LOCUS       NM_001001295            3575 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus DIS3 like exosome 3'-5' exoribonuclease (Dis3l),
            transcript variant 1, mRNA.
ACCESSION   NM_001001295
VERSION     NM_001001295.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3575)
  AUTHORS   Wang,X., Feng,Y.Q., Li,H., Xu,Y., Yu,J., Zhou,M., Qiu,F., Li,N. and
            Wang,Z.
  TITLE     Loss of DIS3L in the initial segment is dispensable for sperm
            maturation in the epididymis and male fertility
  JOURNAL   Reprod Biol 24 (3), 100914 (2024)
   PUBMED   38875746
  REMARK    GeneRIF: Loss of DIS3L in the initial segment is dispensable for
            sperm maturation in the epididymis and male fertility.
REFERENCE   2  (bases 1 to 3575)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
REFERENCE   3  (bases 1 to 3575)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ157436.1, BC056939.1, BM900123.1 and BY497083.1.
            
            On Apr 27, 2010 this sequence version replaced NM_001001295.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032451.1, BC056939.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                CJ157436.1         2-68
            68-3322             BC056939.1         1-3255
            3323-3570           BM900123.1         22-269              c
            3571-3575           BY497083.1         390-394
FEATURES             Location/Qualifiers
     source          1..3575
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 34.62 cM"
     gene            1..3575
                     /gene="Dis3l"
                     /note="DIS3 like exosome 3'-5' exoribonuclease"
                     /db_xref="GeneID:213550"
                     /db_xref="MGI:MGI:2143272"
     exon            1..265
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..3288
                     /gene="Dis3l"
                     /EC_number="3.1.13.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DIS3-like exonuclease 1; DIS3 mitotic control
                     homolog-like"
                     /codon_start=1
                     /product="DIS3-like exonuclease 1 isoform 1"
                     /protein_id="NP_001001295.2"
                     /db_xref="CCDS:CCDS52832.1"
                     /db_xref="GeneID:213550"
                     /db_xref="MGI:MGI:2143272"
                     /translation="MLQKREKVLLLRTFQGRTLRIVREHYLRPSVPCNSPLCPQPAAC
                     RNDGKLLAAEVTHYVIPDWKVVQDYLEVLEFPELKGVIFMQTACQAVQHQRGRRQYNK
                     LRNLLKDARHDCVLFANEFQQHCYLPREKGEAMEKWQTRSIYNSAVWYYHHCEDRMPI
                     VMVTEDEEAIQKYGSETEGVFVISFKNYLDNFWPDLKAAHDLCDSILQSRRERETESQ
                     ETHGKEYPEHLPLEVLEAGIKSGRYIQGILNVNKHRAQIEAFVRLHGASSKDSGLVSD
                     ILIHGSKARNRSIHGDVVVVEMLPKSEWKGRTAALGENDSDDKASGESPSEPMPTGRV
                     VGILQKNWRDYVVTFPSKEEVQSQGKNAQKILVTPWDYRIPKIRISTQQAEALQDFRV
                     VVRIDSWEATSVYPNGHFVRVLGRIGDLEGEIATILVENSISVVPFSEAQMCEMPVNT
                     PENPWKVSPKEEQERKDLRTTHLVFSIDPKGCEDVDDTLSVRTLNNGNLELGVHIADV
                     THFVAPNSYIDVEARTRATTYYLADRRYDMLPSILSADLCSLLGGVDRYAVSVMWELD
                     KTSYEIKKVWYGRTIIRSAYKLFYEAAQELLDGNFSIVDDIPELKALDKQSQQAKLEE
                     LVWAIGKLTDIARHIRAKRDRCGALELEGVEVRVQLDDKKNIRDLIPKQPLEVHETVA
                     ECMILANHWVAKKIWESFPHQALLRQHPPPHQEFFSELRECAKAKGFFIDTRSNKTLA
                     DSLDSANDPKDPLVNKLLRSMATQAMSNALYFSTGSCAEEEFHHYGLALDKYTHFTSP
                     IRRYSDIVVHRLLMAAISKDKKMEIKENLFSNKNLEELCRHINNRNRAAQRSQKQSTE
                     LFQCMYFKDRDAETEERCIADGVIYSIRTNGVLVFIPRFGIKGAAYLKNKDSLVISCG
                     PEGSSEWKPGSLQRSQNKIISTTAGGQSVTFHLFDHVTVRISVQASRCHSDTIRLEIV
                     SNKPYMIPNTELCHQSSLLKSELVKEVTRSVEEAQLAQEVKGKVIQEEHQEYCQTKGR
                     SLYTLLEEIRDLALLDVSDSCAM"
     exon            266..419
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     exon            420..548
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     exon            549..684
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     exon            685..861
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     exon            862..940
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1120
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1290
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1452
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1700
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1793
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..2327
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2482
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2661
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2807
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2982
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     exon            2983..3575
                     /gene="Dis3l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3303..3308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dis3l"
                     /note="hexamer: ATTAAA"
     polyA_site      3322
                     /gene="Dis3l"
                     /note="major polyA site"
     regulatory      3555..3560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dis3l"
                     /note="hexamer: ATTAAA"
     polyA_site      3574
                     /gene="Dis3l"
ORIGIN      
        1 gtgaacgctg ctgcctgccc gaccaggccc gaggggcggg cctcaggcct cggtctcgcc
       61 tgagcctgcc gcctgccgcc cgccgcccgc cgcttcccgg ccacagtgcc gggcgacgcc
      121 gccagcatgc tgcagaagcg ggagaaggtg ctgctgctga ggaccttcca gggtcggacg
      181 ctgcggatcg tgcgtgaaca ctacctgcgg cccagcgtgc cttgcaacag cccgctgtgc
      241 ccgcagcctg ccgcctgccg caacgatggg aagctcctgg ctgccgaagt cactcattac
      301 gtgatcccag actggaaagt tgtccaggat tacctcgagg ttctggagtt cccggagttg
      361 aagggagtta ttttcatgca aacggcctgt caagctgtgc agcaccagag aggccggaga
      421 cagtataaca aactgcgaaa cctcctgaag gatgctcgcc atgactgcgt tctctttgct
      481 aacgagttcc agcagcactg ttacctcccc cgggaaaagg gggaagccat ggagaagtgg
      541 cagaccagga gcatatacaa ctcagcggtt tggtactatc accactgtga ggacaggatg
      601 cccatcgtta tggtgacaga agatgaagag gccattcaga agtatggaag tgaaacagaa
      661 ggcgtatttg tcatttcttt caagaattac ctggacaact tctggccaga tttgaaggct
      721 gcccacgatc tctgtgactc catccttcag tctcgccggg aaagggagac tgagagtcag
      781 gaaacccatg ggaaagagta cccagaacat cttcccctag aagtactgga agcgggcatc
      841 aaatctggac gctacatcca gggaattctg aatgtcaaca agcacagagc tcagattgaa
      901 gctttcgttc gcctacacgg agccagcagt aaggactcag gcttggtcag cgacatcctc
      961 atccatggct cgaaggctcg gaaccgctcc atccatggag acgtcgtggt ggtggagatg
     1021 ctccccaaaa gtgagtggaa agggagaaca gccgccctgg gtgagaacga cagtgatgac
     1081 aaggcctcgg gcgagtcccc gagtgagccc atgcccacag gtcgagtggt aggcatcctt
     1141 cagaagaact ggcgagatta tgtggtgaca tttccatcca aagaagaggt ccagtctcag
     1201 ggcaaaaatg ctcagaagat cctggttacg ccgtgggatt acagaatccc taagatccgc
     1261 atcagcaccc agcaagcaga agccctccag gatttcaggg tggttgtgcg cattgactcc
     1321 tgggaggcaa catcagtgta tccaaatgga cattttgtgc gtgtcttagg gagaatcggt
     1381 gatctggaag gggagattgc aaccatcctg gtagagaaca gtatctctgt ggtccccttc
     1441 tcagaagccc agatgtgtga gatgccagtg aacacaccag aaaacccttg gaaagtgagt
     1501 cccaaagaag agcaagagcg gaaggacctg aggaccaccc acctcgtgtt cagcatcgac
     1561 cccaaaggtt gtgaagatgt ggatgacaca ctctcagtca gaaccttgaa taacggcaac
     1621 ctggagctgg gggtccacat cgctgacgtc acacactttg tggcccctaa ctcttacatc
     1681 gatgttgaag ctagaacgag ggccaccact tactacctag cggaccgtcg ctatgacatg
     1741 ctgccttcca tcctcagcgc agacctctgc tccctcctgg gaggcgttga ccggtatgct
     1801 gtgtcagtca tgtgggaatt agataaaacc tcttatgaaa ttaagaaggt gtggtacggc
     1861 agaaccatta tccgatcagc ttacaaactg ttctacgagg cggcccagga actactggac
     1921 ggaaacttca gcattgttga tgatattcca gaacttaaag ccttggacaa gcagagccaa
     1981 caggccaaac tagaggagtt agtgtgggca attggaaagt tgacagacat agctcgccac
     2041 atccgagcaa agagagaccg ctgtggagcc ttggagctgg aaggggtaga ggttcgagtc
     2101 cagctggatg acaagaagaa catccgtgac ctcatcccca agcagcccct ggaggttcac
     2161 gagacggtgg ctgagtgcat gatcctagcc aaccactggg tggccaagaa gatctgggag
     2221 agcttccccc accaggctct gctgcgccag caccctccac cacaccagga gtttttctca
     2281 gagctccggg aatgtgctaa agcaaaaggc ttcttcatag acacacggtc caataaaacc
     2341 ctggctgact ctctggatag tgcaaatgac cccaaggacc ccctggtaaa caagctgctg
     2401 cgctccatgg ccacccaggc catgtccaac gcgctctact tctctacggg atcctgcgca
     2461 gaggaggagt tccatcatta cgggctggcc ttagataaat acacccactt tacctctcca
     2521 ataagaagat actcagatat tgtagtacat cggctattaa tggcagccat ttcaaaagac
     2581 aagaaaatgg agattaaaga aaatttgttc agcaacaaaa atcttgagga attatgcaga
     2641 cacattaaca acagaaaccg agcggcacag cggtctcaga agcagtccac cgagctcttc
     2701 cagtgcatgt actttaaaga ccgagatgca gaaactgagg agcgctgcat agctgatgga
     2761 gttatttatt ccattagaac aaatggtgta cttgtattta taccaaggtt tgggattaaa
     2821 ggtgctgctt atctgaagaa taaagatagc ttagtgatct cctgtggccc agagggcagc
     2881 tctgaatgga agccaggatc cctacaaaga tctcaaaaca agatcatctc taccacagct
     2941 ggagggcagt ctgttacatt tcatctattt gaccatgtga cggtaagaat ttctgtccag
     3001 gcctcgcgct gccactctga tacaatcagg cttgaaatag taagcaacaa gccatacatg
     3061 atcccaaaca cagaactctg tcaccagagc tccctgctga agagtgagtt agtgaaggaa
     3121 gtaacccgat ctgtggagga agcgcagctt gcacaagaag tcaaaggcaa ggtgattcag
     3181 gaagagcatc aagaatactg ccagacaaag ggaagaagtc tgtacacact tctggaggag
     3241 ataagggacc tagctcttct ggatgtctct gacagttgtg caatgtgaaa tacttccatg
     3301 tcattaaaga cctttgtctt aagtggtgta cttttttttc tttcttcctt tcttcttttc
     3361 tttctttgtt gttgttgagg gtttctctgt gtagcccttg ctgtcctgga actcactatg
     3421 taaaccaggc tgtccttgaa ttaagaaatc cgcccacctc tgcctcccaa gtgctggggt
     3481 taaaggtgtg tgccaccacg cccagctttt tttttttttt aaacacctct tgcctctgtc
     3541 ttcagactgt tgggattaaa gatatatgcc accac
//
