LOCUS       NM_026062               2724 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus divergent protein kinase domain 1A (Dipk1a), mRNA.
ACCESSION   NM_026062
VERSION     NM_026062.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2724)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2724)
  AUTHORS   Ingham,N.J., Rook,V., Di Domenico,F., James,E., Lewis,M.A.,
            Girotto,G., Buniello,A. and Steel,K.P.
  TITLE     Functional analysis of candidate genes from genome-wide association
            studies of hearing
  JOURNAL   Hear Res 387, 107879 (2020)
   PUBMED   31927188
REFERENCE   3  (bases 1 to 2724)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2724)
  AUTHORS   Pritsker,M., Doniger,T.T., Kramer,L.C., Westcot,S.E. and
            Lemischka,I.R.
  TITLE     Diversification of stem cell molecular repertoire by alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14290-14295 (2005)
   PUBMED   16183747
REFERENCE   5  (bases 1 to 2724)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   6  (bases 1 to 2724)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY131147.1, AK048979.1, AK053273.1 and DT926079.1.
            
            On May 7, 2009 this sequence version replaced NM_026062.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.173699.1, AK050305.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BY131147.1         2-45
            45-2291             AK048979.1         2-2248
            2292-2708           AK053273.1         2097-2513
            2709-2724           DT926079.1         359-374             c
FEATURES             Location/Qualifiers
     source          1..2724
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 52.23 cM"
     gene            1..2724
                     /gene="Dipk1a"
                     /gene_synonym="2900024C23Rik; Fam69a"
                     /note="divergent protein kinase domain 1A"
                     /db_xref="GeneID:67266"
                     /db_xref="MGI:MGI:1914516"
     exon            1..129
                     /gene="Dipk1a"
                     /gene_synonym="2900024C23Rik; Fam69a"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1362
                     /gene="Dipk1a"
                     /gene_synonym="2900024C23Rik; Fam69a"
                     /note="protein FAM69A; family with sequence similarity 69,
                     member A"
                     /codon_start=1
                     /product="divergent protein kinase domain 1A"
                     /protein_id="NP_080338.1"
                     /db_xref="CCDS:CCDS39200.1"
                     /db_xref="GeneID:67266"
                     /db_xref="MGI:MGI:1914516"
                     /translation="MARSLCAGAWLRKPHYLQARLSYMRVKYLFFSWLVVFVGSWIIY
                     VQYSTYTELCRGKDCKKIICDKYKTGVIDGPACNSLCVTETLYFGKCLSNKPSNQMYL
                     GVWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKAK
                     LGDQGNLSELVNLILTVADGDRDGQVSLGEAKSAWALLQLNEFLLMVILQDKEHTPKL
                     MGFCGDLYVMESVEYTSLYGISLPWVMELFIPSGFRRSMDQLFTPSWPRKAKIAIGLL
                     EFVEDVFHGPYGNFLMCDTSAKNLGYNEKYDLKMVDMRKIVPETNLKELIKDRHCESD
                     LDCVYGTDCRTSCDLSTMKCTSEVIQPNLAKACQLLKDYLLHGAPSEIREELEKQLYS
                     CIALKVTANQMEMEHSLILNNLKTLLWKKISYTNDS"
     exon            130..264
                     /gene="Dipk1a"
                     /gene_synonym="2900024C23Rik; Fam69a"
                     /inference="alignment:Splign:2.1.0"
     exon            265..372
                     /gene="Dipk1a"
                     /gene_synonym="2900024C23Rik; Fam69a"
                     /inference="alignment:Splign:2.1.0"
     exon            373..549
                     /gene="Dipk1a"
                     /gene_synonym="2900024C23Rik; Fam69a"
                     /inference="alignment:Splign:2.1.0"
     exon            550..2724
                     /gene="Dipk1a"
                     /gene_synonym="2900024C23Rik; Fam69a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1781..1786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dipk1a"
                     /gene_synonym="2900024C23Rik; Fam69a"
                     /note="hexamer: ATTAAA"
     polyA_site      1802
                     /gene="Dipk1a"
                     /gene_synonym="2900024C23Rik; Fam69a"
     regulatory      2405..2410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dipk1a"
                     /gene_synonym="2900024C23Rik; Fam69a"
                     /note="hexamer: AATAAA"
     polyA_site      2430
                     /gene="Dipk1a"
                     /gene_synonym="2900024C23Rik; Fam69a"
                     /note="major polyA site"
     regulatory      2631..2636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dipk1a"
                     /gene_synonym="2900024C23Rik; Fam69a"
                     /note="hexamer: ATTAAA"
     polyA_site      2668
                     /gene="Dipk1a"
                     /gene_synonym="2900024C23Rik; Fam69a"
ORIGIN      
        1 aggggcgggg aggccggcgg gcggccgcgc tcgggtccgc ctccgactgc ggcgcggcgg
       61 ggcgatgtga gtgccatggc gaggagtctc tgcgcggggg cctggctgag gaaaccccat
      121 tacctccagg ctcggttgtc ctacatgcgg gtgaagtatc ttttcttttc ctggctggtg
      181 gtttttgtcg gaagctggat catatatgtg cagtattcaa cctatacaga gctatgcaga
      241 gggaaggact gtaagaaaat catatgtgac aaatacaaga ccggagttat tgacggacct
      301 gcatgcaaca gcctctgtgt cacagaaaca ctgtactttg gaaaatgtct gtccaacaag
      361 cccagcaacc agatgtattt aggagtttgg gataatctac caggtgttgt gaagtgtcaa
      421 atggaacaag ctcttcatct tgattttgga actgaattgg agccaagaaa agaaatagtg
      481 ctatttgata aaccaaccag gggaactact gtacagaaat tcaaagaaat ggtgtacagt
      541 ctctttaagg caaaattagg tgaccaaggg aacctctctg aattggttaa tctcatcttg
      601 acagtggctg acggagacag agatggccag gtctccctag gagaagccaa gtcagcatgg
      661 gcacttcttc agttgaatga gtttctcctg atggtgatac ttcaagataa agaacacacc
      721 cccaaactaa tgggattctg tggtgatctc tacgtgatgg aaagtgttga atatacctct
      781 ctgtatggaa taagtctacc atgggttatg gaacttttta ttccatctgg gttcagaagg
      841 agcatggatc aattgttcac accatcatgg cccagaaagg caaagatagc cataggactt
      901 ctagaatttg tagaggatgt tttccatggc ccctatggaa actttctcat gtgtgacacc
      961 agtgccaaaa acctaggata taatgagaag tatgacttga aaatggtgga tatgagaaaa
     1021 attgtgccag agacaaacct aaaggaactt attaaggacc gccactgtga gtctgacctg
     1081 gactgtgtct acggtacaga ctgtagaact agctgtgacc tgagtacaat gaagtgcact
     1141 tctgaagtaa tacaaccaaa cttggcaaaa gcctgtcagt tactcaaaga ctacctactg
     1201 cacggtgctc ccagtgaaat tcgggaagaa ttagaaaaac agctttattc ttgtattgct
     1261 ctcaaagtca cagcaaatca aatggaaatg gaacattctt tgatattaaa taacctaaaa
     1321 acgttattgt ggaagaaaat ttcctacaca aatgactctt agttcatttg gactactgcc
     1381 atcattgaga atctacttat gattttgagc atttaaagag tggcttctgc cccccaggcc
     1441 tgtggagtca tcatcttaaa tgcatgttgt aacaataatg gcaggtgtag ggccaagatg
     1501 tccaaaactc atccctgccc ttttacaagt ccacaagtat attcactgtt aactatcttg
     1561 actttaaaaa aaaaaaatta atgctgtgaa aatcctcatt ccataaacag tgagtgttct
     1621 gtagatgtta gccagtccca ttgccggaca ttgtttgcat tgaagctgct gtttaaacaa
     1681 ggaaatttat acatgaattt actaatgttt tagcatggta aaactttgca cattaacaca
     1741 aattaagaat gccacacagg taaattcaaa tgactcattt attaaaaagt tcagttaata
     1801 tagcatgatt tactgtgtac ttacacactt taacttcaga tggagtcaac tgtggaatgg
     1861 cttttagctt cggcatatat tctacatgct gaagttagca tgcagttatc actgtgactg
     1921 aaactcatta tctttaagct ctgataggtt catcttagta tcgtcacatt atctttgctg
     1981 gggatgtagg taagcagtta actgtttacc tgacctgtgt agccccagta ccacagagcc
     2041 tgacactgtg aggcaaggca aagatgataa agatgcacag cacctcagct aagactggat
     2101 taagtcagga agacaattct tgctccttct gggatgaagg gctatttact aagaggcata
     2161 agcacctaat gctttcccaa gtgaacctga tattcaaggt ttaatatttg accctttcaa
     2221 gttattttcc tatgtacatt catgtctggc atgtaccata aaaatgaaac gtcctagaca
     2281 cccccttctc ctcaaaccaa atttcaccgt tgttctcaaa tctttaaagc catggattag
     2341 caccagttgt tcacttccaa gattgacctt gagatacttt cttcccacta atcaatttgt
     2401 ttgtaataaa tgtcctgatg atcatgctaa ttaccagatc tgaaaatctg aaagataagg
     2461 acacctccca ggaagactag aaacccaaga aacactcatg agatttgcag gaacccatgt
     2521 aagctggttt ttcctggaga aagactctca gctaggcatg gtaatacttg cccttaatcc
     2581 caccagtggt aggttatggt gcaacacaaa aggtaaaatt aatttaatta attaaataac
     2641 tatctacttc tttgcttttg taatttcaca ctatttccta tagtctcatt aataacagct
     2701 taacacagaa aaagctgctt gatc
//
