LOCUS       NM_144553               2966 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus DLG associated protein 5 (Dlgap5), mRNA.
ACCESSION   NM_144553
VERSION     NM_144553.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2966)
  AUTHORS   Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, Laidlaw
            BJ, Araki K, Ahmed R, Kaech SM and Craft J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   2  (bases 1 to 2966)
  AUTHORS   Breuer M, Kolano A, Kwon M, Li CC, Tsai TF, Pellman D, Brunet S and
            Verlhac MH.
  TITLE     HURP permits MTOC sorting for robust meiotic spindle bipolarity,
            similar to extra centrosome clustering in cancer cells
  JOURNAL   J Cell Biol 191 (7), 1251-1260 (2010)
   PUBMED   21173113
  REMARK    GeneRIF: The process of bipolar spindle assembly in the presence of
            multiple MTOCs in female meiosis resembles the clustering of extra
            centrosomes during cancer cell division. HURP plays an essential
            role in both processes.
REFERENCE   3  (bases 1 to 2966)
  AUTHORS   Tsai CY, Chou CK, Yang CW, Lai YC, Liang CC, Chen CM and Tsai TF.
  TITLE     Hurp deficiency in mice leads to female infertility caused by an
            implantation defect
  JOURNAL   J Biol Chem 283 (39), 26302-26306 (2008)
   PUBMED   18676373
  REMARK    GeneRIF: HURP has an essential function in uterine biology
REFERENCE   4  (bases 1 to 2966)
  AUTHORS   Wang YC, Lee YH, Huang GC, Lin YH, Fan-Chiang MH, Chiu AW and Huang
            YL.
  TITLE     Enhanced transformation and chemosensitivity of NIH3T3 cells
            transduced with hepatoma up-regulated protein
  JOURNAL   Biochem Biophys Res Commun 340 (1), 244-249 (2006)
   PUBMED   16364248
  REMARK    GeneRIF: These results indicate that the HURP gene might be a
            potential oncogenic gene and capable of enhancing the
            chemosensitivity of deoxycytosine analogs in NIH3T3 cells.
REFERENCE   5  (bases 1 to 2966)
  AUTHORS   Tsou AP, Yang CW, Huang CY, Yu RC, Lee YC, Chang CW, Chen BR, Chung
            YF, Fann MJ, Chi CW, Chiu JH and Chou CK.
  TITLE     Identification of a novel cell cycle regulated gene, HURP,
            overexpressed in human hepatocellular carcinoma
  JOURNAL   Oncogene 22 (2), 298-307 (2003)
   PUBMED   12527899
  REMARK    GeneRIF: endogenous levels of HURP mRNA were found to be tightly
            regulated during cell cycle progression and in regenerating mouse
            liver after partial hepatectomy [HURP]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123665.9, AK085882.1 and AB076696.1.
            
            [WARNING] On Oct 7, 2023 this sequence was replaced by NM_144553.3.
            
            On Mar 21, 2009 this sequence version replaced NM_144553.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB076696.1, BC058087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               AC123665.9         81973-82271         c
            300-2783            AK085882.1         81-2564
            2784-2966           AB076696.1         2784-2966
FEATURES             Location/Qualifiers
     source          1..2966
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 24.6 cM"
     gene            1..2966
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /note="DLG associated protein 5"
                     /db_xref="GeneID:218977"
                     /db_xref="MGI:MGI:2183453"
     exon            1..299
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            300..535
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..2727
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /note="discs, large homolog-associated protein 5; hepatoma
                     up-regulated protein homolog; discs, large homolog 7"
                     /codon_start=1
                     /product="disks large-associated protein 5"
                     /protein_id="NP_653136.2"
                     /db_xref="CCDS:CCDS26987.1"
                     /db_xref="GeneID:218977"
                     /db_xref="MGI:MGI:2183453"
                     /translation="MLVSRFASRFRKDSSTEMVRTNLAHRKSLSQKENRHRVYERNRH
                     FGLKDVNIPLEGRELGNIHETSQDLSPEKASSKTRSVKMVLSDQRKQLLQKYKEEKQL
                     QKLKEQREKAKRGVFKVGLYRPAAPGFLVTDQRGAKAEPEKAFPHTGRITRSKTKEYM
                     EQTKIGSRNVPKATQSDQRQTSEKQPLDRERKVMQPVLFTSGKGTESAATQRAKLMAR
                     TVSSTTRKPVTRATNEKGSERMRPSGGRPAKKPEGKPDKVIPSKVERDEKHLDSQTRE
                     TSEMGPLGVFREVESLPATAPAQGKERKSFAPKHCVFQPPCGLKSYQVAPLSPRSANA
                     FLTPNCDWNQLRPEVFSTTTQDKANEILVQQGLESLTDRSKEHVLNQKGASTSDSNHA
                     SVKGVPCSEASEGQTSQPPHDVPYFRKILQSETDRLTSHCQEWEGKLDLDIPDEAKGL
                     IRTTVGQTRLLIKERFRQFEGLVDNCEYKRGEKETTCTDLDGFWDMVSFQVDDVNQKF
                     NNLIKLEASGWKDSNNPSKKVLRKKIVPGRTSKAKQDDDGRAAARSRLAAIKNAMKGR
                     PQQEVQAHAAAPENTKEVDKIVFDAGFFRIESPVKSFSVLSSERRSQRFGTPLSASKV
                     VPEGRAAGDLLRQKMPLKKPDPQSSKSEHVDRTFSDGLESRCHVEDTPCPGEQDSSDI
                     EHDVNKINVKMDCFSVETNLPLPAGDANTNQKEAISAVEGASSAVTSQDLLMSNPETN
                     TSSQSNTSQEEAEASQSVLLHKSLTSECHLLEPPGLSCTSPCTREETRQPDRSRQFSF
                     GGDLILFSPL"
     exon            536..729
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            730..792
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            793..877
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1000
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1071
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1346
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1426
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1553
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1639
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1800
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1893
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2113
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2294
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2352
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2572
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2619
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2964
                     /gene="Dlgap5"
                     /gene_synonym="Dap-5; Dlg7; Hurp; mKIAA0008"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtttatagt gtgtcgctgc cacgcctagc gggtttaccg cctccctcct ccccctcgcc
       61 ctcccgctcc caaccctttg ccttccaaac aatttaaatg tcgcacagaa ccaacctatc
      121 gcaagcctcg ttcgagggga aggggcggga gcttccggaa gtgttggcaa aagtccctcc
      181 aatcagcggc tggcagcggg aaatttcagt tccgtgaagg gtcggtccgg gagttccttc
      241 tgcggatcgg tggagttttc tgtgttgcga cattgttgtg gatccagaaa ctgcttcagg
      301 atgctggtgt cacgttttgc cagtcggttt cggaaagact cgagcactga gatggttaga
      361 accaacttgg ctcatagaaa gtctctgtct cagaaggaga acagacacag ggtgtatgag
      421 cgaaacagac acttcggttt gaaggacgtc aacattccac tggaagggcg agagcttggt
      481 aatatacacg agacatcgca agacctctct ccagagaagg ccagctccaa aacaaggtca
      541 gtaaaaatgg tcctgagtga ccaacggaag cagctcctcc agaagtacaa ggaagaaaaa
      601 caacttcaaa aactgaaaga acagcgagag aaagccaaac gtggagtgtt caaagtgggt
      661 ctctatagac ccgctgcgcc tggctttctt gtcacagacc agaggggtgc gaaagctgag
      721 ccagaaaagg cttttccaca tactggacgg attacaagat caaagaccaa agaatatatg
      781 gagcagacta agattggtag caggaatgtt cctaaagcaa cccagagtga ccaaagacaa
      841 acttctgaaa aacaaccatt agacagagag agaaaagtta tgcagcctgt gctgttcacg
      901 tcagggaaag ggactgaatc agcggctact cagagggcca agctgatggc ccgaacagtg
      961 tcatccacta caagaaagcc agtcacaaga gccacgaatg agaaaggatc agaaagaatg
     1021 agaccaagtg gagggagacc tgccaaaaaa ccagaaggca agccggacaa ggttattcct
     1081 tccaaagttg agcgggacga aaagcatttg gattcgcaga ccagggaaac aagtgaaatg
     1141 ggtccgctcg gagtcttccg agaagtggaa agcttgcctg caacagcccc tgcccaaggg
     1201 aaggaaagga agtcctttgc ccccaagcac tgtgtcttcc agcccccgtg tggtctgaag
     1261 agctaccagg tggctcccct gagccctaga agtgccaacg ctttcctgac acccaattgt
     1321 gattggaacc agttaagacc agaagttttt agcactacaa ctcaagacaa agcaaatgaa
     1381 atcttggtac agcaaggatt ggagtcgcta acagaccgta gtaaagaaca tgtcttaaat
     1441 cagaagggtg cttctacttc agattcaaat cacgcttctg tgaaaggagt cccatgctct
     1501 gaagcgagcg aaggccagac ctctcagccc ccccacgatg tgccatactt cagaaaaatc
     1561 ctccaatcag aaactgacag gctgacctcg cactgccagg agtgggaggg gaagctggac
     1621 ctggacatcc ctgatgaagc taaaggtctt atccgtacaa cggttggtca aacaagactc
     1681 cttatcaagg agagattcag acagtttgaa ggactggtgg acaactgcga gtataaacgg
     1741 ggtgaaaagg agacgacctg cacagatctg gatggattct gggatatggt tagttttcag
     1801 gtcgatgatg tgaaccagaa attcaacaac ctgatcaaac ttgaggcgtc aggatggaaa
     1861 gacagcaata atccaagcaa aaaagtcctc cggaaaaaaa ttgtgcccgg tagaacaagc
     1921 aaagcaaagc aggatgacga cggacgagcg gcagctagga gtcgccttgc agccataaag
     1981 aatgcaatga aaggcaggcc acagcaggaa gtgcaggccc acgcagcagc tccggagaac
     2041 acaaaggaag ttgacaaaat agtgtttgat gctgggtttt tcagaatcga gagcccagtg
     2101 aagtcattct cagtcctgtc ttctgaacgt cgttctcaaa gatttggaac acctctgtct
     2161 gccagcaaag ttgtgcctga gggcagggct gcaggggacc ttctgagaca gaagatgcca
     2221 ctgaagaagc cggaccctca gagcagcaag agcgagcatg ttgatcggac gttttcagat
     2281 ggtcttgaaa gcaggtgcca cgtagaagac accccctgtc ctggagagca agattcaagt
     2341 gacatagagc atgatgtaaa taaaataaat gtcaagatgg attgtttctc tgttgaaacg
     2401 aatttgcctc ttcctgctgg tgatgctaat accaatcaaa aagaagcaat ctcagctgtg
     2461 gaaggagcga gctctgcagt cacctcccag gatttgctga tgagcaaccc tgagacaaat
     2521 acctcctcac agagcaacac ctcacaagaa gaagctgagg cgtcgcagtc agtactgtta
     2581 cataaaagtc tcacttctga atgccacctt cttgaaccac caggcctcag ctgcaccagc
     2641 ccctgcactc gggaggagac cagacagcca gatcgcagca gacagttctc ctttggaggt
     2701 gacctcattc tcttctcacc actatgaccc tgaagggaac accaggaggg ctttaaattt
     2761 aacatgactt ttaatattaa tttaaataaa cattcagtgc tcgcctttaa tcccagcact
     2821 ccgggaggta gaggcaggcg gatttctgag ttcgaggcca gcctggtcta cagagtgagt
     2881 tccaggacag ccaggactat acagagaaac cctgtctcga aaaaccaaaa taaataaata
     2941 aataaataaa caaacaaaca aacaaa
//
