LOCUS       NM_015814               3431 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus dickkopf WNT signaling pathway inhibitor 3 (Dkk3),
            transcript variant 2, mRNA.
ACCESSION   NM_015814
VERSION     NM_015814.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3431)
  AUTHORS   Song,J., Chen,Y., Chen,Y., Qiu,M., Xiang,W., Ke,B. and Fang,X.
  TITLE     DKK3 promotes renal fibrosis by increasing MFF-mediated
            mitochondrial dysfunction in Wnt/beta-catenin pathway-dependent
            manner
  JOURNAL   Ren Fail 46 (1), 2343817 (2024)
   PUBMED   38682264
  REMARK    GeneRIF: DKK3 promotes renal fibrosis by increasing MFF-mediated
            mitochondrial dysfunction in Wnt/beta-catenin pathway-dependent
            manner.
REFERENCE   2  (bases 1 to 3431)
  AUTHORS   Hu,L., Liu,X.Y., Zhao,L., Hu,Z.B., Li,Z.X., Liu,W.T., Song,N.N.,
            Hu,Y.Q., Jiang,L.P., Zhang,L., Tao,Y.C., Zhang,Q., Chen,J.Y.,
            Lang,B., Wang,Y.B., Yue,L. and Ding,Y.Q.
  TITLE     Ventricular Netrin-1 deficiency leads to defective pyramidal
            decussation and mirror movement in mice
  JOURNAL   Cell Death Dis 15 (5), 343 (2024)
   PUBMED   38760361
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3431)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3431)
  AUTHORS   Martin Flores,N., Podpolny,M., McLeod,F., Workman,I., Crawford,K.,
            Ivanov,D., Leonenko,G., Escott-Price,V. and Salinas,P.C.
  TITLE     Downregulation of Dickkopf-3, a Wnt antagonist elevated in
            Alzheimer's disease, restores synapse integrity and memory in a
            disease mouse model
  JOURNAL   Elife 12, 89453 (2024)
   PUBMED   38285009
  REMARK    GeneRIF: Downregulation of Dickkopf-3, a Wnt antagonist elevated in
            Alzheimer's disease, restores synapse integrity and memory in a
            disease mouse model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3431)
  AUTHORS   Cooney,R.A., Saal,M.L., Geraci,K.P., Maynard,C., Cleaver,O.,
            Hoang,O.N., Moore,T.T., Hwang,R.F., Axelrod,J.D. and Vladar,E.K.
  TITLE     A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling
            switch controls multiciliogenesis
  JOURNAL   J Cell Sci 136 (16) (2023)
   PUBMED   37505110
  REMARK    GeneRIF: A WNT4- and DKK3-driven canonical to noncanonical Wnt
            signaling switch controls multiciliogenesis.
REFERENCE   6  (bases 1 to 3431)
  AUTHORS   Ang,S.J., Stump,R.J., Lovicu,F.J. and McAvoy,J.W.
  TITLE     Spatial and temporal expression of Wnt and Dickkopf genes during
            murine lens development
  JOURNAL   Gene Expr Patterns 4 (3), 289-295 (2004)
   PUBMED   15053977
REFERENCE   7  (bases 1 to 3431)
  AUTHORS   Stump,R.J., Ang,S., Chen,Y., von Bahr,T., Lovicu,F.J., Pinson,K.,
            de Iongh,R.U., Yamaguchi,T.P., Sassoon,D.A. and McAvoy,J.W.
  TITLE     A role for Wnt/beta-catenin signaling in lens epithelial
            differentiation
  JOURNAL   Dev Biol 259 (1), 48-61 (2003)
   PUBMED   12812787
REFERENCE   8  (bases 1 to 3431)
  AUTHORS   Heller,R.S., Dichmann,D.S., Jensen,J., Miller,C., Wong,G.,
            Madsen,O.D. and Serup,P.
  TITLE     Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in
            transgenic mice suggesting a role for Wnts in pancreas and foregut
            pattern formation
  JOURNAL   Dev Dyn 225 (3), 260-270 (2002)
   PUBMED   12412008
REFERENCE   9  (bases 1 to 3431)
  AUTHORS   Krupnik,V.E., Sharp,J.D., Jiang,C., Robison,K., Chickering,T.W.,
            Amaravadi,L., Brown,D.E., Guyot,D., Mays,G., Leiby,K., Chang,B.,
            Duong,T., Goodearl,A.D., Gearing,D.P., Sokol,S.Y. and McCarthy,S.A.
  TITLE     Functional and structural diversity of the human Dickkopf gene
            family
  JOURNAL   Gene 238 (2), 301-313 (1999)
   PUBMED   10570958
REFERENCE   10 (bases 1 to 3431)
  AUTHORS   Monaghan,A.P., Kioschis,P., Wu,W., Zuniga,A., Bock,D., Poustka,A.,
            Delius,H. and Niehrs,C.
  TITLE     Dickkopf genes are co-ordinately expressed in mesodermal lineages
  JOURNAL   Mech Dev 87 (1-2), 45-56 (1999)
   PUBMED   10495270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166834.2 and AK004853.1.
            
            On Jan 30, 2018 this sequence version replaced NM_015814.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (b) is
            shorter at the N-terminus compared to isoform a. Variants 2 and 3
            both encode the same isoform (b).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004853.1, SRR1660811.100602.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC166834.2         68362-68435
            75-3431             AK004853.1         1-3357
FEATURES             Location/Qualifiers
     source          1..3431
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 58.74 cM"
     gene            1..3431
                     /gene="Dkk3"
                     /gene_synonym="dkk-3; mDkk-3"
                     /note="dickkopf WNT signaling pathway inhibitor 3"
                     /db_xref="GeneID:50781"
                     /db_xref="MGI:MGI:1354952"
     exon            1..166
                     /gene="Dkk3"
                     /gene_synonym="dkk-3; mDkk-3"
                     /inference="alignment:Splign:2.1.0"
     exon            167..402
                     /gene="Dkk3"
                     /gene_synonym="dkk-3; mDkk-3"
                     /inference="alignment:Splign:2.1.0"
     exon            403..540
                     /gene="Dkk3"
                     /gene_synonym="dkk-3; mDkk-3"
                     /inference="alignment:Splign:2.1.0"
     exon            541..624
                     /gene="Dkk3"
                     /gene_synonym="dkk-3; mDkk-3"
                     /inference="alignment:Splign:2.1.0"
     exon            625..717
                     /gene="Dkk3"
                     /gene_synonym="dkk-3; mDkk-3"
                     /inference="alignment:Splign:2.1.0"
     exon            718..862
                     /gene="Dkk3"
                     /gene_synonym="dkk-3; mDkk-3"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1019
                     /gene="Dkk3"
                     /gene_synonym="dkk-3; mDkk-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..3431
                     /gene="Dkk3"
                     /gene_synonym="dkk-3; mDkk-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3406..3411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dkk3"
                     /gene_synonym="dkk-3; mDkk-3"
                     /note="hexamer: AATAAA"
     polyA_site      3428
                     /gene="Dkk3"
                     /gene_synonym="dkk-3; mDkk-3"
                     /note="major polyA site"
ORIGIN      
        1 cgggcggagg cgtggtggac tgggggggcg caggctgcag gctttctgga tacaggcgct
       61 tttgcatcct agccgcacac agtgcctctc cagctgctct gtggcagccc agctaccggt
      121 cgtgaccaga tccagcttgc agctcagctt tgttcattcg aattgggcgg cggccagcgc
      181 ggaacaaaca tgcagcggct cgggggtatt ttgctgtgta cactgctggc ggcggcggtc
      241 cccactgctc ctgctccttc cccgacggtc acttggactc cggcggagcc gggcccagct
      301 ctcaactacc ctcaggagga agctacgctc aatgagatgt ttcgagaggt ggaggagctg
      361 atggaagaca ctcagcacaa actgcgcagt gccgtggagg agatggaggc ggaagaagca
      421 gctgctaaaa cgtcctctga ggtgaacctg gcaagcttac ctcccaacta tcacaatgag
      481 accagcacgg agaccagggt gggaaataac acagtccatg tgcaccagga agttcacaag
      541 ataaccaaca accagagtgg acaggtggtc ttttctgaga cagtcattac atctgtaggg
      601 gatgaagaag gcaagaggag ccatgaatgt atcattgatg aagactgtgg gcccaccagg
      661 tactgccagt tctccagctt caagtacacc tgccagccat gccgggacca gcagatgcta
      721 tgcacccgag acagtgagtg ctgtggagac cagctgtgtg cctggggtca ctgcacccaa
      781 aaggccacca aaggtggcaa tgggaccatc tgtgacaacc agagggattg ccagcctggc
      841 ctgtgttgtg ccttccaaag aggcctgctg ttccccgtgt gcacacccct gcccgtggag
      901 ggagagctct gccatgaccc caccagccag ctgctggatc tcatcacctg ggaactggag
      961 cctgaaggag ctttggaccg atgcccctgc gccagtggcc tcctatgcca gccacacagc
     1021 cacagtctgg tgtacatgtg caagccagcc ttcgtgggca gccatgacca cagtgaggag
     1081 agccagctgc ccagggaggc cccggatgag tacgaagatg ttggcttcat aggggaagtg
     1141 cgccaggagc tggaagacct ggagcggagc ctagcccagg agatggcatt tgaggggcct
     1201 gcccctgtgg agtcactagg cggagaggag gagatttagg cccagaccca gctgagtcac
     1261 tggtagatgt gcaatagaaa tggctaattt attttcccag gagtgtcccc aagtgtggaa
     1321 tggccgcagc tccttcccag tagcttttcc tctggcttga caaggtacag tgcagtacat
     1381 ttcttccagc cgccctgctt ctctgacttg ggaaagacag gcatggcggg taagggcagc
     1441 ggtgagtcgt ccctcgctgt tgctagaaac gctgtcttgt tcttcatgga tggaagattt
     1501 gtttgaaggg agaggatggg aaggggtgaa gtctgctcat gatggatttg ggggatacag
     1561 ggaggaggat gcctgccttg cagacgtgga cttggcaaaa tgtaaccttt gcttttgtct
     1621 tgcgccgctc ccatgggctg aggcagtggc tacacaagag ctatgctgct ctgtggcctc
     1681 ccacatattc atccctgtgt ttcagctcct acctcactgt cagcacagcc cttcatagcc
     1741 acgccccctc ttgctcacca cagcctagga ggggaccaga ggggacttct ctcagagccc
     1801 catgctctct ctctcaaccc cataccagcc tctgtgccag cgacagtcct tccaaatgga
     1861 gggagtgaaa tcctttggtt ttattatttt ctccttcaag gcacgcctgc cactaaggtc
     1921 aggctgactt gcatgtccct ctaacgttcg tagcagtgtg gtggacactg tcttccaccg
     1981 actgcttcaa tacctctgaa agccagtgct cggagtgcag ttcgtgtaaa ttaatttgca
     2041 ggaagtatac ttggctaatt gtagggctag gattgtgaat gaaatttgca aagtcgctta
     2101 gcaacaatgg aaagcctttc tcagtcacac cgagaagtca caaccaagcc aggttgtgta
     2161 gagtacagct gtgacataca gacagaagaa ggctgggctg gatgtcaggc ctcagatgac
     2221 ggtttcaggt gccaggaact attaccattc tgtatctatc cagagttatt aaaattgaaa
     2281 gttgcacaca tttgtataag catgcctttc tcctgagttt taaattatat gtatacacaa
     2341 acatgtggcc ctcaaagatc atgcacaaac cactactctt tgctaattct tggacttttc
     2401 tctttgattt tcaataaata caaatcccct tcatgcaaaa aaattaaaac aatctgtagt
     2461 ataaagagac aaaaaaattc catagaagca gattttccag gcatctgcag tttccctctt
     2521 ttagaatcgg aattcgttgg aactctcatc cttgtctgga tgggaattag ctttaacaga
     2581 gaaactactt caccctctcc tgaaagaaca aatggaatat atgagtcttc tcttggaggc
     2641 tctttccact caaatgcagt tctggggctg tgctagcatt gatactgtaa caaaacggct
     2701 gaagcaatga acttatatat ttaaaaagtt aggttaattg ggttcaccat ttcaggtttc
     2761 agtcctgatc ccatggggtt gaaactaagg agaggcagca cagcgtggca agggaatgtg
     2821 gtagagtcaa gctgctccct ttctggctaa caggagagtg ggcaatgtgc agtcttgtga
     2881 gaatgcccag gtcctggggg gaagggagtg ccctggacat caccttaaag gtggagactt
     2941 ctgcagcttt ggttttagtt actcttctgg gtgctacaat caaacgccca acaagaagcc
     3001 acctgaggga tgagggttta ttttggctcc tggttcaagc agggagtcct tcgtggcagg
     3061 agtgcaaggt tgcttcctgc agtgtggagg atcaggaagc aaagaaagag caatgcaaga
     3121 ctcagctttc tctctttccc tgattattta ttctggaacc ccaacccttg gggtggtgcc
     3181 gaccgcagta agagtgagtg tcctttcctt agaaccctct gaaaactctt ggcctcatag
     3241 aaatgtgcag aggtgtgtca cctaaattgt tcaaatccat tctgttccaa gacatgggag
     3301 cgctatgtgc taagtcttcc acataagagc accgagtacc tcttaaacgc ctgtaaatcg
     3361 catctgaaga taccacagta aagagatgta aacatttagg aaaacaataa atgtaactga
     3421 tgaagtcacc t
//
