LOCUS       NP_766081               1102 aa            linear   ROD 01-MAY-2025
DEFINITION  protein diaphanous homolog 2 [Mus musculus].
ACCESSION   NP_766081
VERSION     NP_766081.1
DBSOURCE    REFSEQ: accession NM_172493.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1102)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1102)
  AUTHORS   Yao,X., Wang,C., Yu,W., Sun,L., Lv,Z., Xie,X., Tian,S., Yan,L.,
            Li,L. and Liu,J.
  TITLE     BCAS2 regulates oocyte meiotic prophase I by participating in mRNA
            alternative splicing
  JOURNAL   FASEB J 38 (1), e23361 (2024)
   PUBMED   38085152
REFERENCE   3  (residues 1 to 1102)
  AUTHORS   Chiereghin,C., Robusto,M., Lewis,M.A., Caetano,S., Massa,V.,
            Castorina,P., Ambrosetti,U., Steel,K.P., Duga,S., Asselta,R. and
            Solda,G.
  TITLE     In-depth genetic and molecular characterization of diaphanous
            related formin 2 (DIAPH2) and its role in the inner ear
  JOURNAL   PLoS One 18 (1), e0273586 (2023)
   PUBMED   36689403
  REMARK    GeneRIF: In-depth genetic and molecular characterization of
            diaphanous related formin 2 (DIAPH2) and its role in the inner ear.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1102)
  AUTHORS   Thumkeo,D., Katsura,Y., Nishimura,Y., Kanchanawong,P., Tohyama,K.,
            Ishizaki,T., Kitajima,S., Takahashi,C., Hirata,T., Watanabe,N.,
            Krummel,M.F. and Narumiya,S.
  TITLE     mDia1/3-dependent actin polymerization spatiotemporally controls
            LAT phosphorylation by Zap70 at the immune synapse
  JOURNAL   Sci Adv 6 (1), eaay2432 (2020)
   PUBMED   31911947
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1102)
  AUTHORS   Shindo,R., Ohmuraya,M., Komazawa-Sakon,S., Miyake,S., Deguchi,Y.,
            Yamazaki,S., Nishina,T., Yoshimoto,T., Kakuta,S., Koike,M.,
            Uchiyama,Y., Konishi,H., Kiyama,H., Mikami,T., Moriwaki,K.,
            Araki,K. and Nakano,H.
  TITLE     Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate
            Lymphoid Cell-Dependent Lethal Ileitis
  JOURNAL   iScience 15, 536-551 (2019)
   PUBMED   31132747
REFERENCE   6  (residues 1 to 1102)
  AUTHORS   Wen,Y., Eng,C.H., Schmoranzer,J., Cabrera-Poch,N., Morris,E.J.,
            Chen,M., Wallar,B.J., Alberts,A.S. and Gundersen,G.G.
  TITLE     EB1 and APC bind to mDia to stabilize microtubules downstream of
            Rho and promote cell migration
  JOURNAL   Nat Cell Biol 6 (9), 820-830 (2004)
   PUBMED   15311282
REFERENCE   7  (residues 1 to 1102)
  AUTHORS   Yasuda,S., Oceguera-Yanez,F., Kato,T., Okamoto,M., Yonemura,S.,
            Terada,Y., Ishizaki,T. and Narumiya,S.
  TITLE     Cdc42 and mDia3 regulate microtubule attachment to kinetochores
  JOURNAL   Nature 428 (6984), 767-771 (2004)
   PUBMED   15085137
  REMARK    GeneRIF: Cdc42, and its effector, mDia3, regulate microtubule
            attachment to kinetochores
REFERENCE   8  (residues 1 to 1102)
  AUTHORS   Shimada,A., Nyitrai,M., Vetter,I.R., Kuhlmann,D., Bugyi,B.,
            Narumiya,S., Geeves,M.A. and Wittinghofer,A.
  TITLE     The core FH2 domain of diaphanous-related formins is an elongated
            actin binding protein that inhibits polymerization
  JOURNAL   Mol Cell 13 (4), 511-522 (2004)
   PUBMED   14992721
REFERENCE   9  (residues 1 to 1102)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (residues 1 to 1102)
  AUTHORS   Bione,S., Sala,C., Manzini,C., Arrigo,G., Zuffardi,O., Banfi,S.,
            Borsani,G., Jonveaux,P., Philippe,C., Zuccotti,M., Ballabio,A. and
            Toniolo,D.
  TITLE     A human homologue of the Drosophila melanogaster diaphanous gene is
            disrupted in a patient with premature ovarian failure: evidence for
            conserved function in oogenesis and implications for human
            sterility
  JOURNAL   Am J Hum Genet 62 (3), 533-541 (1998)
   PUBMED   9497258
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL683856.10, AL732443.6, AL954869.9, AL683857.8 and AL807775.8.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY312280.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1102
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 52.36 cM"
     Protein         1..1102
                     /product="protein diaphanous homolog 2"
                     /note="diaphanous homolog 2"
                     /calculated_mol_wt=125255
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:O60879; propagated from
                     UniProtKB/Swiss-Prot (O70566.2)"
     Region          102..287
                     /region_name="Drf_GBD"
                     /note="Diaphanous GTPase-binding Domain; pfam06371"
                     /db_xref="CDD:461886"
     Region          295..483
                     /region_name="Drf_FH3"
                     /note="Diaphanous FH3 Domain; pfam06367"
                     /db_xref="CDD:461885"
     Region          541..569
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70566.2)"
     Region          582..615
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70566.2)"
     Region          629..1003
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; pfam02181"
                     /db_xref="CDD:396655"
     Region          683..703
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70566.2)"
     Region          1011..1051
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70566.2)"
     Region          1067..1102
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70566.2)"
     CDS             1..1102
                     /gene="Diaph2"
                     /gene_synonym="Dia3; Diap2; Drf2; E430022I22Rik"
                     /coded_by="NM_172493.3:212..3520"
                     /db_xref="CCDS:CCDS53180.1"
                     /db_xref="GeneID:54004"
                     /db_xref="MGI:MGI:1858500"
ORIGIN      
        1 meelgaaasg agggggggee hgggrsnkrg agnraaneee trnkpklniq iktladdvrd
       61 ritsfrksat krekpviqhs idyqtavvei ppalivhddr slilsekevl dlfekmmedm
      121 nlneekkapl rkkdfsikre mvvqyisats ksgglknskh eftlssqeyv helrsgisde
      181 kllncleslr vsltshpvsw vnnfgyeglg vlldvlekll dkkqqenidk knqykviqcl
      241 kafmnnkfgl qrilgdersl lllaraidpk qqnmmteivk ilsaicivge enildkllgg
      301 itaaaelnnr erfspivegl ennealhlqv acmqfinalv tspydldfri hlrneflrcg
      361 lkamlptlke ienegldiql rvfeenkedd lselshrlnd iraemddine vyhllynmlk
      421 dtaaepylls ilqhfllirn dyyirpqyyk iieecvsqiv lhcsgmdpdf kyrqridfdf
      481 thlldacvnk akveeneqka mefskkfdee ftarqeaqae lqkrdekike leteiqqlrg
      541 qgvpsaipgp ppppplpgag pcpppppppp pppplpgvvp ppppplpgmp gipppppppl
      601 sgvppppppp ggvfpllsgp ielpygmkqk klykpdipmk rinwskiepk elsencvwlk
      661 lkeekyenad lfaklaltfp sqmkgqrnte aaeenrsgpp kkkvkelril dtktaqnlsi
      721 flgsyrmpye eikniilevn eemlsealiq nlvkylpdqn alrelaqlks eyddlcepeq
      781 fgvvmstvkm lrprltsilf kltfeehvnn ikpsiiavtl aceelkkses fkrllelill
      841 vgnymnsgsr naqslgfkin flckikdtks adqkstllhf laeicdekyr dilkfpdele
      901 hvesagkvsa qilksnlvam eqsilhlekn iknfppaesh hdkfvekmms ftqnareqyd
      961 klstmhsnml klyeslgeyf ifdpntvnme effgdlntfr tlflealken hkrkemeeks
     1021 rraklakeka eqeklerqkk kkqlidinke gdetgvmdnl lealqsgaaf rdrrkriprn
     1081 pdnrrppler srsrhngams sk
//
