LOCUS       NM_023232               1939 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus diablo, IAP-binding mitochondrial protein (Diablo),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_023232
VERSION     NM_023232.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1939)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   2  (bases 1 to 1939)
  AUTHORS   Wang,X., Lu,M., Gu,H., Xiao,T., Hu,G., Luo,M., Guo,X. and Xia,Y.
  TITLE     Conjugation of the Fn14 Ligand to a SMAC Mimetic Selectively
            Suppresses Experimental Squamous Cell Carcinoma in Mice
  JOURNAL   J Invest Dermatol 143 (2), 242-253 (2023)
   PUBMED   36063885
  REMARK    GeneRIF: Conjugation of the Fn14 Ligand to a SMAC Mimetic
            Selectively Suppresses Experimental Squamous Cell Carcinoma in
            Mice.
REFERENCE   3  (bases 1 to 1939)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   4  (bases 1 to 1939)
  AUTHORS   Stewart,K., Tang,Y.C., Shafer,M.E.R., Graham-Paquin,A.L. and
            Bouchard,M.
  TITLE     Modulation of apoptotic response by LAR family phosphatases-cIAP1
            signaling during urinary tract morphogenesis
  JOURNAL   Proc Natl Acad Sci U S A 114 (43), E9016-E9025 (2017)
   PUBMED   29073098
REFERENCE   5  (bases 1 to 1939)
  AUTHORS   Yoon,K., Jang,H.D. and Lee,S.Y.
  TITLE     Direct interaction of Smac with NADE promotes TRAIL-induced
            apoptosis
  JOURNAL   Biochem Biophys Res Commun 319 (2), 649-654 (2004)
   PUBMED   15178455
REFERENCE   6  (bases 1 to 1939)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1939)
  AUTHORS   Li,S., Zhao,Y., He,X., Kim,T.H., Kuharsky,D.K., Rabinowich,H.,
            Chen,J., Du,C. and Yin,X.M.
  TITLE     Relief of extrinsic pathway inhibition by the Bid-dependent
            mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis
  JOURNAL   J Biol Chem 277 (30), 26912-26920 (2002)
   PUBMED   12011074
  REMARK    GeneRIF: mitochondrial activation by Bid is required for reversing
            the inhibitor-of-apoptosis proteins inhibition through Smac release
REFERENCE   8  (bases 1 to 1939)
  AUTHORS   Okada,H., Suh,W.K., Jin,J., Woo,M., Du,C., Elia,A., Duncan,G.S.,
            Wakeham,A., Itie,A., Lowe,S.W., Wang,X. and Mak,T.W.
  TITLE     Generation and characterization of Smac/DIABLO-deficient mice
  JOURNAL   Mol Cell Biol 22 (10), 3509-3517 (2002)
   PUBMED   11971981
  REMARK    GeneRIF: data suggest the existence of a redundant molecule or
            molecules capable of compensating for a loss of Smac/DIABLO
            function.
REFERENCE   9  (bases 1 to 1939)
  AUTHORS   Verhagen,A.M., Silke,J., Ekert,P.G., Pakusch,M., Kaufmann,H.,
            Connolly,L.M., Day,C.L., Tikoo,A., Burke,R., Wrobel,C.,
            Moritz,R.L., Simpson,R.J. and Vaux,D.L.
  TITLE     HtrA2 promotes cell death through its serine protease activity and
            its ability to antagonize inhibitor of apoptosis proteins
  JOURNAL   J Biol Chem 277 (1), 445-454 (2002)
   PUBMED   11604410
REFERENCE   10 (bases 1 to 1939)
  AUTHORS   Verhagen,A.M., Ekert,P.G., Pakusch,M., Silke,J., Connolly,L.M.,
            Reid,G.E., Moritz,R.L., Simpson,R.J. and Vaux,D.L.
  TITLE     Identification of DIABLO, a mammalian protein that promotes
            apoptosis by binding to and antagonizing IAP proteins
  JOURNAL   Cell 102 (1), 43-53 (2000)
   PUBMED   10929712
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY080746.1, AK012760.1 and AK133194.1.
            
            On Jan 24, 2006 this sequence version replaced NM_023232.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054109.1, AK002887.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BY080746.1         13-15
            4-1093              AK012760.1         2-1091
            1094-1939           AK133194.1         1074-1919
FEATURES             Location/Qualifiers
     source          1..1939
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.02 cM"
     gene            1..1939
                     /gene="Diablo"
                     /gene_synonym="0610041G12Rik; 1700006L01Rik; Smac"
                     /note="diablo, IAP-binding mitochondrial protein"
                     /db_xref="GeneID:66593"
                     /db_xref="MGI:MGI:1913843"
     exon            1..94
                     /gene="Diablo"
                     /gene_synonym="0610041G12Rik; 1700006L01Rik; Smac"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..758
                     /gene="Diablo"
                     /gene_synonym="0610041G12Rik; 1700006L01Rik; Smac"
                     /note="second mitochondria-derived activator of caspase;
                     diablo homolog, mitochondrial; direct IAP binding protein
                     with low PI; direct IAP-binding protein with low pI"
                     /codon_start=1
                     /product="diablo IAP-binding mitochondrial protein
                     precursor"
                     /protein_id="NP_075721.3"
                     /db_xref="CCDS:CCDS39270.1"
                     /db_xref="GeneID:66593"
                     /db_xref="MGI:MGI:1913843"
                     /translation="MAALRSWVTRSVCSLFRYRQRFPVLANSKKRCFSELIKPWHKTV
                     LTGFGMTLCAVPIAQKSEPQSLSNEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYT
                     KAVYTLVSLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVG
                     LSEMAAEAAYQTGADQASITARNHIQLVKSQVQEVRQLSQKAETKLAEAQTKELHQKA
                     QEVSDEGADQEEEAYLRED"
     exon            95..221
                     /gene="Diablo"
                     /gene_synonym="0610041G12Rik; 1700006L01Rik; Smac"
                     /inference="alignment:Splign:2.1.0"
     exon            222..353
                     /gene="Diablo"
                     /gene_synonym="0610041G12Rik; 1700006L01Rik; Smac"
                     /inference="alignment:Splign:2.1.0"
     exon            354..464
                     /gene="Diablo"
                     /gene_synonym="0610041G12Rik; 1700006L01Rik; Smac"
                     /inference="alignment:Splign:2.1.0"
     exon            465..561
                     /gene="Diablo"
                     /gene_synonym="0610041G12Rik; 1700006L01Rik; Smac"
                     /inference="alignment:Splign:2.1.0"
     exon            562..1939
                     /gene="Diablo"
                     /gene_synonym="0610041G12Rik; 1700006L01Rik; Smac"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1341..1346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Diablo"
                     /gene_synonym="0610041G12Rik; 1700006L01Rik; Smac"
                     /note="hexamer: ATTAAA"
     polyA_site      1365
                     /gene="Diablo"
                     /gene_synonym="0610041G12Rik; 1700006L01Rik; Smac"
                     /note="major polyA site"
     regulatory      1529..1534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Diablo"
                     /gene_synonym="0610041G12Rik; 1700006L01Rik; Smac"
                     /note="hexamer: CATAAA"
     regulatory      1535..1540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Diablo"
                     /gene_synonym="0610041G12Rik; 1700006L01Rik; Smac"
                     /note="hexamer: AATAAA"
     polyA_site      1540
                     /gene="Diablo"
                     /gene_synonym="0610041G12Rik; 1700006L01Rik; Smac"
     polyA_site      1559
                     /gene="Diablo"
                     /gene_synonym="0610041G12Rik; 1700006L01Rik; Smac"
ORIGIN      
        1 tgcgtcactt ccggcgcgtg cgtccggcgt cggtccgccg cgggatggcg gctctgagaa
       61 gttgggtgac tcggagcgtc tgctctctgt tcaggtacag acagcgtttt cctgtcttgg
      121 ctaactctaa gaaacgctgt ttctcagaat tgataaaacc atggcacaaa actgtgttga
      181 ctggatttgg catgacactg tgtgcggttc ctattgctca gaaatcggag cctcagtctc
      241 tcagtaacga agcattgatg aggagggctg tgtctttggt aacagatagc acctctacct
      301 ttctgtctca aaccacctac gcgctgattg aagcaatcac cgagtatact aaggctgttt
      361 acacgttagt gtctctgtac cgacaatata caagtttact tgggaagatg aattcccagg
      421 aggaagatga ggtgtggcag gtaattatag gagccagagt tgagatgact tcaaaacagc
      481 aggaatattt gaagttggag accacttgga tgacagcggt tggcctttca gagatggctg
      541 ctgaggctgc ctatcaaact ggagcagatc aggcctccat aactgccagg aatcacatcc
      601 agttggtgaa gtcacaggta caggaggtgc gccagctctc ccagaaggca gaaaccaagt
      661 tggctgaagc acagacaaaa gagctgcacc agaaagcaca ggaagtgagt gatgaggggg
      721 ctgaccagga agaggaggcc tacctgcgtg aagattgagg gcctgagccc agtgccctgt
      781 ccatccactc tgtggggaaa gcggtggatg gtatccacct aatgttgtcc cagctctgca
      841 gagctaacag tcctgccatt gacagtcaga ccagagcctt ctgtgagctg tgcctggccc
      901 cttgtctgct cacaccctct gtgcctggtt cttagctctg ggcgtggctc agcactgtcc
      961 ctcagcactg ctcctctctt gctgatcttt tagctcacac ccaaagcatt tcaccaacct
     1021 gggccaacag aggaggggcc tttcctgcca cacccttaag ttcagtagct gtttaactac
     1081 agtttttaat gttactcgga tgttcaagtg tgatttagtg cttgcttctc cacagggaag
     1141 tggggggctt gtctggtttg taacatttct gtgtttataa tgtcctttct ccctgtgagc
     1201 acagctcagc tatggagtta ctcagggcgt gaacagctca cctggtgctc cccacaggcc
     1261 cttctctaac acgtacttct tgtttgttcc ttctttgaat ttctctgctg tatccaaagg
     1321 aagagaagtt tagtgtttgc attaaaaaag agagattgag agtgagagtg agtcttcagg
     1381 ctgtcctgca gcgtcttcct tcgctcccta ggcagtggga gctgggggcc ctggggtcct
     1441 aaggctccct ggcagctgac actcccattc agcacatgct agagaagttt gccaggtttc
     1501 agcactttta attaaataag gttgttagca taaaaataaa gatcatttcc tgctgaccac
     1561 cagggaccag ttttcagaat tgtttctcct ggtgatagga gttgagtcac tctaaagctg
     1621 ttgctccacc cacccctcgg ggctagggct tgtgggtagc tgcacactta agcctctcat
     1681 ctgtcaccag cgcccacatg gtccacatct ccagggggct gagacggtgc accagcagga
     1741 gccctttgta cagacaaggg tccctgggat tgaggggctg ttggattcca aatgtcttga
     1801 agccagcatg gtgtatggga gtcaccccca gcttcctcag gcacatcccc acaaagacat
     1861 cgtcaatagg aaagagctct gcctcctcca tggccatgtg aagatgcctc acagtagcct
     1921 gggacatgac gtagccgcc
//
