LOCUS       NM_007860               1707 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus deiodinase, iodothyronine, type I (Dio1), mRNA.
ACCESSION   NM_007860 XM_915998
VERSION     NM_007860.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1707)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1707)
  AUTHORS   Oelkrug,R., Harder,L., Pedaran,M., Hoffmann,A., Kolms,B.,
            Inderhees,J., Gachkar,S., Resch,J., Johann,K., Johren,O., Krause,K.
            and Mittag,J.
  TITLE     Maternal thyroid hormone receptor beta activation in mice sparks
            brown fat thermogenesis in the offspring
  JOURNAL   Nat Commun 14 (1), 6742 (2023)
   PUBMED   37875497
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1707)
  AUTHORS   Peluso,T., Nittoli,V., Reale,C., Porreca,I., Russo,F., Roberto,L.,
            Giacco,A., Silvestri,E., Mallardo,M., De Felice,M. and Ambrosino,C.
  TITLE     Chronic Exposure to Chlorpyrifos Damages Thyroid Activity and
            Imbalances Hepatic Thyroid Hormones Signaling and Glucose
            Metabolism: Dependency of T3-FOXO1 Axis by Hyperglycemia
  JOURNAL   Int J Mol Sci 24 (11), 9582 (2023)
   PUBMED   37298533
  REMARK    GeneRIF: Chronic Exposure to Chlorpyrifos Damages Thyroid Activity
            and Imbalances Hepatic Thyroid Hormones Signaling and Glucose
            Metabolism: Dependency of T3-FOXO1 Axis by Hyperglycemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1707)
  AUTHORS   Martinez,M.E., Pinz,I., Preda,M., Norton,C.R., Gridley,T. and
            Hernandez,A.
  TITLE     DIO3 protects against thyrotoxicosis-derived cranio-encephalic and
            cardiac congenital abnormalities
  JOURNAL   JCI Insight 7 (21), e161214 (2022)
   PUBMED   36166296
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1707)
  AUTHORS   Kryukov,G.V., Castellano,S., Novoselov,S.V., Lobanov,A.V.,
            Zehtab,O., Guigo,R. and Gladyshev,V.N.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
REFERENCE   6  (bases 1 to 1707)
  AUTHORS   Svenson,K.L., Cheah,Y.C., Shultz,K.L., Mu,J.L., Paigen,B. and
            Beamer,W.G.
  TITLE     Strain distribution pattern for SSLP markers in the SWXJ
            recombinant inbred strain set: chromosomes 1 to 6
  JOURNAL   Mamm Genome 6 (12), 867-872 (1995)
   PUBMED   8747926
REFERENCE   7  (bases 1 to 1707)
  AUTHORS   Maia,A.L., Kieffer,J.D., Harney,J.W. and Larsen,P.R.
  TITLE     Effect of 3,5,3'-Triiodothyronine (T3) administration on dio1 gene
            expression and T3 metabolism in normal and type 1
            deiodinase-deficient mice
  JOURNAL   Endocrinology 136 (11), 4842-4849 (1995)
   PUBMED   7588215
REFERENCE   8  (bases 1 to 1707)
  AUTHORS   Maia,A.L., Berry,M.J., Sabbag,R., Harney,J.W. and Larsen,P.R.
  TITLE     Structural and functional differences in the dio1 gene in mice with
            inherited type 1 deiodinase deficiency
  JOURNAL   Mol Endocrinol 9 (8), 969-980 (1995)
   PUBMED   7476994
REFERENCE   9  (bases 1 to 1707)
  AUTHORS   Berry,M.J., Grieco,D., Taylor,B.A., Maia,A.L., Kieffer,J.D.,
            Beamer,W., Glover,E., Poland,A. and Larsen,P.R.
  TITLE     Physiological and genetic analyses of inbred mouse strains with a
            type I iodothyronine 5' deiodinase deficiency
  JOURNAL   J Clin Invest 92 (3), 1517-1528 (1993)
   PUBMED   8104199
REFERENCE   10 (bases 1 to 1707)
  AUTHORS   Schoenmakers,C.H., Pigmans,I.G., Poland,A. and Visser,T.J.
  TITLE     Impairment of the selenoenzyme type I iodothyronine deiodinase in
            C3H/He mice
  JOURNAL   Endocrinology 132 (1), 357-361 (1993)
   PUBMED   8419134
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645723.11 and BC089608.1.
            
            On Apr 26, 2016 this sequence version replaced NM_007860.3.
            
            Summary: The protein encoded by this gene belongs to the
            iodothyronine deiodinase family. It catalyzes the activation, as
            well as the inactivation of thyroid hormone by outer and inner ring
            deiodination, respectively. The activation reaction involves the
            conversion of the prohormone thyroxine
            (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland,
            to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by
            5'-deiodination. This protein is expressed predominantly in the
            liver and kidney and provides most of the circulating T3, which is
            essential for growth, differentiation and basal metabolism in
            vertebrates. This protein is a selenoprotein, containing the rare
            amino acid selenocysteine (Sec) at its active site. Sec is encoded
            by the UGA codon, which normally signals translation termination.
            The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop
            structure, designated the Sec insertion sequence (SECIS) element,
            that is necessary for the recognition of UGA as a Sec codon, rather
            than as a stop signal. [provided by RefSeq, Apr 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019786.1, AK002549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            protein contains selenocysteine :: PMID: 8419134
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AL645723.11        207998-208022       c
            26-1707             BC089608.1         1-1682
FEATURES             Location/Qualifiers
     source          1..1707
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.18 cM"
     gene            1..1707
                     /gene="Dio1"
                     /gene_synonym="5DI; D1; ITDI1; TXDI1"
                     /note="deiodinase, iodothyronine, type I"
                     /db_xref="GeneID:13370"
                     /db_xref="MGI:MGI:94896"
     exon            1..387
                     /gene="Dio1"
                     /gene_synonym="5DI; D1; ITDI1; TXDI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..824
                     /gene="Dio1"
                     /gene_synonym="5DI; D1; ITDI1; TXDI1"
                     /EC_number="1.21.99.4"
                     /note="UGA stop codon recoded as selenocysteine; DIOI;
                     type 1 DI; type-I 5'-deiodinase"
                     /codon_start=1
                     /transl_except=(pos:426..428,aa:Sec)
                     /product="type I iodothyronine deiodinase"
                     /protein_id="NP_031886.3"
                     /db_xref="CCDS:CCDS18436.1"
                     /db_xref="GeneID:13370"
                     /db_xref="MGI:MGI:94896"
                     /translation="MGLPQLWLWLKRLVIFLQVALEVAVGKVLMTLFPGRVKQSILAM
                     GQKTGMARNPRFAPDNWVPTFFSIQYFWFVLKVRWQRLEDRAEFGGLAPNCTVVCLSG
                     QKCNIWDFIQGSRPLVLNFGSCTUPSFLLKFDQFKRLVDDFASTADFLIIYIEEAHAT
                     DGWAFKNNVDIRQHRSLQERVRAARMLLARSPQCPVVVDTMQNQSSQLYAALPERLYV
                     IQEGRICYKGKAGPWNYNPEEVRAVLEKLCTPPRHVPQL"
     exon            388..531
                     /gene="Dio1"
                     /gene_synonym="5DI; D1; ITDI1; TXDI1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..731
                     /gene="Dio1"
                     /gene_synonym="5DI; D1; ITDI1; TXDI1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..1689
                     /gene="Dio1"
                     /gene_synonym="5DI; D1; ITDI1; TXDI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1582..1651
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Dio1"
                     /gene_synonym="5DI; D1; ITDI1; TXDI1"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      1671..1676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dio1"
                     /gene_synonym="5DI; D1; ITDI1; TXDI1"
                     /note="hexamer: ATTAAA"
     polyA_site      1689
                     /gene="Dio1"
                     /gene_synonym="5DI; D1; ITDI1; TXDI1"
                     /note="major polyA site"
ORIGIN      
        1 ggcctctcct tcagtctgca ggctcagagc cacttctgcc ccgtgctgag atggggctgc
       61 cccagctatg gctgtggctg aagcggcttg tgatattcct gcaggtggcc ttggaggtgg
      121 ctgtaggcaa ggtgctaatg acgctgttcc cagggagagt caaacagagc atcctggcca
      181 tgggccagaa gaccgggatg gccaggaacc cccgattcgc ccctgacaac tgggtcccca
      241 ccttcttcag catccagtac ttctggtttg tcctgaaggt ccgctggcag agactggaag
      301 acagggctga gtttgggggg ctggccccca actgcaccgt ggtctgcctc tcaggacaga
      361 agtgcaacat ctgggatttc attcaaggca gcaggcccct ggtgttgaac tttggcagtt
      421 gcacctgacc ttcatttctt ctcaaatttg accagttcaa gagactcgta gatgactttg
      481 cctccacagc cgatttcctc atcatttaca ttgaagaagc tcacgccaca gatggctggg
      541 cttttaagaa caacgtggac atccggcagc accggagcct ccaggagcgc gtgcgggcag
      601 cccgcatgct gctggccagg agcccccagt gccctgtggt ggtggacaca atgcagaacc
      661 agagcagcca gctctacgcg gccctgcctg agaggctcta cgtgatacag gagggcagga
      721 tctgctacaa gggtaaagct ggcccttgga actacaatcc tgaggaagtc cgagctgtcc
      781 tggaaaagct ttgcactcca cctagacacg tgcctcagct ctaggggacc agcaggaagg
      841 ctccccaagc ttggtacttt cccacaccag tacagatgtc ttttaccttt gacctgtgtt
      901 cccagatgaa gtactagctc agatttttct gatctaaaca aataactacc agggaggcaa
      961 tgcagctcac agcacaaact gtgacaacca gaaataaagc aatgctgagc tgttagcaaa
     1021 agtaagttac agctccacac tgctcccaca gcagagacca atccagagtg tccaccttct
     1081 ggtgggaggg cactcactca catgcttgga tgacagactt ctgaagtgtc gtgactcctg
     1141 aagatgacgt caaaagctca atccatgtgt ccaattttgc cacttataga cccaatcgta
     1201 taaaatgctg aactggtttg tttagcacaa gcaagaggca ggcatgttct gcttgtagga
     1261 accataggca ttggaaacac ttttctggcc gaaagattga aatctgttga gattgttggt
     1321 gataggtgtt tccatggcaa catagaatct cattctactc cctctaccat cttgaaatag
     1381 attgcacagg aatctggctc tctggcactg atgccaaagc tttataactt taactaaacc
     1441 aaatcgcagg cgccagcaaa agctgccatg taggccctgt tgtgactctg tcctcctggg
     1501 tcacagtctc ttactggtct tttgtgttcg atagcattgg actgataggt agccatggct
     1561 tcatctgtca tgtctgcttc tttttatatt tgtgtatgat ggtcacagtg taaagttccc
     1621 acagctgtga cttgattttt aaaaatgtcg gaagatgcag caagctaaca attaaaatct
     1681 gtcaggctaa aaaaaaaaaa aaaaaaa
//
