LOCUS       NM_010052               4339 bp    mRNA    linear   ROD 11-APR-2023
DEFINITION  Mus musculus delta like non-canonical Notch ligand 1 (Dlk1),
            transcript variant 1, mRNA.
ACCESSION   NM_010052
VERSION     NM_010052.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4339)
  AUTHORS   Comerford SA, Hinnant EA, Chen Y and Hammer RE.
  TITLE     Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed
            bile duct development and loss of hepatocyte viability; a
            ribosomopathy-like phenotype that is partially p53-dependent
  JOURNAL   PLoS Genet 19 (1), e1010595 (2023)
   PUBMED   36656901
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4339)
  AUTHORS   Shen H, He T, Wang S, Hou L, Wei Y, Liu Y, Mo C, Zhao Z, You W, Guo
            H and Li B.
  TITLE     SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by
            facilitating PRDM16-PPARgamma complex
  JOURNAL   Theranostics 12 (18), 7699-7716 (2022)
   PUBMED   36451857
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4339)
  AUTHORS   Vu Hong A, Bourg N, Sanatine P, Poupiot J, Charton K, Gicquel E,
            Massourides E, Spinazzi M, Richard I and Israeli D.
  TITLE     Dlk1-Dio3 cluster miRNAs regulate mitochondrial functions in the
            dystrophic muscle in Duchenne muscular dystrophy
  JOURNAL   Life Sci Alliance 6 (1), e202201506 (2022)
   PUBMED   36265896
  REMARK    GeneRIF: Dlk1-Dio3 cluster miRNAs regulate mitochondrial functions
            in the dystrophic muscle in Duchenne muscular dystrophy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4339)
  AUTHORS   Angelozzi M, Pellegrino da Silva R, Gonzalez MV and Lefebvre V.
  TITLE     Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly
            proliferative, and myofibroblast-like osteodermal progenitors
  JOURNAL   Cell Rep 40 (2), 111045 (2022)
   PUBMED   35830813
REFERENCE   5  (bases 1 to 4339)
  AUTHORS   Kobayashi S, Wagatsuma H, Ono R, Ichikawa H, Yamazaki M, Tashiro H,
            Aisaka K, Miyoshi N, Kohda T, Ogura A, Ohki M, Kaneko-Ishino T and
            Ishino F.
  TITLE     Mouse Peg9/Dlk1 and human PEG9/DLK1 are paternally expressed
            imprinted genes closely located to the maternally expressed
            imprinted genes: mouse Meg3/Gtl2 and human MEG3
  JOURNAL   Genes Cells 5 (12), 1029-1037 (2000)
   PUBMED   11168589
  REMARK    GeneRIF: Dlk1 gene, like the human ortholog, is imprinted, with
            preferential expression from the paternal allele.
REFERENCE   6  (bases 1 to 4339)
  AUTHORS   Takada S, Tevendale M, Baker J, Georgiades P, Campbell E, Freeman
            T, Johnson MH, Paulsen M and Ferguson-Smith AC.
  TITLE     Delta-like and gtl2 are reciprocally expressed, differentially
            methylated linked imprinted genes on mouse chromosome 12
  JOURNAL   Curr Biol 10 (18), 1135-1138 (2000)
   PUBMED   10996796
  REMARK    GeneRIF: Meg3/Gtl2 and Dlk1/Peg9 genes are imprinted, with
            reciprocal expression from the maternal and paternal alleles,
            respectively.
REFERENCE   7  (bases 1 to 4339)
  AUTHORS   Lee YL, Helman L, Hoffman T and Laborda J.
  TITLE     dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the
            EGF-like superfamily. Identification of polymorphic variants of
            this RNA
  JOURNAL   Biochim Biophys Acta 1261 (2), 223-232 (1995)
   PUBMED   7711066
REFERENCE   8  (bases 1 to 4339)
  AUTHORS   Smas CM, Green D and Sul HS.
  TITLE     Structural characterization and alternate splicing of the gene
            encoding the preadipocyte EGF-like protein pref-1
  JOURNAL   Biochemistry 33 (31), 9257-9265 (1994)
   PUBMED   7519443
REFERENCE   9  (bases 1 to 4339)
  AUTHORS   Smas CM and Sul HS.
  TITLE     Pref-1, a protein containing EGF-like repeats, inhibits adipocyte
            differentiation
  JOURNAL   Cell 73 (4), 725-734 (1993)
   PUBMED   8500166
REFERENCE   10 (bases 1 to 4339)
  AUTHORS   Laborda J, Sausville EA, Hoffman T and Notario V.
  TITLE     dlk, a putative mammalian homeotic gene differentially expressed in
            small cell lung carcinoma and neuroendocrine tumor cell line
  JOURNAL   J Biol Chem 268 (6), 3817-3820 (1993)
   PUBMED   8095043
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK162458.1 and AC165954.3.
            
            [WARNING] On May 24, 2023 this sequence was replaced by
            NM_010052.6.
            
            On Jun 26, 2010 this sequence version replaced NM_010052.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162458.1, BC052159.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 11168589
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1622              AK162458.1         2-1623
            1623-4339           AC165954.3         20554-23270         c
FEATURES             Location/Qualifiers
     source          1..4339
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 60.17 cM"
     gene            1..4339
                     /gene="Dlk1"
                     /gene_synonym="DLK-1; DlkI; FA1; Ly107; Peg9; pG2; pref-1;
                     SCP1; ZOG"
                     /note="delta like non-canonical Notch ligand 1"
                     /db_xref="GeneID:13386"
                     /db_xref="MGI:MGI:94900"
     exon            1..272
                     /gene="Dlk1"
                     /gene_synonym="DLK-1; DlkI; FA1; Ly107; Peg9; pG2; pref-1;
                     SCP1; ZOG"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1363
                     /gene="Dlk1"
                     /gene_synonym="DLK-1; DlkI; FA1; Ly107; Peg9; pG2; pref-1;
                     SCP1; ZOG"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein delta homolog 1; fetal antigen 1;
                     preadipocyte factor 1; stromal cell derived protein 1;
                     adipocyte differentiation inhibitor protein; delta-like 1
                     homolog"
                     /codon_start=1
                     /product="protein delta homolog 1 isoform 1 precursor"
                     /protein_id="NP_034182.2"
                     /db_xref="CCDS:CCDS26168.1"
                     /db_xref="GeneID:13386"
                     /db_xref="MGI:MGI:94900"
                     /translation="MIATGALLRVLLLLLAFGHSTYGAECDPPCDPQYGFCEADNVCR
                     CHVGWEGPLCDKCVTAPGCVNGVCKEPWQCICKDGWDGKFCEIDVRACTSTPCANNGT
                     CVDLEKGQYECSCTPGFSGKDCQHKAGPCVINGSPCQHGGACVDDEGQASHASCLCPP
                     GFSGNFCEIVAATNSCTPNPCENDGVCTDIGGDFRCRCPAGFVDKTCSRPVSNCASGP
                     CQNGGTCLQHTQVSFECLCKPPFMGPTCAKKRGASPVQVTHLPSGYGLTYRLTPGVHE
                     LPVQQPEQHILKVSMKELNKSTPLLTEGQAICFTILGVLTSLVVLGTVAIVFLNKCET
                     WVSNLRYNHMLRKKKNLLLQYNSGEELAVNIIFPEKIDMTTFNKEAGDEEI"
     exon            273..336
                     /gene="Dlk1"
                     /gene_synonym="DLK-1; DlkI; FA1; Ly107; Peg9; pG2; pref-1;
                     SCP1; ZOG"
                     /inference="alignment:Splign:2.1.0"
     exon            337..467
                     /gene="Dlk1"
                     /gene_synonym="DLK-1; DlkI; FA1; Ly107; Peg9; pG2; pref-1;
                     SCP1; ZOG"
                     /inference="alignment:Splign:2.1.0"
     exon            468..609
                     /gene="Dlk1"
                     /gene_synonym="DLK-1; DlkI; FA1; Ly107; Peg9; pG2; pref-1;
                     SCP1; ZOG"
                     /inference="alignment:Splign:2.1.0"
     exon            610..4339
                     /gene="Dlk1"
                     /gene_synonym="DLK-1; DlkI; FA1; Ly107; Peg9; pG2; pref-1;
                     SCP1; ZOG"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacagtacga aaaggcggcg cgcgggccgc agcggcagct cctcggcagc cgcacttagc
       61 agcgtgcgcc ccggtgcaac cctggctttc ttcccgctgg acgcccgtgc ccccttcgtg
      121 gtccgcaacc agaagcccag cgcagccccc ggagcagccc ctgcaccgcc tccgctcccc
      181 ggaccgcgac ccaggccgcc ccgagatgat cgcgaccgga gccctcctgc gcgtcctctt
      241 gctcctgctg gctttcggcc acagcaccta tggggctgaa tgcgacccac cctgtgaccc
      301 ccagtatgga ttctgcgagg ctgacaatgt ctgcaggtgc catgttggct gggagggtcc
      361 cctctgtgac aagtgtgtaa ctgcccctgg ctgtgtcaat ggagtctgca aggaaccatg
      421 gcagtgcatc tgcaaggatg gctgggacgg gaaattctgc gaaatagacg ttcgggcttg
      481 cacctcaacc ccctgcgcca acaatggaac ttgcgtggac ctggagaaag gccagtacga
      541 atgctcctgc acacctgggt tctctggaaa ggactgccag cacaaggctg ggccctgcgt
      601 gatcaatggt tctccctgcc agcacggagg cgcctgcgtg gatgatgagg gccaggcctc
      661 gcatgcttcc tgcctgtgcc cccctggctt ctcaggcaac ttctgtgaga tcgtagccgc
      721 aaccaacagc tgtaccccta acccatgcga gaacgatggc gtctgcaccg acatcggggg
      781 tgacttccgt tgccgctgcc cagctggatt cgtcgacaag acctgcagcc gcccggtgag
      841 caactgcgcc agtggcccgt gccagaacgg gggcacctgc ctccagcaca cccaggtgag
      901 cttcgagtgt ctgtgcaagc ccccgttcat gggtcccacg tgcgcgaaga agcgcggggc
      961 tagccccgtg caggtcaccc acctgcccag cggctatggg ctcacctacc gcctgacccc
     1021 cggggtgcac gagctgcctg ttcagcagcc cgagcaacac atcctgaagg tgtccatgaa
     1081 agagctcaac aagagtaccc ctctcctcac cgagggacag gccatctgct tcaccatcct
     1141 gggcgtgctc accagcctgg tggtgctggg caccgtggcc atcgtctttc tcaacaagtg
     1201 cgaaacctgg gtgtccaacc tgcgctacaa ccacatgctt cgcaagaaga agaacctcct
     1261 gttgcagtat aacagcggcg aggagctggc ggtcaatatc atcttccccg agaagattga
     1321 catgaccact ttcaacaagg aggctggtga tgaggagatc taagcagcgt tccccacccc
     1381 cactcccagg cccttcaccc caccccaccc caggcccttc tctattaccg gggttcctta
     1441 gagctctcta cgcagtctgc gctttttgtg gtggagtttg ctctattgtg tggaatcgag
     1501 tgaacgctat gcttacatat attgtcttgt gttgctgtgt gccatgctac cacgctatct
     1561 aagaacccct tcctccctat taatgcatga taatgaataa taataataag aatttcatct
     1621 ctaaatgagt taaagaaata agtatgttat tctaaactct tatcaagtat caaatataaa
     1681 atatcaaaaa gaccaaaaaa aaacatggta acagaaccag gacttagtgc tgaggtccct
     1741 ctcctggggg gggtgtcagc caccaggtcc tcgtgaaacc ataagagtgt tgtgcttgac
     1801 cactcactgt gaaaagggct aaactctttc gttcgttaat tctcacgcac actcacatca
     1861 agtctcacac cgcaaccctt agatctttcc gattgattgt gactctgcag tgtgtagtgg
     1921 ctgtgtgcca ggcagagaga gaccccaggt tggctgctgg cagagaggtc gggacctagt
     1981 cctaacccag ctgcgcactc gctgtgtgac ccttggcgag attcccccac ctccaaccct
     2041 gggccacttc cccacccctc cccataaggg aggggtgcag acacccaaac accaaagtcc
     2101 tctctagctc ccaaattcag aattaggaac gatggatata taccaaaaca cttcttgact
     2161 ccaagagtag gacctgatgg agacttggtc tcatcctggg atccgaaagg ttttggccta
     2221 tcctggctgt acacttgata ttgacgtcga tcccgatagc gtttctcaaa atggggagcc
     2281 tcctggctca tgtccagttt gggaaaaatt ggccccttta ggtcaaaaat gtgccatttg
     2341 gtgttgcctc ttgagcaacc cattccctac cctagcccaa gactccacct catgcccctc
     2401 aaaccccacc ccatatctgc ccctcaccct gatgtagagt agagatgtgc tttcagactt
     2461 cagtgtacct cgaaccacaa gtgccccccc cccgggcaga atctgagtga gcaatgcagc
     2521 ccccaccaag gtttgcacag gctttagtga cactatggct tgtggggtgt tttcttgttc
     2581 tgtagcaaaa gcgggaaagc agctgtccac agccatggat gtacctttgt gtggctgaag
     2641 ttaggaccct cagatcccca aacacctagc cagcttctta agtagaattt tgacttattt
     2701 tttaaaagag catctatctt ttttttgcaa aacaaaacaa aaaaacaaaa caaaaaaaaa
     2761 gtagaaagaa atgggagaga gccctgtgta gctccctgac tcttgtttgg ggtctgggtg
     2821 ctacacagtc cttgggtccc cgttaggaat attttgcttc ttagattatt tgggtaggaa
     2881 cctatgctcc taagctttaa gtgtgagccg tgtttacctt gctctgagta cttgcttgca
     2941 agtcattgtc accgttgctg ttcgaatcat gatcacagca cacacttcat ggtcatcagc
     3001 cattggtcat acgcgtctcc gttgtcacac attatcgacc caatcacccc tccaacctct
     3061 accccaggtt catttcaccc aaagccctga ctcaaagaat ctctccccag ccattggtca
     3121 ttcattacct tcagcccaag ccccttccag tcccaccctg aaacccctcc cccatttggc
     3181 cccagcctca tcctgatgag ggtgtgtccc agctccccaa atctccacca cctcccatgt
     3241 ccctgcctcc tagcccctct tcccctggtt ccctccctcc ctccctccag gcccctcccc
     3301 tgcctcaatc agtcccgccc tgaggcaaac cagccccatc acaatcacct cattatccca
     3361 tctcattttg agttcatttt aagaaataaa atcgaaaaaa atttaaaaaa aaagtattga
     3421 catatgccag gagggtttct gatacccttc ctggcctctc agcgtgagac cttgaccgag
     3481 tctgcgaata attctgctcc tcggtttccc aatttggaat tctacaattg gacaaaacag
     3541 cctatttctc cacgccactt tttttttttt ttgatctccc tgttgtggag agcagccgtg
     3601 tctctgtgtc tctcctgata aagggggccc ggctgttctc ttagcaactc ctcctccatc
     3661 caaaagatcc atcatccacc atccatccag ccagggagtg tttccaagca cctgcagagt
     3721 gtaaggcagt gagtgttctt ggagctgtgg gatgtgcagg ccgaggggca tagtctggga
     3781 ggggagtaga catgcatgtg cccccaggaa gccaagcaca gggcaggcaa aaacccaaaa
     3841 ctccgtggaa gccggatggt ccagagcagg tgcctccctc agagtgccac cacctcacct
     3901 tccaacgtga ccaaagatca agaaaccaac atcaatgagg cggccccgtc aaaattccac
     3961 ggcatccacc cacacaacag gagcagcgtt tgcagtctca ccctggtctt cacgtccgca
     4021 gaaagggtcc atctgcgacc tcacgatatc tgctgagagc atcagatctc tggctgccca
     4081 tacacatctc ctgtgtttgg tgtagtgcag tgtacgcaac gggtggtgaa gctaaaagac
     4141 agctgtctgg gacattttca aactaatctg accccaaatt aaaagtggtg ataattctgt
     4201 aaccaaaatg tcaatgaaat gtccaccagg gcgctctttc tagcttcccc catatttttt
     4261 ctttggcagg caagtccaga cgcaatgcaa aaagaaacaa caaccttgtt tattgttaaa
     4321 taaaggaaca agggcttta
//
