LOCUS       NM_015789                903 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus dickkopf-like 1 (Dkkl1), mRNA.
ACCESSION   NM_015789
VERSION     NM_015789.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 903)
  AUTHORS   Ge,T., Yuan,L., Xu,L., Yang,F., Xu,W., Niu,C., Li,G., Zhou,H. and
            Zheng,Y.
  TITLE     Coiled-coil domain containing 159 is required for spermatid head
            and tail assembly in micedagger
  JOURNAL   Biol Reprod 110 (5), 877-894 (2024)
   PUBMED   38236177
REFERENCE   2  (bases 1 to 903)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 903)
  AUTHORS   Seitz,R., Weber,G., Albrecht,S., Fuchshofer,R., Tamm,E.R. and
            Ohlmann,A.
  TITLE     Cross-Inhibition of Norrin and TGF-beta Signaling Modulates
            Development of Retinal and Choroidal Vasculature
  JOURNAL   Invest Ophthalmol Vis Sci 59 (6), 2240-2251 (2018)
   PUBMED   29715368
REFERENCE   4  (bases 1 to 903)
  AUTHORS   Perdigoto,C.N., Dauber,K.L., Bar,C., Tsai,P.C., Valdes,V.J.,
            Cohen,I., Santoriello,F.J., Zhao,D., Zheng,D., Hsu,Y.C. and
            Ezhkova,E.
  TITLE     Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact
            to Regulate Merkel Cell Specification during Skin Development
  JOURNAL   PLoS Genet 12 (7), e1006151 (2016)
   PUBMED   27414999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 903)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 903)
  AUTHORS   Kohn,M.J., Kaneko,K.J. and DePamphilis,M.L.
  TITLE     DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome
            during mammalian spermatogenesis
  JOURNAL   Mol Reprod Dev 71 (4), 516-522 (2005)
   PUBMED   15892050
REFERENCE   7  (bases 1 to 903)
  AUTHORS   Kaneko,K.J., Rein,T., Guo,Z.S., Latham,K. and DePamphilis,M.L.
  TITLE     DNA methylation may restrict but does not determine differential
            gene expression at the Sgy/Tead2 locus during mouse development
  JOURNAL   Mol Cell Biol 24 (5), 1968-1982 (2004)
   PUBMED   14966277
  REMARK    GeneRIF: Results suggest that DNA methylation is not the primary
            determinant of Soggy/Tead2 expression.
REFERENCE   8  (bases 1 to 903)
  AUTHORS   Bennett,C.N., Ross,S.E., Longo,K.A., Bajnok,L., Hemati,N.,
            Johnson,K.W., Harrison,S.D. and MacDougald,O.A.
  TITLE     Regulation of Wnt signaling during adipogenesis
  JOURNAL   J Biol Chem 277 (34), 30998-31004 (2002)
   PUBMED   12055200
REFERENCE   9  (bases 1 to 903)
  AUTHORS   Kaneko,K.J. and DePamphilis,M.L.
  TITLE     Soggy, a spermatocyte-specific gene, lies 3.8 kb upstream of and
            antipodal to TEAD-2, a transcription factor expressed at the
            beginning of mouse development
  JOURNAL   Nucleic Acids Res 28 (20), 3982-3990 (2000)
   PUBMED   11024178
REFERENCE   10 (bases 1 to 903)
  AUTHORS   Krupnik,V.E., Sharp,J.D., Jiang,C., Robison,K., Chickering,T.W.,
            Amaravadi,L., Brown,D.E., Guyot,D., Mays,G., Leiby,K., Chang,B.,
            Duong,T., Goodearl,A.D., Gearing,D.P., Sokol,S.Y. and McCarthy,S.A.
  TITLE     Functional and structural diversity of the human Dickkopf gene
            family
  JOURNAL   Gene 238 (2), 301-313 (1999)
   PUBMED   10570958
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA466481.1, AK131694.1 and BE134426.1.
            
            On Aug 13, 2009 this sequence version replaced NM_015789.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002215.1, AF274312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                CA466481.1         4-59
            57-708              AK131694.1         2-653
            709-903             BE134426.1         5-199               c
FEATURES             Location/Qualifiers
     source          1..903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.19 cM"
     gene            1..903
                     /gene="Dkkl1"
                     /gene_synonym="mSgy; SGY; SGY-1; SGY1; Soggy"
                     /note="dickkopf-like 1"
                     /db_xref="GeneID:50722"
                     /db_xref="MGI:MGI:1354963"
     exon            1..128
                     /gene="Dkkl1"
                     /gene_synonym="mSgy; SGY; SGY-1; SGY1; Soggy"
                     /inference="alignment:Splign:2.1.0"
     exon            129..298
                     /gene="Dkkl1"
                     /gene_synonym="mSgy; SGY; SGY-1; SGY1; Soggy"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..838
                     /gene="Dkkl1"
                     /gene_synonym="mSgy; SGY; SGY-1; SGY1; Soggy"
                     /note="dickkopf-like protein 1; protein soggy-1; soggy 1"
                     /codon_start=1
                     /product="dickkopf-like protein 1 precursor"
                     /protein_id="NP_056604.2"
                     /db_xref="CCDS:CCDS21235.1"
                     /db_xref="GeneID:50722"
                     /db_xref="MGI:MGI:1354963"
                     /translation="MCRLRVLLLLLPLAFVSSSALPIHDVDSQQNTSGFLGLQRLLQS
                     FSRLFLKNDLLRDLDNFFSSPMDFRDLPRNFHQEENQEHRMGNHTLSSHLQIDKVTDN
                     QTGEVLISEKVEASIEPERNPEGDWKVPKVEAKEPPVPVQKVTDSLHPEPRQVAFWIM
                     KMPRRRTQPDVQDGGRWLIEKRHRMQAIRDGLRGGAREDSLEDGVHIPQHAKLPVRKT
                     HFLYILRPSQQL"
     exon            299..439
                     /gene="Dkkl1"
                     /gene_synonym="mSgy; SGY; SGY-1; SGY1; Soggy"
                     /inference="alignment:Splign:2.1.0"
     exon            440..529
                     /gene="Dkkl1"
                     /gene_synonym="mSgy; SGY; SGY-1; SGY1; Soggy"
                     /inference="alignment:Splign:2.1.0"
     exon            530..903
                     /gene="Dkkl1"
                     /gene_synonym="mSgy; SGY; SGY-1; SGY1; Soggy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      882..887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dkkl1"
                     /gene_synonym="mSgy; SGY; SGY-1; SGY1; Soggy"
                     /note="hexamer: AATAAA"
     polyA_site      903
                     /gene="Dkkl1"
                     /gene_synonym="mSgy; SGY; SGY-1; SGY1; Soggy"
                     /note="major polyA site"
ORIGIN      
        1 gacacccaac gaacgctcca gtaatttgcc caggctcgag accagaactg gatattaact
       61 gtccgtatcc ggcggtgtcc ggagccgggt gaccgggtgt ccagcagaag gcgcgaatga
      121 aggcaaagcc tcccacccac ctgcaatgtg tcgactgagg gtcttgctgc tgctgctccc
      181 cttggccttc gtgtcctcct ctgctctccc catccatgat gtcgactctc agcagaacac
      241 ctccgggttc ctgggccttc agaggcttct ccaaagcttt agtcgactgt tcctaaaaaa
      301 tgacctgcta cgagacctgg acaacttctt ctcctccccc atggacttcc gagaccttcc
      361 taggaacttc catcaggaag agaaccagga gcacagaatg ggcaaccata ccctctccag
      421 ccacctacag atagacaagg tgactgacaa ccagacaggg gaggtgctca tctcggagaa
      481 agtcgaggcc tccattgagc cagaacggaa cccggaaggg gactggaagg ttcccaaagt
      541 agaagcaaaa gagcccccgg tgcctgtgca gaaggtcacc gacagcttgc acccagagcc
      601 ccggcaggtg gctttctgga tcatgaagat gccaaggcgg aggacccagc ccgatgtcca
      661 ggatggaggc cgctggctca tagaaaagcg acatcgcatg caggccatcc gggatgggct
      721 ccgtggaggc gcccgtgagg acagcctgga ggatggggtc catatccccc aacacgccaa
      781 gctgcctgtc agaaagacac actttctcta catcctcagg ccatcccaac agctgtaagt
      841 ggggaccaga tgtcccacac cctaccccaa caccatatgg aaataaaggt tttcttacat
      901 cta
//
