LOCUS       NM_020265               3705 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus dickkopf WNT signaling pathway inhibitor 2 (Dkk2),
            mRNA.
ACCESSION   NM_020265
VERSION     NM_020265.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3705)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 3705)
  AUTHORS   Pina,J.O., Raju,R., Roth,D.M., Winchester,E.W., Padilla,C.,
            Iben,J., Faucz,F.R., Cotney,J.L. and D'Souza,R.N.
  TITLE     Spatial Multi-omics Reveals the Role of the Wnt Modulator, Dkk2, in
            Palatogenesis'
  JOURNAL   J Dent Res 103 (13), 1412-1420 (2024)
   PUBMED   38910391
REFERENCE   3  (bases 1 to 3705)
  AUTHORS   Xian,G., Huang,R., Xu,M., Zhao,H., Xu,X., Chen,Y., Ren,H., Xu,D.
            and Zeng,Q.
  TITLE     Noncoding RNA regulates the expression of Krm1 and Dkk2 to
            synergistically affect aortic valve lesions
  JOURNAL   Exp Mol Med 56 (7), 1560-1573 (2024)
   PUBMED   38945954
  REMARK    GeneRIF: Noncoding RNA regulates the expression of Krm1 and Dkk2 to
            synergistically affect aortic valve lesions.
REFERENCE   4  (bases 1 to 3705)
  AUTHORS   Kumar,N., Prakash,P.G., Wentland,C., Kurian,S.M., Jethva,G.,
            Brinkmann,V., Mollenkopf,H.J., Krammer,T., Toussaint,C.,
            Saliba,A.E., Biebl,M., Jurgensen,C., Wiedenmann,B., Meyer,T.F.,
            Gurumurthy,R.K. and Chumduri,C.
  TITLE     Decoding spatiotemporal transcriptional dynamics and epithelial
            fibroblast crosstalk during gastroesophageal junction development
            through single cell analysis
  JOURNAL   Nat Commun 15 (1), 3064 (2024)
   PUBMED   38594232
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3705)
  AUTHORS   Chen,J., Zhang,X., DeLaughter,D.M., Trembley,M.A., Saifee,S.,
            Xiao,F., Chen,J., Zhou,P., Seidman,C.E., Seidman,J.G. and Pu,W.T.
  TITLE     Molecular and Spatial Signatures of Mouse Embryonic Endothelial
            Cells at Single-Cell Resolution
  JOURNAL   Circ Res 134 (5), 529-546 (2024)
   PUBMED   38348657
REFERENCE   6  (bases 1 to 3705)
  AUTHORS   Stump,R.J., Ang,S., Chen,Y., von Bahr,T., Lovicu,F.J., Pinson,K.,
            de Iongh,R.U., Yamaguchi,T.P., Sassoon,D.A. and McAvoy,J.W.
  TITLE     A role for Wnt/beta-catenin signaling in lens epithelial
            differentiation
  JOURNAL   Dev Biol 259 (1), 48-61 (2003)
   PUBMED   12812787
REFERENCE   7  (bases 1 to 3705)
  AUTHORS   Heller,R.S., Dichmann,D.S., Jensen,J., Miller,C., Wong,G.,
            Madsen,O.D. and Serup,P.
  TITLE     Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in
            transgenic mice suggesting a role for Wnts in pancreas and foregut
            pattern formation
  JOURNAL   Dev Dyn 225 (3), 260-270 (2002)
   PUBMED   12412008
REFERENCE   8  (bases 1 to 3705)
  AUTHORS   Li,L., Mao,J., Sun,L., Liu,W. and Wu,D.
  TITLE     Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt
            signaling pathway via LRP-6 independently of dishevelled
  JOURNAL   J Biol Chem 277 (8), 5977-5981 (2002)
   PUBMED   11742004
REFERENCE   9  (bases 1 to 3705)
  AUTHORS   Mao,B., Wu,W., Li,Y., Hoppe,D., Stannek,P., Glinka,A. and Niehrs,C.
  TITLE     LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
  JOURNAL   Nature 411 (6835), 321-325 (2001)
   PUBMED   11357136
REFERENCE   10 (bases 1 to 3705)
  AUTHORS   Monaghan,A.P., Kioschis,P., Wu,W., Zuniga,A., Bock,D., Poustka,A.,
            Delius,H. and Niehrs,C.
  TITLE     Dickkopf genes are co-ordinately expressed in mesodermal lineages
  JOURNAL   Mech Dev 87 (1-2), 45-56 (1999)
   PUBMED   10495270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127260.3.
            
            On Jun 18, 2009 this sequence version replaced NM_020265.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096448.1, AK031749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-963               AC127260.3         76286-77248
            964-1114            AC127260.3         164778-164928
            1115-1270           AC127260.3         165963-166118
            1271-3705           AC127260.3         168864-171298
FEATURES             Location/Qualifiers
     source          1..3705
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 61.32 cM"
     gene            1..3705
                     /gene="Dkk2"
                     /note="dickkopf WNT signaling pathway inhibitor 2"
                     /db_xref="GeneID:56811"
                     /db_xref="MGI:MGI:1890663"
     exon            1..963
                     /gene="Dkk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             742..1521
                     /gene="Dkk2"
                     /note="dickkopf-related protein 2; dickkopf 2; dkk-2;
                     mDkk-2; dickkopf homolog 1; dickkopf homolog 2"
                     /codon_start=1
                     /product="dickkopf-related protein 2 precursor"
                     /protein_id="NP_064661.2"
                     /db_xref="CCDS:CCDS17844.1"
                     /db_xref="GeneID:56811"
                     /db_xref="MGI:MGI:1890663"
                     /translation="MAALMRVKDSSRCLLLLAAVLMVESSQLGSSRAKLNSIKSSLGG
                     ETPAQSANRSAGMNQGLAFGGSKKGKSLGQAYPCSSDKECEVGRYCHSPHQGSSACML
                     CRRKKKRCHRDGMCCPGTRCNNGICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDL
                     GWQNLGRPHSKMPHIKGHEGDPCLRSSDCIDGFCCARHFWTKICKPVLHQGEVCTKQR
                     KKGSHGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI"
     exon            964..1114
                     /gene="Dkk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1270
                     /gene="Dkk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..3705
                     /gene="Dkk2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1757..1762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dkk2"
                     /note="hexamer: AAGAAA"
     polyA_site      1776
                     /gene="Dkk2"
                     /note="major polyA site"
     regulatory      3677..3682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dkk2"
                     /note="hexamer: ATTAAA"
     polyA_site      3705
                     /gene="Dkk2"
                     /note="major polyA site"
ORIGIN      
        1 aagagagcac tggccctccg cgcagcgcat cactgcttcg ctggcagggc ttagtggccc
       61 cgtgtgaacc aagggacaac tcctaaccgc accagtggga gtgcgcttgc tgggacctcc
      121 gctcgcctca gctctccaga gtccggtgga ggggttgggg gagactctga tcaccagtca
      181 caaaccccgc ggacctggaa aagagggact tgagtggtgc aaaggttgag agctaaagca
      241 caggagagga cagaggagca gaggagccgg gggaaacaag agaaaagaaa ggaagaaaaa
      301 gaaaaagaag cagcagctgg ggagaaccct gtgcgcggtt aagggaggat tccatcaccg
      361 cggaaaatcg tgcaaaagcg caaaggtgct gaacaccaaa cgaagccggc agggcgatct
      421 gcagggctgg gtctaacagc accttgggtc acgcctcctt ggcgagaagg cgtctggcct
      481 ttgattgctt ccagggactg cagaacttcc tgcccgtcag aggagcgggt ctcgctgggg
      541 tcgcgtttgc tccaggcttg aggcttgaga ctaagttctt aagagtcccg agtgtctgat
      601 ccaggaaggg ttgggggaac tgtgtctgtg aggagcccac gcgccccacg tgaggggttg
      661 agtgtcggcg ggcgtcctca ctcccctggc attcccatct tttcagggct ccacccaact
      721 ccgggaaccc cttacccgga gatggccgcg ctgatgcggg tcaaggattc atcccgctgc
      781 cttctcctac tggccgcggt gctgatggtg gagagctcac agctaggcag ctcgcgggcc
      841 aaactcaact ccatcaagtc ctctctagga ggggagactc ctgctcagtc agccaaccga
      901 tctgcaggca tgaaccaagg actggctttc ggcggcagta agaagggcaa aagcctgggg
      961 caggcctacc cttgcagcag tgataaggaa tgtgaagttg gaagatactg ccacagtccc
     1021 caccaaggat catcagcctg catgctctgt aggaggaaaa agaaacgatg ccacagagat
     1081 gggatgtgtt gccctggtac ccgctgcaat aatggaatct gcatcccagt cactgagagc
     1141 atcctcaccc cacatatccc agctctggat ggcacccggc atagagatcg caaccatggt
     1201 cactattcca accatgacct gggatggcag aatctaggaa ggccacactc caagatgcct
     1261 catataaaag gacatgaagg agacccatgc ctacggtcat cagactgcat tgatgggttt
     1321 tgttgtgctc gccacttctg gaccaaaatc tgcaaaccag tgctccatca gggggaagtc
     1381 tgtaccaaac aacgcaagaa gggttcgcac gggctggaga ttttccagag gtgtgactgt
     1441 gcaaagggcc tgtcctgcaa agtgtggaaa gatgccacct actcttccaa agccagactc
     1501 catgtatgcc agaagatctg ataaacactg gaagagtcat cactagcaga ctgtgaattt
     1561 gtgtatttaa tgcattatgg catgatggaa acctggattg gaatgcggaa gaatgaggga
     1621 tgtggtaaga atgtggagca gaagagggca ggactgaatc aagtagagtc gacaacaacc
     1681 aaagtactac cagtgcttcc gttatgtgcc tcatctatgt aaataatgta cacatttgtg
     1741 aaaatgctat tattaaaaga aagcacacca tggaaattac tgacgaatac catgtgattt
     1801 tccaagagtt tggctagagc tgtagggggc atttccttca gattggcaat ggctttaaaa
     1861 ataacttaaa gctacatttc tactcaaagc tacagtttaa taaattactc tcactctctc
     1921 ttaacctaag aggatctcta aaacatgggg aacgctgaag aacagggaat gaaaatgttc
     1981 agcatcatta atcatcttac aaaaatcacc tttgcctttt ctcaaataaa ggccttggta
     2041 gacaagagga aaaggcagtc agtattttcc aaatcacttc aagatactgg tatgtcattt
     2101 aggcataaga acagggtaaa caatcagtag tcctggccaa gttgttaagg caatgggcta
     2161 gaaaaggata aatgtgtctc tttaggccac tcatttctat ttcaaaaacc taatttcacc
     2221 tgaattaata aggttagatg taagacaaaa gcagaatctg tattgtgaag gaatggcatt
     2281 gccaatgtca ttcccgctcg agctggagcc attaatcatg tgcaatacaa gcacagggca
     2341 gaattgtctc agattgcaaa accactgaag ttgtctgaca catgaggaga actgaatgac
     2401 gggatgagca cataccctat ctgtgatata ctgataaata cctttatcct tgcatagctg
     2461 ggggccagta gggtgatgca ggcactagag atgtgagtga tatctgtact tcgtggagca
     2521 cagcagggaa gtaggtggaa ccttgtcatt tgtgcaggct ttaaggtcac atgtctgaag
     2581 cacaggctgg attgtcatga ctgccatcag aggctccaga agcaaagttc aagctctcca
     2641 tgaaatttgc tctcatgcag gtaagctggg tgcaatgcag cctgccctcc ccatcatgct
     2701 tttgaggctg taagataatc tcaatatgag gggattttac aaagtgggtt cccttgggcc
     2761 aggtgatatg agaggaacca atctctctaa gctttagagt gatgatgtca tcagaagttt
     2821 atatactaac ctctcgatgg agtatgtcat tactaaagac atagttccta ttttctgaaa
     2881 ctattgaaaa tgaaaaagta ataacatatc tctaatctat agaaattccc tgaaatcgtt
     2941 tcactatttt ctgattaaac acatttctga atactacatc tagagcatag aggacaaaaa
     3001 taaaaagaaa gaagaaaata gaaagaaaga gagagagaaa gcaagcaagc aagcaagcaa
     3061 gcaagaaaga aagaaagaaa gaaagaaaga aagaaaagga aagaaagaaa gagaaggaaa
     3121 gagagagggg gagagaaaga aagaaagaaa gaaagaaaga aagaaagaaa gaaaaagaga
     3181 gagagagaga gagagagaga gaaataaaga aaaggctaaa cctgctgctg cttaagctct
     3241 tatagaccac acatcatttt tgtttgactt atatcccatc tgcaatctca aagtccagtc
     3301 caacaagagt tccagcttcg gacacacatt tggtcaggat gatggtggtt agtgctctgc
     3361 atgtgtctgc tagaacaaaa ctcataagct aatttaccca agagcaaacc ttatgtggtt
     3421 taagctttgt gatgtgaaaa tggagtattt tggtcagaat ttcctacatt tcatacgaca
     3481 cctaccacct agttttcgca ttattcccct tatattcacc ctctcaaaaa ttattatttg
     3541 aaataattta tttacaggaa atgttaatga gatgtatttt cttatagaga tgtttcttac
     3601 agaaagcttt gtagcagaat atatttgcag ctgtcaactt tgtaatttag gggaaatgta
     3661 taataagata aaatatatta aatttttctc tttcaaaaag ttgaa
//
