LOCUS       NM_001081419            6370 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus disco interacting protein 2 homolog A (Dip2a), mRNA.
ACCESSION   NM_001081419 XM_986714
VERSION     NM_001081419.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6370)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6370)
  AUTHORS   Ma,J., Li,K., Sun,X., Liang,J.N., An,X.Q., Tian,M., Li,J., Yan,F.,
            Yin,Y., Yang,Y.A., Chen,F.Y., Zhang,L.Q., He,X.X., He,Z.X.,
            Guo,W.X., Zhu,X.J. and Yu,H.L.
  TITLE     Dysregulation of AMPK-mTOR signaling leads to comorbid anxiety in
            Dip2a KO mice
  JOURNAL   Cereb Cortex 33 (8), 4977-4989 (2023)
   PUBMED   36227200
  REMARK    GeneRIF: Dysregulation of AMPK-mTOR signaling leads to comorbid
            anxiety in Dip2a KO mice.
REFERENCE   3  (bases 1 to 6370)
  AUTHORS   Zhang,Y., Qu,Y., Yang,J., Liu,J., Li,S. and He,X.
  TITLE     A pilot study to investigate the alteration of gut microbial
            profile in Dip2a knockout mice
  JOURNAL   Int Microbiol 25 (2), 267-274 (2022)
   PUBMED   34562157
  REMARK    GeneRIF: A pilot study to investigate the alteration of gut
            microbial profile in Dip2a knockout mice.
REFERENCE   4  (bases 1 to 6370)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6370)
  AUTHORS   Bai,L.L., Zhang,L.Q., Ma,J., Li,J., Tian,M., Cao,R.J., He,X.X.,
            He,Z.X., Yu,H.L. and Zhu,X.J.
  TITLE     DIP2A is involved in SOD-mediated antioxidative reactions in murine
            brain
  JOURNAL   Free Radic Biol Med 168, 6-15 (2021)
   PUBMED   33781892
  REMARK    GeneRIF: DIP2A is involved in SOD-mediated antioxidative reactions
            in murine brain.
REFERENCE   6  (bases 1 to 6370)
  AUTHORS   Zhang,L., Jia,R., Palange,N.J., Satheka,A.C., Togo,J., An,Y.,
            Humphrey,M., Ban,L., Ji,Y., Jin,H., Feng,X. and Zheng,Y.
  TITLE     Large genomic fragment deletions and insertions in mouse using
            CRISPR/Cas9
  JOURNAL   PLoS One 10 (3), e0120396 (2015)
   PUBMED   25803037
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6370)
  AUTHORS   Adams,D.C., Karolak,M.J., Larman,B.W., Liaw,L., Nolin,J.D. and
            Oxburgh,L.
  TITLE     Follistatin-like 1 regulates renal IL-1beta expression in cisplatin
            nephrotoxicity
  JOURNAL   Am J Physiol Renal Physiol 299 (6), F1320-F1327 (2010)
   PUBMED   20861081
REFERENCE   8  (bases 1 to 6370)
  AUTHORS   Endoh-Yamagami,S., Karkar,K.M., May,S.R., Cobos,I., Thwin,M.T.,
            Long,J.E., Ashique,A.M., Zarbalis,K., Rubenstein,J.L. and
            Peterson,A.S.
  TITLE     A mutation in the pericentrin gene causes abnormal interneuron
            migration to the olfactory bulb in mice
  JOURNAL   Dev Biol 340 (1), 41-53 (2010)
   PUBMED   20096683
REFERENCE   9  (bases 1 to 6370)
  AUTHORS   Mukhopadhyay,M., Pelka,P., DeSousa,D., Kablar,B., Schindler,A.,
            Rudnicki,M.A. and Campos,A.R.
  TITLE     Cloning, genomic organization and expression pattern of a novel
            Drosophila gene, the disco-interacting protein 2 (dip2), and its
            murine homolog
  JOURNAL   Gene 293 (1-2), 59-65 (2002)
   PUBMED   12137943
REFERENCE   10 (bases 1 to 6370)
  AUTHORS   Pletcher,M.T., Roe,B.A., Chen,F., Do,T., Do,A., Malaj,E. and
            Reeves,R.H.
  TITLE     Chromosome evolution: the junction of mammalian chromosomes in the
            formation of mouse chromosome 10
  JOURNAL   Genome Res 10 (10), 1463-1467 (2000)
   PUBMED   11042146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050040.1, AK052899.1, AB093213.2 and AI845124.1.
            
            On Dec 10, 2011 this sequence version replaced NM_001081419.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               AK050040.1         2-258
            258-374             AK052899.1         200-316
            375-6353            AB093213.2         45-6023
            6354-6370           AI845124.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..6370
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.76 cM"
     gene            1..6370
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /note="disco interacting protein 2 homolog A"
                     /db_xref="GeneID:64451"
                     /db_xref="MGI:MGI:2385920"
     exon            1..185
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..4783
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /EC_number="6.2.1.1"
                     /note="DIP2 homolog A; DIP2 disco-interacting protein 2
                     homolog A"
                     /codon_start=1
                     /product="disco-interacting protein 2 homolog A"
                     /protein_id="NP_001074888.2"
                     /db_xref="CCDS:CCDS35944.2"
                     /db_xref="GeneID:64451"
                     /db_xref="MGI:MGI:2385920"
                     /translation="MADRGCPLEAAPLPAEVLESLAELELELSEGDITQKGYEKKRAK
                     LLARYIPLIQGVDPCLQTENRIPGPLLTAATAKPQKSRATNSRDERFRSDVHTEAVQA
                     ALAKYKERKMPMPSKRRSALVHSSVETYTPPDTSSASEDEGSLRRPGRLTSTLLQSHS
                     GIEPWLDRVIQGSSTSSSASSTSSHPGGRPAAAPSASTALAGLTAHAHIDLHSAPPDV
                     TTGLVEHSSYERPQMASVRGIPRGHGRNVLETADGVPVNSRVSSKIQQLLNTLKRPKR
                     PPLKEFFVDDFEELLEVQQPDPNQPKPEGDQMAVLKGEPLSVGTNGPLSLLAALQLWG
                     TTQPKAPCLTALDTAGKATCTLTYGKLWSRSLKLAYTLLNKLTSKNEPLLNPGDRVAL
                     VFPNSDPVMFMVAFYGCLLAELVPVPIEVPLTRKDAGSQQVGFLLGSCGVTLALTTDA
                     CQKGLPKAPTGEVATFKGWPPLAWLVIDGKHLTRPPKDWYPLAQDTGSRTAYIEYKTS
                     KEGSTVGVTVSHSSLLAQCQALTQACGYTEAETLTNVLDFKRDAGLWHGVLTSVMNRM
                     HVITIPYALMKVNPLSWIQKVCSYKARAALVKSRDMHWSLLAQRGQRDVCLSSLRMLI
                     VADGANPWSISSCDAFLNVFQSRGLRPEVICPCASSPEALTVAIRRPPDLGGPPPRKA
                     VLSMNGLSYGVIRVDTEEKLSVLTVQDVGQVMPGASVCVVKVDGAPYLCKTDEIGEIC
                     VNSVATGTAYYGLLGITKNTFETVPVTADGVPVSDRPFTRTGLLGFIGPDNLVFVVGK
                     LDGLMVVGVRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDDRIVLVAEQRPDA
                     SEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKAPLGGIHISETKQRFLEGTLH
                     PCNVLMCPHTCVTNLPKPRQKQPEVGPASMIVGNLVAGKRIAQASGRELAHLEDSDQA
                     RKFLFLADVLQWRAHTTPDHPLFLLLNAKGTVTSTATCIQLHKRAERVAAALMEKGRL
                     DAGDHVALVYPPGVDLIAAFYGCLYCGCVPVTVRPPHPQNLGTTLPTVKMIVEVSKSA
                     CVLSTQAITRLLKSKEAAAAVDVRTWPTILDTDDIPKKKVASIFRPPSPDVLAYLDFS
                     VSTTGILAGVKMSHAATSALCRSIKLQCELYPSRQIAICLDPYCGLGFALWCLCSVYS
                     GHQSVLVPPLELESNVSLWLSAVSQYKARVTFCSYSVMEMCTKGLGAQTGALRMKGVN
                     LSCVRTCMVVAEERPRISLTQSFSKLFKDLGLPARAVSTTFGCRVNVAICLQGTTGPD
                     PTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVKVIIAHTETKGPLGDSHLG
                     EIWVSSPHNATGYYTVYGEETLHADHFSARLSFGDTQTIWARTGYLGFLRRTELTDAS
                     GERHDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWTNLLVVVVEL
                     DGLEQDALDLVALVTNVVLEEHYLVVGVVVIVDPGVIPINSRGEKQRMHLRDGFLADQ
                     LDPIYVAYNM"
     exon            186..257
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            258..374
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            375..494
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            495..722
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            723..851
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            852..971
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1169
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1261
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1372
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1496
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1606
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1709
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1774
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1868
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1988
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2103
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2243
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2380
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2461
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2589
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2704
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2906
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3016
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3097
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3221
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3343
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            3344..3455
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3565
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3696
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            3697..3865
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            3866..4036
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            4037..4098
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            4099..4156
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            4157..4231
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            4232..4406
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            4407..4530
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     exon            4531..6355
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6333..6338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /note="hexamer: AATAAA"
     polyA_site      6355
                     /gene="Dip2a"
                     /gene_synonym="4931420H10Rik; Dip2; Kiaa0184-hp;
                     mKIAA0184"
                     /note="major polyA site"
ORIGIN      
        1 gaagcagccc cggccgcgcc ccgcccgctg ccggctgcgg gcggccgctg cgggtctgca
       61 ggccccggtt gggggaacgc ctgagccacc ggccatggcc gaccgcggat gccctctgga
      121 ggcggcgccg ctgcccgccg aggtgctcga gagcctggcg gagctggagc tggagctgtc
      181 cgaaggtgac atcactcaga aaggatatga gaagaagagg gcgaagctgc tggctcggta
      241 catccccctc attcaaggag tagacccatg tctgcagaca gagaatagaa ttcccgggcc
      301 cttgctgacg gcagctaccg ctaaaccaca gaagtctcgg gctaccaact ccagggatga
      361 gcgcttccgg tcagatgttc acacggaagc cgtgcaagca gctttggcca agtacaagga
      421 gaggaagatg cccatgcctt caaagagacg ctccgccctt gtgcactcct ccgttgagac
      481 ctacacgcct ccagacacgt catctgcctc agaagatgag ggctctttac ggcgacctgg
      541 gcgactcacc tccactctgc tccagagcca ttccggcatc gagccctggc tcgacagggt
      601 cattcagggc tcctccactt catcctctgc atcctccacc tcatcccacc cgggagggag
      661 acctgctgct gctcccagtg cctccactgc gctcgcaggc ctcacggccc acgcccacat
      721 agatctgcac tctgccccac cggatgtcac cactgggctt gtggagcact catcctacga
      781 gcgtccccag atggcctctg tgcgaggcat tcctcgaggg cacggcagga acgtgctgga
      841 gaccgcggac ggtgtgcctg tgaacagcag agtgtcctcc aaaatccagc agctactgaa
      901 caccctgaag aggccaaagc gccctcctct gaaggaattt tttgtggatg attttgagga
      961 gttactggaa gttcagcaac cagatccgaa ccagcccaag cctgaggggg atcagatggc
     1021 cgtactgaag ggagagcctc tgtcagtggg gactaatggg ccactgtctc tgttggctgc
     1081 actgcagctc tggggcacaa cacagccgaa agccccctgt ctgactgcct tggacacagc
     1141 ggggaaagcc acctgcaccc tgacctatgg caaactctgg agtcggagtc taaaattagc
     1201 gtatactcta cttaacaaac tgactagtaa gaatgagccc ctgcttaacc ctggagacag
     1261 agtggcactc gtgtttccaa acagtgaccc tgtcatgttc atggtggcgt tctacgggtg
     1321 tctcctggcg gagctggtcc ctgtccctat agaagtacca ctaacgagaa aggatgcagg
     1381 cagccagcag gttgggtttc tcctgggcag ctgtggggtg accctggccc tgaccacaga
     1441 tgcttgtcag aagggtctgc ccaaggcacc gacaggcgag gtggccactt tcaaaggttg
     1501 gccccccctc gcctggctgg tgattgatgg gaagcatctg acgaggcctc caaaggactg
     1561 gtacccgctg gcccaggaca cagggtccag gactgcctac attgaatata aaaccagcaa
     1621 agaaggcagc acagtagggg tcaccgtatc ccactcatcc ctgctggcgc agtgccaggc
     1681 cctgacccag gcgtgcgggt acacggaagc tgaaacgtta acgaatgtgc tggacttcaa
     1741 aagggatgct ggtttgtggc acggagtctt aacaagtgtc atgaatagga tgcatgtcat
     1801 caccatccca tatgccctca tgaaggtcaa cccactctcc tggattcaga aagtgtgttc
     1861 ctataaagcc cgggctgccc tggtaaagtc ccgagatatg cactggtcgc tcttggcaca
     1921 gcgaggtcag agggatgtct gtctcagctc tctgcgcatg ttgattgtgg cagacggcgc
     1981 taacccatgg tcaatatctt cctgcgatgc cttcctcaac gtcttccagt ccagaggtct
     2041 gaggccagag gtcatctgtc cttgtgccag ttctcctgag gcgctgacag tagccatccg
     2101 caggcctcca gatctgggag gacctcctcc aagaaaagct gtcctgtcaa tgaacggcct
     2161 gagctacggt gtgatccgag ttgacactga ggagaagctg tcggttctca ctgttcagga
     2221 tgtcggccag gtgatgcccg gagctagtgt gtgtgttgtg aaggtagatg gtgcccctta
     2281 tctctgtaaa actgatgaaa ttggagaaat ctgtgtcaat tctgttgcaa ctgggacagc
     2341 atactatgga ctgcttggaa tcacgaagaa tacatttgag accgtcccgg tcactgcgga
     2401 cggagtccct gtctctgacc ggcctttcac caggacaggc cttctgggat ttatcggacc
     2461 tgataacctg gtcttcgtcg tgggcaagtt ggacgggctg atggtcgtag gagtccgcag
     2521 acacaatgca gatgacattg tggctactgc cctggctgtg gagcccatga agtttgtcta
     2581 cagaggcagg atcgctgtgt tctctgtgac tgtgctgcac gatgaccgga ttgtcttggt
     2641 ggctgagcag cggcctgacg cttcggagga agacagcttc caatggatga gccgtgtgct
     2701 acaggccatc gacagcatcc accaggtggg tgtgtactgt ttggccctag ttcctgccaa
     2761 cactttgccc aaggctcctc tgggaggaat tcacatttct gaaacgaagc agcgctttct
     2821 ggaagggacg ctccacccat gtaacgtgtt gatgtgccct cacacgtgcg ttaccaacct
     2881 tcccaagcct cgccagaaac agccagaagt tggaccagcc tcgatgattg ttgggaacct
     2941 ggttgctgga aaaaggatcg cacaggcctc tgggagagag ctggcccacc tggaggacag
     3001 cgaccaggct cgcaagttcc tgttcctggc agacgtgctg cagtggcggg ctcacaccac
     3061 tcctgaccac cctctgttcc tgctgctgaa tgctaagggc acggtcacca gcactgcaac
     3121 ctgtatccag ctgcacaaaa gggctgagag agtggctgcc gctctgatgg agaaggggcg
     3181 gctagatgct ggggaccatg tggctttggt gtaccctcca ggggtggatc ttattgctgc
     3241 attctatggc tgcctgtact gtggctgtgt gcctgtcact gtgcgacccc cacaccccca
     3301 gaaccttggc acaacattgc ccactgtgaa gatgattgta gaggtcagca aatctgcgtg
     3361 tgtcctcagc acacaggcca tcacacggct gctcaagtcc aaagaggcag ctgccgctgt
     3421 agatgtcagg acctggccaa ccatcctaga tacagatgac attccaaaaa agaaggtggc
     3481 tagcattttc agaccgccct ccccagacgt gctcgcgtac ttggacttca gtgtgtcaac
     3541 gacagggatc ttagctggag ttaagatgtc gcacgcagcc acaagtgcct tgtgccgttc
     3601 cataaagctt cagtgtgagc tgtacccctc acggcagatc gccatctgcc tggaccctta
     3661 ctgtggcctc gggtttgcac tgtggtgtct gtgcagcgtc tactctgggc accagtcagt
     3721 gctcgttccc ccactggagc tggagagcaa cgtgtccctc tggctgtctg ccgtcagcca
     3781 gtacaaggcc cgagttacct tctgttccta ctcagtgatg gaaatgtgca ccaagggcct
     3841 gggtgctcag acaggcgccc ttaggatgaa gggggtgaac ctgtcgtgtg tgcgcacatg
     3901 catggtagtg gctgaggagc ggccccggat ctcgttaaca cagtcattct ccaagctgtt
     3961 caaagacctg ggcctccctg ctcgtgctgt gagcaccacc tttgggtgca gggtcaatgt
     4021 agctatctgc ctccagggca caacaggccc agaccccacg accgtctacg tggacatgcg
     4081 ggcactgcgc catgacagag ttcgtctggt ggaacggggt tctccgcata gtctaccatt
     4141 gatggagtct ggaaagatcc tcccgggagt gaaggtcatc attgctcaca ctgagaccaa
     4201 agggcccctc ggagactcac acctgggtga gatctgggtg agcagtcccc acaatgccac
     4261 tgggtactac acagtctatg gggaggaaac acttcatgct gaccacttca gtgcccggct
     4321 gagctttgga gacacccaga ccatttgggc aaggactggc taccttggct tccttcgcag
     4381 gacagagctg acagatgcca gtggagagcg ccatgatgca ctgtatgtcg ttgggtctct
     4441 ggatgaaacg ctagaactga gaggcatgcg gtatcacccc atcgacatag aaacctccgt
     4501 gatccgtgca cacaggagca ttgcagagtg tgccgtgttc acctggacca acctgctggt
     4561 ggtggtggtg gagctggatg ggctggagca ggacgccctg gacctggtgg ccctggtgac
     4621 caacgtcgtg ctggaggagc actaccttgt ggtgggcgtg gtggtcatcg tggatcccgg
     4681 agtgatcccc atcaactctc ggggcgagaa gcaacgcatg cacctgcgag atggcttcct
     4741 ggctgaccag ctggacccca tctacgtggc ctacaatatg tgagcccagc tggacagagc
     4801 tggctgtagg aaccagcaga ggtgtggggc aaagctagct gcagggttcc cgccctgggg
     4861 ggaggggtct cacagctcct ctcagcagtg tcctgaatgt catgttagaa catcctccga
     4921 accggctaaa gcagtgtttt ggatctgcca agtgtaccta ccaaaacaca aggggaagag
     4981 gcgggaaggg aagggaaggg gaggggaggg gaggcctggt gttacactgt ggctgttctc
     5041 cgctatactg caaacttgca ctttttttag gctaaaagaa attattcctg atttctaaat
     5101 atatataatt tcctgattat ttattcccac ttgtaataac aagcatatat gtaaggtcta
     5161 tgctggagag aacttttgag ccaagcctgc ccaggaaggc ggatggaaag agccgcccca
     5221 ttctccatgc ccacagccca ggctccatgc agccgcacag cctcctttgt ccagtgtgat
     5281 tactgaagca ggtgtgcctg ctcgtctgtg tgtgtcgtca ctaatgctca gcaagtgcca
     5341 ttttggactg tttagttaga tcctgtttca gaaagataaa ccagcatttg atttaaaatc
     5401 acttttgtag cctgtaacat agtgacgtta aactgcaagt tctcatgaga tcacagtatt
     5461 catcctctca cgaagcacac tgagttattt ttatgagcag atctggacac atgagtggca
     5521 gcctacagtc ttctcattgt gctagccagg cctcttacac agctgagccg ccatgggagt
     5581 ttgtctgtct agggtggaca tagctgcagc ctcttggctt tgcatttgag ttatgtgcct
     5641 ataaaacttg gccaaaccat ttttagttca ttttatccaa acttgaaatc cgagtgatct
     5701 aatattgtac ttacgtcaga aaagagaatg taaaatcttt tagatactta taagagtttg
     5761 aagtcaagca tgaatctaag attattttta tataactaat caaagattaa tgttatcaag
     5821 ttggcggggt ttagggactt ggaaggatgg agacatttat gaatcatatc tacttcacag
     5881 agacagctag attttttttc tagagttagc ctggacacgt gcttcagcga gttcagctga
     5941 ctggttctac tctcatgtct cacgtcagga aacaggacgt ggcagagccc tgttgctcct
     6001 ggtatcaaac tgtggggtag tatgttaaaa catactggaa ttgtaataat cctgttataa
     6061 ctatgtacag actccatgta acttattggc ctcagagtct agtggcagac tggtagggtt
     6121 cgaggtagat ggctgtgaag ggacccgaac tacctaccca ctgtctcaac gttgtcattt
     6181 tatatcagac agcacctgta aacttttgta ctgaaaactc agtggcagta agaacgtatc
     6241 tggtaagtta agattttaag aatcatatta aaatgtttta aggttactct ctgggaattc
     6301 tgtatatcac actaattttt ttatatcatg ttaataaaag ctattgactt tgtaaaaaaa
     6361 aaaaaaaaaa
//
