LOCUS       NM_001405509            4605 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus DExH-box helicase 9 (Dhx9), transcript variant 1,
            mRNA.
ACCESSION   NM_001405509 XM_011247918
VERSION     NM_001405509.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4605)
  AUTHORS   Ren,X., Liu,Q., Zhou,P., Zhou,T., Wang,D., Mei,Q., Flavell,R.A.,
            Liu,Z., Li,M., Pan,W. and Zhu,S.
  TITLE     DHX9 maintains epithelial homeostasis by restraining
            R-loop-mediated genomic instability in intestinal stem cells
  JOURNAL   Nat Commun 15 (1), 3080 (2024)
   PUBMED   38594251
  REMARK    GeneRIF: DHX9 maintains epithelial homeostasis by restraining
            R-loop-mediated genomic instability in intestinal stem cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4605)
  AUTHORS   Futterer,A., Rodriguez-Acebes,S., Mendez,J., Gutierrez,J. and
            Martinez-A,C.
  TITLE     PARP1, DIDO3, and DHX9 Proteins Mutually Interact in Mouse
            Fibroblasts, with Effects on DNA Replication Dynamics, Senescence,
            and Oncogenic Transformation
  JOURNAL   Cells 13 (2), 159 (2024)
   PUBMED   38247850
  REMARK    GeneRIF: PARP1, DIDO3, and DHX9 Proteins Mutually Interact in Mouse
            Fibroblasts, with Effects on DNA Replication Dynamics, Senescence,
            and Oncogenic Transformation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4605)
  AUTHORS   Takada,Y., Fierro,L., Sato,K., Sanada,T., Ishii,A., Yamamoto,T. and
            Kotani,T.
  TITLE     Mature mRNA processing that deletes 3' end sequences directs
            translational activation and embryonic development
  JOURNAL   Sci Adv 9 (47), eadg6532 (2023)
   PUBMED   38000026
REFERENCE   4  (bases 1 to 4605)
  AUTHORS   Calame,D.G., Guo,T., Wang,C., Garrett,L., Jolly,A., Dawood,M.,
            Kurolap,A., Henig,N.Z., Fatih,J.M., Herman,I., Du,H., Mitani,T.,
            Becker,L., Rathkolb,B., Gerlini,R., Seisenberger,C., Marschall,S.,
            Hunter,J.V., Gerard,A., Heidlebaugh,A., Challman,T.,
            Spillmann,R.C., Jhangiani,S.N., Coban-Akdemir,Z., Lalani,S.,
            Liu,L., Revah-Politi,A., Iglesias,A., Guzman,E., Baugh,E.,
            Boddaert,N., Rondeau,S., Ormieres,C., Barcia,G., Tan,Q.K.G.,
            Thiffault,I., Pastinen,T., Sheikh,K., Biliciler,S., Mei,D.,
            Melani,F., Shashi,V., Yaron,Y., Steele,M., Wakeling,E.,
            Ostergaard,E., Nazaryan-Petersen,L., Millan,F., Santiago-Sim,T.,
            Thevenon,J., Bruel,A.L., Thauvin-Robinet,C., Popp,D., Platzer,K.,
            Gawlinski,P., Wiszniewski,W., Marafi,D., Pehlivan,D., Posey,J.E.,
            Gibbs,R.A., Gailus-Durner,V., Guerrini,R., Fuchs,H., Hrabe de
            Angelis,M., Holter,S.M., Cheung,H.H., Gu,S. and Lupski,J.R.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Monoallelic variation in DHX9, the gene encoding the DExH-box
            helicase DHX9, underlies neurodevelopment disorders and
            Charcot-Marie-Tooth disease
  JOURNAL   Am J Hum Genet 110 (8), 1394-1413 (2023)
   PUBMED   37467750
  REMARK    GeneRIF: Monoallelic variation in DHX9, the gene encoding the
            DExH-box helicase DHX9, underlies neurodevelopment disorders and
            Charcot-Marie-Tooth disease.
REFERENCE   5  (bases 1 to 4605)
  AUTHORS   Yamada,M., Nitta,Y., Uehara,T., Suzuki,H., Miya,F., Takenouchi,T.,
            Tamura,M., Ayabe,S., Yoshiki,A., Maeno,A., Saga,Y., Furuse,T.,
            Yamada,I., Okamoto,N., Kosaki,K. and Sugie,A.
  TITLE     Heterozygous loss-of-function DHX9 variants are associated with
            neurodevelopmental disorders: Human genetic and experimental
            evidences
  JOURNAL   Eur J Med Genet 66 (8), 104804 (2023)
   PUBMED   37369308
  REMARK    GeneRIF: Heterozygous loss-of-function DHX9 variants are associated
            with neurodevelopmental disorders: Human genetic and experimental
            evidences.
REFERENCE   6  (bases 1 to 4605)
  AUTHORS   Zhang,S., Herrmann,C. and Grosse,F.
  TITLE     Nucleolar localization of murine nuclear DNA helicase II (RNA
            helicase A)
  JOURNAL   J Cell Sci 112 (Pt 16), 2693-2703 (1999)
   PUBMED   10413677
REFERENCE   7  (bases 1 to 4605)
  AUTHORS   Lee,C.G., da Costa Soares,V., Newberger,C., Manova,K., Lacy,E. and
            Hurwitz,J.
  TITLE     RNA helicase A is essential for normal gastrulation
  JOURNAL   Proc Natl Acad Sci U S A 95 (23), 13709-13713 (1998)
   PUBMED   9811865
REFERENCE   8  (bases 1 to 4605)
  AUTHORS   Yamazaki,K., Oki,T. and Tanaka,I.
  TITLE     Cloning of 5'-flanking region and a polymorphic CTT trinucleotide
            repeat within 5'-untranslated region of mouse R-type calcium
            channel alpha1-subunit (Cchra1) gene, and its genetic mapping
  JOURNAL   Gene 214 (1-2), 199-204 (1998)
   PUBMED   9651528
REFERENCE   9  (bases 1 to 4605)
  AUTHORS   Lee,C.G., Eki,T., Okumura,K., da Costa Soares,V. and Hurwitz,J.
  TITLE     Molecular analysis of the cDNA and genomic DNA encoding mouse RNA
            helicase A
  JOURNAL   Genomics 47 (3), 365-371 (1998)
   PUBMED   9480750
REFERENCE   10 (bases 1 to 4605)
  AUTHORS   Miazek,A., Brockhaus,M., Langen,H., Braun,A. and Kisielow,P.
  TITLE     Intrathymic education of alpha beta and gamma delta T cells is
            accompanied by cell surface expression of RNA/DNA helicase
            [corrected]
  JOURNAL   Eur J Immunol 27 (12), 3269-3282 (1997)
   PUBMED   9464815
  REMARK    Erratum:[Eur J Immunol 1998 Mar;28(3):1123]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099712.21 and AC098709.3.
            
            On Apr 26, 2022 this sequence version replaced XM_011247918.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.3702786.1,
                                           SRR17253012.4982704.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AC099712.21        102365-102483       c
            120-252             AC099712.21        98572-98704         c
            253-393             AC099712.21        97574-97714         c
            394-511             AC099712.21        95964-96081         c
            512-627             AC099712.21        93698-93813         c
            628-776             AC099712.21        92873-93021         c
            777-823             AC098709.3         1444-1490
            824-960             AC098709.3         3870-4006
            961-1050            AC098709.3         4392-4481
            1051-1212           AC098709.3         4591-4752
            1213-1290           AC098709.3         4850-4927
            1291-1482           AC098709.3         5342-5533
            1483-1624           AC098709.3         7412-7553
            1625-1707           AC098709.3         8197-8279
            1708-1864           AC098709.3         9965-10121
            1865-1965           AC098709.3         11376-11476
            1966-2179           AC098709.3         12085-12298
            2180-2274           AC098709.3         12441-12535
            2275-2348           AC098709.3         12740-12813
            2349-2501           AC098709.3         14449-14601
            2502-2662           AC098709.3         16011-16171
            2663-2774           AC098709.3         16764-16875
            2775-2936           AC098709.3         17434-17595
            2937-3064           AC098709.3         17688-17815
            3065-3294           AC098709.3         18664-18893
            3295-3410           AC098709.3         18985-19100
            3411-3611           AC098709.3         19422-19622
            3612-4605           AC098709.3         20400-21393
FEATURES             Location/Qualifiers
     source          1..4605
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 65.37 cM"
     gene            1..4605
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /note="DExH-box helicase 9"
                     /db_xref="GeneID:13211"
                     /db_xref="MGI:MGI:108177"
     exon            1..119
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            120..252
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..4296
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9;
                     ATP-dependent RNA helicase A; DEAH (Asp-Glu-Ala-His) box
                     polypeptide 9; DEAH box protein 9; D-E-A-D
                     (aspartate-glutamate-alanine-aspartate) box polypeptide 9;
                     DEAD (aspartate-glutamate-alanine-aspartate) box
                     polypeptide 9; leukophysin; nuclear DNA helicase II"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase A isoform 1"
                     /protein_id="NP_001392438.1"
                     /db_xref="GeneID:13211"
                     /db_xref="MGI:MGI:108177"
                     /translation="MGDIKNFLYAWCGKRKMTPAYEIRAVGNKNRQKFMCEVRVEGFN
                     YAGMGNSTNKKDAQSNAARDFVNYLVRINEVKSEEVPAVGIVPPPPILSDTSDSTASA
                     AEGLPAPMGGPLPPHLALKAEAENNSGVESSGYGSPGPTWDRGANLKDYYSRKEEQEV
                     QATLESEEVDLNAGLHGNWTLENAKARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEM
                     TIYIKQLGRRIFAREHGSNKKLAAQSCALSLVRQLYHLGVIEAYSGLTKKKEGERVEP
                     YKVFLSPDLELQLQNVVQELDLEIVPPPVDPSMPVILNIGKLAHFEPSQRQNAVGVVP
                     WSPPQSNWNPWTSSNIDEGPLAYASTEQISMDLKNELTYQMEQDHNLQSVLQERELLP
                     VKKFEAEILEAISSNSVVIIRGATGCGKTTQVPQYILDDFIQNDRAAECNIVVTQPRR
                     ISAVAVAERVAYERGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKLEAGIRGI
                     SHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSATIDTTMFCEYFFNCPIIEV
                     YGRTFPVQEYFLEDCIQMTQFIPPPKDKKKKDKEDDGGEDDDANCNLICGDEYGPETK
                     LSMSQLNEKETPFELIEALLKYIETLNVPGAVLVFLPGWNLIYTMQKHLENNSHFGSH
                     RYQILPLHSQIPREEQRKVFDPVPDGVTKVILSTNIAETSITINDVVYVIDSCKQKVK
                     LFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFDRLETHMTPEMFR
                     TPLHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGR
                     ILAKLPIEPRFGKMMIMGCIFYVGDAVCTISAATCFPEPFISEGKRLGYIHRNFAGNR
                     FSDHVALLSVFQAWDDARMSGEEAEIRFCEQKRLNMATLRMTWEAKVQLKEILINSGF
                     PEDCLLTQVFTNTGPDNNLDVVISLLAFGVYPNVCYHKEKRKILTTEGRNALIHKSSV
                     NCPFSSQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLLLFASKKVQSDGQIVFID
                     DWIRLQISHEAAACITALRAAMEALVVEVSKQPNIISQLDPVNEHMLNTIRQISRPSA
                     AGINLMIGSVRYGDGPRPPKMARYDNGSGYRRGYGGGGYGGGGYGGGYGSGGFGGGFG
                     SGGGFGGGFNSGGGGFGSGGGGFGSGGGGFGGGGGGFSGGGGGGFGGGRGGGGGGFGG
                     SGGFGSGGGGYGVGGGGYGGGGGGGYGGGSGGYGGGGGGYGGGEGYSISPNSYRGNYG
                     GGGGGYRGGSQGGYRNNFGGDYRGSSGDYRGSGGGYRGSGGFQRRGYGGGYFGQGRGG
                     GGGGGY"
     exon            253..393
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            394..511
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            512..627
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            628..776
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            777..823
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            824..960
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1050
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1212
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1290
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1482
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1624
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1707
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1864
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1965
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2179
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2274
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2348
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2501
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2662
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2774
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2936
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3064
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3294
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3410
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            3411..3611
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     exon            3612..4605
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4578..4583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /note="hexamer: AATAGA"
     regulatory      4585..4590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /note="hexamer: AATAAA"
     polyA_site      4600
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
     polyA_site      4605
                     /gene="Dhx9"
                     /gene_synonym="Ddx9; HEL-5; mHEL-5; NDHII; RHA"
                     /note="major polyA site"
ORIGIN      
        1 gccatttcgc cgctgcttcc atgcgggtga ggtgtgttct ttcgccgttc tcgtggaagg
       61 ttggcgctgc gaactcgcct aagaaggctg tgctctcggg cacggaaaag cggaggaggg
      121 tgtgaagaag acacctgaat catgggtgac attaaaaatt ttctgtatgc ctggtgtggc
      181 aaaaggaaga tgactccagc ctatgaaatt agagcagtag gaaacaaaaa cagacagaaa
      241 ttcatgtgtg aggttcgagt agaagggttt aattatgctg gtatgggcaa ttccaccaat
      301 aaaaaggatg cacagagcaa tgctgccaga gactttgtta actatttggt tcgaataaat
      361 gaagtaaaga gtgaagaagt tccagctgtt gggattgtac cacccccacc catacttagc
      421 gacacctctg atagcacagc aagtgctgca gaagggttac cagcaccaat gggaggacca
      481 cttcctcctc atctggctct caaagcagaa gcagaaaata attctggagt tgagtcttct
      541 ggctatggct ctcctggacc tacttgggac cgaggagcca accttaaaga ttactactca
      601 agaaaggaag aacaagaagt acaagcgact ctagagtcag aagaagtgga tttaaatgct
      661 gggcttcatg gaaattggac actggaaaat gctaaggctc gtctgaacca gtatttccaa
      721 aaagaaaaga tccaaggaga atataagtac acccaagtgg gtcccgacca caacaggagc
      781 tttattgcag aaatgaccat ttatatcaag cagcttggca gaaggatttt cgcacgtgaa
      841 catggatcta ataagaaatt agcagcacag tcatgtgccc tctcacttgt ccgacagctc
      901 tatcatcttg gagtgattga ggcttactct gggcttacaa agaagaaaga aggagagaga
      961 gtggagcctt acaaagtttt cctttctcca gatttggagc ttcagctgca aaatgtggtt
     1021 caagagctag atcttgaaat tgtgccccca cctgttgatc cttctatgcc agttatactt
     1081 aacattggga aattggctca ttttgaacca tctcagagac aaaatgcagt gggagtggtt
     1141 ccttggtcac ctccacaatc caactggaat ccttggacaa gtagcaacat tgatgaggga
     1201 ccccttgctt atgcttctac agaacaaata agcatggacc ttaagaatga attaacatac
     1261 cagatggaac aagatcataa tttacaaagt gtgttacaag agagagagtt gctgcctgtg
     1321 aagaaatttg aagctgaaat tctggaagcc attagttcaa attcagttgt gattatccga
     1381 ggggctactg gttgtggtaa aaccacacaa gttccacagt acattttgga tgactttatc
     1441 cagaatgaca gagcagccga atgcaatatt gttgtgacac agcccagaag gatcagtgca
     1501 gttgcagtgg cagagcgagt tgcttatgag agaggagaag agcctggaaa aagctgtggt
     1561 tacagtgttc gatttgagtc tatacttcca cgccctcatg ccagtataat gttttgtact
     1621 gtaggtgtgc ttctaagaaa actagaagcc ggcattcgag gaatcagtca tgttattgtg
     1681 gatgaaattc atgaaagaga tattaatact gacttccttt tggtagtact gcgtgatgtg
     1741 gttttggctt atcctgaagt ccgtattgtt cttatgtctg caactattga taccaccatg
     1801 ttctgtgaat atttcttcaa ttgccccatc attgaggttt atggaaggac tttcccagtt
     1861 caagagtatt ttctggaaga ctgcattcag atgactcaat tcattcctcc tccaaaggac
     1921 aagaaaaaga aggataagga ggatgatggt ggtgaagatg atgatgcaaa ttgcaaccta
     1981 atatgtggtg acgaatatgg gccagaaaca aagttgagca tgtctcagtt gaatgaaaag
     2041 gaaactcctt ttgaacttat tgaggcgctt cttaaataca ttgaaaccct taatgttcct
     2101 ggagctgtgt tggtattttt acctggctgg aacttgattt atactatgca aaagcattta
     2161 gaaaataatt cgcatttcgg aagtcaccgg tatcagattc tacctctcca ttctcagatt
     2221 cctcgtgagg aacagcgcaa agtgtttgat ccagtaccag atggagtaac caaggttatt
     2281 ttgtccacaa acattgctga aacaagcatt accataaatg atgttgttta cgtcattgac
     2341 tcctgcaaac aaaaagtgaa actatttact gctcacaaca atatgaccaa ctatgctact
     2401 gtatgggcat caaaaacaaa ccttgagcag aggaaagggc gagctggccg tgtacgacct
     2461 gggttctgtt tccacctttg tagtcgagct cgttttgaca gactagagac ccacatgaca
     2521 ccagagatgt ttagaacacc attgcatgaa attgctctga gcataaaact tctgcgtcta
     2581 ggaggaattg gccaattcct tgcaaaggca atcgaacctc cacctttgga tgctgtaatt
     2641 gaagcagagc atactctaag agaacttgat gctttagatg ccaatgatga gttgactcct
     2701 cttggacgaa tcctggctaa actccccatt gaacctcgtt ttggaaaaat gatgataatg
     2761 gggtgtattt tctatgtggg agatgctgtc tgtaccatct ctgctgctac ctgcttccca
     2821 gaacccttta tcagcgaagg aaaacgcctg ggatacatac accggaattt tgctggaaac
     2881 agattttctg atcacgtggc tcttttatca gtattccaag cctgggatga tgctaggatg
     2941 agtggagaag aagcagaaat acgtttttgt gagcagaaga gactcaatat ggctacactg
     3001 agaatgactt gggaggccaa agtacagctt aaagagattc tgattaactc tggatttccc
     3061 gaagattgtt tattgacaca agtgtttact aacactggac cagataataa tttggatgtt
     3121 gttatctctc tgctggcttt tggtgtgtac cccaatgtat gctatcataa ggagaagaga
     3181 aagattctta ccactgaagg gcgcaatgca cttatccaca agtcatctgt gaactgtcct
     3241 ttcagcagcc aagacatgaa gtacccatct cctttctttg tttttggtga aaagattaga
     3301 acccgagcca tctctgctaa aggcatgacc ttagtgaccc ccttacagct acttctcttt
     3361 gcctccaaga aagtccagtc ggatgggcag attgtgttta tagatgactg gatcagactg
     3421 caaatatctc atgaagctgc agcatgcatc acagccctcc gggcagccat ggaagctctg
     3481 gttgttgaag tgtccaaaca accaaatatt atcagccaat tggaccctgt aaatgaacat
     3541 atgctaaaca caatccgaca gatttctagg ccctcagctg ctggtatcaa ccttatgatt
     3601 ggaagtgtaa ggtacggcga tggtccacga cctcccaaga tggcccgata tgataatgga
     3661 agtggatata gaaggggata tggtggggga ggatatggtg gcggaggata tggtggcgga
     3721 tacggtagtg gaggctttgg aggaggcttt ggaagtgggg gaggctttgg aggaggcttt
     3781 aacagcggtg ggggaggctt tggtagtggt gggggaggct ttggcagtgg tggaggtgga
     3841 tttggtggtg gtggaggagg cttcagtggt ggaggaggtg gtggatttgg tggtggcaga
     3901 ggaggtggag gtggcggatt tgggggtagt gggggctttg gaagtggtgg gggagggtat
     3961 ggtgttggag gtggtggcta tggaggaggt ggtggtggtg gctatggagg aggcagtgga
     4021 ggatatggag gtgggggagg gggttatggt ggtggggaag gttatagtat aagccccaac
     4081 tcttaccgtg ggaattatgg tggtggcggg ggagggtata gaggaggttc ccaaggaggc
     4141 tacagaaaca actttggtgg agactacaga gggtccagtg gagactaccg gggatccggt
     4201 gggggctata gaggatctgg aggattccag cgaaggggtt atggaggtgg ttattttgga
     4261 caaggaagag gaggaggggg tggtggtggc tattaagact ggactctgtc ggagcctgtg
     4321 catacagttg aaaaatgcat gctgtatgtt tttccaagat gtttatttgc accaaaaaag
     4381 taaacccatt tcccacttaa tctgtagttc atgtgtagtt tcaagcaaca aatgtagact
     4441 agtgattttg ttttatattg tgtaatgtaa aatatgacct gttatacaag tatcatacat
     4501 acagtttgta tttttttttc ttgaaggggt aaaggtttgc cttttaactt aacttgacat
     4561 tttcttggtt ttcatttaat agaaaataaa gtattatact gaaaa
//
