LOCUS       NM_026866               5030 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus dispatched RND transporter family member 1 (Disp1),
            transcript variant 1, mRNA.
ACCESSION   NM_026866
VERSION     NM_026866.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5030)
  AUTHORS   Hall,E.T., Dillard,M.E., Cleverdon,E.R., Zhang,Y., Daly,C.A.,
            Ansari,S.S., Wakefield,R., Stewart,D.P., Pruett-Miller,S.M.,
            Lavado,A., Carisey,A.F., Johnson,A., Wang,Y.D., Selner,E.,
            Tanes,M., Ryu,Y.S., Robinson,C.G., Steinberg,J. and Ogden,S.K.
  TITLE     Cytoneme signaling provides essential contributions to mammalian
            tissue patterning
  JOURNAL   Cell 187 (2), 276-293 (2024)
   PUBMED   38171360
REFERENCE   2  (bases 1 to 5030)
  AUTHORS   Wang,Q., Asarnow,D.E., Ding,K., Mann,R.K., Hatakeyama,J., Zhang,Y.,
            Ma,Y., Cheng,Y. and Beachy,P.A.
  TITLE     Dispatched uses Na+ flux to power release of lipid-modified
            Hedgehog
  JOURNAL   Nature 599 (7884), 320-324 (2021)
   PUBMED   34707294
  REMARK    GeneRIF: Dispatched uses Na(+) flux to power release of
            lipid-modified Hedgehog.
REFERENCE   3  (bases 1 to 5030)
  AUTHORS   Hall,E.T., Dillard,M.E., Stewart,D.P., Zhang,Y., Wagner,B.,
            Levine,R.M., Pruett-Miller,S.M., Sykes,A., Temirov,J., Cheney,R.E.,
            Mori,M., Robinson,C.G. and Ogden,S.K.
  TITLE     Cytoneme delivery of Sonic Hedgehog from ligand-producing cells
            requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex
  JOURNAL   Elife 10, e61432 (2021)
   PUBMED   33570491
  REMARK    GeneRIF: Cytoneme delivery of Sonic Hedgehog from ligand-producing
            cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor
            complex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5030)
  AUTHORS   Suzuki,A., Abdallah,N., Gajera,M., Jun,G., Jia,P., Zhao,Z. and
            Iwata,J.
  TITLE     Genes and microRNAs associated with mouse cleft palate: A
            systematic review and bioinformatics analysis
  JOURNAL   Mech Dev 150, 21-27 (2018)
   PUBMED   29475039
REFERENCE   5  (bases 1 to 5030)
  AUTHORS   Stewart,D.P., Marada,S., Bodeen,W.J., Truong,A., Sakurada,S.M.,
            Pandit,T., Pruett-Miller,S.M. and Ogden,S.K.
  TITLE     Cleavage activates dispatched for Sonic Hedgehog ligand release
  JOURNAL   Elife 7, e31678 (2018)
   PUBMED   29359685
  REMARK    GeneRIF: The results showed that a protein called Furin activates
            Dispatched by splitting it at a specific point. When the
            break-point on Dispatch was genetically modified, Furin could no
            longer cleave the protein. As a consequence, Dispatched did not
            reach the correct location within cells to help Hedgehog move away
            from signal-releasing cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5030)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   7  (bases 1 to 5030)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 5030)
  AUTHORS   Kawakami,T., Kawcak,T., Li,Y.J., Zhang,W., Hu,Y. and Chuang,P.T.
  TITLE     Mouse dispatched mutants fail to distribute hedgehog proteins and
            are defective in hedgehog signaling
  JOURNAL   Development 129 (24), 5753-5765 (2002)
   PUBMED   12421714
  REMARK    GeneRIF: Disp is required for the movement of Hh protein from its
            sites of synthesis in mice
REFERENCE   9  (bases 1 to 5030)
  AUTHORS   Ma,Y., Erkner,A., Gong,R., Yao,S., Taipale,J., Basler,K. and
            Beachy,P.A.
  TITLE     Hedgehog-mediated patterning of the mammalian embryo requires
            transporter-like function of dispatched
  JOURNAL   Cell 111 (1), 63-75 (2002)
   PUBMED   12372301
REFERENCE   10 (bases 1 to 5030)
  AUTHORS   Caspary,T., Garcia-Garcia,M.J., Huangfu,D., Eggenschwiler,J.T.,
            Wyler,M.R., Rakeman,A.S., Alcorn,H.L. and Anderson,K.V.
  TITLE     Mouse Dispatched homolog1 is required for long-range, but not
            juxtacrine, Hh signaling
  JOURNAL   Curr Biol 12 (18), 1628-1632 (2002)
   PUBMED   12372258
  REMARK    GeneRIF: Shh signaling is required within the notochord to maintain
            Shh expression and to prevent notochord degeneration. Disp1, unlike
            Smo, is not required for this juxtacrine signaling by Shh.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122792.10, AK138276.1, BC043102.1 and BB732349.1.
            
            On May 17, 2013 this sequence version replaced NM_026866.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript.  Variants 1, 2, 3, and 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138276.1, AY150698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC122792.10        111469-111512       c
            45-1314             AK138276.1         2-1271
            1315-5028           BC043102.1         1188-4901
            5029-5030           BB732349.1         435-436
FEATURES             Location/Qualifiers
     source          1..5030
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..5030
                     /gene="Disp1"
                     /gene_synonym="1190008H24Rik; DispA"
                     /note="dispatched RND transporter family member 1"
                     /db_xref="GeneID:68897"
                     /db_xref="MGI:MGI:1916147"
     exon            1..207
                     /gene="Disp1"
                     /gene_synonym="1190008H24Rik; DispA"
                     /inference="alignment:Splign:2.1.0"
     exon            208..295
                     /gene="Disp1"
                     /gene_synonym="1190008H24Rik; DispA"
                     /inference="alignment:Splign:2.1.0"
     exon            296..423
                     /gene="Disp1"
                     /gene_synonym="1190008H24Rik; DispA"
                     /inference="alignment:Splign:2.1.0"
     exon            424..945
                     /gene="Disp1"
                     /gene_synonym="1190008H24Rik; DispA"
                     /inference="alignment:Splign:2.1.0"
     CDS             440..5005
                     /gene="Disp1"
                     /gene_synonym="1190008H24Rik; DispA"
                     /note="dispatched A; twelve-pass transmembrane protein;
                     dispatched homolog 1; mdispa"
                     /codon_start=1
                     /product="protein dispatched homolog 1"
                     /protein_id="NP_081142.3"
                     /db_xref="CCDS:CCDS56661.1"
                     /db_xref="GeneID:68897"
                     /db_xref="MGI:MGI:1916147"
                     /translation="MAVISGSDSVLLSNGSISTSTSNPSPLSPSDGDLPAQHLGPRET
                     PRTKASPNGCLQLNGTVKSSFLPLDNQRTPQTPTQCCHPCPYHHPVSSHSNHQECHPE
                     AGLAASPALASCRMQPHSEYSASLCPNHSPVYQAAHCLQPSPSFCLHHPWPDHFQHQP
                     VRQHLTIIRPSRPFKFPRSYAALLADWPVVVLGMCTLLIVVCALVGVLVPELPDFSDP
                     LLGFEPRGTTIGQRLVTWNNMMRNTGYKATLANYPYKYAEEQARSHRDDRWSDDHHER
                     ERREVDWNFQKDSFFCDVPSDGYSRVVFASAGGETLWNLPAIKSMCDVDNSRIRSHPQ
                     FSDLCQRTTAVSCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGT
                     LGPDCWDKAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMTPKTADYAVPALKY
                     SMLFSPTEKGESMMNIYLDNFENWNSSDGITTVTGIEFGIKHSLFQDYLLMDTVYPAI
                     AIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFNFEFFPFMNLTALIILV
                     GIGADDAFVLCDVWNYTKFDKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVS
                     NITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERYLLNIFTCFRKPQPQAYDKSCW
                     AVLCQKCRRVLFAVSEASRIFFEKVLPCIVIKFRYLWLIWFLALTVGGAYIVCVNPKM
                     KLPSLELSEFQVFRSSHPFERYDAEFKKLFMFERVHHGEELHMPITVIWGVSPEDSGD
                     PLNPKSKGELTLDSTFNIASPASQAWILHFCQKLRNQTFFHQTEQQDFTSCFIETFKQ
                     WMENQDCDEPALYPCCSHCSFPYKQEVFELCIKKAIMELDRSTGYHLNNKTPGPRFDI
                     NDTIRAVVLEFQSTFLFTLAYEKMQQFYKEVDSWISHELSSAPEGLSRGWFVSNLEFY
                     DLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGW
                     ELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRMGSAIAMAALTT
                     FVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFFFQCLCRCLGPQGTCGQIPFPTK
                     LQCSPFSHTLSARPGDRGPSKTHAASAYSVDARGQKSQLEHEFYELQPLASHSCTSSE
                     KTTYEEPHTCSEFFNGQAKNLRMPVPAAYSSELTKSPSSEPGSALLQSCLEQDTVCHF
                     SLNPRCNCRDAYTHLQYGLPEIHCQQMGDSLCHKCASTAGGFVQIQSSVAPLKASHQA
                     AEGLLHPAQHMLPPGMQNSRPRNFFLHSVQHFQAQENLGRTSTHSTDERLPRTAELSP
                     PPSDSRSTESFQRACCHPENNQRRLCKSRDPGDTEGSGGTKSKVSGLPNQTDKEEKQV
                     EPSLLQTDETVNSEHLNHNESNFTFSHLPGEAGCRSCPNSPQSCRSIMRSKCGTEDCQ
                     TPNLEANVPAVPTHSDLSGESLLIKTL"
     exon            946..975
                     /gene="Disp1"
                     /gene_synonym="1190008H24Rik; DispA"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1099
                     /gene="Disp1"
                     /gene_synonym="1190008H24Rik; DispA"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1227
                     /gene="Disp1"
                     /gene_synonym="1190008H24Rik; DispA"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1325
                     /gene="Disp1"
                     /gene_synonym="1190008H24Rik; DispA"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1423
                     /gene="Disp1"
                     /gene_synonym="1190008H24Rik; DispA"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..5030
                     /gene="Disp1"
                     /gene_synonym="1190008H24Rik; DispA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5004..5009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Disp1"
                     /gene_synonym="1190008H24Rik; DispA"
                     /note="hexamer: AATAAA"
     polyA_site      5028
                     /gene="Disp1"
                     /gene_synonym="1190008H24Rik; DispA"
                     /note="major polyA site"
ORIGIN      
        1 cggtcccgct ggcgaccgcg gcccgcgcca ggcggaagcg cggctccggg ccaggatccg
       61 cgagctccgg ctggagcaga gttcggagcc tcagtgtccc ggacgcccgt ggtcggtgtg
      121 gatgcttctc ggcgctgcgt ccccgcggtc cggggaggcc gaggaggcac gcgggagtcg
      181 gcgcggcggg agagcaggga tctcggggtt tctgagaatg aagacccatc gtggttgttg
      241 aattatatgt agtaattgat gtaccaactg tcacaacagc gtcattgaaa acgaggttgc
      301 ctcgagcttc agtgactgca gaagactcca gactgagggt ctgtagagat gagctgtgct
      361 ctgagattgg cagtaaggtg aatcatgtga ccctcccagc caaggtgtct atccatgcgg
      421 aaggaccaag aacccgggca tggctgtgat cagcggaagt gactctgtgc tcctgagcaa
      481 tggcagcatc tcgaccagca cctccaaccc tagtcccctc agccccagtg atggagacct
      541 cccagcccag cacctcggac ccagagaaac cccaagaaca aaagcaagcc caaatggatg
      601 cctgcaactt aatggcacag ttaagtcatc ctttctgcct ttagacaacc aaagaacacc
      661 tcagacgcca actcaatgct gccacccttg tccataccat caccctgtga gcagccatag
      721 caatcaccag gagtgccatc ccgaggctgg ccttgcagcc tcccccgctt tggcctcgtg
      781 tcgcatgcag ccacattccg aatactctgc atctctgtgt ccaaaccatt cacccgtgta
      841 tcaggctgcg cactgccttc agccctcgcc atctttctgc cttcatcacc cgtggcctga
      901 ccatttccag catcaacctg tacggcagca cctgaccatc atcaggccgt ccagaccttt
      961 caagttcccg agaagttacg cagccctgct ggctgactgg cctgtggtgg tcctgggcat
     1021 gtgcacgctg ctcatcgtgg tctgtgccct ggtgggggtc ctagtgccag agctccccga
     1081 cttctcggac ccgctgctgg gttttgaacc aagagggacc acgataggac agaggctggt
     1141 cacgtggaat aacatgatgc gaaacacagg gtacaaagca acattggcca actatcctta
     1201 taagtatgca gaggagcaag cccgaagcca ccgggatgac cgatggtcag acgatcacca
     1261 tgagagagag agaagagaag tggactggaa cttccagaaa gacagcttct tctgcgatgt
     1321 tccaagtgat ggatactcca gagtagtgtt tgcttcagca ggaggggaga ctctgtggaa
     1381 tttacctgca attaagtcga tgtgtgatgt ggataattcc aggatcagat cccaccccca
     1441 gttcagcgat ctctgccaga ggaccactgc cgtctcctgc tgcccgagct ggaccctggg
     1501 gaattacatc gccattctga ataacagatc gtcctgtcag aagattgttg agcgagatgt
     1561 ctctcacacg ctgaagctgc tccggacctg cgccaagcac taccaaaacg gcaccctggg
     1621 gccagactgc tgggacaagg cggccagaag gaaggaccag ctcaagtgta ccaacgtgcc
     1681 gcgcaagtgt accaaataca acgccgtgta ccagattctc cactatctgg tagacaagga
     1741 cttcatgacc ccaaagacgg ctgactacgc cgtgccagct ttaaagtaca gcatgctctt
     1801 ctcccccacg gagaaagggg agagcatgat gaacatttac ctggacaact tcgaaaactg
     1861 gaactcctcg gacggcatca ccaccgtcac cggcatcgag tttggcatca aacacagctt
     1921 gttccaggat tacctcctca tggacaccgt gtaccccgcc atcgccatcg ccattgtcct
     1981 gctcatcatg tgtgtctaca ccaagtccat gttcatcacg ctcatgacca tgtttgccat
     2041 catcagctcg ctcattgtct cctacttcct ctaccgagtc gtctttaact tcgagttttt
     2101 cccctttatg aacctcacgg cgctcatcat cctggtcggg attggcgcgg acgacgcttt
     2161 tgtcctgtgc gacgtctgga actacaccaa gttcgacaag cctcgcgcgg aaacttcgga
     2221 ggcggtgagt gtcaccttgc agcacgcggc cctctccatg tttgtcacca gcttcaccac
     2281 tgccgctgcc ttctacgcta actacgtcag caacatcacg gccatcaggt gcttcggggt
     2341 gtacgcgggg accgccatat tggtgaatta cgtcttgatg gtcacctggc tcccggctgt
     2401 gattgttctg cacgagcggt acctcctcaa tatattcacc tgcttcagga agccccagcc
     2461 acaagcctac gacaagagct gctgggcagt gctctgtcag aagtgccgca gggtgctctt
     2521 tgccgtctca gaggcatcgc ggattttctt tgaaaaggtg ctgccgtgca tagtcatcaa
     2581 gtttcgctac ctttggctca tctggttcct cgccctgact gtgggcgggg cctacatcgt
     2641 gtgcgtaaac ccaaagatga aactgccgtc gctggagctg tctgagttcc aggtgttccg
     2701 gtcctctcat cctttcgagc gctatgatgc cgagttcaag aagctcttca tgtttgagcg
     2761 ggttcaccac ggagaggagc tgcatatgcc catcacggtg atctggggcg tgtccccaga
     2821 agacagcggc gaccctctga accccaagag caaaggggag ctgacactag atagcacgtt
     2881 caacattgct agcccagcct cccaggcctg gattttacac ttctgtcaga agctgaggaa
     2941 tcagaccttc ttccaccaga cggagcagca ggacttcacc agctgtttca tcgagacctt
     3001 caaacagtgg atggagaacc aggactgtga cgagcctgcc ctgtatccct gctgcagcca
     3061 ctgcagcttc ccctataagc aagaggtttt cgagctgtgc atcaagaagg ccatcatgga
     3121 gctggacaga agcacgggat atcatctgaa taacaagacc cccgggccaa ggttcgacat
     3181 caacgacacc atcagggcgg tggtgctgga gttccagagc accttcctct tcaccctggc
     3241 ctacgagaag atgcagcagt tctacaagga ggtggactcg tggatttccc acgagctgag
     3301 ttcggccccc gagggcctca gccgcggctg gtttgtcagc aacctggagt tctacgacct
     3361 gcaggacagc ctttccgacg gcaccctcat cgccatgggg ctctcggtgg ccgttgcctt
     3421 cagcgtgatg ctgctgacca cgtggaatat catcataagc ctgtacgcca tcgtctccat
     3481 agctggaacc atatttgtca cagtcgggtc cctggtcctg ctgggctggg agctgaacgt
     3541 gctggagtcc gtcaccatct cggtcgcagt cggcctgtct gtagactttg ccgtccacta
     3601 cggggtggcg taccgcttgg ctccagatcc cgaccgagaa ggcaaggtca tcttctctct
     3661 gagccgtatg ggctctgcga tcgccatggc tgcactgacc accttcgtgg cgggggccat
     3721 gatgatgccc tccacggtcc tggcttacac gcagctgggc acgttcatga tgctcgtcat
     3781 gtgcgtgagc tgggccttcg ccaccttctt cttccagtgc ctgtgtcggt gcctggggcc
     3841 acaaggcacc tgcggccaga tccctttccc tacaaaactc cagtgcagtc ccttttccca
     3901 caccttgtct gcaaggcctg gggacagggg accaagcaaa acacatgccg ccagtgcgta
     3961 cagcgtagat gccaggggcc agaaatccca actggagcat gagttttacg agttacagcc
     4021 cctggcatct cacagctgca cttcctcgga gaagactacg tacgaagagc cacacacctg
     4081 ctccgaattt ttcaacggcc aagcaaagaa tttaaggatg cctgtgcctg cagcctacag
     4141 cagcgaactc accaaaagcc ccagcagtga gccaggctca gccttgctgc agtcctgtct
     4201 ggagcaggac accgtgtgcc atttctctct caatccgaga tgtaactgcc gagacgccta
     4261 cacacactta cagtacggat taccagaaat ccactgccag cagatgggtg actccttatg
     4321 ccacaagtgt gcctccactg caggcggctt tgtccagatt cagagttcgg tggcacctct
     4381 gaaggcctca caccaagccg ccgagggcct tctgcaccct gcccagcaca tgctgccccc
     4441 agggatgcag aattctcggc ctaggaattt ctttctccac tcagtgcagc actttcaggc
     4501 ccaagaaaac ctgggtcgca ccagcacaca cagcacggat gagcgtcttc ccaggacagc
     4561 agagctgtca ccgccaccgt ctgacagcag gagcactgag tctttccaaa gagcttgttg
     4621 ccatcctgag aataaccaaa ggagactctg caaaagtaga gacccagggg acacagaggg
     4681 cagtggaggg acaaaatcca aggtctctgg tttaccaaac cagactgaca aggaggagaa
     4741 gcaagtggag ccaagcctgc tgcagaccga tgaaactgtg aactcagaac atttaaatca
     4801 taacgaatca aactttacat tcagccattt accaggggag gctggctgca ggtcctgccc
     4861 aaacagtcca cagagttgta gaagcatcat gagatcgaag tgcgggactg aggactgcca
     4921 gacgccaaac cttgaagcca atgtgcctgc tgtaccaaca cactcagacc tgtctggcga
     4981 gagtctgtta ataaaaacac tataataaac ctagcattgc cttcagaagc
//
