
      481 cgccagtact cctcgggtca tatagacttt cctggcatcc ctgggtcttt gaagaagaaa
      541 gaaaagagga tactctagga gagcaagggc gtccagcggt accatgggcc gtcggagcgc
      601 gctagccctt gccgtggtct ctgccctgct gtgccaggtc tggagctccg gcgtatttga
      661 gctgaagctg caggagttcg tcaacaagaa ggggctgctg gggaaccgca actgctgccg
      721 cgggggctct ggcccgcctt gcgcctgcag gaccttcttt cgcgtatgcc tcaagcacta
      781 ccaggccagc gtgtcaccgg agccaccctg cacctacggc agtgctgtca cgccagtgct
      841 gggtgtcgac tccttcagcc tgcctgatgg cgcaggcatc gaccccgcct tcagcaaccc
      901 catccgattc cccttcggct tcacctggcc aggtaccttc tctctgatca ttgaagccct
      961 ccatacagac tctcccgatg acctcgcaac agaaaaccca gaaagactca tcagccgcct
     1021 gaccacacag aggcacctca ctgtgggaga agaatggtct caggaccttc acagtagcgg
     1081 ccgcacagac ctccggtact cttaccggtt tgtgtgtgac gagcactact acggagaagg
     1141 ttgctctgtg ttctgccgac ctcgggatga cgcctttggc cacttcacct gcggggacag
     1201 aggggagaag atgtgcgacc ctggctggaa aggccagtac tgcactgacc caatctgtct
     1261 gccagggtgt gatgaccaac atggatactg tgacaaacca ggggagtgca agtgcagagt
     1321 tggctggcag ggccgctact gcgatgagtg catccgatac ccaggttgtc tccatggcac
     1381 ctgccagcaa ccctggcagt gtaactgcca ggaaggctgg gggggccttt tctgcaacca
     1441 agacctgaac tactgtactc accataagcc gtgcaggaat ggagccacct gcaccaacac
     1501 gggccagggg agctacacat gttcctgccg acctgggtat acaggtgcca actgtgagct
     1561 ggaagtagat gagtgtgctc ctagcccctg caagaacgga gcgagctgca cggaccttga
     1621 ggacagcttc tcttgcacct gccctcccgg cttctatggc aaggtctgtg agctgagcgc
     1681 catgacctgt gcagatggcc cttgcttcaa tggaggacga tgttcagata accctgacgg
     1741 aggctacacc tgccattgcc ccttgggctt ctctggcttc aactgtgaga agaagatgga
     1801 tctctgcggc tcttcccctt gttctaacgg tgccaagtgt gtggacctcg gcaactctta
     1861 cctgtgccgg tgccaggctg gcttctccgg gaggtactgc gaggacaatg tggatgactg
     1921 tgcctcctcc ccgtgtgcaa atgggggcac ctgccgggac agtgtgaacg acttctcctg
     1981 tacctgccca cctggctaca cgggcaagaa ctgcagcgcc cctgtcagca ggtgtgagca
     2041 tgcaccctgc cataatgggg ccacctgcca ccagaggggc cagcgctaca tgtgtgagtg
     2101 cgcccagggc tatggcggcc ccaactgcca gtttctgctc cctgagccac caccagggcc
     2161 catggtggtg gacctcagtg agaggcatat ggagagccag ggcgggccct tcccctgggt
     2221 ggccgtgtgt gccggggtgg tgcttgtcct cctgctgctg ctgggctgtg ctgctgtggt
     2281 ggtctgcgtc cggctgaagc tacagaaaca ccagcctcca cctgaaccct gtgggggaga
     2341 gacagaaacc atgaacaacc tagccaattg ccagcgcgag aaggacgttt ctgttagcat
     2401 cattggggct acccagatca agaacaccaa caagaaggcg gactttcacg gggaccatgg
     2461 agccgagaag agcagcttta aggtccgata ccccactgtg gactataacc tcgttcgaga
     2521 cctcaaggga gatgaagcca cggtcaggga tacacacagc aaacgtgaca ccaagtgcca
     2581 gtcacagagc tctgcaggag aagagaagat cgccccaaca cttaggggtg gggagattcc
     2641 tgacagaaaa aggccagagt ctgtctactc tacttcaaag gacaccaagt accagtcggt
     2701 gtatgttctg tctgcagaaa aggatgagtg tgttatagcg actgaggtgt aagatggaag
     2761 cgatgtggca aaattcccat ttctcttaaa taaaattcca aggatatagc cccgatgaat
     2821 gctgctgaga gaggaaggga gaggaaaccc agggactgct gctgagaacc aggttcaggc
     2881 gaagctggtt ctctcagagt tagcagaggc gcccgacact gccagcctag gctttggctg
     2941 ccgctggact gcctgctggt tgttcccatt gcactatgga cagttgcttt gaagagtata
     3001 tatttaaatg gacgagtgac ttgattcata taggaagcac gcactgccca cacgtctatc
     3061 ttggattact atgagccagt ctttccttga actagaaaca caactgcctt tattgtcctt
     3121 tttgatactg agatgtgttt ttttttttcc tagacgggaa aaagaaaacg tgtgttattt
     3181 ttttgggatt tgtaaaaata tttttcatga tatctgtaaa gcttgagtat tttgtgacgt
     3241 tcattttttt ataatttaaa ttttggtaaa tatgtacaaa ggcacttcgg gtctatgtga
     3301 ctatattttt ttgtatataa atgtatttat ggaatattgt gcaaatgtta tttgagtttt
     3361 ttactgtttt gttaatgaag aaattcattt taaaaatatt tttccaaaat aaatataatg
     3421 aactacaaaa aaaaaaaaaa aaaa
//
