LOCUS       NP_082591                958 aa            linear   ROD 09-FEB-2025
DEFINITION  exosome complex exonuclease RRP44 isoform 1 [Mus musculus].
ACCESSION   NP_082591 XP_127907
VERSION     NP_082591.2
DBSOURCE    REFSEQ: accession NM_028315.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 958)
  AUTHORS   Wang,Z., Wu,D., Xu,X., Yu,G., Li,N., Wang,X., Li,J.L. and Dean,J.
  TITLE     DIS3 ribonuclease is essential for spermatogenesis and male
            fertility in mice
  JOURNAL   Development 151 (13) (2024)
   PUBMED   38953252
  REMARK    GeneRIF: DIS3 ribonuclease is essential for spermatogenesis and
            male fertility in mice.
            Erratum:[Development. 2024 Sep 1;151(17):dev204238. doi:
            10.1242/dev.204238.. PMID: 39225297]
REFERENCE   2  (residues 1 to 958)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 958)
  AUTHORS   Wu,D. and Dean,J.
  TITLE     Reduced female fertility due to sequestration of RNA Pol II by
            pervasive transcription in exosome RNase-depleted oocytes
  JOURNAL   Cell Rep 42 (10), 113247 (2023)
   PUBMED   37831603
REFERENCE   4  (residues 1 to 958)
  AUTHORS   Qiu,F., Wang,X., Zhou,M., Yu,J. and Wang,Z.
  TITLE     Epididymal DIS3 exosome ribonuclease is not necessary for mouse
            sperm maturation or fertility
  JOURNAL   Biochem Biophys Res Commun 666, 36-44 (2023)
   PUBMED   37172450
  REMARK    GeneRIF: Epididymal DIS3 exosome ribonuclease is not necessary for
            mouse sperm maturation or fertility.
REFERENCE   5  (residues 1 to 958)
  AUTHORS   Wu,D. and Dean,J.
  TITLE     RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse
            pre-implantation cell differentiation
  JOURNAL   Cell Rep 42 (2), 112047 (2023)
   PUBMED   36724075
  REMARK    GeneRIF: RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote
            mouse pre-implantation cell differentiation.
REFERENCE   6  (residues 1 to 958)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
REFERENCE   7  (residues 1 to 958)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   8  (residues 1 to 958)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (residues 1 to 958)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (residues 1 to 958)
  AUTHORS   Lim,J., Kuroki,T., Ozaki,K., Kohsaki,H., Yamori,T., Tsuruo,T.,
            Nakamori,S., Imaoka,S., Endo,M. and Nakamura,Y.
  TITLE     Isolation of murine and human homologues of the fission-yeast dis3+
            gene encoding a mitotic-control protein and its overexpression in
            cancer cells with progressive phenotype
  JOURNAL   Cancer Res 57 (5), 921-925 (1997)
   PUBMED   9041195
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ176790.1, AK012840.1, CN705423.1, AK032091.1 and AC154843.2.
            
            On Apr 13, 2007 this sequence version replaced NP_082591.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..958
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 49.25 cM"
     Protein         1..958
                     /product="exosome complex exonuclease RRP44 isoform 1"
                     /note="exosome complex exonuclease RRP44; protein DIS3
                     homolog; ribosomal RNA-processing protein 44; DIS3 mitotic
                     control homolog"
                     /calculated_mol_wt=108707
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2L1; propagated from
                     UniProtKB/Swiss-Prot (Q9CSH3.4)"
     Region          9..197
                     /region_name="PIN_Rrp44-like"
                     /note="VapC-like PIN domain of yeast exosome subunit Rrp44
                     endoribonuclease and other eukaryotic homologs; cd09862"
                     /db_xref="CDD:350211"
     Site            18
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2L1; propagated from
                     UniProtKB/Swiss-Prot (Q9CSH3.4)"
     Site            order(20..24,26,28,95,99..100,106,110,124,127)
                     /site_type="other"
                     /note="exosome subunit interface [polypeptide binding]"
                     /db_xref="CDD:350211"
     Site            order(31,36,39,159)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:350211"
     Region          206..929
                     /region_name="VacB"
                     /note="Exoribonuclease R [Transcription]; COG0557"
                     /db_xref="CDD:440323"
     Site            215
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9CSH3.4)"
     CDS             1..958
                     /gene="Dis3"
                     /gene_synonym="2810028N01Rik"
                     /coded_by="NM_028315.2:98..2974"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS49555.1"
                     /db_xref="GeneID:72662"
                     /db_xref="MGI:MGI:1919912"
ORIGIN      
        1 mlrsktflkk traggvvkiv rehylrddig cgapacsacg gahagpalel qprdqasslc
       61 pwphyllpdt nvllhqidvl ehpairnviv lqtvmqevrn rsapiykrir dvtnnqekhf
      121 ytftnehhke tyieqeqgen andrndrair vaakwynehl krvaadsqlq vilitndrkn
      181 kekavqegip aftceeyvks ltanpelidr laylsdemne iesgkiifse hlplsklqqg
      241 iksgsylqgt frasrenyle atvwihgdke eekeiliqgi khlnravhed ivavellprs
      301 qwvapssvvl ddegqneddv ekdeerelll ktavsekmlr ptgrvvgiik rnwrpycgml
      361 sksdikesrr hlftpadkri pririetrqa salegrriiv aidgwprnsr ypnghfvknl
      421 gdvgeketet evlllehdvp hqpfsqavls flprmpwsit eedmknredl rhlcvcsvdp
      481 pgctdiddal hcrelsngnl evgvhiadvs hfirpgnald qesarrgttv ylcekridmv
      541 pellssnlcs lrsnvdrlaf sciwemnhna eilktrftks vinskaslty aeaqmridsa
      601 amnddittsl rglnqlakil kkgriekgal tlsspeirfh mdsethdpid lqtkelretn
      661 smveefmlla nisvakkihe efsehallrk hpapppsnyd ilvkaakskn lqiktdtaks
      721 ladsldraes pdfpylntll rilatrcmmq avyfcsgmdn dfhhyglasp iythftspir
      781 ryadiivhrl lavaigadct ypeltdkhkl sdicknlnfr hkmaqyaqra svafhtqlff
      841 kskgivseea yilfvrknai vvlipkygle gtvffeekdk pkprlaydde ipslriegtv
      901 fhvfdkvkvk itldssnlqh qkirmalvep qipginippn vadkaltapg gkkrklek
//
