LOCUS       NM_001408326            3387 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus divergent protein kinase domain 1C (Dipk1c),
            transcript variant 1, mRNA.
ACCESSION   NM_001408326
VERSION     NM_001408326.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3387)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3387)
  AUTHORS   Wu,Z., Mei,F., Gan,Y., Liu,A., Hu,J., Jin,Y. and Yin,Y.
  TITLE     FAM69C functions as a kinase for eIF2alpha and promotes stress
            granule assembly
  JOURNAL   EMBO Rep 24 (5), e55641 (2023)
   PUBMED   36929224
  REMARK    GeneRIF: FAM69C functions as a kinase for eIF2alpha and promotes
            stress granule assembly.
REFERENCE   3  (bases 1 to 3387)
  AUTHORS   Mei,F., Hu,J., Wu,Z., Zhang,G., Liu,A., Li,X., Zhu,M., Gan,Y.,
            Liang,L., Zhao,X., Yuan,Y., Meng,X., Li,Y., Jin,Y., Jia,J. and
            Yin,Y.
  TITLE     FAM69C, a kinase critical for synaptic function and memory, is
            defective in neurodegenerative dementia
  JOURNAL   Cell Rep 40 (3), 111101 (2022)
   PUBMED   35858575
REFERENCE   4  (bases 1 to 3387)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142448.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784649.363809.1,
                                           SRR14777530.385644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               AC142448.3         138691-138889       c
            200-859             AC142448.3         128363-129022       c
            860-1024            AC142448.3         122076-122240       c
            1025-3387           AC142448.3         117321-119683       c
FEATURES             Location/Qualifiers
     source          1..3387
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 57.53 cM"
     gene            1..3387
                     /gene="Dipk1c"
                     /gene_synonym="B230399E16Rik; Fam69c"
                     /note="divergent protein kinase domain 1C"
                     /db_xref="GeneID:240479"
                     /db_xref="MGI:MGI:3041188"
     exon            1..199
                     /gene="Dipk1c"
                     /gene_synonym="B230399E16Rik; Fam69c"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1243
                     /gene="Dipk1c"
                     /gene_synonym="B230399E16Rik; Fam69c"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM69C; family with sequence similarity 69, member
                     C"
                     /codon_start=1
                     /product="divergent protein kinase domain 1C isoform 1"
                     /protein_id="NP_001395255.1"
                     /db_xref="GeneID:240479"
                     /db_xref="MGI:MGI:3041188"
                     /translation="MARAAGERGRAARCGRWRRGALLAFAAWTAGWVLAAALLLRAHP
                     SVLSERCTDEKSRRILAALCQDYRRGWLTGALCEDLCVGGELLYQRCLYYERGKKVLQ
                     AQWRGRTVVLKSKREAFSSFPPLTLLEEEAGAGAPGIPEAELLLMVAGEVKNTLGLEL
                     PNNSIAPLWPARQGPGWRQQLASAWSLLQQEEYVYFSLLPDLSRHILPVLGSCGHFYA
                     VEYLAAGSPHHKALFPLDDAGQAQAISHIALSFLDMVSHFDSDFSHRLHLCDVKPENF
                     AIKRDFTVVAIDVDMAFFEPKMREILEQNCTGDEDCNFFDCFSKCDLRVHKCGAQRVN
                     SNLQVICDKIFRHWFSSTHRSPAVSLQLRLQLQQAVQECAQHGGSSGNSWTASSSVFW
                     KLRWLLQATLKELQEAEK"
     exon            200..859
                     /gene="Dipk1c"
                     /gene_synonym="B230399E16Rik; Fam69c"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1024
                     /gene="Dipk1c"
                     /gene_synonym="B230399E16Rik; Fam69c"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..3387
                     /gene="Dipk1c"
                     /gene_synonym="B230399E16Rik; Fam69c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2044..2049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dipk1c"
                     /gene_synonym="B230399E16Rik; Fam69c"
                     /note="hexamer: AATAAA"
     polyA_site      2068
                     /gene="Dipk1c"
                     /gene_synonym="B230399E16Rik; Fam69c"
                     /note="major polyA site"
     regulatory      3359..3364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dipk1c"
                     /gene_synonym="B230399E16Rik; Fam69c"
                     /note="hexamer: AATAAA"
     polyA_site      3387
                     /gene="Dipk1c"
                     /gene_synonym="B230399E16Rik; Fam69c"
ORIGIN      
        1 agggctggca atggcgcggg cggcgggcga gcggggccgg gctgcacggt gcgggcgctg
       61 gcggcggggc gcgctcctcg ccttcgccgc gtggaccgcc ggctgggtgc tggcagctgc
      121 gctgctgctc cgcgcacacc cgagcgtcct ctccgagcgc tgcacggatg agaagagccg
      181 gcgcatcctg gctgcgctgt gccaggacta tcgccgtggc tggctcacgg gcgccctgtg
      241 cgaggacctg tgtgtgggcg gggagctgct gtaccaacgc tgcctgtatt acgagcgtgg
      301 taagaaggtg ctgcaggctc agtggcgtgg ccggaccgtt gtcctcaaat ccaagaggga
      361 ggccttctcc agcttcccgc ccctcactct gctggaggag gaagcagggg caggtgcccc
      421 cggcatccct gaggctgagc tgctcctgat ggtggccggg gaggtcaaga acacgctagg
      481 cttggagctg cccaacaaca gcatagcccc gctatggcct gccaggcagg gccctggctg
      541 gcggcaacag ctggccagtg cgtggtcact gctccaacag gaggaatacg tatacttcag
      601 cctgcttcca gatctgagcc gccacatcct accggtgctg ggatcctgcg gtcactttta
      661 tgcagtggag tacttggctg ctggtagccc tcaccacaag gctctcttcc cactggatga
      721 tgctggccaa gcacaggcta ttagccacat tgccctcagc ttcctggaca tggtgagcca
      781 tttcgacagt gacttttccc accggctcca cctctgtgat gtcaaacctg agaacttcgc
      841 catcaagagg gactttacgg tggtagctat tgacgtagac atggcctttt ttgagcctaa
      901 aatgagggaa atccttgagc agaactgcac gggagatgaa gattgcaatt tcttcgattg
      961 tttctccaag tgtgatctcc gagtgcacaa gtgtggagcc cagcgtgtca acagcaacct
     1021 gcaagtcatc tgtgataaaa tattccgaca ctggttctcc tcaacacaca ggagcccggc
     1081 tgtctccctc cagcttcggc tgcagctaca gcaggccgtg caggagtgtg ctcagcacgg
     1141 gggctcctcg gggaattcct ggacagcctc atccagtgtg ttctggaagc ttcgatggct
     1201 cttgcaggcc actctgaaag aactgcagga ggcggagaag tagcctctct cttgcctttg
     1261 ccatcaagag tagacagagg aagcgacctt caagggactc ctcctgtagt tgctatgcaa
     1321 atgagctgtc agagcccgtg gcatgctctt ctgaagtgtg cagctgagct ccccttctgt
     1381 ggctgtgacg tggacctctc ttgctcctgc ccagctcggt tcgatctggt ttcgtggcga
     1441 cctccggtct gtcactcctt ccgcagtgac cgaagggagg agtttcacca gagttgccag
     1501 tctggaaccc tctgaggact gtacacagac cttgccacta tagacaagag gctgctgctc
     1561 ttccttgtta gctgctaaca agctaaagcg tggctgtggg catactgatg gatatgtttg
     1621 caaataattg tgtgcataat gttgcaccca tgagtgtatg agtgggtttg tatatatgaa
     1681 tgtgtattgt atacacatga gtatgttgtg tgtaaataag catgggattg tgtgtatgta
     1741 agtgggattg cacatgttct cataattatg agtgttcctg tgcacgcaag tgtgtgtgtg
     1801 tgtgtgtgtg tgtgtgtgtg tgtgcacatt cgcatgccca tgacccagtc atcgtgcctg
     1861 tgaatctgtg ctcatggatg aatccatgtg aatccaccca gaagtgcatg catgtgtaca
     1921 tccagaagtg agtaagtggg tgggcactcg gagcctgtat ggagaggtgg cttttcagtg
     1981 tgtccctagg aatcttgcct agctggcaaa gaagtgctat ttttcccccc tggaattaaa
     2041 tgcaataaaa tgtgtgtcct tagcggcaca atttgctttg gggagtatgt ggaaaggcag
     2101 cttttagtgc ttcccattct gtggaattct agggagcact ttaccatgca tcgaccgcag
     2161 cgcatctttc ttctgagctg gaccaggtgt ctgcggaatg cagtgtgtct tgcagcgaca
     2221 gagacagttt atgtaaagtg ctggggtggc ctctgaccac aggcagaact gaggaagagc
     2281 ttgtctgtgc gtaccgactg aagacccagc cgagggcagc ggacacttct tgtggacatt
     2341 tgatgatgct cttttccaat ggccagctcg cacgaagcca gccaagctgt gcattgctcc
     2401 ccaacagaga gtggaaccag caagccttat gcttaccatc ttgcttctac tcagaacagg
     2461 gaccccaaac tctacaagtc acagggaagg ggactcaaga acagtaggat gtctcgaaga
     2521 ttgggaaggt gtgctagggg cttattagga gaaaaggaca aaatttggag ttttaaacat
     2581 gtacagaatg acagagcctc accttttctc ttcatataag acctttgcag tccagagaac
     2641 tgcctcttta actcctgtgg atgcagttct cagggctgtg cacacagatg acatcctccc
     2701 tactctgagc agtggcacta ggggatggag gcgggtcgga ggtcacacca gtcctgaagc
     2761 tgtctatgat cctgaaggca ggagatgtct gtttcctgcc gcccccatcc cctcagccca
     2821 cctaccagca atttgccaga gaaggctgac tttcttaaag gctatcatct atcctgtgct
     2881 ggaagacttg ctttttgttt ctgtcctttg atgggagcct gcgcaggtca ctctgccaga
     2941 agtgagcaaa agcccacgta ggtgcccagg tctaggctag cagggagata gcctagaagg
     3001 tagggagaaa gctctgggat tcctatgagg cttagcaact tttctgtctc tgcacgggga
     3061 gtcaaatgac tccttagtag ccctctggct actgaccagc cgctgttagt ttttattcga
     3121 ttctaaatgg aaacaaatgt tttgtttacc atggagactg tgcaatatat gatcacccca
     3181 cacaatagca tccctttctg catgtttttg gctacacaca cacacacaca cacacacaca
     3241 cacacacaca gactccttgc ctaaggatct attttaaggc agtggttctt aaattgtggt
     3301 gaaattcact ttttaaaaat gtttaaacct ttttcaaaat actgctttta tataatataa
     3361 taaacagaca tgatggtatt atcagta
//
