LOCUS       NM_019670               4592 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus diaphanous related formin 3 (Diaph3), mRNA.
ACCESSION   NM_019670
VERSION     NM_019670.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4592)
  AUTHORS   Qiu,C., Zhang,L., Yong,C., Hu,R., Sun,Y., Wang,B., Fang,L.,
            Zhu,G.J., Lu,Q., Wang,J., Ma,X., Zhang,L. and Wan,G.
  TITLE     Stub1 promotes degradation of the activated Diaph3: A negative
            feedback regulatory mechanism of the actin nucleator
  JOURNAL   J Biol Chem 300 (10), 107813 (2024)
   PUBMED   39322015
  REMARK    GeneRIF: Stub1 promotes degradation of the activated Diaph3: A
            negative feedback regulatory mechanism of the actin nucleator.
REFERENCE   2  (bases 1 to 4592)
  AUTHORS   Lin,L., Wang,L., Li,A., Li,Y. and Gu,X.
  TITLE     CircDiaph3 aggravates H/R-induced cardiomyocyte apoptosis and
            inflammation through miR-338-3p/SRSF1 axis
  JOURNAL   J Bioenerg Biomembr 56 (3), 235-245 (2024)
   PUBMED   38613636
  REMARK    GeneRIF: CircDiaph3 aggravates H/R-induced cardiomyocyte apoptosis
            and inflammation through miR-338-3p/SRSF1 axis.
REFERENCE   3  (bases 1 to 4592)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4592)
  AUTHORS   Li,Z., Su,M., Xie,X., Wang,P., Bi,H., Li,E., Ren,K., Dong,L.,
            Lv,Z., Ma,X., Liu,Y., Zhao,B., Peng,Y., Liu,J., Liu,L., Yang,J.,
            Ji,P. and Mei,Y.
  TITLE     mDia formins form hetero-oligomers and cooperatively maintain
            murine hematopoiesis
  JOURNAL   PLoS Genet 19 (12), e1011084 (2023)
   PUBMED   38157491
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4592)
  AUTHORS   Cangkrama,M., Liu,H., Whipman,J., Zubair,M., Matsushita,M., Di
            Filippo,M., Kopf,M., Innocenti,M. and Werner,S.
  TITLE     A Protumorigenic mDia2-MIRO1 Axis Controls Mitochondrial
            Positioning and Function in Cancer-Associated Fibroblasts
  JOURNAL   Cancer Res 82 (20), 3701-3717 (2022)
   PUBMED   35997559
  REMARK    GeneRIF: A Protumorigenic mDia2-MIRO1 Axis Controls Mitochondrial
            Positioning and Function in Cancer-Associated Fibroblasts.
REFERENCE   6  (bases 1 to 4592)
  AUTHORS   Arlotta,P., Molyneaux,B.J., Chen,J., Inoue,J., Kominami,R. and
            Macklis,J.D.
  TITLE     Neuronal subtype-specific genes that control corticospinal motor
            neuron development in vivo
  JOURNAL   Neuron 45 (2), 207-221 (2005)
   PUBMED   15664173
REFERENCE   7  (bases 1 to 4592)
  AUTHORS   Peng,J., Wallar,B.J., Flanders,A., Swiatek,P.J. and Alberts,A.S.
  TITLE     Disruption of the Diaphanous-related formin Drf1 gene encoding
            mDia1 reveals a role for Drf3 as an effector for Cdc42
  JOURNAL   Curr Biol 13 (7), 534-545 (2003)
   PUBMED   12676083
  REMARK    GeneRIF: Activated Cdc42 binds to Drf3/mDia2 in cells in regions
            associated with the generation of filopodia.
REFERENCE   8  (bases 1 to 4592)
  AUTHORS   Satoh,S. and Tominaga,T.
  TITLE     mDia-interacting protein acts downstream of Rho-mDia and modifies
            Src activation and stress fiber formation
  JOURNAL   J Biol Chem 276 (42), 39290-39294 (2001)
   PUBMED   11509578
REFERENCE   9  (bases 1 to 4592)
  AUTHORS   Tominaga,T., Sahai,E., Chardin,P., McCormick,F., Courtneidge,S.A.
            and Alberts,A.S.
  TITLE     Diaphanous-related formins bridge Rho GTPase and Src tyrosine
            kinase signaling
  JOURNAL   Mol Cell 5 (1), 13-25 (2000)
   PUBMED   10678165
REFERENCE   10 (bases 1 to 4592)
  AUTHORS   Alberts,A.S., Bouquin,N., Johnston,L.H. and Treisman,R.
  TITLE     Analysis of RhoA-binding proteins reveals an interaction domain
            conserved in heterotrimeric G protein beta subunits and the yeast
            response regulator protein Skn7
  JOURNAL   J Biol Chem 273 (15), 8616-8622 (1998)
   PUBMED   9535835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085191.1, AF094519.1 and AC158988.3.
            
            On Apr 17, 2018 this sequence version replaced NM_019670.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085191.1, AF094519.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               BC085191.1         1-110
            111-3626            AF094519.1         1-3516
            3627-3650           BC085191.1         3627-3650
            3651-4586           BC085191.1         3652-4587
            4587-4592           AC158988.3         132966-132971
FEATURES             Location/Qualifiers
     source          1..4592
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 43.95 cM"
     gene            1..4592
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /note="diaphanous related formin 3"
                     /db_xref="GeneID:56419"
                     /db_xref="MGI:MGI:1927222"
     exon            1..227
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..3626
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /codon_start=1
                     /product="protein diaphanous homolog 3"
                     /protein_id="NP_062644.1"
                     /db_xref="CCDS:CCDS36990.1"
                     /db_xref="GeneID:56419"
                     /db_xref="MGI:MGI:1927222"
                     /translation="MERHRARALGRDSKSSRRKGLQSAPPAGPYEPGEKRPKLHLNIR
                     TLTDDMLDKFASIRIPGSKKERPPLPHLKTVSGISDSSSLSSETMENNPKALPESEVL
                     KLFEKMMEDMNLNEDKKAPLREKDFGIKKEMVMQYINTASKTGSLRSSRQISPQEFLH
                     ELKMGYTDERLFTYLESLRVSLTSHPVSWVQSFGHEGLGLLLDILEKLINGQIQEKVV
                     KKTQHKVIQCLRALMNTQYGLERIMSDKRSLSLLAKAMDPRQPAMMADVVKLLSAVCI
                     VGEESILEEVLEALTSAGEERKIDRFFSIVEGLRHNSVNLQVACMQLINALVTSPDDL
                     DFRLHLRNEFMRCGLKEILPNLKGIKNDGLDIQLKVFDEHKEEDLSEFFHRLEDIRAE
                     LDEASDVYSMLWDTVKETRAEGHFLSILQHLLLIRNDRFIREQYFKLIDECVSQIVLH
                     RDGTDPDFTYRKRLDLDLSQFVDVCIDQAKLDEWEEKASEHCKKFEKECTDHQETQAQ
                     LQKREAKINELQAELQAFKSQFGALPPGTKIPLQPSVEGEAGPSALPPAPPALSGGVP
                     PPPPPPPPPPPPLPGMPMPFGGPVPPPPPLGFLGGQSSIPLNLPFGLKPKKEFKPEIS
                     MRRLNWLKIGPNEMSENCFWIKVNENKYENRDLLCKLENTFCCQEKEKRNTNDFDEKK
                     VIKKRMKELKFLDPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNLIKHL
                     PDEEQLKSLSQFRSDYNSLCEPEQFAVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPD
                     IMAVSTACEEIKKSKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDTKSAD
                     QKTTLLHFLVDVCEEKHADILHFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKN
                     LETFPPPEDLHDKFVIKMSSFVISANEQYEKLSTLLGSMTQLYQSIMGYYAVDMKKVS
                     VEEFFNDLNNFRTSFMLALKENIKKREAAEKEKRARIAKERAEKERLERQQEKKRLLE
                     MKTEGDETGVMDSLLEALQSGAAFRDRRKRTPKLKDIRQSLSPMSQRPVLKVCNHENQ
                     KMQLTEGSRPHHSINCNSTRTPVAKELNYNLDTHASTGRIKAVEKEACNAESNKKKEM
                     ELLGSVAKSESVPEVEALLARLRAL"
     exon            228..260
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            261..437
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            438..542
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..673
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            674..748
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            749..818
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            819..955
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1061
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1172
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1291
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1408
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1527
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1592
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1697
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..2006
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2121
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2217
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2312
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2414
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2654
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2784
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2909
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3074
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3210
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3306
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..3366
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..4592
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4562..4567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /note="hexamer: AATAAA"
     polyA_site      4586
                     /gene="Diaph3"
                     /gene_synonym="4930417P13Rik; Dia2; Diap3; Drf3;
                     p134MDia2"
                     /note="major polyA site"
ORIGIN      
        1 gatagattgg cccagccgtg tgcagcggtt aatgcgcagt gggcgtggga ccgggaagtt
       61 gagcccgcgg agcaaagccc cagatcaggt cgcgacctag acccgggaag atggagaggc
      121 accgggcgcg cgctctcggc cgggacagca agtcgtcgcg gaggaagggc ttgcagtccg
      181 cgccgcccgc tggcccctac gagcccgggg agaagcgacc caagttgcat ttaaatatta
      241 gaacactgac agatgatatg ctggacaaat ttgccagtat aagaattcca gggagcaaga
      301 aagagagacc tccccttccc cacctgaaga ctgtgtctgg gatcagtgac agctcatcac
      361 tgtcctcaga gacaatggaa aacaacccaa aggcgctgcc agagagtgaa gtcttgaagc
      421 tttttgagaa gatgatggaa gatatgaatt taaatgaaga taaaaaggca ccattgcggg
      481 aaaaagactt cggtatcaaa aaagaaatgg tgatgcagta cattaatact gcttctaaga
      541 caggaagtct tagaagtagc cgacagatct cacctcagga atttctccat gagctgaaaa
      601 tgggttacac agacgagaga cttttcacgt atctggagtc actccgagta tcattgacca
      661 gtcatcctgt gagttgggtg caaagctttg gacacgaggg actcggatta ttgctggaca
      721 ttttggaaaa actaattaat gggcaaatcc aagaaaaagt tgtgaagaag actcagcaca
      781 aagtcatcca gtgtctgaga gccctgatga acacacagta tggcttagaa aggattatga
      841 gtgacaagag gagtctttcc ttgttggcaa aagccatgga tcccaggcag cccgctatga
      901 tggcagacgt ggtgaagctt ctgtctgcag tgtgcattgt cggcgaggaa agcatccttg
      961 aagaagtgtt agaagccttg acttcagctg gagaagaaag aaagattgac agattttttt
     1021 ccattgtgga aggcctccgg cataactcag tgaacctgca agttgcttgt atgcagctca
     1081 taaatgctct cgttacatct cctgatgatt tggacttcag gcttcacctc agaaatgaat
     1141 ttatgcgttg tggattgaaa gagatattgc caaacttaaa gggcattaag aatgatggcc
     1201 tggatataca acttaaagtc tttgatgagc acaaagaaga agatttgagt gagtttttcc
     1261 atcgccttga agacattaga gctgaacttg atgaagcatc tgatgtttac agcatgttat
     1321 gggacacagt taaggaaact cgagcagagg gacattttct ttctattctt cagcatctcc
     1381 tgctcattcg caatgatcgt tttataagag agcagtattt caaattaatt gatgagtgtg
     1441 tgtcacagat tgtattacat agagatggaa cggaccctga cttcacatac agaaaaagac
     1501 tagatttgga cttaagtcag tttgtagatg tttgcataga tcaggccaaa ctagatgagt
     1561 gggaagagaa agcatccgaa cattgcaaga aatttgaaaa agagtgtact gaccaccaag
     1621 aaacccaggc tcaattgcag aaaagagagg caaagattaa tgagcttcaa gcagagttac
     1681 aagcttttaa atcccagttt ggtgccttgc cacctggtac aaaaattcct ttgcaacctt
     1741 cagtagaagg tgaagctggc ccttcagccc ttcctcctgc cccaccagca ctcagtggag
     1801 gagtgccgcc tcccccaccg ccccctcctc caccaccccc accactccca ggaatgccaa
     1861 tgccatttgg tggccctgta ccaccaccac ctcctctggg attcctgggt gggcaaagct
     1921 ctattccatt aaacctgcca tttggtttga aaccaaagaa agaatttaag cctgaaatca
     1981 gcatgagaag attgaattgg ttaaagatcg gaccaaatga aatgtctgag aactgcttct
     2041 ggatcaaagt aaatgaaaat aagtatgaaa atagggattt gctttgtaaa cttgagaaca
     2101 ctttttgttg ccaagaaaaa gagaaaagga atacaaatga ctttgatgag aagaaagtta
     2161 ttaagaagag aatgaaggaa cttaaatttc tagatcctaa aattgctcag aacctttcaa
     2221 tcttcctgag ctccttccgg gtgccatatg agaaaatcag gacgatgata ttggaagtgg
     2281 atgaaacaca gttgtcagag tccatgattc agaacttaat aaagcacctt cctgatgagg
     2341 agcagttgaa gtcattgtcc cagtttagaa gtgactataa cagtttgtgt gagcctgagc
     2401 agttcgctgt tgtgatgagc aatgtgaaga gactccggcc acggctcagt gctattctct
     2461 ttaagcttca atttgaagag caggtgaaca acatcaaacc tgacatcatg gctgtcagta
     2521 ctgcctgcga ggagatcaag aagagcaaag gctttagcaa gttgctggaa cttgtgttgc
     2581 taatgggaaa ctacatgaat gctggctccc ggaatgctca aaccttcgga tttgacctta
     2641 gctctctctg taaactgaag gatacaaaat ctgcagatca gaaaaccaca ctcctccatt
     2701 tcctggtaga tgtatgtgaa gaaaagcatg ctgacatcct tcactttgtg gacgatttgg
     2761 cacatttaga caaagctagc agagtctctg tagaaatgct ggaaaagaac gtgaagcaga
     2821 tgggaaggca gcttcaacag cttgagaaga atttggaaac ctttccccct cctgaggact
     2881 tgcatgacaa gtttgtgata aagatgtcca gcttcgttat cagtgcgaac gagcagtatg
     2941 aaaaactctc cacactactg ggcagcatga cacaattgta ccagagtata atgggctact
     3001 atgctgtcga catgaagaag gtttccgtgg aagagttttt taatgatctg aacaacttca
     3061 gaacttcatt tatgctagca ttaaaggaaa acatcaaaaa acgagaagca gcagaaaagg
     3121 agaaacgtgc caggatagcg aaagagcgag cagagaaaga gcgacttgaa cgccagcaag
     3181 agaaaaagcg cttactagaa atgaaaactg agggagatga gacaggagtg atggatagtc
     3241 tgctggaggc cttgcagtca ggggctgcct tccgcgacag aagaaaaagg acaccaaagc
     3301 tgaaagatat tcggcagagt ctcagcccga tgtctcagag gcctgttctc aaagtttgta
     3361 accatgaaaa tcagaaaatg cagttgacag aagggtcacg tccacaccac agtatcaatt
     3421 gcaactccac caggactcca gtcgccaagg agcttaatta taatctagac actcatgcgt
     3481 ctacagggag gatcaaggca gttgagaagg aagcctgtaa tgcagaaagc aacaaaaaaa
     3541 aggaaatgga acttcttggc tctgttgcta aaagcgaatc agttcctgaa gttgaagccc
     3601 tgctggcaag attacgagct ttataaatga aactggttaa aaaaaaaaaa tgattaagcc
     3661 aaacaccaag ccatgctttc agctgtaaca cttgaaaagt tacttttatg taagtgactt
     3721 tatatagttc taaattatga tatatattag aaaaagtaaa gctaaataca tgattgcaat
     3781 acttttcctg tatgcttgaa gtttttgcat tactcaagat tgtaatgggc tttaatgctt
     3841 ttatttttgt cttctggtat tcctttattc tgtatttgcc aattaaatta tacctgttgc
     3901 tttagagagc aaggaaacag ccatgtgttc aactgtgtcc ttaagaaaat gaaatctttc
     3961 taagtaattt ttaccacttc aacattaatg aaagagcatc aggttgaaga cttggtgtct
     4021 gtccctacct acttcaaatt tgctatctga atagccccaa atgtttccaa tacagagtca
     4081 gaaatgtgtg tgtgtgcaag ccacaatgac cagtattggc tcacattaac taacactgga
     4141 agacacactt ccaaaaacga tgcagtagga atgtttgcac tttctttgca aaacatacag
     4201 gcattttgca aagtaggaat atgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     4261 gtgtgtgtgt gtgtgtgtgt gtgcatatat atcatcacaa catcacagta ctacctaggt
     4321 cttagccaag gggacacttt caccctcagt actatggctt tgacctaaaa ttaccatttg
     4381 gaaatttccc aaggaataaa ttttttattt ttgacaaact taggatttca ttttttttta
     4441 agctgacaat cagtaactgt gacaacaatc tgatgttttg gggacagttt ccatatgcaa
     4501 atgtttcagt tgtacctcac ttggcaccat tcctttgtta tttccttatc aagaataaat
     4561 aaataaactt gctgcttgca ctaaaagacg ta
//
