LOCUS       NM_001302081            4223 bp    mRNA    linear   ROD 04-OCT-2023
DEFINITION  Mus musculus DLG associated protein 3 (Dlgap3), transcript variant
            2, mRNA.
ACCESSION   NM_001302081 XM_006503103
VERSION     NM_001302081.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4223)
  AUTHORS   Gattuso JJ, Wilson C, Hannan AJ and Renoir T.
  TITLE     Acute administration of the NMDA receptor antagonists ketamine and
            MK-801 reveals dysregulation of glutamatergic signalling and
            sensorimotor gating in the Sapap3 knockout mouse model of
            compulsive-like behaviour
  JOURNAL   Neuropharmacology 239, 109689 (2023)
   PUBMED   37597609
REFERENCE   2  (bases 1 to 4223)
  AUTHORS   Soto JS, Jami-Alahmadi Y, Chacon J, Moye SL, Diaz-Castro B,
            Wohlschlegel JA and Khakh BS.
  TITLE     Astrocyte-neuron subproteomes and obsessive-compulsive disorder
            mechanisms
  JOURNAL   Nature 616 (7958), 764-773 (2023)
   PUBMED   37046092
REFERENCE   3  (bases 1 to 4223)
  AUTHORS   Kajs BL, van Roessel PJ, Davis GL, Williams LM, Rodriguez CI and
            Gunaydin LA.
  TITLE     Valence processing alterations in SAPAP3 knockout mice and human
            OCD
  JOURNAL   J Psychiatr Res 151, 657-666 (2022)
   PUBMED   35661523
  REMARK    GeneRIF: Valence processing alterations in SAPAP3 knockout mice and
            human OCD.
REFERENCE   4  (bases 1 to 4223)
  AUTHORS   Zhang Y, Wu J, Yan Y, Gu Y, Ma Y, Wang M, Zhang H, Tao K, Lu Y, Yu
            W, Jing W, Wang X and Tian X.
  TITLE     SAPAP3 regulates epileptic seizures involving GluN2A in
            post-synaptic densities
  JOURNAL   Cell Death Dis 13 (5), 437 (2022)
   PUBMED   35513389
  REMARK    GeneRIF: SAPAP3 regulates epileptic seizures involving GluN2A in
            post-synaptic densities.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4223)
  AUTHORS   Davis GL, Minerva AR, Lario A, Simmler LD, Rodriguez CI and
            Gunaydin LA.
  TITLE     Ketamine increases activity of a fronto-striatal projection that
            regulates compulsive behavior in SAPAP3 knockout mice
  JOURNAL   Nat Commun 12 (1), 6040 (2021)
   PUBMED   34654803
  REMARK    GeneRIF: Ketamine increases activity of a fronto-striatal
            projection that regulates compulsive behavior in SAPAP3 knockout
            mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4223)
  AUTHORS   Chua JJ, Schob C, Rehbein M, Gkogkas CG, Richter D and Kindler S.
  TITLE     Synthesis of two SAPAP3 isoforms from a single mRNA is mediated via
            alternative translational initiation
  JOURNAL   Sci Rep 2, 484 (2012)
   PUBMED   22761992
REFERENCE   7  (bases 1 to 4223)
  AUTHORS   Welch JM, Lu J, Rodriguiz RM, Trotta NC, Peca J, Ding JD, Feliciano
            C, Chen M, Adams JP, Luo J, Dudek SM, Weinberg RJ, Calakos N,
            Wetsel WC and Feng G.
  TITLE     Cortico-striatal synaptic defects and OCD-like behaviours in
            Sapap3-mutant mice
  JOURNAL   Nature 448 (7156), 894-900 (2007)
   PUBMED   17713528
REFERENCE   8  (bases 1 to 4223)
  AUTHORS   Willard MD, Willard FS, Li X, Cappell SD, Snider WD and Siderovski
            DP.
  TITLE     Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth
            factor-mediated differentiation
  JOURNAL   EMBO J 26 (8), 2029-2040 (2007)
   PUBMED   17380122
REFERENCE   9  (bases 1 to 4223)
  AUTHORS   Welch JM, Wang D and Feng G.
  TITLE     Differential mRNA expression and protein localization of the
            SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of
            the mouse
  JOURNAL   J Comp Neurol 472 (1), 24-39 (2004)
   PUBMED   15024750
REFERENCE   10 (bases 1 to 4223)
  AUTHORS   Yehiely F, Bamborough P, Da Costa M, Perry BJ, Thinakaran G, Cohen
            FE, Carlson GA and Prusiner SB.
  TITLE     Identification of candidate proteins binding to prion protein
  JOURNAL   Neurobiol Dis 3 (4), 339-355 (1997)
   PUBMED   9173930
  REMARK    Erratum:[Neurobiol Dis 2002 Jun;10(1):67-8]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158868.1 and AI850878.1.
            
            [WARNING] On Dec 8, 2023 this sequence was replaced by
            NM_001302081.2.
            
            On Sep 25, 2014 this sequence version replaced XM_006503103.1.
            
            Transcript Variant: This variant (2) has an alternate 5' UTR exon,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158868.1, SRR7974084.14274.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4206              AK158868.1         2-4207
            4207-4223           AI850878.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..4223
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 61.33 cM"
     gene            1..4223
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; DAP3; Prpl8; Sapap3"
                     /note="DLG associated protein 3"
                     /db_xref="GeneID:242667"
                     /db_xref="MGI:MGI:3039563"
     exon            1..485
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; DAP3; Prpl8; Sapap3"
                     /inference="alignment:Splign:2.1.0"
     exon            486..568
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; DAP3; Prpl8; Sapap3"
                     /inference="alignment:Splign:2.1.0"
     exon            569..1720
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; DAP3; Prpl8; Sapap3"
                     /inference="alignment:Splign:2.1.0"
     CDS             620..3553
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; DAP3; Prpl8; Sapap3"
                     /note="prion protein ligand 8; PSD-95/SAP90-binding
                     protein 3; SAP90/PSD 95 associated protein 3; discs, large
                     homolog-associated protein 3"
                     /codon_start=1
                     /product="disks large-associated protein 3"
                     /protein_id="NP_001289010.1"
                     /db_xref="CCDS:CCDS18665.1"
                     /db_xref="GeneID:242667"
                     /db_xref="MGI:MGI:3039563"
                     /translation="MRGYHGDRGSHPRPARFADQQHMDVGPAARAPYLLGSREAFSTE
                     PRFCAPRAGLGHLSPEGPLSLSEGPSSVGPEGGPGGVGAGGGSSTFPRMYPGQGPFDT
                     CEDCVGHPQGKGATRLPPTLLDQFEKQLPVQQDGFHTLPYQRGPAGPGPGPGSGAAPE
                     ARSESPSRIRHLVHSVQKLFAKSHSLEAPGKRDYNGPKADGRGSSGGDSYSGPGSGGT
                     PTSHHHHHHHHHHHHQSRHGKRSKSKDRKGDGRHQTKATGWWSSDDNLDSDSGFLGGR
                     PPGEPGGPFCLDAPDGSYRDLSFKGRSGGSEGRCLACTGMSMSLDGQSVKRSAWHTMM
                     VSQGRDGYPGAGPGKGLLGPETKAKARTYHYLQVPQDDWGGYPTGGKDGEIPCRRMRS
                     GSYIKAMGDEESGDSDGSPKTSPKALARRFASRRSSSVDTARINCCVPPRIHPRSSIP
                     GYSRSLTTGQLSEEFNQQLEAVCGSVFGELESQAVDALDLPGCFRMRSHSYLRAIQAG
                     CSQDDDCLPLLAAPASVSGRPGSSFNFRKAPPPIPPGSQAPPRISITAQSSTDSAHES
                     FTAAEGPARRCSSADGLDGPTMGARTLELAPVPPRASPKPPTLIIKTIPGREELRSLA
                     RQRKWRPSIGVQVETISDSDTENRSRREFHSIGVQVEEDKRRARFKRSNSVTAGVQAD
                     LELEGLAGLATVATEDKALQFGRSFQRHASEPQPGPRAPTYSVFRTVHTQGQWAYREG
                     YPLPYEPPATDGSPGPTPVPAPGPGSGRRDSWMERGSRSLPDSGRTSPCPRDGEWFIK
                     MLRAEVEKLEHWCQQMEREAEDYELPEEILEKIRSAVGSTQLLLSQKVQQFFRLCQQS
                     LDPTAFPVPTFQDLAGFWDLLQLSIEDVTLKFLELQQLKANSWKLLEPKEEKKVPPPI
                     PKKPSRGRGVPVKERSLDSVDRQRQEARKRLLAAKRAASFRHSSATESADSIEIYIPE
                     AQTRL"
     exon            1721..1926
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; DAP3; Prpl8; Sapap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..1999
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; DAP3; Prpl8; Sapap3"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2213
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; DAP3; Prpl8; Sapap3"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2527
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; DAP3; Prpl8; Sapap3"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2613
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; DAP3; Prpl8; Sapap3"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..3098
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; DAP3; Prpl8; Sapap3"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3190
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; DAP3; Prpl8; Sapap3"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3334
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; DAP3; Prpl8; Sapap3"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..4207
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; DAP3; Prpl8; Sapap3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttaacaaag ggacagaatg ggcccagggt tcttcttcct tccagtccag agctcagtat
       61 gggagtgggc tgggggtggt gatacaggga atccaagctc tcagctttcc aagtcttctg
      121 cctccgtgcc ctttgagctc aggtagcccc tgcccccctc cccctgctct ctgttctttc
      181 tcatcctctc ctcttcctgt gtgtaaatat taaaaagctg agcctgcagg gctgatgtag
      241 acatggggag agaatgaaat taaaaaggat tccctcgccc ccatcccaac acccccgccc
      301 tgcagtcccc cgctcctgtt tcttcccctc tcttttcccc tcactcagta gttccacatg
      361 cctctcctcc ccccagtcca gatgggagct ggctccttca gaaagggggt tcaggacagg
      421 gtgtggggag ctacctcttc cttcctcctc ccagcacatc tgcctacagg gctgagagcc
      481 cccacgagcc agtggtcctg cgcctgctga agttaggatt ctgcctggtg gtggggatcc
      541 tgacatcaag gatgggacac cccggatgga ggttcctggg gcctggcccc caacaatatg
      601 aagagccttt gctgaggcca tgaggggtta ccatggcgac cgaggcagcc atccccgccc
      661 agcccgcttt gctgaccaac agcatatgga cgtgggccca gctgccaggg ccccgtacct
      721 gctgggctcc agggaggcct tctccaccga gccccgcttc tgtgctccga gagctggcct
      781 gggacacctt tctccagaag gacccctgag cctgagtgag ggtccatcat cagtaggccc
      841 tgagggaggc ccaggggggg tgggggctgg gggaggcagc agtaccttcc ccaggatgta
      901 ccccggccag ggccccttcg acacctgtga agactgtgtg ggccacccac agggcaaggg
      961 tgccacccga ctgcctccca cactcctgga ccagtttgaa aagcaattgc cagtccaaca
     1021 agatggcttc cacacactcc cataccagcg aggtccagca gggcctggtc ctggacctgg
     1081 atctggcgct gcccccgagg ctcgcagcga gagtcctagc cgcatccggc acctggttca
     1141 ctcagtgcag aagctctttg ccaagtccca ctctctggag gcacccggga agcgagacta
     1201 taacgggccc aaggccgacg gaagaggtag ctctggggga gacagctact ctggtccagg
     1261 ctctggaggc acccccacct cccaccacca ccatcaccac caccatcacc accaccacca
     1321 gtcccggcat ggcaaacgga gcaagagcaa ggaccgcaag ggggatgggc gacaccagac
     1381 caaggccaca ggctggtgga gctctgatga caatttggac agtgacagtg gctttctggg
     1441 tgggagacct cctggagagc ctggtggccc cttctgcctg gatgctccag atgggtccta
     1501 cagggacttg agcttcaagg ggcgttcggg cgggtcggaa ggccgctgcc ttgcctgcac
     1561 tggcatgtcc atgtccctgg atggacagtc agtcaagcga agtgcctggc ataccatgat
     1621 ggtcagccag ggccgggatg gatacccagg ggccgggcca ggcaaggggc tcctgggtcc
     1681 agagaccaag gccaaagcca ggacttatca ctatttgcag gtgccgcaag atgactgggg
     1741 gggttacccc acgggtggca aggatgggga gatcccctgc cgcaggatgc ggagcggcag
     1801 ctacatcaaa gccatggggg atgaggagag tggagactca gatggtagcc ccaagacgtc
     1861 tccaaaagca cttgcccgac gctttgcctc ccgccgttcc tccagcgtgg acacagccag
     1921 gatcaactgc tgtgtcccac cccggatcca tccccggagt tccatccctg gctacagccg
     1981 ttccctcaca actggacagc taagcgaaga gtttaaccag cagctggagg ccgtgtgcgg
     2041 gtccgtgttt ggggagcttg agtcccaggc cgtggacgcc ctggacctgc ccggctgttt
     2101 ccgcatgcgg agccacagct acctccgggc catccaggcc ggctgctctc aagacgacga
     2161 ctgcctaccc ctccttgctg cccctgcctc tgtctcaggg aggcccggct cctccttcaa
     2221 cttcagaaag gccccgcccc ccatcccgcc gggaagccag gccccacccc gcatctccat
     2281 caccgcccag agcagcaccg actctgccca cgagagcttc accgcagcag agggcccggc
     2341 ccggcgctgc agctccgcgg acgggctgga cggccccacc atgggcgcac gcaccctcga
     2401 gttggcaccg gtgccacccc gagccagtcc caagcccccc acactcatca tcaagaccat
     2461 ccctggccgg gaggagctgc ggagcttggc acgacagcgg aagtggcggc cgtccattgg
     2521 ggtgcaggtg gagacaatct cagactcgga caccgagaac aggagtcgaa gagaattcca
     2581 ctccattggc gttcaggtgg aagaggacaa gaggcgggcg aggttcaagc gctccaacag
     2641 cgtgacagcc ggtgtgcagg cagacctgga gctggagggc ctggccggcc tggccactgt
     2701 ggccacagaa gacaaggccc tgcagttcgg acgctccttc cagaggcacg cctctgagcc
     2761 ccagcccggc cctcgggccc ccacctactc agtcttccgc acggtccaca cacagggcca
     2821 gtgggcctac cgcgagggct acccactgcc gtatgagccg ccggccaccg atgggtcgcc
     2881 tggccctacc cctgtcccag cccccggtcc cgggtccggc cgccgtgatt cctggatgga
     2941 gcggggttca cgtagcctcc ccgactcagg ccgcacgtcc ccctgcccac gggatggcga
     3001 gtggttcatc aagatgctgc gggcagaggt ggagaaactg gaacactggt gccagcagat
     3061 ggagcgtgag gcggaggact atgagctgcc cgaggagatc ttagagaaga ttcgcagtgc
     3121 cgtgggcagt acgcaacttc tcctgtctca gaaggtccag cagttcttca ggctgtgtca
     3181 gcaaagcttg gaccccactg cgttccctgt gcccaccttc caggacctgg ccggtttctg
     3241 ggacctcctg cagctctcca ttgaggatgt gaccctcaag ttcctggaac tacaacaact
     3301 caaggccaac agctggaaac tcctggagcc gaaggaggag aagaaggtcc ctccgccgat
     3361 accaaagaag ccctcgcggg ggcggggcgt gccggtgaag gagcgctccc tggactcggt
     3421 ggaccggcag cggcaggaag cgcgcaagcg gctcctggcg gccaagcgcg ccgcctcgtt
     3481 ccgccacagt tcggctaccg agagcgcgga cagcatcgag atctacatcc ccgaggccca
     3541 gaccaggctg tgacccgccc gggccgccca gtccgacccg ggcccgcggt tttctacccg
     3601 tactgtacac ccagcgtcga ggtcactgtg aacgcgggca gctccgtgcg cccgccctgc
     3661 cggcaccgca cgccccggct tctgcccgcc gcgctttcgt gggtttttta ccttcctgat
     3721 cccacgcaaa ggcgcccggg ctaggctggg ggtcgtgcct ctccgccctg cgcccctcac
     3781 ttggaactcc catcttcctg gtccgacgct ttgaccccct cacctttttc cccccatggg
     3841 caccatctct gccattattt tacccctcca cgggccaggc cgggccgggt cccccatctg
     3901 ggctctgcgt cccccccaca ccccgcgggg ctgggcttcg tggggatcaa gcttcgtggc
     3961 tttttatgaa gaatcccgaa ccccgcctag gagcccgccc caccttccca gggctccacc
     4021 ctcagccctc tgcccacagg gcccagggac cacagtggct ggaccaatcc aggaccaggg
     4081 cgcctgggcc tctccccttt cccacatctg gggaggggag acaggggctt tccctcacca
     4141 cacctgtggc tgttcccaca tccctttgag tatcccagga aaaataaaac cgcagaactg
     4201 caccggaaaa aaaaaaaaaa aaa
//
