LOCUS       NM_144831               4344 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus DEAH-box helicase 8 (Dhx8), mRNA.
ACCESSION   NM_144831 XM_484084
VERSION     NM_144831.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4344)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4344)
  AUTHORS   Hage,A., Bharaj,P., van Tol,S., Giraldo,M.I., Gonzalez-Orozco,M.,
            Valerdi,K.M., Warren,A.N., Aguilera-Aguirre,L., Xie,X., Widen,S.G.,
            Moulton,H.M., Lee,B., Johnson,J.R., Krogan,N.J., Garcia-Sastre,A.,
            Shi,P.Y., Freiberg,A.N. and Rajsbaum,R.
  TITLE     The RNA helicase DHX16 recognizes specific viral RNA to trigger
            RIG-I-dependent innate antiviral immunity
  JOURNAL   Cell Rep 38 (10), 110434 (2022)
   PUBMED   35263596
REFERENCE   3  (bases 1 to 4344)
  AUTHORS   Gee,S., Krauss,S.W., Miller,E., Aoyagi,K., Arenas,J. and
            Conboy,J.G.
  TITLE     Cloning of mDEAH9, a putative RNA helicase and mammalian homologue
            of Saccharomyces cerevisiae splicing factor Prp43
  JOURNAL   Proc Natl Acad Sci U S A 94 (22), 11803-11807 (1997)
   PUBMED   9342318
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB654249.1 and BC065064.1.
            
            On or before Dec 20, 2004 this sequence version replaced
            XM_484084.1, NM_144831.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065064.1, AK220485.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                BB654249.1         2-72
            72-4344             BC065064.1         1-4273
FEATURES             Location/Qualifiers
     source          1..4344
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.48 cM"
     gene            1..4344
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /note="DEAH-box helicase 8"
                     /db_xref="GeneID:217207"
                     /db_xref="MGI:MGI:1306823"
     exon            1..233
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..3820
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /EC_number="3.6.4.13"
                     /note="DEAD (aspartate-glutamate-alanine-aspartate) box
                     polypeptide 8; DEAH (Asp-Glu-Ala-His) box polypeptide 8;
                     DEAH box protein 8; RNA helicase"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DHX8"
                     /protein_id="NP_659080.2"
                     /db_xref="CCDS:CCDS25479.1"
                     /db_xref="GeneID:217207"
                     /db_xref="MGI:MGI:1306823"
                     /translation="MAVAVAAAGVLMGSEPGPAEELAKLEYLSLVSKVCTELDNHLGI
                     NDKDLAEFVISLAEKNTTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSK
                     DPVVKPKTEKEKLRELFPVLCQPDNPSARTMLDEEDVKVAVDVLKELEALMPSAAGQE
                     KQRDPEHRDRTKKKKRSRSRDRDRDRDRDRDRDRDRDRDRDKDRERDRDRERDRERDR
                     ERDHKRRHRSRSRSHSRTRERTKGKSRYRSRSRSQSPFKDRKDREKYGERNLDRWRDK
                     HVDRPPPEEPAIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVA
                     DVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNEETSMRNPD
                     RPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGIL
                     PKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAK
                     ERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHA
                     FGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ
                     YLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVI
                     KYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVT
                     SATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPG
                     DILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGS
                     RKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGR
                     AGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDA
                     PPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEML
                     TIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYE
                     NFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQE
                     GYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAF
                     FKVSDPTKLSKQKKQQRLEPLYNRYEEPNAWRISRAFRRR"
     exon            234..319
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            320..392
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            393..478
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            479..588
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            589..1020
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1165
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1369
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1457
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1555
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1703
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1885
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2080
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2266
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2477
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2659
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2800
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2956
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3094
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3223
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3420
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            3421..3600
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     exon            3601..4319
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4319
                     /gene="Dhx8"
                     /gene_synonym="Ddx8; mDEAH6; mKIAA4096"
                     /note="major polyA site"
ORIGIN      
        1 aaaagagacg agcgccgacc cggaagtgga agctgtggct tcgcgttctg gccggccgga
       61 aggagaccaa agggaagttg tagccatggc tgtagccgtg gccgccgccg gggtcctaat
      121 gggctcggag cccggcccgg cggaagaact cgctaaactt gagtacctgt ctttggtgtc
      181 gaaggtttgc acggagctgg acaatcactt gggcatcaac gacaaggatc tggctgaatt
      241 tgtcatcagt cttgctgaga aaaatactac ctttgatact tttaaggctt ctctggtcaa
      301 aaatggtgca gaattcacag attctcttat tagcaacctc ctgcgtctca tacagaccat
      361 gcggcctcct gcaaagcctt ctaccagtaa agatccggtt gttaaaccca aaaccgaaaa
      421 agaaaagctg agggaactct tccccgtcct ctgccagccg gacaaccctt cagctcggac
      481 catgttggat gaggaagatg tgaaagtcgc tgtggacgtc ttgaaagagc tggaagcttt
      541 aatgcccagc gcagcaggcc aagagaaaca aagagaccct gagcacaggg acaggacaaa
      601 gaagaagaag aggagtcgga gccgagaccg agatcgagac cgagaccgag accgggaccg
      661 ggaccgggac cgggacaggg accgtgacaa ggaccgagaa cgagatagag atcgagaacg
      721 agacagagag cgagatagag agagagacca taagcggaga caccgatcac gctctcggtc
      781 acattctaga acccgggaga ggactaaggg gaaatctaga tacagatcta ggagcagaag
      841 tcagagtccc ttcaaagatc ggaaagaccg agaaaagtat ggggagagga acttggacag
      901 atggcgggat aagcatgtgg accgccctcc cccggaagag cctgccattg gagatattta
      961 caatggcaaa gtgaccagta tcatgcagtt cggttgcttt gtgcagctgg aaggcctaag
     1021 gaagcggtgg gaaggcctgg tgcacatctc tgagctccga cgggaaggtc gagtggccaa
     1081 tgtggctgat gttgtgagta aaggccagag agtcaaggtc aaagttctgt ccttcactgg
     1141 aaccaagacc agcctgagca tgaaggatgt ggaccaagag acaggagaag acctaaaccc
     1201 aaacagacgg agaaatctgg ttggcgagac caatgaagag acgtcaatgc ggaacccaga
     1261 cagacccact cacctctccc ttgtcagcgc tcctgaagta gaggatgact cgctggagcg
     1321 caagcggctc acccgaatct ctgacccaga gaagtgggag atcaaacaga tgattgctgc
     1381 caatgtgctt tccaaagaag agtttccaga cttcgacgaa gagactggca ttctccccaa
     1441 ggtggatgat gaagaagatg aggatcttga aattgaactg gttgaagagg agcctccgtt
     1501 cctgagaggg cataccaagc agagcatgga tatgagcccc atcaaaatcg ttaagaaccc
     1561 agatggctca ctctcccaag cagccatgat gcagagtgcc ctggccaagg aaagacggga
     1621 gctgaagcag gcccagcggg aagcagagat ggattctata cccatggggc tcaacaaaca
     1681 ctgggttgat cccttgcccg atgcggaagg caggcagatc gctgccaaca tgagggggat
     1741 tgggatgatg cccaacgaca ttcctgagtg gaagaagcat gcctttgggg gcaacaaagc
     1801 ttcttatggg aagaagaccc agatgtcaat ccttgagcag agagagagcc tgcccatcta
     1861 caaactgaag gagcagctgg tgcaggctgt gcatgacaat cagatcctaa ttgtaattgg
     1921 agagacaggg tctgggaaga caacacagat cacccagtac ctggcagagg caggctatac
     1981 ttccaggggc aagattgggt gtacccagcc cagaagagtg gcagctatgt ctgtggccaa
     2041 aagagtctca gaagagtttg gttgttgcct tggtcaagag gtgggctaca ccattcgatt
     2101 tgaggattgc accagcccag aaacagtcat caagtacatg acagatggca tgctgctaag
     2161 agagtgcctg attgaccccg atctcactca gtatgccatc attatgttgg atgaagcaca
     2221 cgagaggacc attcacacag atgtgctctt tggattgttg aaaaagacag ttcaaaaacg
     2281 acaagacatg aagctgattg tcacctcagc cacgctggat gcggtgaagt tttctcagta
     2341 cttctatgaa gcacccatct tcacaatccc aggtcgaacc tatccagtgg aaattctgta
     2401 cacaaaggag ccggaaacag actatttgga cgctagcctg atcacggtca tgcagatcca
     2461 tctgacagag ccgccaggtg acatcttggt tttcttgact ggtcaggaag agatcgacac
     2521 tgcttgtgag atcctgtatg aaagaatgaa gtccctggga cctgatgtcc cagagttgat
     2581 catcctccca gtgtactctg cccttccgag tgagatgcag acccgaatct ttgatccagc
     2641 tccccctggt agcagaaagg tggtgattgc caccaacatt gcagaaacat ctctgaccat
     2701 cgacggcatc tactatgtgg ttgaccctgg atttgtgaag cagaaagtgt acaattctaa
     2761 aacagggatc gatcagcttg tggtgacacc tatttctcag gctcaagcaa agcagagagc
     2821 tggccgggct gggagaactg gcccaggaaa gtgttacaga ctgtacacgg agcgtgccta
     2881 ccgcgatgaa atgctgacca ccaatgtacc ggaaatccag agaaccaacc tggccagcac
     2941 agtgctgtcc ctcaaggcca tgggtattaa tgacctgctg tcctttgact tcatggatgc
     3001 cccaccgatg gaaactctga tcacggccat ggagcagctg tatacactgg gggccctgga
     3061 cgacgagggc ctgctcactc gcctgggccg caggatggca gagttccctc tggagccaat
     3121 gctgtgcaaa atgctcatca tgtctgtgca tctgggctgc agcgaagaga tgctaactat
     3181 cgtgtccatg ctgtctgtgc agaacgtctt ctaccgaccc aaggataaac aggcccttgc
     3241 agatcagaag aaagccaaat tccaccagac agaaggggac cacctcaccc tgctggccgt
     3301 atacaactcc tggaagaaca acaaattctc caacccgtgg tgctatgaga attttattca
     3361 ggctcgttcc ctacgccgtg cccaggacat tcggaagcag atgttaggca taatggacag
     3421 gcacaagctg gacgtggtct cctgtggcaa atccacagtc cgagtgcaga aggccatctg
     3481 cagtgggttc ttccggaacg ctgccaagaa ggacccacag gaaggctacc ggactctgat
     3541 agaccagcag gtggtgtata tccacccctc cagtgctctc ttcaacagac agcccgaatg
     3601 ggtggtatac cacgaacttg tgctgaccac aaaggaatac atgcgtgagg tcaccaccat
     3661 cgacccccgg tggcttgtgg agtttgctcc ggctttcttc aaagtttctg acccaaccaa
     3721 gctaagcaag cagaagaaac agcagcgcct ggagcctctg tacaatcggt atgaggagcc
     3781 gaacgcctgg agaatctccc gagccttccg ccggcgctga aagacagctg actacttgcc
     3841 tctcctgtat catggcttcc tgtgactgat gacaagctag tcctgtggtg actgatctta
     3901 aactgagcat tttcgaagcc tgactctctt catagtgtaa gatagaaaca tttaagcagg
     3961 gctttggcca gagcctttaa tcctagcgct tgggatgcag aggccggaag atctctgagt
     4021 tcaagggcag cctggtctac agagcgagtt ccaggacagc cagggccaca cagagaaacc
     4081 ctgtcttgaa aaaagccaca cacacaaaag aacaatcaga taaggtgtgc atcctgggaa
     4141 aggcaaggga catgagtaac tgatgcatgg cagacccaca agggcctgat accccagctc
     4201 tgcttgctga aggaatgaac catgacactc gtgttccatg tcagccccac tctctaccca
     4261 ctccccagcc tctgtactca gatttctacc tcctggaaat atttattttt ttaaggaaaa
     4321 aaaaaaaaaa aaaaaaaaaa aaaa
//
