LOCUS       NM_001024474            4348 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus DIRAS family, GTP-binding RAS-like 2 (Diras2), mRNA.
ACCESSION   NM_001024474
VERSION     NM_001024474.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4348)
  AUTHORS   Chang,Y., Chen,Q., Li,H., Xu,J., Tan,M., Xiong,X. and Sun,Y.
  TITLE     The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor
            cascade in pancreatic cancer cells
  JOURNAL   Dev Cell 59 (10), 1317-1332 (2024)
   PUBMED   38574733
REFERENCE   2  (bases 1 to 4348)
  AUTHORS   Grunewald,L., Chiocchetti,A.G., Weber,H., Scholz,C.J.,
            Schartner,C., Freudenberg,F. and Reif,A.
  TITLE     Knockdown of the ADHD Candidate Gene Diras2 in Murine Hippocampal
            Primary Cells
  JOURNAL   J Atten Disord 25 (4), 572-583 (2021)
   PUBMED   30623719
  REMARK    GeneRIF: Knockdown of the ADHD Candidate Gene Diras2 in Murine
            Hippocampal Primary Cells.
REFERENCE   3  (bases 1 to 4348)
  AUTHORS   Grunewald,L., Becker,N., Camphausen,A., O'Leary,A., Lesch,K.P.,
            Freudenberg,F. and Reif,A.
  TITLE     Expression of the ADHD candidate gene Diras2 in the brain
  JOURNAL   J Neural Transm (Vienna) 125 (6), 913-923 (2018)
   PUBMED   29488099
  REMARK    GeneRIF: Our findings support the idea of DIRAS2 as a candidate
            gene for attention-deficit/hyperactivity disorder
REFERENCE   4  (bases 1 to 4348)
  AUTHORS   Inagawa,M., Nakajima,K., Makino,T., Ogawa,S., Kojima,M., Ito,S.,
            Ikenishi,A., Hayashi,T., Schwartz,R.J., Nakamura,K., Obayashi,T.,
            Tachibana,M., Shinkai,Y., Maeda,K., Miyagawa-Tomita,S. and
            Takeuchi,T.
  TITLE     Histone H3 lysine 9 methyltransferases, G9a and GLP are essential
            for cardiac morphogenesis
  JOURNAL   Mech Dev 130 (11-12), 519-531 (2013)
   PUBMED   23892084
REFERENCE   5  (bases 1 to 4348)
  AUTHORS   Terami,H., Hidaka,K., Shirai,M., Narumiya,H., Kuroyanagi,T.,
            Arai,Y., Aburatani,H. and Morisaki,T.
  TITLE     Efficient capture of cardiogenesis-associated genes expressed in ES
            cells
  JOURNAL   Biochem Biophys Res Commun 355 (1), 47-53 (2007)
   PUBMED   17286962
REFERENCE   6  (bases 1 to 4348)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041534.1, AK136096.1, BC086799.1 and BF449664.1.
            
            On Sep 14, 2006 this sequence version replaced NM_001024474.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.77828.1,
                                           SRR1660815.271136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AK041534.1         444-647
            205-1914            AK136096.1         206-1915
            1915-4343           BC086799.1         1732-4160
            4344-4348           BF449664.1         262-266
FEATURES             Location/Qualifiers
     source          1..4348
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 27.3 cM"
     gene            1..4348
                     /gene="Diras2"
                     /gene_synonym="2900052J15Rik"
                     /note="DIRAS family, GTP-binding RAS-like 2"
                     /db_xref="GeneID:68203"
                     /db_xref="MGI:MGI:1915453"
     exon            1..417
                     /gene="Diras2"
                     /gene_synonym="2900052J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            418..4348
                     /gene="Diras2"
                     /gene_synonym="2900052J15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             454..1053
                     /gene="Diras2"
                     /gene_synonym="2900052J15Rik"
                     /note="distinct subgroup of the Ras family member 2"
                     /codon_start=1
                     /product="GTP-binding protein Di-Ras2"
                     /protein_id="NP_001019645.1"
                     /db_xref="CCDS:CCDS26516.1"
                     /db_xref="GeneID:68203"
                     /db_xref="MGI:MGI:1915453"
                     /translation="MPEQSNDYRVAVFGAGGVGKSSLVLRFVKGTFRESYIPTVEDTY
                     RQVISCDKSICTLQITDTTGSHQFPAMQRLSISKGHAFILVYSITSRQSLEELKPIYE
                     QICEIKGDVESIPIMLVGNKCDESPNREVQSSEAEALARTWKCAFMETSAKLNHNVKE
                     LFQELLNLEKRRTVSLQIDGKKSKQQKRKEKLKGKCVVM"
     regulatory      4324..4329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Diras2"
                     /gene_synonym="2900052J15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4343
                     /gene="Diras2"
                     /gene_synonym="2900052J15Rik"
                     /note="major polyA site"
ORIGIN      
        1 actgtgcttg caggagcttg aggagggtgg agccggaggc cgggaggcta gagccagaga
       61 gcaccgcgtg ggaggactgc acagggccag gcgcgcgtgc gggcggtgca gggagcggtg
      121 ctggaggttg taaggctgtg cagagagctc gggcgggtgc ataaggcaga gaggggcaga
      181 cagagagggg cagcacaggg ggcaggacgt tgcattgggc gttgcactgg aggtgcaggg
      241 ctctggacat tgcactgggg gtgcggtgca cagggcggtg cggggcgcag ggcagctgac
      301 agcgtcatca ggcgggagca gcgcgcactc cgcctcagca gccaccgcat cgcgctgcgc
      361 gcagcgggtc ccggagctgc gcctggagac ctgcggctct gagccggctc tccccaggta
      421 tctcctggtc agtagctgga gttctgaagc aacatgccgg aacagagcaa cgactaccgg
      481 gtggcggtgt ttggggcagg cggtgttggc aagagctccc tcgttttgag gtttgtgaaa
      541 gggaccttca gggagagcta catcccgact gtggaagaca cctaccggca ggtgatcagc
      601 tgtgacaaga gcatatgcac gctgcagatc accgacacca ccgggagcca ccagtttccg
      661 gccatgcagc ggctgtccat ctccaaaggc cacgccttca tcctggtcta ctccatcacc
      721 agccggcagt ccctggagga actcaagccc atctatgagc agatctgcga gatcaagggg
      781 gatgtggaga gcatccccat catgctggtg ggtaacaagt gtgatgagag ccccaaccgt
      841 gaggtccaga gcagcgaggc agaggcccta gcccgcacat ggaagtgcgc cttcatggag
      901 acgtccgcca agctcaacca caacgtgaag gaactctttc aggaactcct caacctggag
      961 aagcgcagga ccgtgagcct ccagatcgac ggcaagaaga gcaagcagca gaagaggaag
     1021 gagaagctca agggcaagtg cgtggtcatg tgagaggcct tcgtgcagga gctgctgctc
     1081 tcgggcctct ctcttcctcc cctctgtgaa cccccactgt cgtcagggca gcatgtccga
     1141 tgcccgtgtg ttaaacattg catttggctg cgacacaccc tgcaatgtcc ttcagaggca
     1201 ttccacacac cccactagcc cacccccctc aggagatgca gaacctgcga tgcatcttag
     1261 catcccagga agctgaggcc agtcctgagt gggctttagc catttgaaga tgaggggact
     1321 cagagctgtg gacacaggag aacctgagag tactgtgtga tgcatgtgac agcaggttag
     1381 accatggcta ccagtaccat cctgcatcag gcagcttagt tcagaagtca ctaacatctt
     1441 tgggggagga gtaggcaggc agatgagaaa ccagttggac ctgtggatcc cagtggttcc
     1501 cgtgagtgga tttttagtgg gattaaagac aaaataccat aacccccatc taagcgatac
     1561 tcatgctatt cctactgaca cacactgagg gattgccccc cttttcctca aagccttctt
     1621 tgtaagcacc gggtcagcct gttaggagta tacacttcat atgtaatgcc aaggccactt
     1681 gtggcatgat gctgtgtcag catttcttca gtttttgagt caggacattg tgacatcatg
     1741 taaacattgc aataaccacc ctgtatgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     1801 gtgtgtgtgt gtgtatgtgt gtgtgtgtcc cctatacttt gagggttcta gaaatgtgaa
     1861 ctgactttct tctgaccttc gagggttgcc acttcttgca gccctctgat ttttaaataa
     1921 aaggaaataa agtaggcatg tttttagact ccctcttccc ctcccccaag atggttttcc
     1981 tgtcttaaat aactccacga gtacccagct gggaaccagc caaccaagag cgtctaaata
     2041 accagaagca catccatttt ttttctaaat gacgcgagca tgtagatgct atgcgttaca
     2101 ccttaatgaa atactttgaa gcagacgtcg ttcactgtgt ttttaacgat ttatctacat
     2161 cagaagtaga ttgctagaaa atacatttaa tttgtagtaa atcttctcct cgttccttgc
     2221 taaatgctct taaaagttcc tcagagcaac gtgcagccca gacgcaatcc tctcctaagg
     2281 acttttgagt gcaccccgta tccttcagaa ggaatcatag ctactgcgtg agggatcagt
     2341 ggccacagtg gctgcagata ggttgggcta atctctcttt cctgggcaca gtgcccacgg
     2401 cttagtgtaa tttgcctgcc atcctggagt tcggctggat tttgattctt ggaaattctt
     2461 acttctatag tcaatgagaa ggcacatgct ggtcttgggt gccagctcga ccattctcta
     2521 agccatctta ccactgacca gtccgcaggt agaggaggct gtagcactgt gtgagcctat
     2581 acagtactct catggccagc aggcatggcc agtgggcaga ggtcccaatg ctggggtgtt
     2641 ttggtcggcc tcttgctcca ccaaagcctc cgaagcacac tgtgttcaaa cacttgcttc
     2701 cttcagacct ctataattca gtctggccct ctctgctctg ccaatcataa ctcaccctgg
     2761 tgatgtgctg agggccaggg agttccctca gaaaaccgta tgcctcagca atcttaccat
     2821 ctccttagac ctctagaaca aaacccttgg ggttatctgg gcaagcagcc acactgagaa
     2881 atgaggaagc ccaggaacca agcaagaaga gcctggagcc cttgtgcccc atccaaaccc
     2941 actctgagtc tcttctatct tccccatttg ttcccagtgg ccattctcta tcacagtgag
     3001 atggagttat ggaattttct agaatgtctt caatttgttg ttccatttct cctctcagag
     3061 aaaacatatc accttgtcgt ttagatttgg ggaacagcga gggaaagacc actgctctgt
     3121 ggatgatgtg acacatacgt tatctacaca tcatatagga tatatatata tatatatata
     3181 tatatttatg gcgatccctt tacagtaaaa tcctgtctgt cctaccgact gtcaccgtgc
     3241 ttcagacaca agcattgtgc cccatgattc cctgtttcca gtgaccgcac atcagggttc
     3301 tttcagccct gtatgtcagt ttccatattc ctaagtgttt cagtcttcat tgacacgagg
     3361 atcttgctat agctccatcc acagtctttg ctcctctcta tgctgtctgt gagtttagag
     3421 ggtgggaggt gaagcctccc tccttgggct tcattttgac actacattct atagattgag
     3481 ccgaacactg ggtagctatc ttaacatcac ctttggcaaa cttccctctg actcaggggc
     3541 tgaggacaca gtactatcgg gccagtggct ttcagctttg ctttggtccc agcccaagtc
     3601 atgaagctga gactcttggt aatatcctac attgcacatg ggactggaaa cttctgaccc
     3661 agcctcagct cattataaaa cttgaaaact tgctttgaag atggcactct ggggttaagc
     3721 acgggactcc atgagctccc taatccccac tggtcccctc tccattcagt gacaagccat
     3781 gggcaggcat ctaatgcatc aagtccaaca caagagcaat atccaattgt ccactagatc
     3841 taaaattata tatatattat gtaatttatc ttcctgcact tttgaagcat aaagtagtaa
     3901 attgtacata tatatctcta tatatcaata tgctagtata tcggtttcac tctttgtaac
     3961 attctttgta gaagaagatg tactaaatat tttaaaattg cgctgtgata ttcctcccta
     4021 ccccaagttt gtaacgtgtc gctcctactc aagctgtttg gaaacaccca aagccaaagg
     4081 ggcatatgga actcctatag gaaggacacc tcctgggatt cagtggccca caaagacctt
     4141 gtgtcaatca agcatctgtg atcagagtga tcattggcat gtgagacgcc ggcacatgct
     4201 tccactgcag cccttgctgt ttcggttcca tttctgggtg tgtctaacta ctctgtggtt
     4261 acgaggatca ccttgtataa ggttctagtg gcagcgatgg ccccagtcca tggaaccagt
     4321 tacaataaag ctcagttaca gcaccctg
//
