LOCUS       NM_001033145            3950 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus divergent protein kinase domain 2A (Dipk2a), mRNA.
ACCESSION   NM_001033145 XM_147036 XM_905361
VERSION     NM_001033145.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3950)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3950)
  AUTHORS   Bareja,A., Hodgkinson,C.P., Payne,A.J., Pratt,R.E. and Dzau,V.J.
  TITLE     HASF (C3orf58) is a novel ligand of the insulin-like growth factor
            1 receptor
  JOURNAL   Biochem J 474 (5), 771-780 (2017)
   PUBMED   28096202
  REMARK    GeneRIF: HASF is a novel ligand of IGF1R.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3950)
  AUTHORS   Huang,J., Guo,J., Beigi,F., Hodgkinson,C.P., Facundo,H.T.,
            Zhang,Z., Espinoza-Derout,J., Zhou,X., Pratt,R.E., Mirotsou,M. and
            Dzau,V.J.
  TITLE     HASF is a stem cell paracrine factor that activates PKC epsilon
            mediated cytoprotection
  JOURNAL   J Mol Cell Cardiol 66, 157-164 (2014)
   PUBMED   24269490
  REMARK    GeneRIF: HASF (GoPro49) is a stem cell paracrine factor that
            activates PKC epsilon mediated cytoprotection.
REFERENCE   4  (bases 1 to 3950)
  AUTHORS   Elsen,G.E., Hodge,R.D., Bedogni,F., Daza,R.A., Nelson,B.R.,
            Shiba,N., Reiner,S.L. and Hevner,R.F.
  TITLE     The protomap is propagated to cortical plate neurons through an
            Eomes-dependent intermediate map
  JOURNAL   Proc Natl Acad Sci U S A 110 (10), 4081-4086 (2013)
   PUBMED   23431145
REFERENCE   5  (bases 1 to 3950)
  AUTHORS   Miyoshi,G. and Fishell,G.
  TITLE     Dynamic FoxG1 expression coordinates the integration of multipolar
            pyramidal neuron precursors into the cortical plate
  JOURNAL   Neuron 74 (6), 1045-1058 (2012)
   PUBMED   22726835
REFERENCE   6  (bases 1 to 3950)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   7  (bases 1 to 3950)
  AUTHORS   Takatalo,M.S., Tummers,M., Thesleff,I. and Ronnholm,R.
  TITLE     Novel Golgi protein, GoPro49, is a specific dental follicle marker
  JOURNAL   J Dent Res 88 (6), 534-538 (2009)
   PUBMED   19587158
  REMARK    GeneRIF: a novel, specific marker for the dental follicle
REFERENCE   8  (bases 1 to 3950)
  AUTHORS   Takatalo,M., Jarvinen,E., Laitinen,S., Thesleff,I. and Ronnholm,R.
  TITLE     Expression of the novel Golgi protein GoPro49 is developmentally
            regulated during mesenchymal differentiation
  JOURNAL   Dev Dyn 237 (8), 2243-2255 (2008)
   PUBMED   18651652
  REMARK    GeneRIF: GoPro49 is a new gene expressed specifically in
            mesenchymal and cartilaginous tissues during development
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160129.2.
            
            On Sep 29, 2006 this sequence version replaced NM_001033145.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164138
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-863               AC160129.2         201057-201919       c
            864-1167            AC160129.2         188230-188533       c
            1168-3950           AC160129.2         181702-184484       c
FEATURES             Location/Qualifiers
     source          1..3950
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 49.03 cM"
     gene            1..3950
                     /gene="Dipk2a"
                     /gene_synonym="1190002N15Rik; GoPro49; HASF"
                     /note="divergent protein kinase domain 2A"
                     /db_xref="GeneID:68861"
                     /db_xref="MGI:MGI:1916111"
     exon            1..863
                     /gene="Dipk2a"
                     /gene_synonym="1190002N15Rik; GoPro49; HASF"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1499
                     /gene="Dipk2a"
                     /gene_synonym="1190002N15Rik; GoPro49; HASF"
                     /note="Golgi protein GoPro49; UPF0672 protein C3orf58
                     homolog; deleted in autism protein 1 homolog; Golgi
                     Protein of 49 kDa; hypoxia and AKT-induced stem cell
                     factor"
                     /codon_start=1
                     /product="divergent protein kinase domain 2A precursor"
                     /protein_id="NP_001028317.2"
                     /db_xref="CCDS:CCDS40725.1"
                     /db_xref="GeneID:68861"
                     /db_xref="MGI:MGI:1916111"
                     /translation="MWRLVPLKLGRLSRALKLAALGSLLVLMLLHSPSLLASWQRNEL
                     ADRRFLQLNKCPACFGTSWCRRFLNGQVGFETWGRLRLLDFLNVKNVYFAQYGEPREG
                     GRRRVVLKRLGSQRELAQLDQSICKRATGRPRCDLLQAMPRTEFARLNGDVRLLTPEA
                     VEGWSDLVHCPSQRLLDRLVRRYAETKDSGSFLLRNLKDSERMQLLLTLAFNPEPLVL
                     QSFPSDEGWPFAKYLGACGRMVAVNYVGEELWSYFNAPWEKRVDLAWQLMEIAEQLTN
                     NDFEFALYLLDVSFDNFAVGPRDGKVIIVDAENVLVADKRLIRQNKPENWDVWYESKF
                     DDCDKEACLSFSKEILCARVTVDHNYYAVCQNLLSRHATWRGTSGGLLHDPPSEIAKD
                     GRLEALLDECTNPKKRYGRFQAAKELRGYLAQLSHNVR"
     exon            864..1167
                     /gene="Dipk2a"
                     /gene_synonym="1190002N15Rik; GoPro49; HASF"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..3950
                     /gene="Dipk2a"
                     /gene_synonym="1190002N15Rik; GoPro49; HASF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3926..3931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dipk2a"
                     /gene_synonym="1190002N15Rik; GoPro49; HASF"
                     /note="hexamer: AATAAA"
     polyA_site      3950
                     /gene="Dipk2a"
                     /gene_synonym="1190002N15Rik; GoPro49; HASF"
                     /note="major polyA site"
ORIGIN      
        1 ggagtcggag ggcggggagc tcggaggagg gcaccgggag ttgtggagac agccgatcgg
       61 gaagtcgccg cgctcggccg gcgcagcccg tcctcgggtt ccttcgctgc cgccctccgt
      121 ctgcgccgcg ggcctcggcg ccgtggggcg gcccggcggg gtgcgctcgc ccgccccggc
      181 cccggccgct gccgcgcgcg ggcgggatgt ggcgcctggt gcccctgaag ctgggccgcc
      241 tgtcccgtgc actgaagctg gcggcgctcg gcagcctgtt ggtgctgatg ctgctgcact
      301 cgccgtcgct gctcgcctcc tggcagcgca acgagctcgc cgaccggcgc ttcctgcagc
      361 tcaataagtg cccggcgtgc ttcggcacga gctggtgccg ccgtttcctc aacggccagg
      421 tgggcttcga gacgtggggc cgcctgcgcc tgctggactt cctcaacgtg aagaacgtgt
      481 acttcgcgca gtacggcgag ccccgcgagg gcggccgccg gcgcgtggtg ctcaagcgcc
      541 tgggttcgca gcgcgagctg gcgcagctcg accagagcat ctgcaagcgg gccaccggcc
      601 ggccgcgctg cgacctgctc caggccatgc cccgcaccga gttcgcgcgt ctcaacggcg
      661 acgtgcggct gctcacgccg gaggcggtgg agggttggtc ggacctggtg cactgcccct
      721 cgcagcgcct gctggaccgc ctggtgcgcc gctacgcgga gaccaaggac tcgggcagtt
      781 tcctgctgcg taacctcaag gactccgagc gcatgcagct gctgctcacc ctggccttca
      841 accccgagcc gctggtgcta cagagttttc catctgatga aggttggcca tttgcaaaat
      901 atcttggagc ttgtggaaga atggtggctg taaattatgt tggagaagaa ctgtggagtt
      961 attttaatgc accatgggag aagagagttg accttgcttg gcagttaatg gagatagcag
     1021 agcagcttac aaacaatgac tttgaatttg cactctacct cctggacgtc agctttgaca
     1081 actttgcagt tggtccaaga gatgggaaag taatcattgt ggatgccgaa aatgttttag
     1141 ttgccgacaa aagattaatt agacaaaata agcctgagaa ttgggacgta tggtatgaaa
     1201 gcaagtttga cgattgtgac aaggaagctt gcttgtcatt ttcaaaagaa atcctctgtg
     1261 ctcgtgtcac tgtggaccac aattactatg ccgtttgtca gaacctctta tccagacatg
     1321 ccacctggcg cggcacttct ggaggactcc tccatgatcc accaagtgaa attgccaaag
     1381 atggccgact ggaggccttg ctggatgagt gcaccaaccc caagaaacgc tatggccggt
     1441 tccaggccgc aaaagaactg cgtggctatc tggcacagtt aagtcacaat gtgaggtagt
     1501 cagcagtgat ctttacattt tctttgctga aaaagcactg acaaaactaa accaccaaaa
     1561 aaactgccta gaataaacaa agtgtggaag tatggcctcg agaatgatga acttctgata
     1621 gatcttacgt taacacccat caaataagac attactgtac atcaacgttc tcacgacgct
     1681 tctgcaagtc tgttcttcac tttggagatt gagataccat tgactgcttt tccccttccc
     1741 atacctgagt ggatgatatt gctaagctat tggaaaggag tctgatagtt acatggcttg
     1801 tgtatcaaag ggtacttggt acttagtttg catttctacc atgattttgt gaatctcttg
     1861 catttacttt gaatttcaag ttagattggc ctgttttata ggccacattt tccttctgat
     1921 gtgtaaaatc attttccatt ttttaaaagt tttacgcacc caggttacta taggtgttca
     1981 tttaaaattt aatataagta gttttcattc cgtgctatgc ggtacatact taaactgtta
     2041 gggcaggact cccaggttta ctgtttttac agagatctta gtatttcacc atgtaaataa
     2101 tttgcctctc cccagccttc tatgcttttc cactgcatga taacatcatt tcaggttatt
     2161 taagagttaa ctccctcaat gccagtaatt acaggtatac actgaacatg atgttcagca
     2221 tatgctacaa aacgtcactg catcctttgc taaaaggctt cgagaataat acactagcag
     2281 tctacacttc gatcgctttg attgaagaaa caataaaagt caaggtttct aaatgctaac
     2341 tagtccaaga tagtaatgca tatgccaaag aaatattaga cacattccta tgtttagaac
     2401 tgaaaataga attggtcacc ttcgtatccc acttcagtat tttagctgtc actcgtaaat
     2461 taagatctac ctgtcccttt aatgctgaca gttgagctac tgcttattaa aaaaatgtat
     2521 atcgtaaaga ccttctacct tttattcatt ggtagtttct ccaaaatgaa catggtaatc
     2581 attgttggaa tccaattagg catcagaacc ttttactaac tgatacacta ataattttta
     2641 ctgtaaagct tgtgtgccca ttgtgatctt ctttactcag ttgctagata tcagaacatc
     2701 aaatttaaat gtgtgagtag aaaaattaac aaataatgtg taaaattttt gtctatttaa
     2761 aaactgttct ttgtaaaagt tggctctaac tagcacaggt aatatctttc tgtttgaagt
     2821 tgtttctttt gtttgcagta aagtttgggg tagtgcgttc tggcctgact tactgaaatc
     2881 agaaagcgat taaaatatgc acaaccaaag ccaagtttgt ccttctcatt catttagcaa
     2941 ctatttattg tccctcaagc caggagcact tgtagctgct gtgcaccatc tgaacagaca
     3001 tggtcaagac catatcaaac gtgttagcat aggtacttct tcagttgaaa tgccattatt
     3061 taggataaac tttcatgttg tttgattatt gtgatgggaa ttatctttgt accatcttaa
     3121 attagtttgt taatccaaag tggaggaaga cagcaataaa gttaatgcaa gtttaaaact
     3181 gggaagacgg agggtaaggg atgtctatta taaaacagat tattacattg tgtttcttct
     3241 tatacatccg tacattgcat agttctcagt gaaacattga agagcttgct aagctaactt
     3301 cttacaaatt ccaacagatt ttgaagggag taggaaaaaa tcatccaagt cttttgcgtc
     3361 cttagagcta cactaaagta tagagtttca aaacagaaca ccattatatt ttccacctat
     3421 tcataacatg gaggttggga ctcctaggag agccgtctgt ggttccacaa acatcatcat
     3481 gtttttgggg agtgactgtg gttgtggtta cagagcaaga agtcaagaag ccttccaggc
     3541 agtgatggct acttcaggta taactaccat tagagaggat gtggaatttc ttttatcttt
     3601 ggggaagttt tgaaaagata gtcaaggaat taggaattta aaattacagg gaaaaatatg
     3661 tatgtgaaaa gcaataaata ttttgttctc tttgctatca agatgttcac actcagatat
     3721 ttattataca gcaacaattt atatttttaa tcattgccca ttaatagacg cagtgaaata
     3781 tttttgaatc aaaacatttg gggtttgtat gtgcatttaa attgtctttt gtactgtatg
     3841 ttactgttta atttgaatat tttatcagaa ctgtctccct gtgcctttat aatataaagt
     3901 tgtttctgca acttttaatg atcttaataa agaatacttt aagaaccata
//
