LOCUS       NM_145592               1315 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus dickkopf WNT signaling pathway inhibitor 4 (Dkk4),
            mRNA.
ACCESSION   NM_145592
VERSION     NM_145592.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1315)
  AUTHORS   Papagno,V., Sulic,A.M., Satta,J.P., Hoshiar,A.K., Kumar,V.,
            Jernvall,J. and Mikkola,M.L.
  TITLE     Wnt target gene Ascl4 is dispensable for skin appendage development
  JOURNAL   Int J Dev Biol (2024) In press
   PUBMED   38770834
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1315)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1315)
  AUTHORS   Khatif,H. and Bazzi,H.
  TITLE     Generation and characterization of a Dkk4-Cre knock-in mouse line
  JOURNAL   Genesis 62 (1), e23532 (2024)
   PUBMED   37435631
REFERENCE   4  (bases 1 to 1315)
  AUTHORS   Jacob,T., Annusver,K., Czarnewski,P., Dalessandri,T., Kalk,C.,
            Levra Levron,C., Campama Sanz,N., Kastriti,M.E., Mikkola,M.L.,
            Rendl,M., Lichtenberger,B.M., Donati,G., Bjorklund,A.K. and
            Kasper,M.
  TITLE     Molecular and spatial landmarks of early mouse skin development
  JOURNAL   Dev Cell 58 (20), 2140-2162 (2023)
   PUBMED   37591247
REFERENCE   5  (bases 1 to 1315)
  AUTHORS   Sulic,A.M., Das Roy,R., Papagno,V., Lan,Q., Saikkonen,R.,
            Jernvall,J., Thesleff,I. and Mikkola,M.L.
  TITLE     Transcriptomic landscape of early hair follicle and epidermal
            development
  JOURNAL   Cell Rep 42 (6), 112643 (2023)
   PUBMED   37318953
REFERENCE   6  (bases 1 to 1315)
  AUTHORS   Harwood,B.N., Cross,S.K., Radford,E.E., Haac,B.E. and De Vries,W.N.
  TITLE     Members of the WNT signaling pathways are widely expressed in mouse
            ovaries, oocytes, and cleavage stage embryos
  JOURNAL   Dev Dyn 237 (4), 1099-1111 (2008)
   PUBMED   18351675
REFERENCE   7  (bases 1 to 1315)
  AUTHORS   Bazzi,H., Fantauzzo,K.A., Richardson,G.D., Jahoda,C.A. and
            Christiano,A.M.
  TITLE     The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt
            signaling during ectodermal appendage morphogenesis
  JOURNAL   Dev Biol 305 (2), 498-507 (2007)
   PUBMED   17397822
  REMARK    GeneRIF: Dkk4 acts in a negative feedback loop to attenuate
            canonical Wnt signaling and may facilitate a switch to the
            non-canonical Wnt planar cell polarity pathway that is involved in
            cell movements during morphogenesis.
REFERENCE   8  (bases 1 to 1315)
  AUTHORS   Cui,C.Y., Hashimoto,T., Grivennikov,S.I., Piao,Y., Nedospasov,S.A.
            and Schlessinger,D.
  TITLE     Ectodysplasin regulates the lymphotoxin-beta pathway for hair
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 103 (24), 9142-9147 (2006)
   PUBMED   16738056
REFERENCE   9  (bases 1 to 1315)
  AUTHORS   Kemp,C., Willems,E., Abdo,S., Lambiv,L. and Leyns,L.
  TITLE     Expression of all Wnt genes and their secreted antagonists during
            mouse blastocyst and postimplantation development
  JOURNAL   Dev Dyn 233 (3), 1064-1075 (2005)
   PUBMED   15880404
REFERENCE   10 (bases 1 to 1315)
  AUTHORS   Diep,D.B., Hoen,N., Backman,M., Machon,O. and Krauss,S.
  TITLE     Characterisation of the Wnt antagonists and their response to
            conditionally activated Wnt signalling in the developing mouse
            forebrain
  JOURNAL   Brain Res Dev Brain Res 153 (2), 261-270 (2004)
   PUBMED   15527894
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC121835.2.
            
            On Mar 10, 2007 this sequence version replaced NM_145592.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               AC121835.2         155864-156114       c
            252-402             AC121835.2         154760-154910       c
            403-555             AC121835.2         154194-154346       c
            556-1315            AC121835.2         152610-153369       c
FEATURES             Location/Qualifiers
     source          1..1315
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 11.42 cM"
     gene            1..1315
                     /gene="Dkk4"
                     /gene_synonym="Dkk-4"
                     /note="dickkopf WNT signaling pathway inhibitor 4"
                     /db_xref="GeneID:234130"
                     /db_xref="MGI:MGI:2385299"
     exon            1..251
                     /gene="Dkk4"
                     /gene_synonym="Dkk-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..806
                     /gene="Dkk4"
                     /gene_synonym="Dkk-4"
                     /note="dickkopf-related protein 4; dickkopf-4; dickkopf
                     homolog 4"
                     /codon_start=1
                     /product="dickkopf-related protein 4 precursor"
                     /protein_id="NP_663567.1"
                     /db_xref="CCDS:CCDS22180.1"
                     /db_xref="GeneID:234130"
                     /db_xref="MGI:MGI:2385299"
                     /translation="MVLVTLLGLSWFCSPLAALVLDFNNIKSSADVQGAGKGSLCASD
                     RDCSEGKFCLAFHDERSFCATCRRVRRRCQRSAVCCPGTVCVNDVCTAVEDTRPVMDR
                     NTDGQDGAYAEGTTKWPAEENRPQGKPSTKKSQSSKGQEGESCLRTSDCGPGLCCARH
                     FWTKICKPVLREGQVCSRRGHKDTAQAPEIFQRCDCGPGLTCRSQVTSNRQHSRLRVC
                     QRI"
     exon            252..402
                     /gene="Dkk4"
                     /gene_synonym="Dkk-4"
                     /inference="alignment:Splign:2.1.0"
     exon            403..555
                     /gene="Dkk4"
                     /gene_synonym="Dkk-4"
                     /inference="alignment:Splign:2.1.0"
     exon            556..1315
                     /gene="Dkk4"
                     /gene_synonym="Dkk-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1291..1296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dkk4"
                     /gene_synonym="Dkk-4"
                     /note="hexamer: AATAAA"
     polyA_site      1315
                     /gene="Dkk4"
                     /gene_synonym="Dkk-4"
                     /note="major polyA site"
ORIGIN      
        1 acacaccttc cttgggcaga gtctctcttt cagaaaaggc ctctgtgggc gacttgcaga
       61 ttgtacctag ggccactcag cagcgcagcc ttcgaagact caaggggtac tggagctccg
      121 agagaccaga gtgactgagg atggtactgg tgaccttgct tggactcagc tggttttgtt
      181 cacccctggc agccctggtt ctggacttta acaacatcaa gagctccgcg gatgtgcaag
      241 gcgcggggaa gggctcgctg tgtgcatcag acagggactg cagcgaaggg aaattctgct
      301 tagcgtttca cgatgaacgg tccttctgtg ccacgtgccg tagagttcgc aggaggtgtc
      361 agaggagcgc cgtgtgctgc ccaggaacgg tctgtgtgaa tgatgtttgc actgcagtgg
      421 aagacacaag gccagtgatg gacagaaaca ctgacggcca agacggcgcc tatgcagaag
      481 gaaccactaa atggccagca gaggaaaaca gacctcaggg gaagcccagt acgaagaaat
      541 cacaaagcag taagggacag gagggagaaa gctgtcttag aacctctgac tgtggccctg
      601 gactttgctg tgctcgccat ttttggacaa aaatttgcaa gccagttcta cgagagggac
      661 aagtctgctc caggaggggg cacaaagaca ctgcccaagc cccagaaatc ttccagcgtt
      721 gcgactgcgg gcctggacta acgtgccgaa gtcaggtgac cagtaacaga caacattcaa
      781 ggctaagagt atgccaaaga atataagttg taaaaacacg ggacttgttg ttgtgttcac
      841 acagaatcaa tccctggcac taattttatt atatttgtta ttttgttttc tgagacaggg
      901 atctcactgt gtagccctgg ctggccttgc actcattgag atctgcctgc ctctacctcc
      961 tggatgcttt tttttttttt gggggggggg ggcgggggcg ggggaggagc tttctgagac
     1021 agggtctcaa agtaagctat gtaggccagc aaactcatgg cctcaaacgc atgatcccct
     1081 gacctcaagt gcgtcttggg attacaggcg agcatgttac actcagcaca taaataaagc
     1141 ccaatctcct agcaactgag acagacagca agcagatact gagatgctat actctgatga
     1201 gccagcgact tttggctttg cgtctactat ctacagtact gacaggactt tacaataaaa
     1261 cagcccggac acagtgactc aatccgttca aataaatctt ttttaaaaat tgaaa
//
