LOCUS       NM_174854               2597 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus disrupted in schizophrenia 1 (Disc1), transcript
            variant 1, mRNA.
ACCESSION   NM_174854
VERSION     NM_174854.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2597)
  AUTHORS   Park,J., Shimbo,H., Tamura,S., Tomoda,T., Hikida,T., Okado,H. and
            Hirai,S.
  TITLE     Impact of feeding age on cognitive impairment in mice with
            Disrupted-In-Schizophrenia 1 (Disc1) mutation under a high sucrose
            diet
  JOURNAL   Behav Brain Res 476, 115291 (2025)
   PUBMED   39401692
  REMARK    GeneRIF: Impact of feeding age on cognitive impairment in mice with
            Disrupted-In-Schizophrenia 1 (Disc1) mutation under a high sucrose
            diet.
REFERENCE   2  (bases 1 to 2597)
  AUTHORS   Ma,A., Mu,Y., Wei,Z., Sun,M., Li,J., Jiang,H., Zhu,C. and Chen,X.
  TITLE     SRSF10 regulates migration of neural progenitor cells and granule
            cells and affects the formation of dentate gyrus during the
            development of mouse hippocampus
  JOURNAL   Neuroscience 552, 142-151 (2024)
   PUBMED   38960088
REFERENCE   3  (bases 1 to 2597)
  AUTHORS   Zhou,X., Xiao,Q., Liu,Y., Chen,S., Xu,X., Zhang,Z., Hong,Y.,
            Shao,J., Chen,Y., Chen,Y., Wang,L., Yang,F. and Tu,J.
  TITLE     Astrocyte-mediated regulation of BLAWFS1 neurons alleviates
            risk-assessment deficits in DISC1-N mice
  JOURNAL   Neuron 112 (13), 2197-2217 (2024)
   PUBMED   38642554
REFERENCE   4  (bases 1 to 2597)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2597)
  AUTHORS   Mastwal,S., Li,X., Stowell,R., Manion,M., Zhang,W., Kim,N.S.,
            Yoon,K.J., Song,H., Ming,G.L. and Wang,K.H.
  TITLE     Adolescent neurostimulation of dopamine circuit reverses genetic
            deficits in frontal cortex function
  JOURNAL   Elife 12, 87414 (2023)
   PUBMED   37830916
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2597)
  AUTHORS   Brandon,N.J., Handford,E.J., Schurov,I., Rain,J.C., Pelling,M.,
            Duran-Jimeniz,B., Camargo,L.M., Oliver,K.R., Beher,D.,
            Shearman,M.S. and Whiting,P.J.
  TITLE     Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally
            regulated protein complex: implications for schizophrenia and other
            major neurological disorders
  JOURNAL   Mol Cell Neurosci 25 (1), 42-55 (2004)
   PUBMED   14962739
  REMARK    GeneRIF: DISC1 interacts with Nudel through a leucine zipper domain
            and binds to a novel DISC1-interaction domain on Nudel, which is
            independent from the Lis1 binding site.
REFERENCE   7  (bases 1 to 2597)
  AUTHORS   Austin,C.P., Ky,B., Ma,L., Morris,J.A. and Shughrue,P.J.
  TITLE     Expression of Disrupted-In-Schizophrenia-1, a
            schizophrenia-associated gene, is prominent in the mouse
            hippocampus throughout brain development
  JOURNAL   Neuroscience 124 (1), 3-10 (2004)
   PUBMED   14960334
  REMARK    GeneRIF: Disc1 marks the hippocampus from its earliest stages, and
            developmental Disc1 dysfunction may lead to defects in hippocampal
            function that are associated with schizophrenia.
REFERENCE   8  (bases 1 to 2597)
  AUTHORS   Ozeki,Y., Tomoda,T., Kleiderlein,J., Kamiya,A., Bord,L., Fujii,K.,
            Okawa,M., Yamada,N., Hatten,M.E., Snyder,S.H., Ross,C.A. and
            Sawa,A.
  TITLE     Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents
            binding to NudE-like (NUDEL) and inhibits neurite outgrowth
  JOURNAL   Proc Natl Acad Sci U S A 100 (1), 289-294 (2003)
   PUBMED   12506198
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13969]
REFERENCE   9  (bases 1 to 2597)
  AUTHORS   Taylor,M.S., Devon,R.S., Millar,J.K. and Porteous,D.J.
  TITLE     Evolutionary constraints on the Disrupted in Schizophrenia locus
  JOURNAL   Genomics 81 (1), 67-77 (2003)
   PUBMED   12573262
  REMARK    GeneRIF: the amino acid sequence of DISC1 is diverging rapidly,
            although a putative nuclear localization signal and discrete blocks
            of coiled coil are specifically conserved features
REFERENCE   10 (bases 1 to 2597)
  AUTHORS   Ma,L., Liu,Y., Ky,B., Shughrue,P.J., Austin,C.P. and Morris,J.A.
  TITLE     Cloning and characterization of Disc1, the mouse ortholog of DISC1
            (Disrupted-in-Schizophrenia 1)
  JOURNAL   Genomics 80 (6), 662-672 (2002)
   PUBMED   12504857
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672234.27, AJ506179.1, AY177673.1 and AL731650.26.
            
            On Dec 22, 2006 this sequence version replaced NM_174854.1.
            
            Transcript Variant: This variant (1) is the longer transcript and
            it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY177673.1, AF513723.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL672234.27        195875-195909
            36-1085             AJ506179.1         1-1050
            1086-2594           AY177673.1         1051-2559
            2595-2597           AL731650.26        183817-183819
FEATURES             Location/Qualifiers
     source          1..2597
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 73.26 cM"
     gene            1..2597
                     /gene="Disc1"
                     /note="disrupted in schizophrenia 1"
                     /db_xref="GeneID:244667"
                     /db_xref="MGI:MGI:2447658"
     exon            1..90
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            91..1085
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1155
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1303
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1424
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1660
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1715
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1818
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..2007
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2068
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2342
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2460
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2597
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtcaccgc cgtccggggc gcagccggcc gcacgatgca gggcgggggt ccccggggcg
       61 ctccgatcca cagtccgagc cacggcgcag acagtgggca tggcttaccg cctgcagtag
      121 cccctcagag gcggcggctg acacggagac caggctacat gagaagcaca gcgggttctg
      181 ggatcgggtt cctctctcca gcagtgggca tgccacaccc gagctcagca gggctgacag
      241 gccagcagtc ccaacactca cagtccaagg ctggacagtg cggacttgac cctgggagcc
      301 actgccaagc ctcactggtg ggcaagcctt ttctcaagag ctcccttgtc cctgctgtgg
      361 cctctgaggg ccacctgcac ccagcccagc gctctatgag aaaaagacca gtgcactttg
      421 cggttcattc caagaatgac agcagacaat ctgagaggct gactgggtca tttaagcctg
      481 gggacagtgg gttttggcaa gaattattat cttcagacag ctttaagtct ctggctccta
      541 gccttgatgc accctggaac aagggatcaa ggggcctgaa gactgtgaaa cctctggcat
      601 caccggcgtt gaatggcccc gctgatatcg catcccttcc cggcttccaa gacaccttca
      661 cttccagctt cagcttcatc caactctccc ttggtgctgc tggagaacgc ggagaagcag
      721 aaggttgcct gccatccaga gaggccgaac ctctgcatca gaggccccaa gagatggcag
      781 ctgaagcatc tagctcagac aggccccacg gggatcctcg gcatctctgg accttcagtc
      841 ttcacgctgc tccaggcttg gcggacttgg ctcaggtgac aaggagcagc agcaggcaat
      901 cagaatgtgg cacggtctcc tcctcctcct cggacactgg cttctcttcc caggatgcat
      961 cctccgctgg tgggcggggc gaccagggcg gcggctgggc cgatgcccat ggatggcata
     1021 cattgctcag ggaatgggag cccatgctgc aggactacct actgagcaac cgcaggcagc
     1081 tggaggtcac ttccttaatt ttaaagcttc agaaatgtca agaaaaagtg gtcgaggatg
     1141 gcgattacga tactgcagag acattgagac agaggttgga agaactggaa caggagaaag
     1201 gccgcctgtc ctgggctctg ccttcacagc aacctgctct tcgcagcttc ttgggttacc
     1261 tggcagcaca gatacaggtg gccttgcatg gagccaccca aagggccggc agcgatgatc
     1321 cagaagcccc acttgaagga cagctgagga ctaccgccca ggatagcctg cctgcatcca
     1381 tcaccaggag ggactggctt attcgagaga aacagcgatt gcagaaggaa atcgaagctc
     1441 tccaagcacg gatgtctgcg ctggaggcaa aggaaaaacg gctgagccaa gagttggagg
     1501 agcaggaggt gctgctccgg tggccgggct gtgacctgat ggcactggtg gcccagatgt
     1561 ccccaggcca gctgcaggag gtcagcaagg ccttgggaga gaccctgacc tctgccaacc
     1621 aggctccctt ccaggtggag ccacctgaga ccctcaggag cctccgggaa aggacaaaat
     1681 cactgaacct ggctgtcaga gaactcactg ctcaggtgtg ctcaggtgag aagctgtgca
     1741 gctctctgag gaggagactc agtgacctcg acaccaggct gcctgccttg ctggaagcca
     1801 agatgctggc cctatcagga agctgcttct ccacagccaa ggagctcacg gaggagattt
     1861 gggccttgtc gtcagagcgg gaagggctag agatgttcct gggcaggctg ttggcactca
     1921 gctccaggaa cagcagaagg ctgggcatcg tcaaagagga tcacctcagg tgcaggcagg
     1981 acctggcact ccaggacgcc gcccacaaaa cacgcatgaa ggcaaacact gtgaagtgca
     2041 tggaagtgtt ggaaggtcag ctgagcagct gcaggtgccc gctgcttggg agagtgtgga
     2101 aagcagactt ggagacttgt cagttgctaa tgcagagcct gcagcttcag gaagcaggca
     2161 gcagcccaca cgcagaggac gaggagcagg tgcatagcac aggagaggcc gcccagacag
     2221 ctgctctggc tgtccctcga acaccccacc ccgaagaaga aaagtccccc ttgcaggtgc
     2281 tccaggagtg ggacacccac tcagctcttt caccacactg tgctgcaggc ccatggaaag
     2341 aggattctca catcgtttct gctgaagttg gagaaaagtg cgaagccata ggcgtgaagc
     2401 tcctacacct ggaagaccag cttctcggag ccatgtacag tcacgatgag gctctctttc
     2461 agtctctcca gggggagctc cagacggtga aggaaacact gcaggccatg atcctgcagc
     2521 tccagccaac aaaggaggca ggagaggcct cagcttccta tccgacagct ggtgctcagg
     2581 aaaccgaggc ctgaggt
//
