LOCUS       NM_170593               6629 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus dispatched RND transporter family member 2 (Disp2),
            mRNA.
ACCESSION   NM_170593
VERSION     NM_170593.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6629)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6629)
  AUTHORS   Arnes,L., Akerman,I., Balderes,D.A., Ferrer,J. and Sussel,L.
  TITLE     betalinc1 encodes a long noncoding RNA that regulates islet
            beta-cell formation and function
  JOURNAL   Genes Dev 30 (5), 502-507 (2016)
   PUBMED   26944677
REFERENCE   3  (bases 1 to 6629)
  AUTHORS   Hald,J., Galbo,T., Rescan,C., Radzikowski,L., Sprinkel,A.E.,
            Heimberg,H., Ahnfelt-Ronne,J., Jensen,J., Scharfmann,R.,
            Gradwohl,G., Kaestner,K.H., Stoeckert,C. Jr., Jensen,J.N. and
            Madsen,O.D.
  TITLE     Pancreatic islet and progenitor cell surface markers with cell
            sorting potential
  JOURNAL   Diabetologia 55 (1), 154-165 (2012)
   PUBMED   21947380
REFERENCE   4  (bases 1 to 6629)
  AUTHORS   Anderson,K.R., White,P., Kaestner,K.H. and Sussel,L.
  TITLE     Identification of known and novel pancreas genes expressed
            downstream of Nkx2.2 during development
  JOURNAL   BMC Dev Biol 9, 65 (2009)
   PUBMED   20003319
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6629)
  AUTHORS   Ma,Y., Erkner,A., Gong,R., Yao,S., Taipale,J., Basler,K. and
            Beachy,P.A.
  TITLE     Hedgehog-mediated patterning of the mammalian embryo requires
            transporter-like function of dispatched
  JOURNAL   Cell 111 (1), 63-75 (2002)
   PUBMED   12372301
  REMARK    GeneRIF: dispatched plays a role in hedgehog body patterning, as
            demonstrated in transgenic mice
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL772255.12.
            
            On Jun 30, 2010 this sequence version replaced NM_170593.2.
            
            Summary: The pattern of cellular proliferation and differentiation
            that leads to normal development of embryonic structures often
            depends upon the localized production of secreted protein signals.
            Cells surrounding the source of a particular signal respond in a
            graded manner according to the effective concentration of the
            signal, and this response produces the pattern of cell types
            constituting the mature structure. A segment-polarity gene known as
            dispatched has been identified in Drosophila and its protein
            product is required for normal Hedgehog (Hh) signaling. [provided
            by RefSeq, Sep 2015].
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY150699.1, BC118526.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               AL772255.12        74963-75188
            227-556             AL772255.12        81290-81619
            557-586             AL772255.12        81944-81973
            587-710             AL772255.12        82115-82238
            711-826             AL772255.12        82516-82631
            827-954             AL772255.12        82803-82930
            955-1052            AL772255.12        83261-83358
            1053-6629           AL772255.12        84843-90419
FEATURES             Location/Qualifiers
     source          1..6629
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.46 cM"
     gene            1..6629
                     /gene="Disp2"
                     /gene_synonym="B230210L08Rik; DispB; mKIAA1742"
                     /note="dispatched RND transporter family member 2"
                     /db_xref="GeneID:214240"
                     /db_xref="MGI:MGI:2388733"
     exon            1..226
                     /gene="Disp2"
                     /gene_synonym="B230210L08Rik; DispB; mKIAA1742"
                     /inference="alignment:Splign:2.1.0"
     exon            227..556
                     /gene="Disp2"
                     /gene_synonym="B230210L08Rik; DispB; mKIAA1742"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..4280
                     /gene="Disp2"
                     /gene_synonym="B230210L08Rik; DispB; mKIAA1742"
                     /note="dispatched B; dispatched homolog 2; dispatched RND
                     tramsporter family member 2"
                     /codon_start=1
                     /product="protein dispatched homolog 2"
                     /protein_id="NP_733481.1"
                     /db_xref="CCDS:CCDS16584.1"
                     /db_xref="GeneID:214240"
                     /db_xref="MGI:MGI:2388733"
                     /translation="MAPEASPERSCSLHTCPLEDPTGAPVPPPTVSTLQAIDPTSPLT
                     AGHFAFPRAPQDYQEGSSLLGLGDQASLCAHVSNLSTSIDTSQHDGVWKQPSVQRHVV
                     SVRQERTFRMPKSYSHMIADWPVAVIVGCLAFIFLCTLAGLLGSPPLDFSEPLLGFEP
                     RDTEIGRRLEVWKAMQALTGPKNLLSLSPDPEMNSSSLLSTLSPAAWGRAEESVVRTK
                     RMVGPVEVKEEENFFCGRPEKSHAKLVFVSTSGGSLWNLQAIHSMCRIEQEQIRSHIS
                     FGALCQRSAANECCPSWSLGNYLAVLSNRSSCQDTTQADTDRTLALLRFCATFYHRGV
                     LVPACVGSSQDKPPFCAQVPAKCTGSNVVYEFLHYLLDRDFLSPQTADYQVPSLKFAL
                     LFLPIIKTSSLLDIYLDGLGDPIKVSDNYTSISGMDLGLKPRLLKYYLAEDTMYPLIA
                     LVVIFFGMSLYLRSLFITFMSLLGVLGSLMVAYFLYHVAFRMAYFPFVNLAALLLLSG
                     VCVNYTLIFLDMWRLSRGQVPSGGMPHRVGRTMHHFGYLLLVSGLTTSAAFYGSYLSR
                     LPAVRCFALFMGTAVLVHMGLTLLWLPATVVLHERYLAHGCVAQAHGQRGGSDPLRLL
                     LALHRRIRIFRKIISILSRLLFQRLLPCGVIKFRYIWICWFAALAAGGAYIGGVSPRL
                     QLPILLPLGGQFFRSSHPFERFDAEYRQQFLFEDLPPNEGGNLPVVLVWGILPVDTSD
                     PLDPRTNSSVVSDPDFSPSSPEAQEWLLALCHGAQNQSFFGDQPEGWPTLCLVEALQQ
                     WMESPSCGRLGPDLCCGQSEFPWAPQLYLHCLKMMALEQSPDGTRDLGLRFDTHGNLA
                     ALVLKFQTNLPYSTEYGPVHHFYTEISRWLSTEMSKAPPGLNQGWFTSNLELYSLQHS
                     LSTEPAVVLGLALALAFATLLLSTWNVPLSLFSVAAVAGTVLLTVGLLVLLEWQLNTA
                     EALFLSASVGLSVDLTINYCISYHLCPHPDRLSRVAFSLRQISRATAMTTGVLFASGV
                     IMLPSTILLYRKLGIIVMMVKFLGCGFASFFFQSLCCFFGPEKNCGQILWPCAHLPWD
                     AGTEDPDEKGRAGPPGFSEHYELQPLARRRSPSFDTSTATSKLSHRPSILSEDLQIHD
                     GSCCLQHAQAPVSPRDLLLDHQTVFSQCPALQTSSPYKQAGPTPQTWIRQDSQGQKTE
                     PLQALPEGPAHCPKSKVEELPDGLCSSASTLEGLSVSDDTCASEHSVRVPDSVGTSPE
                     VMNGTGHPILERGQLNGKRDTLWLALKETIYDPNMPNSHHSSLSWKGRGGPGDISPVM
                     LPNSQPDLPDVWLRRPSTYTSGYSS"
     exon            557..586
                     /gene="Disp2"
                     /gene_synonym="B230210L08Rik; DispB; mKIAA1742"
                     /inference="alignment:Splign:2.1.0"
     exon            587..710
                     /gene="Disp2"
                     /gene_synonym="B230210L08Rik; DispB; mKIAA1742"
                     /inference="alignment:Splign:2.1.0"
     exon            711..826
                     /gene="Disp2"
                     /gene_synonym="B230210L08Rik; DispB; mKIAA1742"
                     /inference="alignment:Splign:2.1.0"
     exon            827..954
                     /gene="Disp2"
                     /gene_synonym="B230210L08Rik; DispB; mKIAA1742"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1052
                     /gene="Disp2"
                     /gene_synonym="B230210L08Rik; DispB; mKIAA1742"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..6629
                     /gene="Disp2"
                     /gene_synonym="B230210L08Rik; DispB; mKIAA1742"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6603..6608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Disp2"
                     /gene_synonym="B230210L08Rik; DispB; mKIAA1742"
                     /note="hexamer: AAGAAA"
     polyA_site      6613
                     /gene="Disp2"
                     /gene_synonym="B230210L08Rik; DispB; mKIAA1742"
                     /note="major polyA site"
ORIGIN      
        1 accgctgccg ctgcttcagc accagagccc ggacagcggc gccgcccacg ggcatggacg
       61 gtggtagcag ccccagctgc tgcagcgatc ttctctttgc cagtttctga accgcaagca
      121 gcggcctgag gggaatacat tagccccaga aggcagctgc cggaacaagt aggaagaacc
      181 cctccgtaga tcctgctgga agatcttctc agtaagcctg catcaggtcc tagaccaaag
      241 ccatggctcc tgaggcaagc ccagagagaa gctgctccct ccacacctgt ccccttgaag
      301 acccaaccgg tgctccggta ccaccaccaa ccgtgtccac gctccaggct atagacccga
      361 cgagtccgtt aacggctggt cattttgcct ttcctcgagc gcctcaagac tatcaagaag
      421 gaagttcatt attaggatta ggagaccaag catctctatg tgcccatgtc tccaacctca
      481 gcacctccat agacacctct cagcatgatg gggtctggaa gcaaccttct gtgcagcgcc
      541 atgtggtcag tgtcaggcag gaacgcactt tccggatgcc gaagagctat tctcatatga
      601 ttgctgattg gccagtggct gtgatcgtgg ggtgtctggc cttcatcttc ctctgtaccc
      661 tagctgggct gttgggaagc ccaccacttg acttttctga gcctttactg ggttttgagc
      721 ctcgagacac agagataggc cgaaggttag aagtttggaa agccatgcag gccctcactg
      781 gccccaagaa tctgctttct ctttccccag accctgagat gaacagctca agcctcctca
      841 gcaccctgag ccctgcagcc tggggcaggg ccgaggaaag tgtggtccgg accaagagga
      901 tggtggggcc tgtggaagtc aaagaagaag agaacttctt ttgtggccgc cctgagaaga
      961 gccatgcaaa gctggtgttt gtgtccacct ctgggggaag cctgtggaac ctgcaagcca
     1021 tccattccat gtgtcgcata gaacaggagc agatccgctc tcacatcagt tttggggctc
     1081 tgtgccagcg atcagcagcc aatgagtgct gccccagctg gtccttgggc aactatctgg
     1141 ccgtgctgtc taaccgctcc tcctgccaag acactaccca agccgataca gaccgcacat
     1201 tggccctgct acggttctgt gccaccttct accatcgtgg tgtcctggtg cctgcttgtg
     1261 tggggtctag ccaggacaaa cccccgtttt gtgcccaagt tcctgccaag tgtaccggaa
     1321 gcaacgtggt ctatgaattc ctgcactacc tgctagacag agactttctg agtccccaga
     1381 ctgcggatta ccaggtgccc tccctcaagt ttgccctgct cttcctgccc attataaaga
     1441 cctcctctct tctagacatc tacctggacg gcctaggtga cccaattaaa gtctctgaca
     1501 actacacatc tatcagtggc atggacttgg gcctcaagcc cagactgctg aagtattacc
     1561 tagccgaaga caccatgtat cccttgatag ccctggttgt catcttcttt ggcatgtccc
     1621 tctacctgcg ctcactcttc atcacgttca tgtcacttct aggggtgctg ggctccctaa
     1681 tggtggccta ctttctttac catgtggcat tccgcatggc ctacttcccc tttgtcaatc
     1741 tagcggctct ccttctgctt agtggtgtct gtgtcaatta cacgctcatc ttcttggata
     1801 tgtggcgcct cagcaggggt caggtgcctt ccgggggcat gccacaccgt gtaggccgta
     1861 ccatgcacca ctttggctac ctgctcctgg tctcaggcct caccaccagc gcagccttct
     1921 acggcagcta cctgagccgc ctgcccgcag tgcgttgctt tgctcttttc atgggcactg
     1981 ctgtactagt gcacatgggg ctcacactgc tctggcttcc cgccaccgtg gtgctccatg
     2041 agcgctactt ggctcacggc tgtgtggccc aagcgcacgg ccagaggggt ggcagcgacc
     2101 ccctgaggct gttgctggcg ttgcacagac ggatccgtat ttttcgcaag attatttcca
     2161 tcctctcgcg cctgcttttc cagcgcctgc tgccctgtgg tgtcattaag tttcggtaca
     2221 tctggatctg ctggttcgcg gcgttggcgg cagggggcgc ctacatcggc ggcgtcagcc
     2281 ctcgcctgca actgcccatt ctattgccac ttggaggcca gttcttccgt tctagccatc
     2341 cctttgaacg ctttgacgca gagtatcgcc agcagttcct gttcgaggat ctgcctccaa
     2401 acgagggcgg caacttgcca gtggttctgg tgtggggaat cctgccagtg gacactagtg
     2461 atcccctgga ccctcgcacc aacagctcag tggtaagtga tcctgacttc tcgcctagca
     2521 gcccggaggc ccaggagtgg ctcctggctc tctgccatgg agcccagaat cagagcttct
     2581 ttggagatca gccagagggc tggcctacgc tgtgtttagt ggaagcctta cagcagtgga
     2641 tggagagccc tagctgtggc cgcctgggtc ctgatctatg ctgcggacaa tcagaattcc
     2701 cctgggcccc ccagctttac ctgcactgtc tcaagatgat ggctctggag caaagtcctg
     2761 atggcacacg tgacctggga ctccgcttcg atactcatgg caacctggca gctctagttc
     2821 taaagttcca gaccaactta ccctacagta cagagtacgg cccggtccac cacttctaca
     2881 ctgaaatcag ccgctggttg tcaaccgaga tgagcaaggc acctcctggc ctcaaccagg
     2941 gttggttcac cagcaacttg gagctgtaca gcttgcagca tagtctaagc acagagccag
     3001 ctgtcgtgct tggtctggcc ctggcactag cctttgccac actgctgctg agcacctgga
     3061 atgtccccct cagtctgttc tctgtggcag ctgtggctgg caccgtactg ctcacggtgg
     3121 gcttgctggt tcttcttgag tggcaactca acactgccga agctctcttt ctctctgcct
     3181 ctgtgggcct ctctgtagac ttaaccatta actactgcat ctcctatcac ttgtgcccac
     3241 acccggaccg cctgagccgt gtggccttct ctttacgtca gatcagccgg gccacggcga
     3301 tgacgactgg agtgttgttt gcctctggtg tgatcatgct gccttccact atactgctct
     3361 atcggaagct gggcatcatc gtcatgatgg tcaagttcct tggctgtggc tttgccagct
     3421 tcttctttca gtccctgtgc tgtttcttcg ggccagaaaa gaactgtggc cagatcctct
     3481 ggccctgcgc ccatctgccg tgggatgccg ggactgagga tcctgacgag aaggggcgag
     3541 cggggccacc aggattctcc gaacactatg agttgcagcc cctggcacgg cgccggagtc
     3601 ccagcttcga caccagcaca gccaccagca agctttccca tcggccttcc atactctctg
     3661 aagacctgca gatacatgat ggcagctgct gcctccagca tgcccaagcc cctgtctccc
     3721 caagggatct gctcctagac caccagacag tcttcagcca gtgtccagcc ctgcagacct
     3781 cctctccata taagcaggct ggccccaccc cccaaacctg gatcaggcaa gattcccagg
     3841 gacagaaaac tgagcccctg caggcactgc cagaaggccc tgcccactgc cctaagtcca
     3901 aagtggaaga gctccccgat ggcctgtgct cctcagccag caccctggag ggactcagcg
     3961 tctcagatga cacctgtgcc tctgagcata gtgtccgtgt gccagattct gtgggtacct
     4021 ccccagaagt catgaatggc actggacacc ccatacttga gcggggccag ctgaatggga
     4081 agcgcgacac cctctggcta gcactgaagg agaccatcta tgacccaaac atgcccaatt
     4141 ctcaccacag cagcttatcc tggaagggcc gtggagggcc aggcgatatc agccctgtga
     4201 tgcttcccaa cagtcagcca gatctcccag atgtttggct ccgtaggccc agcacctaca
     4261 cctctggcta cagcagctga gagaggccaa ggaaggccag accagggtcc acaaccctgt
     4321 tggtgaagat aaggcagatg ccacactagc ctagagcctg aaggtatttc tccctattga
     4381 catgatgtct taccctccaa gtatggattc taaaccctgc cagatgttct agccttgatc
     4441 tctttgctac ttacccctgc atctggagga ttcagtggga gggccttgca aggtaatacc
     4501 aggctctccc tgtgaccaac taaggactca tctgtcccca cagtgccaac aaggacccct
     4561 actctggaaa ggagggaggc cagatgtgca gttccaggta ttggggaggc tgatcagctg
     4621 tctcccgggt gacaagaagt tcagtgacgc taaggtactc catctttggg atccagttgg
     4681 agtatctcac tgactagaaa aacccttaag aacctccaca gcctattgaa tctcatccct
     4741 tctcattggc tcttaatcgg gacacttcag ttcttgggaa gcttctctgg gctggaagtg
     4801 aacacgggcc tctgtcctgc actgtcctgt tctgctcaca ctcaccagtg tgactagaag
     4861 ctctccaaaa gcaggacaga ggtggatgac aagagagaag caggagacag gaaggtcggc
     4921 tttggagtat ccctaaattc caagattccc ccataggacg ctgactccag aatgttcccc
     4981 tgtaagtgag cagtagttac cccttaccat tgccacacct gccagtcttc ttggaccttt
     5041 gcaaagttac tccacagtgg cctgcagttg gtcaagacac tgagaatggt tgattgattg
     5101 tcccccaaag tcatgtcact gggtagcagc aggattctct cctgactcat gctgccacta
     5161 tagctccctg tctcctcctg agtgtgagct tcagggccct gggcccctgg ctgtcttggt
     5221 cctttgcttc tggcagttac ccagtctctt tgcttgagcc tctctttgtg agccctccct
     5281 ccccttgggg cctccacctc cagaaagagt tgtagtctga gtagaccgga gagttcctca
     5341 tttcctttga gtttccccgc tctgaaactc tctgagatgc ctactagcca tgggcctacc
     5401 gggtcacagg cagccgagct gaagcttagg cttcaaggat gtgcctcttt catggctgag
     5461 gagtacagac aggctttgcc agaagaggta cgaagggaca gaagaatgtg aacagaatct
     5521 agttaagaca agaacacaaa gttgctcttg tggagttgtc caggaccctg aagtctaggt
     5581 atcaggtcct cagtttctga agactaggcc tcccagtaag gttgcttgac ggtgtcactg
     5641 atcagtggca gagtgctctc ctgactcatc ctgccactat ggctccctgt ctcctcctga
     5701 ccaactgcct gcttcagggc cattagcttt ctccacccaa agcactcatg tgacacagct
     5761 caagacacca ggcaccatct gcaagtttac tgaacacctg cattggaaag ggtgttgtaa
     5821 gggagagaga catggaacgg agaactggcc tcctgctggg aagcaggcat tagtgggtca
     5881 gggttactgc cgagctcagg tgcccagcaa taggtgaccg ggaagatctc gtggagaggg
     5941 atgggtttga gctgggcttc agaagatcaa gcagatcaga caggagggag cttggtgatc
     6001 caactccaag ggtcccctaa ggactgttct ttcaataagc tcctgtgtct aaaactcctg
     6061 ctccgagggg tgtgagttta ggggtgctgc tagctcagct tccctttcta gtgcagatct
     6121 ccaggggtct ccaggtccct gggaatatcc atagatcttg gcatgaagac caccaatcta
     6181 ggccatttta tataggagta tcagaaagga gttttccagt gccaaacaat ctaaggcaag
     6241 gctagaggca agccagagga cacttttgtt ttattttgtt gagttcctgt gttattgaga
     6301 cctatctccc accccaagta gcccaggaca agtggagcag aaactcagat gagaacataa
     6361 gaatgtggga aagacagaag acagttttcc ctcagtatcc atggagaact ggttccagca
     6421 caccccgcac cttccagcat actaaaatct gaggatgctc aagtccctcg tgtagaatgg
     6481 tgtagtattt gcatataatg atgcatattc tcctatattt aaatcgtctc tagagtactt
     6541 ataatgccta atatgatgta aatgctatgt cagtccttac accgtgttgt tgtaataatg
     6601 acaagaaaaa taatatgtgt gtggtgagt
//
