LOCUS       NM_177639               6323 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DLG associated protein 1 (Dlgap1), transcript variant
            1, mRNA.
ACCESSION   NM_177639 XM_484660
VERSION     NM_177639.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6323)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6323)
  AUTHORS   Baud,A., Casale,F.P., Barkley-Levenson,A.M., Farhadi,N.,
            Montillot,C., Yalcin,B., Nicod,J., Palmer,A.A. and Stegle,O.
  TITLE     Dissecting indirect genetic effects from peers in laboratory mice
  JOURNAL   Genome Biol 22 (1), 216 (2021)
   PUBMED   34311762
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6323)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6323)
  AUTHORS   Horner,A.E., Norris,R.H., McLaren-Jones,R., Alexander,L.,
            Komiyama,N.H., Grant,S.G.N., Nithianantharajah,J. and
            Kopanitsa,M.V.
  TITLE     Learning and reaction times in mouse touchscreen tests are
            differentially impacted by mutations in genes encoding postsynaptic
            interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2
  JOURNAL   Genes Brain Behav 20 (1), e12723 (2021)
   PUBMED   33347690
  REMARK    GeneRIF: Learning and reaction times in mouse touchscreen tests are
            differentially impacted by mutations in genes encoding postsynaptic
            interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.
REFERENCE   5  (bases 1 to 6323)
  AUTHORS   Zhang,J., Yang,J., Yang,N., Ma,J., Lu,D., Dong,Y., Liang,H., Liu,D.
            and Cang,M.
  TITLE     Dlgap1 negatively regulates browning of white fat cells through
            effects on cell proliferation and apoptosis
  JOURNAL   Lipids Health Dis 19 (1), 39 (2020)
   PUBMED   32169116
  REMARK    GeneRIF: Dlgap1 negatively regulates browning of white fat cells
            through effects on cell proliferation and apoptosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6323)
  AUTHORS   Welch,J.M., Wang,D. and Feng,G.
  TITLE     Differential mRNA expression and protein localization of the
            SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of
            the mouse
  JOURNAL   J Comp Neurol 472 (1), 24-39 (2004)
   PUBMED   15024750
REFERENCE   7  (bases 1 to 6323)
  AUTHORS   Parker,M.J., Zhao,S., Bredt,D.S., Sanes,J.R. and Feng,G.
  TITLE     PSD93 regulates synaptic stability at neuronal cholinergic synapses
  JOURNAL   J Neurosci 24 (2), 378-388 (2004)
   PUBMED   14724236
REFERENCE   8  (bases 1 to 6323)
  AUTHORS   Ehlers,M.D.
  TITLE     Synapse structure: glutamate receptors connected by the shanks
  JOURNAL   Curr Biol 9 (22), R848-R850 (1999)
   PUBMED   10574750
  REMARK    Review article
REFERENCE   9  (bases 1 to 6323)
  AUTHORS   Serpinskaya,A.S., Feng,G., Sanes,J.R. and Craig,A.M.
  TITLE     Synapse formation by hippocampal neurons from agrin-deficient mice
  JOURNAL   Dev Biol 205 (1), 65-78 (1999)
   PUBMED   9882498
REFERENCE   10 (bases 1 to 6323)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154769.2, AC163902.2 and AC079441.37.
            
            On Jun 7, 2008 this sequence version replaced NM_177639.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC154769.2         20407-20503
            98-1140             AC154769.2         111569-112611
            1141-1355           AC163902.2         117790-118004       c
            1356-1533           AC163902.2         53540-53717         c
            1534-1774           AC163902.2         48362-48602         c
            1775-1804           AC079441.37        90132-90161
            1805-2175           AC079441.37        133011-133381
            2176-2267           AC079441.37        137934-138025
            2268-2689           AC079441.37        158724-159145
            2690-2781           AC079441.37        181124-181215
            2782-2934           AC079441.37        187130-187282
            2935-6323           AC079441.37        189961-193349
FEATURES             Location/Qualifiers
     source          1..6323
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 40.85 cM"
     gene            1..6323
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /note="DLG associated protein 1"
                     /db_xref="GeneID:224997"
                     /db_xref="MGI:MGI:1346065"
     exon            1..97
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /inference="alignment:Splign:2.1.0"
     exon            98..1140
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..3144
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /note="isoform 1 is encoded by transcript variant 1; disks
                     large-associated protein 1; SAP90/PSD-95 associated
                     protein 1; PSD-95/SAP90-binding protein 1; guanylate
                     kinase-associated protein; DAP-1 beta; discs, large
                     homolog-associated protein 1"
                     /codon_start=1
                     /product="disks large-associated protein 1 isoform 1"
                     /protein_id="NP_808307.2"
                     /db_xref="CCDS:CCDS28953.1"
                     /db_xref="GeneID:224997"
                     /db_xref="MGI:MGI:1346065"
                     /translation="MKGLSGSRSHHHGITCEAACDSLSHHSDHKPYLLSPVDHHPADH
                     PYYTQRNSFQAECVGPFSDPLASSTFPRRHYTSQQELKDESALVPRTLATKANRLPTN
                     LLDQFERQLPLSRDGYHTLQYKRTAVEHRSDSPGRIRHLVHSVQKLFTKSHSLEGPSK
                     GSVNGGKASPDESQTLRYGKRSKSKERRSESKARSNASNASPTSPSWWSSDDNLDGDM
                     CLYHTPSGVMTMGRCPDRSASQYFMEAYNTISEQAVKASRSNNDIKCSTCANLPVTLD
                     APLLKKSAWSSTLTVSRAREVYQKASVNMDQAMVKSEACQQERSCQYLQVPQDEWSGY
                     TPRGKDDEIPCRRMRSGSYIKAMGDEDSGDSDTSPKPSPKVAARRESYLKATQPSLTE
                     LTTLKISNEHSPKLQIRSHSYLRAVSEVSINRSLDSLDPAGLLTSPKFRSRNESYMRA
                     MSTISQVSEMEVNGQFESVCESVFSELESQAVEALDLPLPGCFRMRSHSYVRAIEKGC
                     SQDDECVSLRSSSPPRTTTTVRTIQSSTGVIKLSSAVEVSSCITTYKKTPPPVPPRTT
                     TKPFISITAQSSTESAQDAYMDGQGQRGDMISQSGLSNSTESLDSMKALTAAIEAANA
                     QIHGPASQHMGSNAAAVTTTTTIATVTTEDRKKDFKKNRCLSIGIQVDDAEEPEKMAE
                     SKTSNKFQSVGVQVEEEKCFRRFTRSNSVTTAVQADLDFHDNLENSLESIEDNSCPGP
                     MARQFSRDASTSTVSIQGSGNHYHACAADDDFDTDFDPSILPPPDPWIDSITEDPLEA
                     VQRSVCHRDGHWFLKLLQAERDRMEGWCKLMEREERENNLPEDILGKIRTAVGSAQLL
                     MAQKFYQFRELCEENLNPNAHPRPTSQDLAGFWDMLQLSIENISMKFDELHQLKANNW
                     KQMDPLDKKERRAPPPVPKKPAKGPAPLIRERSLESSQRQEARKRLMAAKRAASVRQN
                     SATESAESIEIYIPEAQTRL"
     exon            1141..1355
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1533
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1774
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1804
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..2175
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2267
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2689
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2781
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2934
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..6323
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4292..4297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /note="hexamer: AATAAA"
     polyA_site      4312
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /note="major polyA site"
     polyA_site      4623
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
     regulatory      6297..6302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
                     /note="hexamer: AATAAA"
     polyA_site      6314
                     /gene="Dlgap1"
                     /gene_synonym="4933422O14Rik; 9630002F18; D17Bwg0511e;
                     Gkap; GKAP/SAPAP; GKPA/SAPAP; mKIAA4162; Sapap1"
ORIGIN      
        1 acaggttaca tctgctctgg gacttgctga atgtcacctg aaggcccctg tgtctgcttc
       61 agagagctcc tgttgaatga caaagccgct aagagcagtc tttgcccaag aagggtctgg
      121 aacttaacgg ggttcccatg accctgggat tgcttccagt cagcaatgaa agggttatcg
      181 ggtagccgca gccaccacca tgggatcacc tgcgaggcgg cctgtgactc cttgtcacac
      241 cactcagacc acaagccgta cctgctgagc cccgtagacc accaccctgc ggaccatccc
      301 tactacaccc agcggaattc tttccaggcc gagtgcgtag ggcccttcag cgacccgctg
      361 gccagcagca ccttcccgcg caggcactac acctcgcagc aggagctgaa ggacgagagt
      421 gccctggtac cacgcaccct ggccaccaag gcgaatcgtc tccccaccaa cctgctggat
      481 cagtttgaga ggcagctgcc cctcagccgg gatggctatc acacgctaca gtacaagcgc
      541 accgctgtgg agcatcgcag cgatagcccc ggccgcatcc ggcacctggt ccactcggtc
      601 cagaagctct ttactaagtc tcattccctg gaggggccat ccaaaggcag cgtcaacggg
      661 ggcaaggcta gccctgacga gtcgcaaact ctgagatatg gcaagcgcag caagagcaag
      721 gagaggcgat cagaatccaa ggctagatcc aatgcttcta acgcctcccc cacctctccc
      781 agttggtgga gttcagatga caacctggat ggtgacatgt gcctctacca cacgccctcg
      841 ggtgtgatga ccatgggcag gtgtcctgac cgctccgctt cgcagtactt catggaagcc
      901 tacaacacca tcagcgagca ggcagtgaag gcttcccgga gtaacaatga catcaagtgc
      961 tccacctgtg ccaacctgcc agtcacgctg gatgccccgc ttctgaagaa gagtgcctgg
     1021 tcctccactc tcaccgtgag cagagcccga gaggtttatc agaaagcctc ggtgaacatg
     1081 gatcaggcca tggtgaagtc cgaagcttgt caacaagagc ggtcctgcca gtacttacag
     1141 gttccccagg atgaatggtc agggtacaca cctcgcggga aagacgacga gatcccgtgc
     1201 cggaggatgc gcagtggtag ctacatcaaa gccatggggg atgaagacag tggggactcg
     1261 gacacgagcc ccaagccgtc tcccaaggtg gctgcaagaa gagaaagcta tctcaaggcc
     1321 acgcagccgt cccttacaga gctcaccact ctcaagatct ccaatgaaca ctcccccaaa
     1381 ctccagatcc ggagtcacag ctacctgagg gccgtaagtg aagtctccat caacagaagc
     1441 ctggacagcc tggaccctgc aggcttgctc acgtcaccaa agttccgctc cagaaacgag
     1501 agctacatgc gcgccatgag caccataagt caggtgagcg agatggaggt gaacggccag
     1561 ttcgaatccg tgtgcgagtc tgtgttcagc gagctggagt cgcaggcggt ggaagcgctg
     1621 gacctgcccc tgcctggctg cttccgcatg cggagccaca gctatgtgcg ggccatcgaa
     1681 aagggctgct cccaggacga cgaatgcgtg tcgctgcggt cgtcctcccc tccacgcaca
     1741 accaccaccg tgaggaccat ccagagcagc accggtgtca taaaactgag ttctgccgtt
     1801 gaagtgtcat cttgcattac aacatataag aagacaccac ctccagtccc acccagaact
     1861 accacgaaac ctttcatttc tatcacagcc cagagtagca cagagtctgc gcaggatgcc
     1921 tacatggacg ggcaaggcca gcgcggagac atgatcagcc agtctggcct cagcaactcc
     1981 accgaaagtc tggacagtat gaaggctctc acggctgcca tcgaggctgc aaacgcccag
     2041 attcacggcc cagcaagtca acatatgggc agcaatgctg ctgctgtcac caccaccacc
     2101 accatagcca ctgtcaccac cgaggatagg aagaaagact ttaagaaaaa ccgatgtctg
     2161 tctattggga tacaggtgga cgatgccgaa gagccggaga aaatggcaga gagtaagacg
     2221 tccaataagt tccagtccgt gggagtgcaa gtagaagaag agaagtgctt ccgcaggttc
     2281 actcggtcca acagtgtgac aactgcagta caggccgacc tggacttcca tgataatctg
     2341 gaaaattctc tggagtctat agaggacaat tcgtgtcctg gccccatggc cagacagttc
     2401 tcgcgggacg ccagcacctc taccgtcagt atccagggtt caggaaacca ctatcatgcc
     2461 tgtgcagccg atgacgactt tgacacggat tttgacccct ctatcctgcc tcctccggac
     2521 ccctggattg actctatcac agaagaccct ctggaggccg ttcaaaggtc cgtgtgccac
     2581 cgggacggcc actggttcct gaagcttctc caggcagagc gggaccgcat ggaagggtgg
     2641 tgcaagctaa tggagagaga agagagggag aacaacctcc cagaagacat tctagggaaa
     2701 atccgaaccg cggtgggcag tgcccaactt ctcatggcgc agaaattcta ccagttcaga
     2761 gaactgtgtg aagagaacct gaatcccaat gctcacccga gacccacttc ccaggacttg
     2821 gcggggtttt gggacatgct gcagttgtcc atagagaata ttagtatgaa atttgatgaa
     2881 cttcatcagc taaaggccaa taattggaaa cagatggatc ctcttgacaa gaaggagcga
     2941 agggcccctc ctccagtgcc aaagaagccg gcgaagggcc ccgcgccgct gatccgggag
     3001 cgctcgctgg agagctcgca gcgccaggag gcccgcaagc gcctgatggc cgccaagcgc
     3061 gccgcgtcgg tccgccagaa ctcggccacc gagagcgccg agagcatcga gatctacatc
     3121 cccgaggcgc agacccggct ctgaacgccg ccgaggaccg tcccgcatcc ctgccctcgg
     3181 ccacctcccc gccccctccg tctctgagct cagtgacagc caccgccgtg gcgtagttgt
     3241 ccacctcgca ggagccgtcc ccaggccgcc ccgcttcctg gaccactttg cccatcttct
     3301 ccaccgagct tcgctccccc cgtcctgaag cctcatgcag acatccaaac cctttatttt
     3361 ctgggccaag caaacccacc tatgtagaaa acgacacctg taggtcactc acatcctcct
     3421 cagttctctc aagctagtgt gtccctagaa ttcagcaata taaaaccata gggtatttca
     3481 gaaacccagt atcacatagg gtgatccttt gggacttacc gtcttccatg tgaaagaaac
     3541 gagggctcca actcccttta tttgccccca aacagttact ttttacaaac agagagcgct
     3601 ttatttctaa tctcagaaat cacaccatct cattggaatc aaggtgacag agtggggacc
     3661 aagttggcct agggttgggg ggcctgggtg tgtaagagag aagggcggag tgcgcaggta
     3721 cctgcatctg tgccctccct cgcagctgta caaactgcct cactggtact tcatcaacca
     3781 agcttcaaat gtttcaatca gcagaagatt gtaaattcga tctttcaggg aaatcaatct
     3841 attctgaaag gcaataaaag gaagaaagtt aaggcaaaag ggaaataaat accggtgggt
     3901 taagatcctc tgtaaggaat ccatttattt accttaagaa aatttagaac tgaaatgtgt
     3961 ttttttttta aatcaacttt tcttgtactc tatgtattat aatgtcatgg caatggtttt
     4021 taaatgggag ggtgggaaag agttggttct gtcagtttag tgtccatcct ggtggggcca
     4081 cttaaggttt cacacacgga agaacgtttc tgcttctgag gggcggcaag gacaatgcca
     4141 gaggagagtt cgggttctcc gccacccttt gaatgccaca cctgtctagt tcacatttcc
     4201 cgggggcgtt ttctcctttg gtttcctttc actccaatac agagttcacc tgttccccag
     4261 cacaggattt tgttctatgt caaatgaata aaataaaagg ttttctaccc cagttgacac
     4321 gctgcctcat tcccaagagc tgtcgttgtg atcctgaagt tccaggtagt gagagaagtc
     4381 atttgagacg caggggtcaa gaacaaggag gcggcagggc aggcggcatt cataaacgct
     4441 gatagaaagc caaatctttg ggtggattcc aggctggttg ttggcttgca atttagtcgt
     4501 cattgatggg ctgtgtgtcc tagcttccag ctgaagtctt caaatgccct ttacttgcag
     4561 cagtttaaac attcagaatg tggctatctg aaaagatcag ctggcaacct aaagaattag
     4621 aaatttgtca taggaaaaaa aaaaaaaaaa cgaaagactt aaaagaaaaa aaaaatgctt
     4681 gtatcagaga tgcttaaaaa aaaaaaaaaa gaaacaacca aacaaaaaaa agaaacaaaa
     4741 caaacaaaaa ccactctcat agccaggtgc taatttaatt ttctttatga aattaaaaga
     4801 agggatgggt tctggcaacc agtattttca gacatattct aaaaccacta gagaatttgc
     4861 tacctctcag agccatcgaa gctttgaggt tcctttctca acagggcaca aatgtttact
     4921 gctgtggttt acaagaaaag ggctataact tactttaaaa aacaaaacca acaactttta
     4981 actagggcaa agtcagcgct gtgtcaaatt ggagcagaga tttgactcaa gtatttgcta
     5041 gtttaaaaaa aaaaaaaaga cacgttttct ttacagtgga gcagcaatgt aagatcagaa
     5101 gtatttggga gtaaggccaa ctttcacctt gggtagccca tggtcacact gattcaagaa
     5161 agatgtggca ttcacagaac gcagcgttca ttctggtcca ttctggtccc actttgcccc
     5221 actcatgcat tactgcagct ccttgccctg agatagcgct gaggtcagtt tctggtggga
     5281 ttccagatcc tctgacaatg ttttccttgg ggactgattt agcccaggct attttaaaga
     5341 gagacaagag aaggcctatt tatcttgtcc aagtgaacgg catttgtata ttcataagct
     5401 atttttggta agaattttaa atctcttagc tgaatgcctg cagggcatca gaacctttgc
     5461 cttcctgaga aacacagttt aaactgtaca ctttattaaa aaaaataaaa aagcgaatta
     5521 ttgatattag gacatgaccc acacacgata cagcctgtta cccactggaa cccggaaact
     5581 gacagcagga acataacttt tgttgcgttc ttctttttga tgtaatttgt agagatgttt
     5641 tttagttcat aatgaacagt gtatgtaccc tcaaaaatta cttattttgt ttaactttgg
     5701 tataaaggtg ttgggcattt tcttggggcg ggggggaaat tacaaaagag gtttgtctcc
     5761 ctcatcaaaa acaacaacaa aaatacattc aaagaaatca agtatttatt atattttttg
     5821 cagatgtttc catacaattc acataacctt tttgtaaaga gagatgaaga aatggattaa
     5881 agatttttaa tatttgaaat ggtaaataga actaatttat ttgtaatata tttctgttat
     5941 ttatagatgt tcccttaatg tttttctgtg aagtactgct ttaatttaag ccctatcctt
     6001 gtgaatttac catttctttt tttaagaaca tgtctagatg catattttaa ataactggaa
     6061 tgtaaatcat cagcatatct gaattcccta atgtaatttt taaaaattaa tttggtttgg
     6121 ggaaaaaaag attcatttga aagccttcag atggatgggg tagggaagat ttttatggct
     6181 ttctgaattg gaatttcata ggcttattta cctagattgt gtgtggacaa aaaaataaat
     6241 aaaaataaca acctgtaaat agatgaacgt ttcccatcat gtaaaaagaa ggaattaata
     6301 aaataatcaa tgcacttctt tca
//
