LOCUS       NM_030150               2427 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DExH-box helicase 58 (Dhx58), mRNA.
ACCESSION   NM_030150
VERSION     NM_030150.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2427)
  AUTHORS   Jia,K.W., Yao,R.Q., Fan,Y.W., Zhang,D.J., Zhou,Y., Wang,M.J.,
            Zhang,L.Y., Dong,Y., Li,Z.X., Wang,S.Y., Wang,M., Li,Y.H.,
            Zhang,L.X., Lei,T., Gui,L.C., Lu,S., Yang,Y.Y., Wang,S.X., Yu,Y.Z.,
            Yao,Y.M. and Hou,J.
  TITLE     Interferon-alpha stimulates DExH-box helicase 58 to prevent
            hepatocyte ferroptosis
  JOURNAL   Mil Med Res 11 (1), 22 (2024)
   PUBMED   38622688
  REMARK    GeneRIF: Interferon-alpha stimulates DExH-box helicase 58 to
            prevent hepatocyte ferroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2427)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2427)
  AUTHORS   Maurano,M., Snyder,J.M., Connelly,C., Henao-Mejia,J., Sidrauski,C.
            and Stetson,D.B.
  TITLE     Protein kinase R and the integrated stress response drive
            immunopathology caused by mutations in the RNA deaminase ADAR1
  JOURNAL   Immunity 54 (9), 1948-1960 (2021)
   PUBMED   34343497
REFERENCE   4  (bases 1 to 2427)
  AUTHORS   Zheng,W., Ranoa,D.R.E., Huang,X., Hou,Y., Yang,K., Poli,E.C.,
            Beckett,M.A., Fu,Y.X. and Weichselbaum,R.R.
  TITLE     RIG-I-Like Receptor LGP2 Is Required for Tumor Control by
            Radiotherapy
  JOURNAL   Cancer Res 80 (24), 5633-5641 (2020)
   PUBMED   33087322
  REMARK    GeneRIF: RIG-I-Like Receptor LGP2 Is Required for Tumor Control by
            Radiotherapy.
REFERENCE   5  (bases 1 to 2427)
  AUTHORS   Stone,A.E.L., Green,R., Wilkins,C., Hemann,E.A. and Gale,M. Jr.
  TITLE     RIG-I-like receptors direct inflammatory macrophage polarization
            against West Nile virus infection
  JOURNAL   Nat Commun 10 (1), 3649 (2019)
   PUBMED   31409781
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2427)
  AUTHORS   Rothenfusser,S., Goutagny,N., DiPerna,G., Gong,M., Monks,B.G.,
            Schoenemeyer,A., Yamamoto,M., Akira,S. and Fitzgerald,K.A.
  TITLE     The RNA helicase Lgp2 inhibits TLR-independent sensing of viral
            replication by retinoic acid-inducible gene-I
  JOURNAL   J Immunol 175 (8), 5260-5268 (2005)
   PUBMED   16210631
  REMARK    GeneRIF: Lgp2 acts as a negative feedback regulator of antiviral
            signaling by sequestering double-stranded RNA from retinoic
            acid-inducible gene-I (RIG-I).
REFERENCE   7  (bases 1 to 2427)
  AUTHORS   Yoneyama,M., Kikuchi,M., Matsumoto,K., Imaizumi,T., Miyagishi,M.,
            Taira,K., Foy,E., Loo,Y.M., Gale,M. Jr., Akira,S., Yonehara,S.,
            Kato,A. and Fujita,T.
  TITLE     Shared and unique functions of the DExD/H-box helicases RIG-I,
            MDA5, and LGP2 in antiviral innate immunity
  JOURNAL   J Immunol 175 (5), 2851-2858 (2005)
   PUBMED   16116171
REFERENCE   8  (bases 1 to 2427)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 2427)
  AUTHORS   Cui,Y., Li,M., Walton,K.D., Sun,K., Hanover,J.A., Furth,P.A. and
            Hennighausen,L.
  TITLE     The Stat3/5 locus encodes novel endoplasmic reticulum and
            helicase-like proteins that are preferentially expressed in normal
            and neoplastic mammary tissue
  JOURNAL   Genomics 78 (3), 129-134 (2001)
   PUBMED   11735219
REFERENCE   10 (bases 1 to 2427)
  AUTHORS   Miyoshi,K., Cui,Y., Riedlinger,G., Robinson,P., Lehoczky,J.,
            Zon,L., Oka,T., Dewar,K. and Hennighausen,L.
  TITLE     Structure of the mouse Stat 3/5 locus: evolution from Drosophila to
            zebrafish to mouse
  JOURNAL   Genomics 71 (2), 150-155 (2001)
   PUBMED   11161808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY727457.1, AF316999.1 and BP766331.1.
            
            On Jul 8, 2005 this sequence version replaced NM_030150.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029209.1, AK153342.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               BY727457.1         1-101
            102-2011            AF316999.1         1-1910
            2012-2410           BP766331.1         21-419              c
            2411-2427           AF316999.1         2310-2326
FEATURES             Location/Qualifiers
     source          1..2427
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.52 cM"
     gene            1..2427
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /note="DExH-box helicase 58"
                     /db_xref="GeneID:80861"
                     /db_xref="MGI:MGI:1931560"
     exon            1..101
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            102..270
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2139
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /EC_number="3.6.4.13"
                     /note="RNA helicase LGP2; probable ATP-dependent RNA
                     helicase DHX58; RLR; protein D11Lgp2; RIG-I-like receptor
                     Lgp2; probable ATP-dependent helicase LGP2; RIG-I-like
                     receptor 3; DEXH (Asp-Glu-X-His) box polypeptide 58"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DHX58"
                     /protein_id="NP_084426.2"
                     /db_xref="CCDS:CCDS25431.1"
                     /db_xref="GeneID:80861"
                     /db_xref="MGI:MGI:1931560"
                     /translation="MELRPYQWEVILPALEGKNIIIWLPTGAGKTRAAAFVAKRHLET
                     VDRGKVVVLVNRVHLVSQHAEEFRRMLDKHWTVTTLSGDMGSRAGFGLMARSHDLLIC
                     TAELLQLALNSSEEDEHVELREFSLIVVDECHHTHKDTVYNTILSRYLEQKLKKAEPL
                     PQVLGLTASPGTGGATKLQGAIDHILQLCANLDTCHIMSPKNCYSQLLMHNPKPCKQY
                     DLCQRRAQDPFGDLIKKLMNQIHQQLEMPDLKQQFGTQMYEQQVVQLCKDAAEAGLQE
                     QRVYALHLRRYNDALFIHDTVRARDALDMLQDFYDRERTTKTQMVRAESWLLKLFDDH
                     KNVLGQLAARGPENPKLEMLERILLKQFGSPGHTRGIIFTRTRQTASSLLLWLRQQPC
                     LQTVGIKPQMLIGAGNTSQSTHMTQKDQQEVIQEFRDGILSLLVATSVAEEGLDIAQC
                     NVVVRYGLLTNEISMVQARGRARAGQSVYSFLATEGSREMKRELTNEALEVLMEKAVA
                     AVQKMDPDEFKAKIRDLQQASLVKRAARAAHREIQQGQFLPEHVQLLCINCMVAVGYG
                     SDLRKVEGTHHVNVNPNFSVYYTTSQNPVVINKVFKDWRPGGTIRCSNCGEVWGFQMI
                     YKSVTLPVLKIGSILLETPRGKIQAKKWSRVPFSIPVFDILQDCTQSLSELSLD"
     exon            271..472
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            473..663
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            664..780
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            781..907
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1099
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1353
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1503
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1665
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1856
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1953
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2412
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2391..2396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /note="hexamer: ATTAAA"
     polyA_site      2412
                     /gene="Dhx58"
                     /gene_synonym="B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3"
                     /note="major polyA site"
ORIGIN      
        1 agtttcattt ctagagctcc agaaacctcc gcagagacca gcctagtctg ctgctattca
       61 tttccaaacc ccatcctaat cctggccagt gcaggctcca gaatggagct gcgaccctac
      121 cagtgggaag tgatcttacc tgctctggag ggcaagaata tcattatatg gctgcccacg
      181 ggtgctggga agacccgggc agctgccttt gtagccaaga ggcatctaga gacggtagac
      241 agaggcaagg tggtggtact ggtcaatagg gtacacctgg tgagccagca cgccgaggag
      301 ttcaggcgca tgctggataa acactggact gtaacaaccc tgagtgggga catgggatcc
      361 cgagctggct ttggcctgat ggctcggagc cacgacctgc tcatctgtac ggcagagttg
      421 ttacagttgg cactcaacag ctctgaggag gatgaacacg tagagctcag agaattctcg
      481 ctgattgtgg tggacgagtg tcaccacacc cacaaggaca ccgtctacaa caccatcttg
      541 agccggtacc tagaacagaa gctgaagaag gcagagcccc tcccccaggt cctgggtctc
      601 acagcctccc caggcactgg aggggccacc aagctccaag gggccattga tcacatccta
      661 cagctttgtg cgaatttgga tacgtgccac atcatgtcgc caaagaattg ctactcccag
      721 ctgctgatgc ataacccaaa gccctgcaag cagtatgacc tctgccaaag gcgcgcacag
      781 gatccttttg gggacttgat aaaaaagctt atgaaccaaa tccaccaaca actagagatg
      841 cctgacttga agcaacaatt tggaacccag atgtatgagc agcaagtggt acagttgtgc
      901 aaggatgcgg cagaggctgg actccaggaa cagcgggtgt atgcgctgca tttgcggcgc
      961 tacaatgatg cgctatttat ccacgatact gtccgtgccc gggacgccct tgacatgttg
     1021 caagattttt acgacagaga acgcaccaca aaaacacaga tggtgcgtgc tgaaagctgg
     1081 ctgctgaagc tgtttgatga ccataaaaat gtgctgggcc agctagcagc tcggggtcct
     1141 gagaacccga agttggagat gctggaaagg atcttactga agcagtttgg gagtcctggc
     1201 cacactcggg gtatcatctt caccagaacc cgtcagactg cttcctccct cctgctctgg
     1261 cttcggcagc agccttgcct acagactgtg ggcatcaagc cgcagatgct gatcggagca
     1321 gggaacacaa gccagagcac acacatgacc cagaaagacc agcaggaagt gatccaggag
     1381 ttcagggatg gtatcctgag ccttctagtg gccacaagtg tggcagagga ggggctggat
     1441 atcgctcagt gcaatgtggt ggtgcgctat gggctcctga ccaatgagat ctccatggtc
     1501 caggcccggg gtcgtgctcg agctggtcag agtgtgtact ccttcctggc tacagagggc
     1561 agtcgggaga tgaagcggga gctaaccaat gaggctctgg aggtgctgat ggagaaggct
     1621 gtggctgctg tacagaagat ggaccctgat gagttcaagg ccaagatccg ggacttgcag
     1681 caagcatctc tagttaagcg ggcagcacgc gcggcccatc gggagatcca gcaggggcag
     1741 ttcctaccgg agcacgtgca acttctctgc atcaactgta tggtggccgt gggctacggg
     1801 agtgacctgc ggaaagtgga gggcacccac cacgtcaatg tgaaccccaa cttctcggtc
     1861 tactatacca cctcccagaa ccctgtggtc attaacaagg tctttaagga ctggagacct
     1921 ggaggaacca tcaggtgcag taactgtggg gaggtctggg gcttccagat gatctacaaa
     1981 tcagtgacct tgccagtgct caaaatcgga agcatactac tggaaacacc tcgagggaag
     2041 atccaggcca aaaagtggtc ccgggtgcct ttctccatac cagtcttcga tatcctgcag
     2101 gactgcacac aaagcctgtc tgagctctcc ctggactgac ccccttgtga ctgcagtacc
     2161 taggtcaaac tgcagggggc aggagagtcc agcaagccat cctccttccc ctggctagca
     2221 ctctggtcag ggtacccctt tattctgctg cagagatctt aaacacattg gatggagttg
     2281 gaagatgaac gcaggagaat tattatgcca tgatgttcta agaactacaa catccctccc
     2341 ttgcccaagc accttgtagg ttttgttttt gtttttgagg ctcttcataa attaaaggtg
     2401 tagtagagaa taaaaaaaaa aaaaaaa
//
