LOCUS       NM_153530               3129 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DIS3 like 3'-5' exoribonuclease 2 (Dis3l2), transcript
            variant 2, mRNA.
ACCESSION   NM_153530 XM_489708
VERSION     NM_153530.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3129)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3129)
  AUTHORS   Wu,D., Pedroza,M., Chang,J. and Dean,J.
  TITLE     DIS3L2 ribonuclease degrades terminal-uridylated RNA to ensure
            oocyte maturation and female fertility
  JOURNAL   Nucleic Acids Res 51 (7), 3078-3093 (2023)
   PUBMED   36727488
  REMARK    GeneRIF: DIS3L2 ribonuclease degrades terminal-uridylated RNA to
            ensure oocyte maturation and female fertility.
REFERENCE   3  (bases 1 to 3129)
  AUTHORS   Pirouz,M., Wang,C.H., Liu,Q., Ebrahimi,A.G., Shamsi,F., Tseng,Y.H.
            and Gregory,R.I.
  TITLE     The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic
            reticulum-targeted mRNA translation and calcium ion homeostasis
  JOURNAL   Nat Commun 11 (1), 2619 (2020)
   PUBMED   32457326
  REMARK    GeneRIF: The Perlman syndrome DIS3L2 exoribonuclease safeguards
            endoplasmic reticulum-targeted mRNA translation and calcium ion
            homeostasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3129)
  AUTHORS   Pirouz,M., Munafo,M., Ebrahimi,A.G., Choe,J. and Gregory,R.I.
  TITLE     Exonuclease requirements for mammalian ribosomal RNA biogenesis and
            surveillance
  JOURNAL   Nat Struct Mol Biol 26 (6), 490-500 (2019)
   PUBMED   31160785
  REMARK    GeneRIF: 7SB ribosomal RNA can be oligoadenylated by an unknown
            enzyme and/or oligouridylated by TUT4/7 and subsequently processed
            by Dis3l2 and Eri1.
REFERENCE   5  (bases 1 to 3129)
  AUTHORS   Hunter,R.W., Liu,Y., Manjunath,H., Acharya,A., Jones,B.T.,
            Zhang,H., Chen,B., Ramalingam,H., Hammer,R.E., Xie,Y.,
            Richardson,J.A., Rakheja,D., Carroll,T.J. and Mendell,J.T.
  TITLE     Loss of Dis3l2 partially phenocopies Perlman syndrome in mice and
            results in up-regulation of Igf2 in nephron progenitor cells
  JOURNAL   Genes Dev 32 (13-14), 903-908 (2018)
   PUBMED   29950491
  REMARK    GeneRIF: DIS3L2 loss of function results in transcriptional
            activation of the Igf2/H19 locus in nephron progenitor cells, most
            likely by leading to the activation of shared cis-regulatory
            elements that control these genes.
REFERENCE   6  (bases 1 to 3129)
  AUTHORS   Pirouz,M., Du,P., Munafo,M. and Gregory,R.I.
  TITLE     Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding
            RNAs
  JOURNAL   Cell Rep 16 (7), 1861-1873 (2016)
   PUBMED   27498873
  REMARK    GeneRIF: Dis3l2-mediated decay is a quality control pathway for
            noncoding RNAs.
REFERENCE   7  (bases 1 to 3129)
  AUTHORS   Haas,G., Cetin,S., Messmer,M., Chane-Woon-Ming,B., Terenzi,O.,
            Chicher,J., Kuhn,L., Hammann,P. and Pfeffer,S.
  TITLE     Identification of factors involved in target RNA-directed microRNA
            degradation
  JOURNAL   Nucleic Acids Res 44 (6), 2873-2887 (2016)
   PUBMED   26809675
  REMARK    GeneRIF: DIS3L2 interacts with Ago2 and governs target RNA-directed
            miRNA degradation.
REFERENCE   8  (bases 1 to 3129)
  AUTHORS   Faehnle,C.R., Walleshauser,J. and Joshua-Tor,L.
  TITLE     Mechanism of Dis3l2 substrate recognition in the Lin28-let-7
            pathway
  JOURNAL   Nature 514 (7521), 252-256 (2014)
   PUBMED   25119025
  REMARK    GeneRIF: structure of mouse Dis3l2 in complex with an oligoU RNA to
            mimic the uridylated tail of pre-let-7
REFERENCE   9  (bases 1 to 3129)
  AUTHORS   Chang,H.M., Triboulet,R., Thornton,J.E. and Gregory,R.I.
  TITLE     A role for the Perlman syndrome exonuclease Dis3l2 in the
            Lin28-let-7 pathway
  JOURNAL   Nature 497 (7448), 244-248 (2013)
   PUBMED   23594738
  REMARK    GeneRIF: identification of Dis3l2 as the 3'-5' exonuclease
            responsible for the decay of uridylated pre-let-7 in mouse
            embryonic stem cells
REFERENCE   10 (bases 1 to 3129)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102491.19, AC120860.7 and AC138595.10.
            
            On Feb 5, 2010 this sequence version replaced NM_153530.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. The resulting
            isoform (2) lacks an internal segment, compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036177.1, SRR7345562.1165153.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC102491.19        74011-74078         c
            69-216              AC102491.19        33054-33201         c
            217-374             AC102491.19        32384-32541         c
            375-428             AC102491.19        23602-23655         c
            429-530             AC102491.19        17493-17594         c
            531-759             AC120860.7         123738-123966       c
            760-860             AC120860.7         90728-90828         c
            861-1108            AC120860.7         87814-88061         c
            1109-1282           AC120860.7         66612-66785         c
            1283-1362           AC120860.7         14355-14434         c
            1363-1475           AC138595.10        31118-31230
            1476-1583           AC138595.10        44775-44882
            1584-1817           AC138595.10        61467-61700
            1818-1897           AC138595.10        92413-92492
            1898-2081           AC138595.10        115392-115575
            2082-2168           AC138595.10        116205-116291
            2169-2316           AC138595.10        118412-118559
            2317-2447           AC138595.10        118823-118953
            2448-2552           AC138595.10        119063-119167
            2553-2654           AC138595.10        120208-120309
            2655-3129           AC138595.10        120998-121472
FEATURES             Location/Qualifiers
     source          1..3129
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 43.99 cM"
     gene            1..3129
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /note="DIS3 like 3'-5' exoribonuclease 2"
                     /db_xref="GeneID:208718"
                     /db_xref="MGI:MGI:2442555"
     exon            1..68
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            69..216
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2777
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     DIS3-like exonuclease 2; DIS3 mitotic control homolog-like
                     2"
                     /codon_start=1
                     /product="DIS3-like exonuclease 2 isoform 2"
                     /protein_id="NP_705758.1"
                     /db_xref="CCDS:CCDS15124.1"
                     /db_xref="GeneID:208718"
                     /db_xref="MGI:MGI:2442555"
                     /translation="MNHPDYKLNLRSPGTPRGVSSVVGPSAVGASPGDKKSKNKSMRG
                     KKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDGVVAR
                     NRALNGDLVVVKLLPEDQWKAVKPESNDKEIEATYEADIPEEGCGHHPLQQSRKGWSG
                     PDVIIEAQFDDSDSEDRHGNTSGLVDGVKKLSISTPDRGKEDSSTPVMKDENTPIPQD
                     TRGLSEKSLQKSAKVVYILEKKHSRAATGILKLLADKNSDLFKKYALFSPSDHRVPRI
                     YVPLKDCPQDFMTRPKDFANTLFICRIIDWKEDCNFALGQLAKSLGQAGEIEPETEGI
                     LTEYGVDFSDFSSEVLECLPQSLPWTIPPDEVGKRRDLRKDCIFTIDPSTARDLDDAL
                     ACRRLTDGTFEVGVHIADVSYFVPEGSSLDKVAAERATSVYLVQKVVPMLPRLLCEEL
                     CSLNPMTDKLTFSVIWKLTPEGKILEEWFGRTIIRSCTKLSYDHAQSMIENPTEKIPE
                     EELPPISPEHSVEEVHQAVLNLHSIAKQLRRQRFVDGALRLDQLKLAFTLDHETGLPQ
                     GCHIYEYRDSNKLVEEFMLLANMAVAHKIFRTFPEQALLRRHPPPQTKMLSDLVEFCD
                     QMGLPMDVSSAGALNKSLTKTFGDDKYSLARKEVLTNMYSRPMQMALYFCSGMLQDQE
                     QFRHYALNVPLYTHFTSPIRRFADVIVHRLLAAALGYSEQPDVEPDTLQKQADHCNDR
                     RMASKRVQELSIGLFFAVLVKESGPLESEAMVMGVLNQAFDVLVLRFGVQKRIYCNAL
                     ALRSYSFQKVGKKPELTLVWEPDDLEEEPTQQVITIFSLVDVVLQAEATALKYSAILK
                     RPGLEKASDEEPED"
     exon            217..374
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            375..428
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            429..530
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            531..759
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            760..860
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1108
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1282
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1362
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1475
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1583
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1817
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1897
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2081
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2168
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2316
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2447
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2552
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2654
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..3129
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3107..3112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3128
                     /gene="Dis3l2"
                     /gene_synonym="4930429A22Rik; 8030493P09Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtgacccgga agcgcattct ccctagcaac tgcgggtctg cggcgccgcc ggcctcccgg
       61 gagcgacgct cgtgacaact gagctgctga aggcaggagg aactctgagc tgaatagtag
      121 tgggtccctg aatctggaga gaagacgcca ccttggaacc agtaatgaac catcctgact
      181 acaagctgaa ccttcggtct ccggggaccc ccagaggtgt gtcctctgtg gttggcccga
      241 gtgctgttgg tgcttcgcca ggtgacaaaa agtcaaagaa caagtccatg cgagggaaga
      301 aaaagagcat atttgaaacc tacatgtcca aggaggatgt ttcagaaggc ttgaagagag
      361 gaacacttat ccagggtgta ttgagaatca acccaaagaa gtttcatgaa gccttcattc
      421 cttctccgga tggtgatcgg gacattttta ttgatggagt tgttgctcgt aatagagcct
      481 taaatgggga ccttgtggtt gtaaaactgc ttcctgagga tcagtggaag gcagttaaac
      541 cagagagcaa tgacaaagaa atagaagcta cttatgaagc tgacatccct gaagagggct
      601 gtggacatca ccccctgcag cagtcccgga aaggctggag tggtcctgat gtcattatag
      661 aggctcagtt tgatgacagc gactcagaag atagacatgg caacaccagt ggcctggttg
      721 atggtgttaa gaaattgtca atctctactc ctgacagagg aaaagaagat tctagtactc
      781 cagttatgaa agatgagaac acccccatac cacaggacac aagaggctta tcagagaagt
      841 cacttcagaa atcagcaaag gtggtttaca tcttggagaa aaagcattct cgagcagcaa
      901 ctggcatcct gaaactcttg gctgataaga acagtgacct gtttaagaaa tacgccctgt
      961 tttctccttc agaccaccga gtacctagaa tttacgtacc tctcaaggac tgtccccagg
     1021 acttcatgac ccgacctaaa gactttgcca acacgctgtt catctgccgc atcatagact
     1081 ggaaggagga ctgtaatttt gccctggggc aactggctaa gagtcttggg caggctggtg
     1141 aaatcgagcc tgaaacagaa gggatactga cagaatatgg tgtggacttc tctgatttct
     1201 cttcagaagt tcttgaatgt ctccctcaaa gcctgccctg gacaatccca cctgatgagg
     1261 tgggcaagag aagagaccta aggaaagact gtatcttcac cattgatcca tcaactgctc
     1321 gcgaccttga tgatgccctc gcctgcaggc ggctcactga tggcaccttc gaagtgggcg
     1381 tccacatcgc cgatgtgagt tactttgttc ctgagggatc ctctttggat aaagtagctg
     1441 ctgagagagc cacaagtgtc tacttggtcc agaaggtggt ccccatgctt cccaggcttc
     1501 tgtgtgagga actctgcagc ctcaacccca tgactgacaa gctgaccttc tctgtgatct
     1561 ggaagctgac ccctgaaggc aagatccttg aagagtggtt tggccgcact atcatccgtt
     1621 cttgcaccaa actgagctac gaccatgccc agagcatgat cgaaaatcca actgagaaga
     1681 tccctgagga agagcttccc ccaatttctc cagagcacag cgtcgaggag gtgcaccagg
     1741 cagtcctgaa cctgcacagc attgcaaagc aactccgccg ccagcgcttt gtagatggcg
     1801 cactccgttt agatcagctg aagcttgctt ttactctgga ccatgagact ggactgcctc
     1861 aaggatgtca catctatgag taccgagaca gcaacaagct tgtagaggag ttcatgctcc
     1921 tggccaacat ggcggtggcc cacaagatct tccgcacctt ccctgagcag gccctgctgc
     1981 gccggcatcc cccaccacag acgaagatgc tcagtgacct ggtggagttc tgtgaccaga
     2041 tggggctgcc catggatgtc agctctgcag gggccctaaa taaaagcctg actaagacat
     2101 ttggagatga caagtactct ctggcccgga aggaggtgct caccaacatg tactcccggc
     2161 ccatgcagat ggcactgtac ttctgctctg ggatgctgca ggaccaggag cagttccggc
     2221 attatgctct caacgttccc ctctacacac acttcacctc tcccatccgc cgctttgctg
     2281 acgtcatagt gcaccgcctc ctggctgctg ctctgggcta cagtgaacag ccagatgtgg
     2341 agcctgatac cctacagaag caagctgacc actgcaatga ccgtcgcatg gcttccaaac
     2401 gtgtgcagga gctcagcatc ggcctcttct tcgcagttct agtaaaggag agtggccccc
     2461 tggagtccga agccatggtg atgggtgtcc tgaaccaagc tttcgacgtg ctggtgctgc
     2521 gctttggggt gcagaagcgc atctactgca atgcactggc cctgcgatcc tacagcttcc
     2581 agaaggtggg gaagaagcca gagctcactc ttgtttggga gcctgatgac cttgaagagg
     2641 agccaacaca gcaggtcatc accatcttca gcctggtgga tgtggtcctg caggcagagg
     2701 ccacagccct caagtacagt gctatcctga agcgaccagg cctggagaag gcgtctgatg
     2761 aggagcctga ggactgaatg ctagcccaag ccaggcctgt gcctgcccta ccctgctggc
     2821 ttttaggaat aggacctttt gacaccaaag gggattttta atttggtttt taacaactca
     2881 ggggtttgtt tttattttta tttttccttt tattttactt ttgcagctca gtttttaaat
     2941 gaactggaag gttaggggtc agggcagggg atgctgaggc ctggcctgtg cttccctgag
     3001 cagagaggat cccagtcctc ctgggcaggc agccccgctt ctaccaggcg acccactgcc
     3061 cttccctgcc caggaaatgg ggggtttcag caaatcagtg tcatggaata aaatcaagtg
     3121 tgaattgct
//
