LOCUS       NM_028315               3722 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus DIS3 homolog, exosome endoribonuclease and 3'-5'
            exoribonuclease (Dis3), transcript variant 1, mRNA.
ACCESSION   NM_028315 XM_127907
VERSION     NM_028315.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3722)
  AUTHORS   Wang,Z., Wu,D., Xu,X., Yu,G., Li,N., Wang,X., Li,J.L. and Dean,J.
  TITLE     DIS3 ribonuclease is essential for spermatogenesis and male
            fertility in mice
  JOURNAL   Development 151 (13) (2024)
   PUBMED   38953252
  REMARK    GeneRIF: DIS3 ribonuclease is essential for spermatogenesis and
            male fertility in mice.
            Erratum:[Development. 2024 Sep 1;151(17):dev204238. doi:
            10.1242/dev.204238.. PMID: 39225297]
REFERENCE   2  (bases 1 to 3722)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3722)
  AUTHORS   Wu,D. and Dean,J.
  TITLE     Reduced female fertility due to sequestration of RNA Pol II by
            pervasive transcription in exosome RNase-depleted oocytes
  JOURNAL   Cell Rep 42 (10), 113247 (2023)
   PUBMED   37831603
REFERENCE   4  (bases 1 to 3722)
  AUTHORS   Qiu,F., Wang,X., Zhou,M., Yu,J. and Wang,Z.
  TITLE     Epididymal DIS3 exosome ribonuclease is not necessary for mouse
            sperm maturation or fertility
  JOURNAL   Biochem Biophys Res Commun 666, 36-44 (2023)
   PUBMED   37172450
  REMARK    GeneRIF: Epididymal DIS3 exosome ribonuclease is not necessary for
            mouse sperm maturation or fertility.
REFERENCE   5  (bases 1 to 3722)
  AUTHORS   Wu,D. and Dean,J.
  TITLE     RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse
            pre-implantation cell differentiation
  JOURNAL   Cell Rep 42 (2), 112047 (2023)
   PUBMED   36724075
  REMARK    GeneRIF: RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote
            mouse pre-implantation cell differentiation.
REFERENCE   6  (bases 1 to 3722)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
REFERENCE   7  (bases 1 to 3722)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   8  (bases 1 to 3722)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 3722)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 3722)
  AUTHORS   Lim,J., Kuroki,T., Ozaki,K., Kohsaki,H., Yamori,T., Tsuruo,T.,
            Nakamori,S., Imaoka,S., Endo,M. and Nakamura,Y.
  TITLE     Isolation of murine and human homologues of the fission-yeast dis3+
            gene encoding a mitotic-control protein and its overexpression in
            cancer cells with progressive phenotype
  JOURNAL   Cancer Res 57 (5), 921-925 (1997)
   PUBMED   9041195
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ176790.1, AK012840.1, CN705423.1, AK032091.1 and AC154843.2.
            
            On Apr 13, 2007 this sequence version replaced NM_028315.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                CJ176790.1         1-83
            84-395              AK012840.1         1-312
            396-910             CN705423.1         1-515
            911-3140            AK032091.1         1-2230
            3141-3722           AC154843.2         88603-89184         c
FEATURES             Location/Qualifiers
     source          1..3722
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 49.25 cM"
     gene            1..3722
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /note="DIS3 homolog, exosome endoribonuclease and 3'-5'
                     exoribonuclease"
                     /db_xref="GeneID:72662"
                     /db_xref="MGI:MGI:1919912"
     exon            1..325
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2974
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     exosome complex exonuclease RRP44; protein DIS3 homolog;
                     ribosomal RNA-processing protein 44; DIS3 mitotic control
                     homolog"
                     /codon_start=1
                     /product="exosome complex exonuclease RRP44 isoform 1"
                     /protein_id="NP_082591.2"
                     /db_xref="CCDS:CCDS49555.1"
                     /db_xref="GeneID:72662"
                     /db_xref="MGI:MGI:1919912"
                     /translation="MLRSKTFLKKTRAGGVVKIVREHYLRDDIGCGAPACSACGGAHA
                     GPALELQPRDQASSLCPWPHYLLPDTNVLLHQIDVLEHPAIRNVIVLQTVMQEVRNRS
                     APIYKRIRDVTNNQEKHFYTFTNEHHKETYIEQEQGENANDRNDRAIRVAAKWYNEHL
                     KRVAADSQLQVILITNDRKNKEKAVQEGIPAFTCEEYVKSLTANPELIDRLAYLSDEM
                     NEIESGKIIFSEHLPLSKLQQGIKSGSYLQGTFRASRENYLEATVWIHGDKEEEKEIL
                     IQGIKHLNRAVHEDIVAVELLPRSQWVAPSSVVLDDEGQNEDDVEKDEERELLLKTAV
                     SEKMLRPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASA
                     LEGRRIIVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLLEHDVPHQPFSQAVLS
                     FLPRMPWSITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIAD
                     VSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEM
                     NHNAEILKTRFTKSVINSKASLTYAEAQMRIDSAAMNDDITTSLRGLNQLAKILKKGR
                     IEKGALTLSSPEIRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEF
                     SEHALLRKHPAPPPSNYDILVKAAKSKNLQIKTDTAKSLADSLDRAESPDFPYLNTLL
                     RILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADIIVHRLLAVAIGAD
                     CTYPELTDKHKLSDICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVR
                     KNAIVVLIPKYGLEGTVFFEEKDKPKPRLAYDDEIPSLRIEGTVFHVFDKVKVKITLD
                     SSNLQHQKIRMALVEPQIPGINIPPNVADKALTAPGGKKRKLEK"
     exon            326..483
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            484..677
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            678..751
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            752..919
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1084
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1198
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1336
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1483
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1600
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1702
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1767
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1852
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1980
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2067
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2224
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2439
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2608
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2767
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2890
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..3722
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3058..3063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /note="hexamer: AATACA"
     polyA_site      3078
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /note="major polyA site"
     polyA_site      3226
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
     regulatory      3331..3336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /note="hexamer: AACAAG"
     polyA_site      3352
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
     polyA_site      3442
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
ORIGIN      
        1 gagagtgacc tcaccagcca gcgggcaaaa gcgggaatgc gcgtggccgc gcctcggttt
       61 cttagctgac ggccgggatc ccacgccgcg aggcgagatg ctcaggtcca agacgttctt
      121 gaagaagacc cgcgcgggcg gcgtggtgaa gatcgtgcgc gagcactacc tgcgggatga
      181 catcggctgc ggcgcgccgg cttgctcggc ctgcggcggg gcgcacgcgg gcccggccct
      241 ggagctgcag ccccgggacc aggcgagcag cctctgcccg tggccgcact accttctgcc
      301 ggacaccaat gtgctgctgc accagattga tgtcctcgaa cacccggcca tcagaaatgt
      361 cattgtgcta caaacagtga tgcaagaagt gagaaaccgg agcgccccca tctacaagcg
      421 aatcagggat gtgaccaata accaggaaaa gcatttctat accttcacta atgagcacca
      481 taaagaaacc tacatcgagc aagagcaggg agagaatgcc aatgacagga atgacagagc
      541 catccgagtc gcagcgaagt ggtacaacga gcacctgaag agggtggcag cagacagtca
      601 gctgcaagtt atcctgataa ccaatgacag gaagaacaaa gagaaagctg tgcaagaggg
      661 gataccagcc ttcacgtgtg aagaatacgt aaagagcctg actgctaacc ctgaacttat
      721 agaccgtctt gcttacttgt ccgatgaaat gaatgaaata gaaagtggga aaataatatt
      781 ttcagagcat cttcccttaa gcaagctcca acaaggcata aaatctggtt cctatcttca
      841 aggaacattc agagctagca gggaaaatta tttggaggct acagtatgga ttcatggaga
      901 caaagaagag gaaaaagaga tacttataca gggaattaag catctaaaca gagctgtgca
      961 tgaagacatt gtggccgtgg agctactgcc caggagccag tgggtggcac cgtcttccgt
     1021 ggttttagac gatgaaggtc aaaatgaaga cgatgtggag aaagatgagg agagagaact
     1081 cctgcttaag actgctgtaa gtgaaaaaat gttacggcct acaggtcgag ttgtggggat
     1141 aataaaaagg aactggagac cgtattgtgg catgctttcc aagtctgata ttaaggagtc
     1201 aagaagacat ctctttacac ccgctgataa gagaattcca cgaattcgga tagaaaccag
     1261 acaggcttct gcgttagaag gacggagaat tattgtcgct attgatggtt ggcctagaaa
     1321 ttctagatat ccaaatggac actttgtaaa gaatttaggc gatgttggag agaaggagac
     1381 agaaacggaa gtgttgctgc tcgagcacga tgttcctcat cagccctttt cccaggctgt
     1441 gcttagcttc ctgcccagga tgccctggag cattactgag gaggacatga aaaaccgaga
     1501 agacctgaga catctgtgtg tttgcagtgt ggaccctcca gggtgcactg acatagatga
     1561 cgctctgcat tgtagagagc tcagcaatgg aaacttggag gttggtgttc atattgcgga
     1621 tgttagccat tttatcaggc caggaaatgc gttggatcaa gaatctgcaa gaagaggaac
     1681 aactgtttat ctttgtgaaa agaggattga catggttcca gagttgctca gctccaacct
     1741 ctgttcctta agatccaacg ttgacaggtt ggcattttcc tgtatttggg aaatgaatca
     1801 taatgctgaa atattaaaaa cgagatttac caaaagtgtc attaattcaa aggcttctct
     1861 tacgtacgcg gaagcacaga tgagaattga ttcggcggct atgaatgatg atattaccac
     1921 tagtctccgt ggactcaatc agctggctaa aattctaaaa aagggaagga ttgaaaaggg
     1981 ggctttgact ctgtcttctc cagagatccg attccacatg gacagtgaaa cccacgaccc
     2041 aatcgacctg cagacgaaag agctgagaga aacaaattcc atggtggaag aatttatgtt
     2101 acttgctaat atttctgtcg caaaaaaaat tcatgaagag ttttctgaac atgctctgct
     2161 tcggaaacac ccagctccgc ctccctcgaa ttatgacatt cttgttaagg ctgcaaagtc
     2221 caagaatttg caaattaaga ctgatacagc caaatctttg gccgactctt tggaccgggc
     2281 tgaatctccg gatttcccat acctgaatac tctattaagg atactggcca ctcgctgtat
     2341 gatgcaagct gtgtacttct gctctgggat ggataatgat tttcatcact atggcttagc
     2401 ctcccccata tacacacatt tcacctctcc tatcagaaga tatgcagaca taattgtcca
     2461 tcggctatta gctgtggcga ttggggctga ctgtacttac cctgagttga cagacaaaca
     2521 caagctttca gatatatgta aaaacctcaa tttccggcat aaaatggctc agtatgccca
     2581 gcgtgcttcg gtggcttttc atacacagtt gtttttcaaa agcaaaggaa tagtaagtga
     2641 agaagcctat attctctttg taaggaaaaa tgcaattgtg gtgttaattc caaagtatgg
     2701 cttagaaggt acagttttct ttgaagaaaa agataaacca aagccacgcc ttgcttacga
     2761 tgatgagatc ccttccctga gaatagaagg tacagtgttc catgtgtttg ataaggttaa
     2821 agtgaagatc acattagatt catcaaatct tcaacatcag aaaatccgca tggcccttgt
     2881 agaaccacag atcccaggaa taaatattcc tcctaatgtt gcagacaagg ctcttactgc
     2941 accaggggga aagaagagga agcttgagaa gtagctacgt tcaacagaac atccaaagac
     3001 tcaacagcaa caaaatggag agcatactta cagactcctg tgcgatagct acttttaaat
     3061 acatttcaat aattttaaca aatttgcatt tttattgagt tgctgactga atctatctta
     3121 tactgtgctt ctgcaacaac aaaaattatg cagaaaaatt catttgaata tccatcactt
     3181 aaatggtgac aataacaact tcagagatct gtgatgatca tttaaatgga gtactcatct
     3241 tctcatagaa gagccgatta atattatcta agtactttag tagaaaacaa cctgtcaatt
     3301 tctgaggaaa ataacatttt agaagcaaag aacaagcctt tctaaatctt cagctgtcag
     3361 cgtttggcat ttaatctttt tgccatttta atttgcctac ttacattgtg ttcatatatt
     3421 ttgaaaagac ttctctactt taccgtggtc ctccgttgtg agtgttgcag ggctatagga
     3481 agacaaagcc tggggtaccc gcatctggtt tggaaccctg agttttgttg ttcagtcagc
     3541 agccctagtc atggttgcca atagttttcc caagcaaggc gtcaccgagg aggaagaaag
     3601 ggggtactct catgtctgct tactcacaaa aacagatagt ggcttaggaa ttgtggttat
     3661 atccagttat acaggcgagg aggggctgtg gtaaagacag attaaaagga acaaatgaag
     3721 tc
//
