LOCUS       NM_175551               8476 bp    mRNA    linear   ROD 15-JAN-2024
DEFINITION  Mus musculus death inducer-obliterator 1 (Dido1), transcript
            variant 3, mRNA.
ACCESSION   NM_175551
VERSION     NM_175551.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8476)
  AUTHORS   Garcia-Lopez MA, Mora A, Corrales P, Pons T, Sanchez de Diego A,
            Talavera Gutierrez A, van Wely KHM, Medina-Gomez G, Sabio G,
            Martinez-A C and Fischer T.
  TITLE     DIDO is necessary for the adipogenesis that promotes diet-induced
            obesity
  JOURNAL   Proc Natl Acad Sci U S A 121 (3), e2300096121 (2024)
   PUBMED   38194457
  REMARK    GeneRIF: DIDO is necessary for the adipogenesis that promotes
            diet-induced obesity.
REFERENCE   2  (bases 1 to 8476)
  AUTHORS   Gutierrez J, van Wely KHM and Martinez-A C.
  TITLE     Hepatitis, testicular degeneration, and ataxia in DIDO3-deficient
            mice with altered mRNA processing
  JOURNAL   Cell Biosci 12 (1), 84 (2022)
   PUBMED   35672775
  REMARK    Erratum:[Cell Biosci. 2022 Sep 2;12(1):144. PMID: 36056442]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8476)
  AUTHORS   Futterer A, Talavera-Gutierrez A, Pons T, de Celis J, Gutierrez J,
            Dominguez Plaza V and Martinez-A C.
  TITLE     Impaired stem cell differentiation and somatic cell reprogramming
            in DIDO3 mutants with altered RNA processing and increased R-loop
            levels
  JOURNAL   Cell Death Dis 12 (7), 637 (2021)
   PUBMED   34155199
  REMARK    GeneRIF: Impaired stem cell differentiation and somatic cell
            reprogramming in DIDO3 mutants with altered RNA processing and
            increased R-loop levels.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8476)
  AUTHORS   Futterer A, de Celis J, Navajas R, Almonacid L, Gutierrez J,
            Talavera-Gutierrez A, Pacios-Bras C, Bernascone I, Martin-Belmonte
            F and Martinez-A C.
  TITLE     DIDO as a Switchboard that Regulates Self-Renewal and
            Differentiation in Embryonic Stem Cells
  JOURNAL   Stem Cell Reports 8 (4), 1062-1075 (2017)
   PUBMED   28330622
  REMARK    GeneRIF: Embryonic stem cells mainly express DIDO3 and their
            differentiation after leukemia inhibitory factor withdrawal
            requires DIDO1 expression. DIDO3 regulates DIDO1 expression.
REFERENCE   5  (bases 1 to 8476)
  AUTHORS   Tordera RM, Garcia-Garcia AL, Elizalde N, Segura V, Aso E, Venzala
            E, Ramirez MJ and Del Rio J.
  TITLE     Chronic stress and impaired glutamate function elicit a
            depressive-like phenotype and common changes in gene expression in
            the mouse frontal cortex
  JOURNAL   Eur Neuropsychopharmacol 21 (1), 23-32 (2011)
   PUBMED   20937555
REFERENCE   6  (bases 1 to 8476)
  AUTHORS   Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND and Robson P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   7  (bases 1 to 8476)
  AUTHORS   Prieto I, Kouznetsova A, Futterer A, Trachana V, Leonardo E, Alonso
            Guerrero A, Cano Gamero M, Pacios-Bras C, Leh H, Buckle M,
            Garcia-Gallo M, Kremer L, Serrano A, Roncal F, Albar JP, Barbero
            JL, Martinez-A C and van Wely KH.
  TITLE     Synaptonemal complex assembly and H3K4Me3 demethylation determine
            DIDO3 localization in meiosis
  JOURNAL   Chromosoma 118 (5), 617-632 (2009)
   PUBMED   19557426
  REMARK    GeneRIF: results indicate that histone H3 lysine 4 demethylation
            modulates DIDO3 localization in meiosis and suggest epigenetic
            regulation of the synaptonemal complex
REFERENCE   8  (bases 1 to 8476)
  AUTHORS   Trachana V, van Wely KH, Guerrero AA, Futterer A and Martinez-A C.
  TITLE     Dido disruption leads to centrosome amplification and mitotic
            checkpoint defects compromising chromosome stability
  JOURNAL   Proc Natl Acad Sci U S A 104 (8), 2691-2696 (2007)
   PUBMED   17299043
  REMARK    GeneRIF: Dido3, the largest splice variant of the Dido gene, is a
            centrosome-associated protein whose disruption leads to
            supernumerary centrosomes, failure to maintain cellular mitotic
            arrest, and early degradation of the mitotic checkpoint protein
            BubR1.
REFERENCE   9  (bases 1 to 8476)
  AUTHORS   Futterer A, Campanero MR, Leonardo E, Criado LM, Flores JM,
            Hernandez JM, San Miguel JF and Martinez-A C.
  TITLE     Dido gene expression alterations are implicated in the induction of
            hematological myeloid neoplasms
  JOURNAL   J Clin Invest 115 (9), 2351-2362 (2005)
   PUBMED   16127461
  REMARK    GeneRIF: Data suggest that Dido might be one of the tumor
            suppressor genes at chromosome 20q and that the Dido-targeted mouse
            may be a suitable model for studying myeloproliferative diseases
            and myelodysplastic syndromes.
REFERENCE   10 (bases 1 to 8476)
  AUTHORS   Garcia-Domingo D, Leonardo E, Grandien A, Martinez P, Albar JP,
            Izpisua-Belmonte JC and Martinez-A C.
  TITLE     DIO-1 is a gene involved in onset of apoptosis in vitro, whose
            misexpression disrupts limb development
  JOURNAL   Proc Natl Acad Sci U S A 96 (14), 7992-7997 (1999)
   PUBMED   10393935
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL732560.11.
            
            [WARNING] On Jan 18, 2024 this sequence was replaced by
            NM_175551.5.
            
            On Apr 16, 2014 this sequence version replaced NM_175551.3.
            
            Summary: This gene encodes a transcription factor involved in
            apoptosis. The encoded protein functions in cell cycle progression
            and plays a role in chromosomal stability. This protein regulates
            the self-renewal of embryonic stem cells. Disruption of this gene
            in mice causes symptoms similar to
            myelodysplastic/myeloproliferative diseases in humans. Mice lacking
            this gene show severely reduced fertility. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Apr
            2014].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (Dido3, also known as
            isoform 3).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY425952.1, SRR17784644.749755.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AL732560.11        64260-64401         c
            143-327             AL732560.11        54163-54347         c
            328-1159            AL732560.11        51123-51954         c
            1160-1481           AL732560.11        49775-50096         c
            1482-1694           AL732560.11        47263-47475         c
            1695-1914           AL732560.11        46108-46327         c
            1915-2374           AL732560.11        37267-37726         c
            2375-2534           AL732560.11        36990-37149         c
            2535-2651           AL732560.11        35774-35890         c
            2652-2756           AL732560.11        35530-35634         c
            2757-2892           AL732560.11        34582-34717         c
            2893-3415           AL732560.11        33691-34213         c
            3416-3569           AL732560.11        33160-33313         c
            3570-3659           AL732560.11        32564-32653         c
            3660-3855           AL732560.11        31690-31885         c
            3856-8476           AL732560.11        20262-24882         c
FEATURES             Location/Qualifiers
     source          1..8476
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..8476
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /note="death inducer-obliterator 1"
                     /db_xref="GeneID:23856"
                     /db_xref="MGI:MGI:1344352"
     exon            1..142
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            143..327
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            328..1159
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..7100
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /note="isoform Dido3 is encoded by transcript variant 3;
                     death inducer-obliterator-2; death inducer-obliterator-3;
                     death-associated transcription factor 1"
                     /codon_start=1
                     /product="death-inducer obliterator 1 isoform Dido3"
                     /protein_id="NP_780760.2"
                     /db_xref="CCDS:CCDS17182.1"
                     /db_xref="GeneID:23856"
                     /db_xref="MGI:MGI:1344352"
                     /translation="MDDKGHLSNEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDTE
                     VDPSEQQPQQHNLSLRRSGRQPKRTERVEEFLTTVRRRGKKNVPVSLEDSSEPTSSTV
                     TDVETASEGSVESSSEIRSGPVSDSLGKEHPASSEKAKGGEEEEDTSDSDSDGLTLKE
                     LQNRLRRKREQEPVERSLRGSQNRLRKKRREEDSAETGSVQIGSAEQDRPLCKQEPEA
                     SQGPVSQSETDDIENQLEGKATQGNTEENPREAGKPKPECEVYDPNALYCICRQPHNN
                     RFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQVQDETNGSATDEQD
                     SGCRSVGADGTDCTSIGTVEQKSGEDQGIKGRIEKAANPSGKKKLKIFQPVVEAPGAP
                     KCIGPGCSSVAQPDSVYCSNDCILKHAAATMRFLSSGKEQKTKPKEKVKTKPEKFSLP
                     KCSVQVGIKISSVHKRLASEKRENPVKKVMLASRSETSGKEAACESSTPSWASDHNYN
                     AVKPEKPEKPTALSPTLLSKSMKDDRRVEDRTMAAVTIPKKALPSASLVGRQTSPRNL
                     VPKKLPPYSNMAGAKPAIKKLPSGFKGTIPKRPWPSATLSGTSARQAGPTPMTAASKK
                     LPGSAAVVGVTRKPMSANVPAASPAPGRLGPVSPAPSQPNSQIRQNIRRSLKEILWKR
                     VNDSDDLIMTENEVGKIALHIEKEMFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLFHR
                     VLREEISLAKLVRMKPEELVSKELSMWTEKPTKSVIESRTKLLNESKKNTTKPETIPD
                     MEDSPPVSDSEEQQESVRAAPEKSAAPLLDVFSSMLKDTTSQHRAHLFDLNCKICTGQ
                     VPSSEDEPAPKKQKLSASSKKEDFKPRHDSSPPNAVPNTADEGIADTLPENASEPDPE
                     STSSLNQERKCFPESPGDSHPEPSSLGGLSPSSASGGSGVVTTVTMSGRDPRTALSGS
                     CTVTASMAAHLDNSQASETKLDMIKPALTSAVVPKSILAKPSSSPDPRYLSVPPSPSI
                     SESRSPPEGDTTLFLSRLNTIWKGFINMQSVAKFVTKAYPVSGCLDYLSEDLPDTIHI
                     GGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVAYISLYSYFSSRGRFGVVAN
                     NNRHVKDLYLIPLSAKDPVPSKLLPFEGPGLESPRPNIILGLVICQKVKRPSSAGELD
                     KTDEKRTRLQQEELETSVYPKVTAALPSEKKPPKYSVHSIDTAATSTTPPGSPPPPPP
                     LPEPPVLKILSSLKPGSTSTVTAPTTAAITTTASPVTAATSKTASPLEHILQTLFGKK
                     KSFEPSGKESVGSTLSPHQDSKAKGEDTMSAAPLLDPIVQQFGQFSKDKALEEEEEDD
                     RPYDPEEEYNPDRAFHTLLAEPGRPHDVQSVSETAEREEVAYDPEDETILEEAKVTID
                     DLPNRMCMKVSATERPADFTTDASSASLVEQQKMLEELNKQIEEQKRQLEEQEEALRQ
                     QRAAVGVSMAHFSVSDALMSPPPKSSLGKTELFSQEQQAPDPSQGAPNTNHNLDSRQS
                     RDPRQARRLAAENTENESLPRAPTGSTPGPQGTLPARETPAGTAVVQGPGLAAEAKES
                     MAVPWAPGENAVLRPEHDIQKCEHPGNPVSLPLDTSHLPTAGDGAARPAPPRRVLLPT
                     PPSTTFPPSFPLQPKAQNFSSGSREPFSGPTFMSQETSLGSSQYEDPRGAQSAGKNDS
                     PVADMEDSREPQPRPGESTTSFPQPGQRGGGPQPQFPGQREPAPRTFGMSGHHGPSFP
                     GPRGPVPPYSEENLVPNSDGPRGPPPARFGAQKPPIPSLFSGQHGPPPYGDNRGLSPS
                     YLGGPRGGAPAQFEDRKDPHGEKREFQDTPYNEMTGAPAQCEGPDQAQFMGNRAPFQF
                     GGQRRPLLTQMKGPRGGPPPSQFGAQRGPPPGHFVGPRGPHPSQFENSRGTHPGQFEG
                     ARGQAPGFMPGPRGIQPQQFEEQRVNSPPRFAGQRASAPLPYGGPRGPAPFPEKNEQP
                     PSRFHFQGPSSQPVKPPPRPLLELPSHPPQHRKDRWDEAGPATALPSSAGPGQGHEAD
                     GQWATSEFREGKGHEYRSPAFEGRQRERFEAGSKEKPLDEPEAQGLESRQGRAFEDRR
                     RERERGRNWSRERDWERSRDWDRHREWDKGRDRSSNRDRERDNDRAKEWDRSRERSRN
                     RDRDRERRRDRDRSRSRDRDRDRERARDRDRDRGRDRKDRSKSRESPRDQKPEARTSE
                     GGPAAAQA"
     exon            1160..1481
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1694
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1914
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2374
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2534
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2651
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2756
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2892
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..3415
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3416..3569
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3570..3659
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3660..3855
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3856..8476
                     /gene="Dido1"
                     /gene_synonym="6720461J16Rik; C130092D22Rik;
                     D130048F08Rik; DATF-1; Datf1; dido; DIO-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctctagcct cgccgtagct cggtggccgg tcgatttctt ccgcttgccg cgcggcctac
       61 cactctagga cggtagtctc gctggtctct gctctatatc cgtggtagct ctggaaatgg
      121 ctgcgggatc ccggcggccg gggagcttgt ttaagaggca gtccccactg tccctttggt
      181 tgttcgaagc tccggaatct tctcattgat gaactgtgac tgacaacagt ggggtgaggc
      241 ttggccgtct gcttgacctg gccccaggtc tataatttta tgtaggattt ccagccaaag
      301 gtttccaagc tttcagtttt gggacaggta tggatgataa agggcacctg agcaatgagg
      361 aagcacccaa ggctatcaaa cccaccagta aggagttcag gaaaacctgg ggttttcgaa
      421 gaaccacgat tgccaaacgt gagggtgcag gagacacgga ggtggacccc agtgagcagc
      481 aaccacagca gcataacctc tccctgcgcc gcagtggacg gcaaccaaaa cgtactgaga
      541 gggtagaaga gtttcttacc acggttcggc gccgagggaa aaagaatgtg ccggtgtccc
      601 tggaggattc cagtgagccc acatcttcca cagtcactga tgtggagaca gcttccgagg
      661 ggagcgttga aagcagttct gagatcagaa gtggccctgt atctgactcc ttagggaaag
      721 aacatcctgc ctcttctgaa aaggcaaaag gaggtgaaga ggaagaagac acctctgaca
      781 gtgacagtga tggccttacg ttgaaggaac ttcagaaccg ccttcggaga aagcgagagc
      841 aagaacctgt ggagaggtcc ctgagaggca gtcagaatcg cctgaggaag aagcgcagag
      901 aggaagattc tgccgaaact gggagtgtcc aaataggcag tgccgagcag gacagacctc
      961 tctgtaagca ggagcctgag gctagtcagg gaccagtgtc ccagtcagag acagatgaca
     1021 tagaaaatca gttggaaggg aaggcgactc agggaaatac agaggaaaac cccagggaag
     1081 cgggcaaacc aaagcctgag tgtgaggttt acgaccccaa tgccctgtac tgcatctgcc
     1141 gccagcctca caacaacagg tttatgatct gctgtgatcg gtgtgaggag tggttccatg
     1201 gtgactgtgt gggtatttct gaggcccgag ggcggctcct ggaaaggaac ggggaagact
     1261 acatctgccc aaattgcacc attttgcaag tgcaggatga gacaaacggt agcgccaccg
     1321 atgagcagga ctctgggtgc agatctgtgg gtgctgatgg cacagactgc acaagcatag
     1381 ggacagtaga gcagaagtcc ggagaagacc agggcataaa gggtaggatt gagaaggcag
     1441 caaaccccag cggcaagaaa aaactcaaga tattccagcc tgtcgtagag gctcctggtg
     1501 ctcctaaatg cattggccct gggtgttcca gtgtagcaca gcctgactct gtgtattgca
     1561 gtaatgactg cattctcaaa cacgcagcag ctaccatgag atttctaagt tcaggtaaag
     1621 aacaaaaaac aaaacccaag gaaaaggtca agacgaagcc agaaaagttc agtcttccaa
     1681 aatgcagtgt tcaggtgggg attaaaatct cttctgtgca caagagacta gcgtcagaga
     1741 aaagggaaaa cccagtgaag aaagtgatgc tggcttccag gagtgagact tctgggaagg
     1801 aggcagcctg tgagagcagc acaccatcct gggcaagtga ccacaactac aatgctgtga
     1861 agccagagaa gccagagaag cccactgcac tctcgcccac cctattgagt aaatccatga
     1921 aggatgacag gagggtggag gacaggacaa tggcagcagt taccatcccg aagaaagcac
     1981 ttccttcagc ctctttggtg ggcagacaga cttcacctag gaatcttgtt ccaaagaagc
     2041 ttcctcctta ctctaatatg gcaggagcca aaccagccat taagaaactg ccttcaggct
     2101 tcaagggtac catccccaag aggccatggc cctcagccac cctgtcaggc acttctgcca
     2161 ggcaggcagg accaacacct atgacagctg cttccaaaaa gttgcctggc tctgctgctg
     2221 tggtgggagt taccaggaag ccaatgtctg ccaatgttcc tgctgcttct ccagccccag
     2281 gacggcttgg tcctgtgagc ccagctccat cacagcccaa ttcacaaatt cgacaaaata
     2341 taaggcgctc cttgaaagag attttgtgga aaagagtcaa tgacagcgat gacttaataa
     2401 tgacagaaaa tgaagtagga aaaattgccc tccacattga gaaggagatg tttaacttgt
     2461 tccaggttac tgataatcgc tataagagca aatatcgcag catcatgttc aaccttaagg
     2521 atcctaagaa tcaggggctc ttccatcgtg ttcttcgaga agaaatctcc ttggcaaaac
     2581 ttgtcagaat gaagcctgaa gaacttgtat ctaaagagct ttctatgtgg acagagaagc
     2641 ccacaaaatc tgtgatagaa tccaggacta agttgcttaa tgaaagcaag aagaacacta
     2701 ctaaaccaga aaccattcct gacatggaag attctccacc ggtatcagat tcagaagaac
     2761 aacaagagtc agtgcgagcc gcccctgaga agagcgcagc acctctcctg gacgtcttca
     2821 gcagcatgct gaaggacacc acaagccagc accgtgccca tctttttgat ttaaactgta
     2881 aaatctgtac aggtcaggtt ccatcctcgg aggatgaacc agctcctaag aagcaaaagc
     2941 tttcagcttc ttctaagaag gaagacttta agcccaggca tgacagctct ccacctaatg
     3001 cagttcctaa cactgctgat gaagggattg cagacacgct gcctgaaaat gcctctgagc
     3061 cagacccgga gagtacatct agtcttaacc aggagagaaa gtgtttccct gagtctccag
     3121 gcgatagcca tcctgagccc tcgtctctgg gtggcctttc tccctcttct gcctctggtg
     3181 ggagtggggt ggtcaccaca gtcaccatgt ctggtcgaga ccccagaact gccctgagtg
     3241 ggtcgtgcac agtcacagcc tccatggcag cccatctgga caactcccag gcttcagaaa
     3301 ccaaactgga catgataaag cctgcattga cttctgcagt ggtgcccaag tccatactgg
     3361 ctaagccatc ctcctctcct gacccgagat acctgtcagt accaccatca ccaagcattt
     3421 cagaatcacg atccccacca gaaggagata caaccctctt tttgtctcga ctcaacacga
     3481 tttggaaagg atttattaat atgcagagtg tagcaaaatt tgtcactaag gcatatcctg
     3541 tctctgggtg tttggattat ctcagtgagg atttgccaga caccatccac atcggtggaa
     3601 ggattgctcc aaagaccgtg tgggattacg ttggcaaact caagtcatcg gtgtccaagg
     3661 agctctgtct gatccgcttc caccctgcca ctgaggagga ggaggttgca tacatttctc
     3721 tctactccta ttttagcagc cgtggtcgct ttggggttgt agctaataac aacaggcatg
     3781 tcaaggacct gtacctgatt ccactgagtg ctaaggaccc tgtgccatcc aaactcttgc
     3841 cctttgaggg cccaggtctt gaatcaccac gtccaaatat aatacttggg ttagtaatat
     3901 gtcagaaagt gaaacgtcct tcaagtgctg gcgagttaga caagacagat gagaagcgga
     3961 ctcgactcca acaggaagaa ctagaaactt cagtctatcc caaagtaact gcagctttgc
     4021 catccgagaa gaagcctccc aagtacagtg tacactctat agacacagct gctaccagca
     4081 ccacgccccc tggctctcct cccccacctc ctcctcttcc tgaaccccca gtattgaaaa
     4141 tactgtcatc cctcaagcca gggtccacca gcactgtcac agcgcctacc acagcagcaa
     4201 tcactaccac agcttcccct gttactgctg ccacttccaa aacagcctcg cccctggaac
     4261 acatcctgca gactctcttt gggaaaaaga aatcatttga gccgtctgga aaagaatctg
     4321 ttgggtctac tctatctcca catcaggatt ccaaggccaa gggggaggac accatgtcag
     4381 cagctccttt gttggatcca attgttcaac agtttggtca gttctcaaaa gacaaggctc
     4441 tggaggagga ggaggaagat gacaggccct acgaccctga agaagagtac aaccctgatc
     4501 gagcatttca tacactgctc gctgagccag ggaggcctca tgatgtgcag agtgtgtctg
     4561 agacagctga gagggaggag gtggcctatg acccagaaga tgagaccatc ttagaagaag
     4621 ccaaagtgac cattgatgac ttgcccaatc gcatgtgtat gaaagttagc gccacagaaa
     4681 ggcctgccga cttcaccacc gatgcctcca gtgcttcgct ggtagagcag cagaaaatgt
     4741 tagaagagct aaataaacag attgaggagc aaaagaggca gctggaggag caagaagaag
     4801 ctctccgaca gcagagggct gctgtgggtg tgtccatggc acacttttct gtgtccgatg
     4861 cattgatgtc accacctccc aagtcgtctt tgggcaagac agagctgttc tctcaagaac
     4921 agcaagcccc agacccaagt cagggagccc cgaacaccaa ccacaaccta gactcaagac
     4981 aaagtaggga cccaaggcag gccaggcggc tcgctgcaga aaacacagag aatgaatccc
     5041 ttcctagggc ccccacagga agcacacctg gcccacaagg caccctacct gcaagggaga
     5101 ctcctgctgg gactgcagta gtccaggggc ctgggctggc agcagaagcc aaggagtcaa
     5161 tggctgttcc ctgggctcca ggtgaaaacg ctgtgttgag acctgaacat gacatccaaa
     5221 aatgtgagca ccctggtaac cctgtctcat tacccctgga caccagccac cttcctacag
     5281 ctggggatgg cgcagccagg ccagcaccgc cccgcagagt gctgctaccc acacccccta
     5341 gcaccacctt tccacccagc ttccctttgc aacctaaggc ccaaaatttt agttctggaa
     5401 gcagggagcc tttctcaggg cccacattta tgtctcagga aacatctctt ggctcatccc
     5461 aatatgagga ccccaggggt gctcagtctg ctgggaagaa tgacagccca gtagctgata
     5521 tggaggacag cagagagcca cagcctaggc ctggtgagag tactacttca ttcccccaac
     5581 ctgggcagag gggagggggc cctcagcctc agtttcctgg ccagcgtgaa cctgcaccac
     5641 gcacttttgg gatgtcgggt catcatggtc ccagttttcc aggacctagg gggccagtcc
     5701 ctccttattc agaagagaac cttgttccta atagtgatgg accaagaggc cctccacctg
     5761 ccagatttgg ggcacagaag ccaccaatcc cttccttatt ctctgggcaa catgggccac
     5821 ctccctatgg ggacaacagg ggactctcac cttcttatct tggtgggccc cgaggaggag
     5881 caccagccca atttgaagac cgcaaggatc ctcatgggga gaaaagggaa ttccaggaca
     5941 ctccgtacaa cgagatgaca ggtgcccctg ctcagtgtga agggccagat caggcccagt
     6001 tcatggggaa cagggcaccc tttcagtttg gaggccagag acggccactg ctaactcaaa
     6061 tgaaagggcc ccgtggagga cctccaccct ctcagtttgg agcccaaagg ggaccacctc
     6121 ctggtcattt cgtgggccca cgtgggcccc atcctagtca gtttgaaaat tcccggggca
     6181 ctcaccctgg ccagtttgaa ggggccaggg gccaagcacc tggtttcatg ccaggccccc
     6241 ggggtattca gccccagcag ttcgaagagc agagagtgaa ctcgccacca aggtttgccg
     6301 gccagagggc atcggcgccc ctgccatatg gaggaccaag gggccctgca ccctttcctg
     6361 aaaaaaatga gcagccacct tctcgatttc actttcaagg cccatcttca cagcccgtga
     6421 agcctccccc gaggcccctg ttggagctac caagccatcc tcctcagcat aggaaggacc
     6481 gatgggatga ggcaggccca gccactgctc tgccttccag tgctgggcct ggacagggcc
     6541 atgaggccga cgggcagtgg gccacatcag agttccgaga aggcaaaggc catgaatata
     6601 ggagcccagc ttttgaaggg agacagaggg agcgatttga agcaggatct aaagaaaagc
     6661 ctctggacga gcctgaagcc caagggttgg aaagccggca gggccgggca tttgaggata
     6721 ggaggcgaga gcgagagaga ggcagaaact ggagtcgaga aagagactgg gagaggagcc
     6781 gggactggga ccggcatcgg gagtgggata aaggcaggga taggagctcc aacagggaca
     6841 gggagcgaga caacgacagg gctaaggaat gggaccggag ccgcgagaga agccggaatc
     6901 gcgaccggga ccgagaaagg cggcgagacc gagacaggtc ccgcagcaga gaccgagaca
     6961 gggaccgtga gagagcacga gacagggaca gggaccgagg ccgggaccgg aaggaccgca
     7021 gcaagagcag agagagccct cgggaccaga agcctgaggc caggacctct gaggggggcc
     7081 ctgctgcagc ccaggcctag aggccattgc actcggggct ggggacacga cctgctggtg
     7141 tggacaaaga cctgtgtcag ttattgtgta tataggctca gcctggcaaa gaccccttta
     7201 aaagccaagt gcataaaatg tgttgagcaa agagtttttg aaatagctat gaacttatat
     7261 acaggatata atattctgga cttcaggaat tactgtaatt ttgtgtataa tggtttgtta
     7321 caaattttcc caactttaca attctgattt tttaaaaata tttccattta aaattagaga
     7381 aatgggaaaa tgtctacaaa agcatattgc tttttttcag attataaagt tttttccaat
     7441 aacttgactg gtgtaagttt taaggggatt tcagtggacc ttagagctag ctttccctgt
     7501 gtagccatct ctgcttccgt ctatccaggg gctttcctca gtgctgtcct agtcggaaag
     7561 cactattgtc gaggtgagct gggggctgtg cgcaattgca gcggtggaag aactgccttc
     7621 tgaggcccgc ccagctccca gcaatgcagc accttacaag ttttttcaga acttaattag
     7681 aaatagcctg tcctagtaga aattgtaaca tttttaaata acaatttatt tttaaatgtt
     7741 caaatttatc agcctaaaga aagaaagatt cagttcagag catttaagag ggaagagaca
     7801 ggagtcaagc attgcccatt gctgccctct gagtggctct gcagactgac agactccaga
     7861 taggcgatgg gtttggaagc ttctcagtgg gatggggcaa tgtttgtacc aaatctggaa
     7921 acgaagagga tggtggtgaa gcagcctgct tcatggaagg ataactgctg tgtcgccccg
     7981 gttgcctcta aagatgctgt aagaaggctg gctaacgtat ctgactgtgc aaatatgttt
     8041 gatagttcct tttatatttt cataaactta ctttttcaga tagagaatta gcttcgtttg
     8101 ttcttcggag tcttatttca ctgtacatca ctacagattt tttcacttta tagcacagat
     8161 gtttaagttg aaaagacatg ggaaaatagc aatttgggat atttgctatt gtaaaccaaa
     8221 tagtaggcta aattacatga aagtgtcagt ttcaacatct aatatgtgaa ggttttttgt
     8281 ttttttaaaa aagtgtaaag taaaattttc taacttaaat gcacaagcat aaaaatcaag
     8341 tgtgtttctt taggtttact ttgtagaaat ttctgtacat tgtattttgt attgcagagt
     8401 gttatatcac tgtccattga aacacaggac tccataggtt ttgttacttg aagtagaata
     8461 aatatctaca gagttc
//
