LOCUS       NM_016747               5001 bp    mRNA    linear   ROD 11-NOV-2023
DEFINITION  Mus musculus discs large MAGUK scaffold protein 3 (Dlg3),
            transcript variant 1, mRNA.
ACCESSION   NM_016747
VERSION     NM_016747.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5001)
  AUTHORS   Bygrave AM, Sengupta A, Jackert EP, Ahmed M, Adenuga B, Nelson E,
            Goldschmidt HL, Johnson RC, Zhong H, Yeh FL, Sheng M and Huganir
            RL.
  TITLE     Btbd11 supports cell-type-specific synaptic function
  JOURNAL   Cell Rep 42 (6), 112591 (2023)
   PUBMED   37261953
REFERENCE   2  (bases 1 to 5001)
  AUTHORS   Chen X, Fukata Y, Fukata M and Nicoll RA.
  TITLE     MAGUKs are essential, but redundant, in long-term potentiation
  JOURNAL   Proc Natl Acad Sci U S A 118 (28) (2021)
   PUBMED   34244435
  REMARK    GeneRIF: MAGUKs are essential, but redundant, in long-term
            potentiation.
REFERENCE   3  (bases 1 to 5001)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5001)
  AUTHORS   Su D, Liu H, Liu T, Zhang X, Yang W, Song Y, Liu J, Wu Y and Chang
            L.
  TITLE     Dynamic SAP102 expression in the hippocampal subregions of rats and
            APP/PS1 mice of various ages
  JOURNAL   J Anat 232 (6), 987-996 (2018)
   PUBMED   29574717
  REMARK    GeneRIF: Our findings provide fundamental data to support the
            functional differences of SAP102 in different hippocampal
            subregions during postnatal periods
REFERENCE   5  (bases 1 to 5001)
  AUTHORS   Li J, Zhang W, Yang H, Howrigan DP, Wilkinson B, Souaiaia T,
            Evgrafov OV, Genovese G, Clementel VA, Tudor JC, Abel T, Knowles
            JA, Neale BM, Wang K, Sun F and Coba MP.
  TITLE     Spatiotemporal profile of postsynaptic interactomes integrates
            components of complex brain disorders
  JOURNAL   Nat Neurosci 20 (8), 1150-1161 (2017)
   PUBMED   28671696
REFERENCE   6  (bases 1 to 5001)
  AUTHORS   Wang CY, Chang K, Petralia RS, Wang YX, Seabold GK and Wenthold RJ.
  TITLE     A novel family of adhesion-like molecules that interacts with the
            NMDA receptor
  JOURNAL   J Neurosci 26 (8), 2174-2183 (2006)
   PUBMED   16495444
REFERENCE   7  (bases 1 to 5001)
  AUTHORS   Becamel C, Gavarini S, Chanrion B, Alonso G, Galeotti N, Dumuis A,
            Bockaert J and Marin P.
  TITLE     The serotonin 5-HT2A and 5-HT2C receptors interact with specific
            sets of PDZ proteins
  JOURNAL   J Biol Chem 279 (19), 20257-20266 (2004)
   PUBMED   14988405
REFERENCE   8  (bases 1 to 5001)
  AUTHORS   Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C,
            Vicini S and Wenthold RJ.
  TITLE     NMDA receptor trafficking through an interaction between PDZ
            proteins and the exocyst complex
  JOURNAL   Nat Cell Biol 5 (6), 520-530 (2003)
   PUBMED   12738960
  REMARK    GeneRIF: SAP102 interacts with the PDZ-binding domain of Sec8, a
            member of the exocyst complex.  nteractions between the two
            proteins are involved in the delivery of N-methyl-D-aspartate
            receptors to the cell surface in heterologous cells and neurons.
REFERENCE   9  (bases 1 to 5001)
  AUTHORS   Karnak D, Lee S and Margolis B.
  TITLE     Identification of multiple binding partners for the amino-terminal
            domain of synapse-associated protein 97
  JOURNAL   J Biol Chem 277 (48), 46730-46735 (2002)
   PUBMED   12351654
REFERENCE   10 (bases 1 to 5001)
  AUTHORS   Lin L, Peters LL, Ciciotte SL and Chishti AH.
  TITLE     cDNA sequence and chromosomal localization of mouse Dlgh3 gene
            adjacent to the BRCA1 tumor suppressor locus
  JOURNAL   Biochim Biophys Acta 1443 (1-2), 211-216 (1998)
   PUBMED   9838122
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB246207.1, D87117.1 and CD776492.1.
            
            [WARNING] On Dec 6, 2023 this sequence was replaced by NM_016747.5.
            
            On Mar 12, 2014 this sequence version replaced NM_016747.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87117.1, SRR1660815.247598.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-419               CB246207.1         1-419
            420-4983            D87117.1           394-4957
            4984-5001           CD776492.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..5001
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.72 cM"
     gene            1..5001
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /note="discs large MAGUK scaffold protein 3"
                     /db_xref="GeneID:53310"
                     /db_xref="MGI:MGI:1888986"
     exon            1..707
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..2900
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /note="isoform 1 is encoded by transcript variant 1; disks
                     large homolog 3; synapse-associated protein 102; discs,
                     large homolog 3"
                     /codon_start=1
                     /product="disks large homolog 3 isoform 1"
                     /protein_id="NP_058027.1"
                     /db_xref="CCDS:CCDS30307.1"
                     /db_xref="GeneID:53310"
                     /db_xref="MGI:MGI:1888986"
                     /translation="MHKHQHCCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPSGG
                     NGASSGYGGYSSQTLPSQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSG
                     PGWWPECTCTNRDWYEQASPAPLLVNPEALEPSLSVNGSDGMFKYEEIVLERGNSGLG
                     FSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAV
                     EALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYIT
                     KIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSIH
                     LNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVTYPAPPQVPPTRYSPIPRHM
                     LAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRI
                     LSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMS
                     SGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARL
                     VTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDYYGAKNL
                     KGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPH
                     KFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQS
                     VRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKI
                     FDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL"
     exon            708..761
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            762..812
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            813..937
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1107
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1244
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1389
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1549
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1706
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1809
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1924
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2101
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2177
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2223
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2265
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2316
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2418
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2591
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2701
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2793
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..4985
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3; mKIAA1232; SAP102"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgactcca ctcagatcca tcctggggac ctgagcagaa gaggttctcg ccgcacctag
       61 cctttgcctg ggcgcccgat tcttctttgc cgctgggcct cggcccagaa gccacaacgg
      121 gcgacacgga gccgccagtg ctggaggggg agccatgggt gcggggcagc gtgggggcag
      181 aggccccagg acgcccgccc ggccccaggc cccgctcagc cagggcaccc ccacgggtgc
      241 cccctccttc ttggtctgag cagtgcgagt gtgctaggga gcccggcggc ggcggcggcg
      301 gcgtggaaac tggcgtgggc tggggggtcc gagccgcggg gggcagtgcc atgcacaagc
      361 accagcactg ctgtaagtgc cccgagtgct atgaggtgac ccgcctggcc gccctgcggc
      421 gtcttgagcc tcctggctac ggggactggc aggtgccgga cccctatggg ccaagtgggg
      481 gcaatggggc tagctccggt tatggaggct acagctcgca gaccctgcct tcacaggcag
      541 gggctacccc cacccctcgc accaaggcca agctcatccc cacaggccga gatgtggggc
      601 cagtgccccc taagccagtc cccggcaaga gcaccccaaa actcaacggc agtggccccg
      661 gctggtggcc cgagtgcacc tgtaccaacc gggactggta tgagcaggcc agccctgcac
      721 ccctcctagt gaaccccgag gccctggagc ccagcctatc ggtgaatggc agtgatggca
      781 tgttcaagta tgaggagata gtactggaac ggggcaactc tggccttggc ttcagtatcg
      841 caggtggcat cgacaaccct catgtccctg atgaccctgg catctttatt accaagatca
      901 ttcctggtgg agcagctgcc atggatggga ggctgggggt gaatgactgt gtgctacggg
      961 tgaatgaggt ggacgtgtcc gaggtggtgc acagccgggc cgtggaggca ctgaaggagg
     1021 caggccctgt ggtgcggttg gtggtgcgga ggcgacagcc cccacctgag actatcatgg
     1081 aggtcaacct gctcaaaggg ccaaaaggcc taggtttcag cattgctggg ggcattggca
     1141 accagcacat cccaggagac aacagcatct atatcaccaa gatcattgaa ggaggagctg
     1201 ctcagaagga tggacgccta cagattgggg accggctgct tgcggtgaac aataccaatc
     1261 tgcaggatgt gaggcatgag gaagctgtgg cctcactcaa gaacacatca gacatggtct
     1321 atctgaaggt ggccaagcca ggcagcatcc acctcaacga tatgtatgct ccccctgact
     1381 atgccagcac tttcactgcc ttggctgaca atcacataag ccataattcc agcctgggtt
     1441 atcttggggc agtggagagc aaggtcacct accctgctcc acctcaggtg ccccctactc
     1501 gttactctcc tattcccaga cacatgctgg ctgaggaaga ctttaccaga gagccccgca
     1561 agatcatcct gcacaaaggt tctacaggcc tgggcttcaa cattgtagga ggagaagatg
     1621 gagaaggcat ttttgtttcc ttcatcctgg cgggaggccc agcagaccta agtggggagt
     1681 tgcgaagggg agaccggatc ttatcggtaa atggagtcaa cctgaggaat gctacccacg
     1741 agcaagcagc ggctgctctg aaacgggctg gccagtcagt caccattgtg gcccagtata
     1801 gacctgaaga gtacagtcgc tttgaatcca agatccatga cttgcgggaa caaatgatga
     1861 acagcagcat gagttctggg tctgggtctc tccgaaccag tgagaagagg tccttgtatg
     1921 tcagggccct gtttgattat gatcggactc gtgacagctg tctaccaagc cagggactca
     1981 gtttctctta tggtgacatt ctgcacgtca ttaacgcctc tgatgatgag tggtggcaag
     2041 caaggctggt gactcctcat ggagagagtg aacagatcgg tgtgatccct agtaaaaaga
     2101 gggtggaaaa gaaagagcga gctcgattga aaactgtgaa gttccatgcc aggacaggga
     2161 tgattgagtc taatcgggac ttccctgggt taagtgacga ttattatgga gcaaagaacc
     2221 tgaagggagt gacatccaac accagtgaca gcgaaagcag ttccaaagga caagaggatg
     2281 ctattttgtc atatgagcca gtgacacgac aagaaattca ctatgccagg cctgtgatca
     2341 tcttgggccc aatgaaggac cgagtcaacg atgacctcat ctctgagttc ccgcataaat
     2401 ttggatcctg tgtgccacat accacccggc ctcggcgtga taacgaggta gatggacagg
     2461 attaccactt tgtggtttcc cgggaacaaa tggagaagga tattcaggac aacaagttca
     2521 ttgaggcggg ccagttcaat gataatctct atgggaccag catccagtct gtgcgggcag
     2581 ttgcagagag gggcaagcac tgcatcttag atgtctccgg caacgccata aagagactgc
     2641 agcaagcaca actttatccc attgccattt tcatcaagcc caagtccatt gaagcactta
     2701 tggaaatgaa ccgacggcag acatacgaac aagcaaataa gatctttgat aaagccatga
     2761 aactggagca agaatttgga gaatacttta cagccattgt acagggtgac tcactggaag
     2821 agatttataa caaaatcaaa caaatcattg aggaccagtc tgggcactac atttgggtcc
     2881 catcccctga aaaactctga agaatcccct ccaagcattc tcttgtgaac agaagaaatg
     2941 aagcccctct tccctccttc ctcttcattc ctgtccccac ggggagaaca aatgactact
     3001 gttcttgtcc ccctttttag atatgtcaaa aattgagttt tctagtcctg ttctttttta
     3061 aaaaatgttg ttttgttttg gtttctcttt cgggatgatg ccatctcact catcacgtga
     3121 ccgtgcccat tcctgcatgg acctttccca cgcgctagca caggtgcaaa tccatcagag
     3181 ttgttgttct cataaacacc cagcagaagc gaagagaaga gaggaggact gatggaaaga
     3241 cagactctgg acaactgcac agcttgtgaa gtgagcgaaa cagcccacgt gaggaggcgc
     3301 tcccgggcat tcctaccctg tactgcggct tgcagctctg aacggtgcaa cgtaacggct
     3361 acagaaagga tcttatttat atatagatat atatatgtaa tttatataaa atatatagaa
     3421 attattatat atatatatta tacactcttc tataatatat atatatatat tcacatacat
     3481 tgggactaga aaatctatgg agacgtccat caacggtact atgttattag agaaatgctt
     3541 taattttcat attccaatca gatgacatct tttgttccac ctggttggga aggggttgac
     3601 aacagtagta agtgctatac caaagcactc gaatttggtc attctcttca gagctaaggc
     3661 ttgctccagg tggggccaac ctacagcata agagaagggg ctttggctgg gagctggaga
     3721 ttggagacgt gactaaagca gttgctgccc ctgcagggca gtcgttcctg tgcagaaaga
     3781 gagaatgaat ggctaatgat gctccggatg aaattgccta ttgttttatg ccgcctgatg
     3841 tgtctgcatg agaggtttcc tttttgttca tttttaagct gctgttaaac caaaaccatg
     3901 ttgtgctact gtgtcagcct tttcattatt ccagatttta cttttactat ttaagtgaat
     3961 gcgtagaatc ctatttgcca gtgttctaaa ggcttgtgag gttctgaagg agccaggcct
     4021 gggatacagc ggtaacttag gcctggccat ccagtcaaca gagggaaagc aggggctggt
     4081 gagggcagag agtacaagct ggggctcgga gttaccatgc tggacttagc taggggttcc
     4141 ttcacggggc cactgacagg catagggagg tgcttgcctt ctggctcggt gctgggacag
     4201 tggaagagca ccaggcttgg ccagccgtgt agtgagttgg atttggattc ttttcttttg
     4261 caactgctcc atttgcccta ccccagcccc ctcaccaaca gctggtagct tactgtttct
     4321 tcaagaagaa agtagacttt aacgctgtaa atttgagctg tagagctaag actcgcttac
     4381 tggtgagctg tgaaatcttg ttgctttttt cccagagtct gatggcagtg actggtccag
     4441 gtagtttccc tcccgcagcc agtgcaggca gcaggtgtgg tccaggccct accccacccc
     4501 actatgctcc tttgaagcca acgtgcctcc ctcacctcca cactggaggg atgacgcagg
     4561 ggagaacata gaattgcttg gccctcaact gggttaggac catcgcaggt gatgcagggt
     4621 tgacacttta aagcactacc agccacattc aggaactctg ttcacaggta tcctaccagc
     4681 ataatgaggc taactgtgac tcgtggggcc cagagttaga agaaagaaaa ggcagcagct
     4741 ttctcttggg cagtacactg gattgaaggc aaagagggat aaagtgacag atgattgtga
     4801 ctctcgcgag ggggggtgag cgggaagtgt tgattctctg atggtaactg acagcagtgg
     4861 acagtgctca atcctccctc ccagggaaga aaagcaaaga ttcgaagtaa gcatgataat
     4921 agttggttta ccagtgttcc ttccaaggag acatatattt tttaataaat gatagttgca
     4981 atgaaaaaaa aaaaaaaaaa a
//
