LOCUS       NM_001370675            3144 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus discs large MAGUK scaffold protein 4 (Dlg4),
            transcript variant 6, mRNA.
ACCESSION   NM_001370675
VERSION     NM_001370675.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3144)
  AUTHORS   Wutikeli,H., Yu,Y., Zhang,T., Cao,J., Nawy,S. and Shen,Y.
  TITLE     Role of Elavl-like RNA-binding protein in retinal development and
            signal transduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167518 (2025)
   PUBMED   39307290
REFERENCE   2  (bases 1 to 3144)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3144)
  AUTHORS   Ma,Q., Yang,Z., Yang,C., Lin,M., Gong,M., Deng,P., He,M., Lu,Y.,
            Zhang,K., Pi,H., Qu,M., Yu,Z., Zhou,Z. and Chen,C.
  TITLE     A single-cell transcriptomic landscape of cadmium-hindered brain
            development in mice
  JOURNAL   Commun Biol 7 (1), 997 (2024)
   PUBMED   39147853
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3144)
  AUTHORS   Wang,L., Yang,Z., Satoshi,F., Prasanna,X., Yan,Z., Vihinen,H.,
            Chen,Y., Zhao,Y., He,X., Bu,Q., Li,H., Zhao,Y., Jiang,L., Qin,F.,
            Dai,Y., Zhang,N., Qin,M., Kuang,W., Zhao,Y., Jokitalo,E.,
            Vattulainen,I., Kajander,T., Zhao,H. and Cen,X.
  TITLE     Membrane remodeling by FAM92A1 during brain development regulates
            neuronal morphology, synaptic function, and cognition
  JOURNAL   Nat Commun 15 (1), 6209 (2024)
   PUBMED   39043703
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3144)
  AUTHORS   Matsumoto,Y., Miwa,H., Katayama,K.I., Watanabe,A., Yamada,K.,
            Ito,T., Nakagawa,S. and Aruga,J.
  TITLE     Slitrk4 is required for the development of inhibitory neurons in
            the fear memory circuit of the lateral amygdala
  JOURNAL   Front Mol Neurosci 17, 1386924 (2024)
   PUBMED   38736483
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3144)
  AUTHORS   Migaud,M., Charlesworth,P., Dempster,M., Webster,L.C., Watabe,A.M.,
            Makhinson,M., He,Y., Ramsay,M.F., Morris,R.G., Morrison,J.H.,
            O'Dell,T.J. and Grant,S.G.
  TITLE     Enhanced long-term potentiation and impaired learning in mice with
            mutant postsynaptic density-95 protein
  JOURNAL   Nature 396 (6710), 433-439 (1998)
   PUBMED   9853749
REFERENCE   7  (bases 1 to 3144)
  AUTHORS   Kurschner,C., Mermelstein,P.G., Holden,W.T. and Surmeier,D.J.
  TITLE     CIPP, a novel multivalent PDZ domain protein, selectively interacts
            with Kir4.0 family members, NMDA receptor subunits, neurexins, and
            neuroligins
  JOURNAL   Mol Cell Neurosci 11 (3), 161-172 (1998)
   PUBMED   9647694
REFERENCE   8  (bases 1 to 3144)
  AUTHORS   Sprengel,R., Suchanek,B., Amico,C., Brusa,R., Burnashev,N.,
            Rozov,A., Hvalby,O., Jensen,V., Paulsen,O., Andersen,P., Kim,J.J.,
            Thompson,R.F., Sun,W., Webster,L.C., Grant,S.G., Eilers,J.,
            Konnerth,A., Li,J., McNamara,J.O. and Seeburg,P.H.
  TITLE     Importance of the intracellular domain of NR2 subunits for NMDA
            receptor function in vivo
  JOURNAL   Cell 92 (2), 279-289 (1998)
   PUBMED   9458051
REFERENCE   9  (bases 1 to 3144)
  AUTHORS   Irie,M., Hata,Y., Takeuchi,M., Ichtchenko,K., Toyoda,A., Hirao,K.,
            Takai,Y., Rosahl,T.W. and Sudhof,T.C.
  TITLE     Binding of neuroligins to PSD-95
  JOURNAL   Science 277 (5331), 1511-1515 (1997)
   PUBMED   9278515
REFERENCE   10 (bases 1 to 3144)
  AUTHORS   Stathakis,D.G., Hoover,K.B., You,Z. and Bryant,P.J.
  TITLE     Human postsynaptic density-95 (PSD95): location of the gene (DLG4)
            and possible function in nonneural as well as in neural tissues
  JOURNAL   Genomics 44 (1), 71-82 (1997)
   PUBMED   9286702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596185.12.
            
            Transcript Variant: This variant (6) encodes the longest isoform
            (6).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849387
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AL596185.12        128848-128878
            32-130              AL596185.12        129067-129165
            131-171             AL596185.12        129431-129471
            172-237             AL596185.12        138568-138633
            238-291             AL596185.12        142044-142097
            292-342             AL596185.12        142249-142299
            343-467             AL596185.12        142512-142636
            468-637             AL596185.12        142734-142903
            638-774             AL596185.12        143000-143136
            775-919             AL596185.12        143290-143434
            920-1215            AL596185.12        150668-150963
            1216-1318           AL596185.12        151129-151231
            1319-1433           AL596185.12        151392-151506
            1434-1610           AL596185.12        152985-153161
            1611-1647           AL596185.12        153417-153453
            1648-1675           AL596185.12        153546-153573
            1676-1723           AL596185.12        153702-153749
            1724-1825           AL596185.12        153826-153927
            1826-1998           AL596185.12        154216-154388
            1999-2108           AL596185.12        155303-155412
            2109-2200           AL596185.12        155921-156012
            2201-3144           AL596185.12        156234-157177
FEATURES             Location/Qualifiers
     source          1..3144
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.96 cM"
     gene            1..3144
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /note="discs large MAGUK scaffold protein 4"
                     /db_xref="GeneID:13385"
                     /db_xref="MGI:MGI:1277959"
     exon            1..31
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            32..130
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            131..171
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            172..237
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            238..291
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            292..342
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            343..467
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            468..637
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            638..774
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            775..919
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1215
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1318
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1433
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1610
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1647
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1675
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1723
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1825
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1998
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2108
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2200
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..3144
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3144
                     /gene="Dlg4"
                     /gene_synonym="Dlgh4; PSD-95; PSD95; SAP90; SAP90A"
                     /note="major polyA site"
ORIGIN      
        1 gagagaagag agatgtccca gagaccaaga gctcccaggt cagccctctg gctactggcc
       61 cccccactac tgcggtgggc acctcccctc ctcacagtgc tgcacagtga tctcttccag
      121 gccttgctgg acatcctgga ctattatgag gcttgtatct cagagagtca gaaataccgc
      181 taccaagatg aagacacgcc ccctctggaa cacagcccgg cccacctccc caaccaggcc
      241 aattctcccc ctgtgattgt caacacggac accctagaag ccccaggata tgtgaacgga
      301 acagaggggg agatggagta tgaggagatc acattggaaa ggggtaactc aggtctgggc
      361 ttcagcatcg caggtggcac cgacaaccca cacatcggtg acgacccatc catctttatc
      421 accaagatca ttcctggtgg ggctgcagcc caggatggcc gcctcagggt caacgacagc
      481 atcctgtttg tcaatgaagt ggatgtccgg gaggtgaccc attcagctgc agtggaggcc
      541 ctcaaagagg cgggttccat cgttcgcctc tacgtcatgc gccggaaacc cccagctgag
      601 aagatcatag agatcaagct tatcaaaggg cctaaaggac ttggcttcag catcgcaggg
      661 ggcgttggga accagcacat ccctggagat aatagcatct acgtaaccaa gatcatcgaa
      721 ggaggcgctg cccacaagga tggcaggttg cagatcggag acaagatcct ggcggtcaac
      781 agtgtggggc tagaggatgt catgcatgag gacgccgtgg cagccctgaa gaacacatat
      841 gacgttgtgt acctaaaggt ggccaagccc agcaatgcct acctgagtga cagctatgct
      901 cccccagaca tcacaacctc atattctcag cacctggaca atgagatcag tcatagcagc
      961 tacttgggca ccgactaccc cacagccatg acccccactt cccctcggcg ctactccccc
     1021 gtggccaagg acctgctagg ggaggaagat attccccggg aaccaaggcg gatcgtgatc
     1081 catcggggct ccaccggcct gggcttcaac attgtgggcg gcgaggacgg tgaaggcatc
     1141 ttcatctcct tcatccttgc tgggggtcca gctgacctca gtggggagct acggaagggg
     1201 gaccagatcc tgtcggtcaa tggtgttgac ctccgcaatg ccagtcatga acaggctgcc
     1261 attgccctga agaacgcggg tcagacggtc acgatcatcg ctcagtataa accagaagag
     1321 tatagccgat tcgaggccaa gatccatgat cttcgggaac agcttatgaa tagtagcctg
     1381 ggctcaggga ctgcatctct gcgaagcaac cccaagcggg gcttctatat cagggccctg
     1441 tttgactacg acaagaccaa ggactgcggt ttcttgagcc aggccctgag cttccacttt
     1501 ggggatgtgc ttcatgtaat tgacgccagc gacgaagagt ggtggcaagc gcggcgggtc
     1561 cactctgaca gtgagaccga tgacattggc ttcattccca gcaaacggcg ggtcgagcga
     1621 cgagagtggt caaggttaaa ggccaaggac tggggctcca gctctggatc acagggtcga
     1681 gaagactcgg ttctgagcta tgagacggtg acgcagatgg aagtgcacta cgctcgcccc
     1741 atcatcatcc ttgggcctac caaagaccgt gccaacgatg atcttctctc cgagttcccc
     1801 gacaagtttg gatcctgtgt ccctcatacg acacgtccta agcgggaata tgagatagac
     1861 ggccgcgatt accactttgt ctcctcccgg gagaaaatgg agaaggacat tcaggcgcac
     1921 aagttcattg aggctggcca gtacaacagc cacctctacg ggaccagcgt ccagtctgtg
     1981 cgagaggtag cagagcaggg gaagcactgc atccttgatg tctcagccaa tgccgtgcgg
     2041 cggctgcagg cggcccacct gcaccctatc gccatcttca tccgtccccg ctccctggag
     2101 aatgtgctag agatcaataa gcggatcaca gaggagcaag cccggaaagc cttcgacagg
     2161 gccacgaagc tggagcagga gttcacggag tgcttctcag ccatcgtaga gggcgacagc
     2221 tttgaagaga tctatcacaa agtgaaacgt gtcatcgaag acctctcagg cccctacatc
     2281 tgggtcccag cccgagagag actctgattc ctgccctggc ttggcctgga ctcaccctgc
     2341 ctccaccacc tgggcccttg gtctggactg aatagcccaa gcccttcgta ccctagcctt
     2401 tcttcccacc cttcttattt atttcctttc tgactggatc gagcccattg gagggaggac
     2461 actcctctct gcatgtatcc ctgcacccca gatcagggcc cctagacccc aggaacctgg
     2521 ggtctggggg ggagctgggc tcctggttcc gagcccttgc tccttaagac tcctacccct
     2581 gcccgccccc atgcacacac agacccactg ggggcctctg ccctccccat tttctcccac
     2641 acacattcca gaagtcaggg cccctctcaa ggagtacccg ctgtagggat gcagggccac
     2701 aggcttccgc gctctcccga ggcaggggct ggggtcaccc ctgccccatc ataactcccc
     2761 acgccgtttg agttctcctt tattttctcc attcttttct tctcaaaggt ggtttttggg
     2821 gggagaagca ggggggctct cctgagggtc cccccgtctt tcacacacct cccacctttt
     2881 ttctttgccg gtttgcatga gtggaaggtc taactgtggc tttttttttt tctgggattt
     2941 tatttcattt tatttgattt tatttttttg ggaaaagggg agggatgggt ctggggagtg
     3001 gggaatgtgg gaggggggtg ggggggcaaa gggtcagggg ttgggtgtcc gggagccagg
     3061 ggaggacagg aaatgctgcc gccttctgca atttatttat ttttttcttt tgagagagtg
     3121 aaaggaagag acagacactt gaaa
//
