LOCUS       NM_010051               2245 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus dickkopf WNT signaling pathway inhibitor 1 (Dkk1),
            mRNA.
ACCESSION   NM_010051
VERSION     NM_010051.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2245)
  AUTHORS   Pina,J.O., Raju,R., Roth,D.M., Winchester,E.W., Padilla,C.,
            Iben,J., Faucz,F.R., Cotney,J.L. and D'Souza,R.N.
  TITLE     Spatial Multi-omics Reveals the Role of the Wnt Modulator, Dkk2, in
            Palatogenesis'
  JOURNAL   J Dent Res 103 (13), 1412-1420 (2024)
   PUBMED   38910391
REFERENCE   2  (bases 1 to 2245)
  AUTHORS   Thowfeequ,S., Fiorentino,J., Hu,D., Solovey,M., Ruane,S.,
            Whitehead,M., Zhou,F., Godwin,J., Mateo-Otero,Y.,
            Vanhaesebroeck,B., Scialdone,A. and Srinivas,S.
  TITLE     An integrated approach identifies the molecular underpinnings of
            murine anterior visceral endoderm migration
  JOURNAL   Dev Cell 59 (17), 2347-2363 (2024)
   PUBMED   38843837
REFERENCE   3  (bases 1 to 2245)
  AUTHORS   Zhang,Z. and Hu,J.
  TITLE     DKK1 loss promotes endometrial fibrosis via autophagy and
            exosome-mediated macrophage-to-myofibroblast transition
  JOURNAL   J Transl Med 22 (1), 617 (2024)
   PUBMED   38961399
  REMARK    GeneRIF: DKK1 loss promotes endometrial fibrosis via autophagy and
            exosome-mediated macrophage-to-myofibroblast transition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2245)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2245)
  AUTHORS   Liu,X., Zheng,T., Zhang,Y., Zhao,Y., Liu,F., Dai,S., Zhang,M.,
            Zhang,W., Zhang,C., Zhang,M. and Li,X.
  TITLE     Endothelial Dickkopf-1 Promotes Smooth Muscle Cell-derived Foam
            Cell Formation via USP53-mediated Deubiquitination of SR-A During
            Atherosclerosis
  JOURNAL   Int J Biol Sci 20 (8), 2943-2964 (2024)
   PUBMED   38904030
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2245)
  AUTHORS   Zakin,L., Reversade,B., Virlon,B., Rusniok,C., Glaser,P.,
            Elalouf,J.M. and Brulet,P.
  TITLE     Gene expression profiles in normal and Otx2-/- early gastrulating
            mouse embryos
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14388-14393 (2000)
   PUBMED   11114168
REFERENCE   7  (bases 1 to 2245)
  AUTHORS   Grotewold,L., Theil,T. and Ruther,U.
  TITLE     Expression pattern of Dkk-1 during mouse limb development
  JOURNAL   Mech Dev 89 (1-2), 151-153 (1999)
   PUBMED   10559490
REFERENCE   8  (bases 1 to 2245)
  AUTHORS   Monaghan,A.P., Kioschis,P., Wu,W., Zuniga,A., Bock,D., Poustka,A.,
            Delius,H. and Niehrs,C.
  TITLE     Dickkopf genes are co-ordinately expressed in mesodermal lineages
  JOURNAL   Mech Dev 87 (1-2), 45-56 (1999)
   PUBMED   10495270
REFERENCE   9  (bases 1 to 2245)
  AUTHORS   Pearce,J.J., Penny,G. and Rossant,J.
  TITLE     A mouse cerberus/Dan-related gene family
  JOURNAL   Dev Biol 209 (1), 98-110 (1999)
   PUBMED   10208746
REFERENCE   10 (bases 1 to 2245)
  AUTHORS   Glinka,A., Wu,W., Delius,H., Monaghan,A.P., Blumenstock,C. and
            Niehrs,C.
  TITLE     Dickkopf-1 is a member of a new family of secreted proteins and
            functions in head induction
  JOURNAL   Nature 391 (6665), 357-362 (1998)
   PUBMED   9450748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103405.14.
            
            On Nov 17, 2006 this sequence version replaced NM_010051.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050189.1, AK141693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               AC103405.14        124312-124674
            364-532             AC103405.14        124862-125030
            533-682             AC103405.14        126096-126245
            683-2245            AC103405.14        126370-127932
FEATURES             Location/Qualifiers
     source          1..2245
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 25.16 cM"
     gene            1..2245
                     /gene="Dkk1"
                     /gene_synonym="mdkk-1"
                     /note="dickkopf WNT signaling pathway inhibitor 1"
                     /db_xref="GeneID:13380"
                     /db_xref="MGI:MGI:1329040"
     exon            1..363
                     /gene="Dkk1"
                     /gene_synonym="mdkk-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..936
                     /gene="Dkk1"
                     /gene_synonym="mdkk-1"
                     /note="dickkopf-related protein 1; dkk-1; dickkopf-1;
                     dickkopf-like protein 1; dickkopf homolog 1"
                     /codon_start=1
                     /product="dickkopf-related protein 1 precursor"
                     /protein_id="NP_034181.2"
                     /db_xref="CCDS:CCDS29744.1"
                     /db_xref="GeneID:13380"
                     /db_xref="MGI:MGI:1329040"
                     /translation="MMVVCAAAAVRFLAVFTMMALCSLPLLGASATLNSVLINSNAIK
                     NLPPPLGGAGGQPGSAVSVAPGVLYEGGNKYQTLDNYQPYPCAEDEECGSDEYCSSPS
                     RGAAGVGGVQICLACRKRRKRCMRHAMCCPGNYCKNGICMPSDHSHFPRGEIEESIIE
                     NLGNDHNAAAGDGYPRRTTLTSKIYHTKGQEGSVCLRSSDCAAGLCCARHFWSKICKP
                     VLKEGQVCTKHKRKGSHGLEIFQRCYCGEGLACRIQKDHHQASNSSRLHTCQRH"
     exon            364..532
                     /gene="Dkk1"
                     /gene_synonym="mdkk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..682
                     /gene="Dkk1"
                     /gene_synonym="mdkk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..2245
                     /gene="Dkk1"
                     /gene_synonym="mdkk-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1265..1270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dkk1"
                     /gene_synonym="mdkk-1"
                     /note="hexamer: CATAAA"
     polyA_site      1288
                     /gene="Dkk1"
                     /gene_synonym="mdkk-1"
                     /note="major polyA site"
ORIGIN      
        1 agagactcca ccagcggagg tcccgaagtt gaggttccgc agtccagact ctgcagccag
       61 ccgccgtgca aagtgacctc tcttttcctg acctttgcct gtttgcgtcc ttcggagatg
      121 atggttgtgt gtgcagcggc agctgtccgg ttcttggccg tgtttacaat gatggctctc
      181 tgcagcctcc ctctgctagg agccagtgcc accttgaact cagttctcat caattccaac
      241 gcgatcaaga acctgccccc accgctgggt ggtgctgggg ggcagccggg ctctgctgtc
      301 agtgtggcgc cgggagttct ctatgagggc gggaacaagt accagactct tgacaactac
      361 cagccctacc cttgcgctga agatgaggag tgcggctctg acgagtactg ctccagcccc
      421 agccgcgggg cagccggcgt cggaggtgta cagatctgtc tggcttgccg aaagcgcagg
      481 aagcgctgca tgaggcacgc tatgtgctgc cccgggaact actgcaaaaa tggaatatgc
      541 atgccctctg accacagcca ttttcctcga ggggaaattg aggaaagcat cattgaaaac
      601 cttggtaatg accacaacgc cgccgcgggg gatggatatc ccagaagaac cacactgact
      661 tcaaaaatat atcacaccaa aggacaagaa ggctccgtct gcctccgatc atcagactgt
      721 gccgcagggc tgtgttgtgc aagacacttc tggtccaaga tctgtaaacc tgtccttaaa
      781 gaaggtcagg tgtgcaccaa gcacaaacgg aaaggctccc acgggctgga gatattccag
      841 cgctgttact gcggggaagg cctggcttgc aggatacaga aagatcacca tcaagccagc
      901 aattcttcta ggctccacac ctgccagaga cactaaaccg acagtctaaa tatgatggac
      961 tctttttatc taatatatgc tacgaaaatc ctttatgatt tgtcagctca atcccaagga
     1021 tgtaggaatc ttcagtgtgt aattaagcat tccgacaata ccttccaaaa gctctggagt
     1081 gtaaggactt tgtttcttga tggaactccc ctgtgattgc agtaaattac tgtgttgtaa
     1141 atcctcagtg tggcacttac ctgtaaatgc agcaaaactt ttaattattt ttctagaggt
     1201 gtgctacatt gccttgtttc tcttgcatgt aaattttttt tgtacacggt tgattgtctt
     1261 gactcataaa tattctatat tgaagtaatt ttggtttaca gttcttaaat gtgtaaccct
     1321 ttctgcttca atgtctaggg ggtcgaatgt aaggagaaat ggaatagtcg gtgataggca
     1381 tctaaaattt aacatgaaag tatcagttta tttcctgaga tgtgctctct gcttagattc
     1441 tctctctctc tctctccctc tctctctctc tctctctctc tctctctctc acacacacac
     1501 acacacacac acacacacac acacacatct ctcctctcta gttctgtctc tctcagctgg
     1561 tagtccttga aataaaattt aacatttaat aatcattaag ttagaagtat agatacattt
     1621 ggggctctgt gtgtgtgtga gagagagggg gggttaaaat gataagatat attgtctgtg
     1681 tgtgagttag tttaaagaga atgtatctac attgataaaa ctcaaatggc tttggtaata
     1741 tgggcttgaa tttggtataa ctaccttcaa aacttctaac aagtgtggtt ggtgcttttg
     1801 cctataatcc caggattttg gaggctgagg cagagggatg cccatgaact caggtccatt
     1861 ctggccaact ctttctatag aacaatgttc agtttcaaaa aaaacatcaa ccaaaagtag
     1921 ttaacaacca attaatattc acctaagtga ccaacagtta ttggaaggga gggaatgccc
     1981 aagcaagtga ttccagatga tgggcagaat tcagaagaga ttatgcagaa ggaagcctgc
     2041 caacttaagc caaataatta attctgaata ttttagatcc tctgacatgc tgaagaattg
     2101 tttcaatcac tttgatttaa aaaataatta ctaaacaatc ataaattcta gaatgtaaca
     2161 cttctcttgc caagaaatta tttcattttt tgcttcacct gtactccatt gattggaatg
     2221 agaatggctt tattaaaaaa aaaaa
//
