LOCUS       NM_026191               3724 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus DEAH-box helicase 40 (Dhx40), mRNA.
ACCESSION   NM_026191
VERSION     NM_026191.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3724)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3724)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 3724)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3724)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   5  (bases 1 to 3724)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   6  (bases 1 to 3724)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY329362.1, AK010512.1, CF749423.1 and BP771378.1.
            
            On Apr 11, 2007 this sequence version replaced NM_026191.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010512.1, BC058276.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BY329362.1         2-24
            24-2819             AK010512.1         4-2799
            2820-3267           CF749423.1         278-725
            3268-3724           BP771378.1         49-505              c
FEATURES             Location/Qualifiers
     source          1..3724
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.82 cM"
     gene            1..3724
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /note="DEAH-box helicase 40"
                     /db_xref="GeneID:67487"
                     /db_xref="MGI:MGI:1914737"
     exon            1..223
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..2451
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /EC_number="3.6.4.13"
                     /note="DEAH box protein 40; DEAH (Asp-Glu-Ala-His) box
                     polypeptide 40"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DHX40"
                     /protein_id="NP_080467.3"
                     /db_xref="CCDS:CCDS36268.1"
                     /db_xref="GeneID:67487"
                     /db_xref="MGI:MGI:1914737"
                     /translation="MSRFPAVAGRAPRRQEEGERPIELQEERPSAVRIADREEKGCTS
                     QEGGTTPTFPIQKQRKKLIQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMIG
                     VTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILG
                     DPNLSKFSVIILDEAHERTLTTDILFGLLKKLFQDKSPNRKEHLKVVVMSATMELAKL
                     SAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIHLNEMAGDIL
                     VFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPP
                     PPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQ
                     RSGRAGRTASGKCFRIYSKEFWSQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFP
                     YLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIRAASLDCE
                     DLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFATLAVIFEQCKSS
                     GAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPRETFEGPKHEVLRRCLC
                     AGYFKNVARRSVGRTFCTMDGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYAR
                     IVCPIRYEWVRDLLPKLHELNAHDLSSVARREMREDARRKWTNKENVKQLKDGISKEV
                     LKKMQRRNDDKSISDARARFLERKQQRIQDHSDTLKETG"
     exon            224..391
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            392..537
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            538..657
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            658..885
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            886..952
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1084
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1184
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1271
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1454
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1535
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1693
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1808
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1917
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2012
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2082
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2311
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..3724
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2803..2808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /note="hexamer: ATTAAA"
     polyA_site      2824
                     /gene="Dhx40"
                     /gene_synonym="2410016C14Rik; ARG147; DDX40; PAD"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcacgc gcggaagtaa acacccctac gtcatcaggg cgcgtcctcg cctttcccct
       61 cccatctcct cggctccgtg gacgtgttcg cttcttctcc ggaccgggtc tatgtcccgg
      121 tttcccgccg tcgcgggcag ggcgccaagg cggcaggagg aaggcgagcg gccaatagag
      181 ctccaggaag agcggccgtc agctgttcgc atcgctgaca gagaagagaa aggatgcaca
      241 tcacaggagg gaggaacaac tccaacgttt cctattcaga aacaaagaaa aaagctcatt
      301 caagctgtga gggacaactc gttcctcatc gttactggaa atacaggaag tggtaaaaca
      361 actcaactcc ctaaatacct ttatgaagca gggttttcac aacatggtat gattggtgtg
      421 actcagccac gaaaagtagc cgccatatca gttgctcaga gggttgctga ggaaatgaaa
      481 tgcactttgg gatctaaagt aggataccaa gttcgttttg atgattgcag ctccaaggaa
      541 acagcaatca aatacatgac tgatggatgt ttactcaaac atattttggg agatccaaat
      601 cttagcaaat tcagtgtcat tattttggat gaagcccatg aaagaacttt aactacagat
      661 atcttatttg gtttactgaa gaagctgttt caggataagt ctcctaacag gaaagagcat
      721 ttaaaggtgg tagtgatgtc agcaactatg gaactagcca agctctctgc attctttgga
      781 aattgcccca tatttgatat acctggaaga ctctatccag tcagagagaa attctgcaat
      841 ttgatcggac cacgagacag agaaaatact gcatatattc aagcgattgt gaaagtgacc
      901 atggatattc atttgaatga aatggctgga gacatcttag tttttctgac tggccagttt
      961 gagatagaga agagttgcga gctgctcttt cagatggcgg agtctgttga ctatgattat
     1021 gatgtacaag ataccacgct agatggcttg ttgattctgc catgttacgg ctctatgaca
     1081 acagatcaac agaggagaat atttttgcca cctcctcctg gaattagaaa atgtgttata
     1141 tccaccaata tttctgcaac atctttgaca atagatggga tcagatatgt ggtggatgga
     1201 ggctttgtga agcaattaaa tcacaaccca agattagggc tggacatcct ggaggtggtt
     1261 cctatttcaa aaagtgaagc attacaacgc agtggccgtg cgggcaggac cgcctcagga
     1321 aagtgcttta ggatttacag taaagagttt tggagccagt gtatgcctga ccatgtgatc
     1381 ccagagatta agagaactag tttgacatct gtagttctga cattaaagtg ccttgccata
     1441 catgatgtca taaggtttcc atatttggat ccacctaatg agagacttat tttggaagca
     1501 cttaaacaac tttatcagtg tgatgctatt gacaggagtg gccatgtgac aagattggga
     1561 ttatccatgg tggagttccc tctcccccca catctgacgt gtgcagtgat cagggctgct
     1621 tctcttgact gtgaagattt gctgcttcca atagcagcaa tgctatctgt ggaaaatgtc
     1681 ttcatcagac ctgttgatcc agagtaccag aaggaagcag aacagagaca tcgggaattg
     1741 gcagcgaaag ctggaggatt taatgacttt gcaactttag ctgtcatttt tgaacagtgc
     1801 aaatcaagtg gagctccggc ttcgtggtgc cagaagcact ggattcactg gcggtgctta
     1861 ttctctgcat ttcgtgtgga agctcaactt cgggaactga tcaggaaact aaagcagcaa
     1921 agtgatttcc caagagagac ttttgaaggc cctaaacatg aagtactacg aagatgtctt
     1981 tgtgcaggct acttcaaaaa tgttgctcga agatctgttg gcagaacatt ttgcacaatg
     2041 gatgggcgtg gaagtccagt tcatatccat ccttcctcag cacttcatga acaggaaacc
     2101 aaacttgaat ggataatttt tcatgaagta ttagttacca ccaaagtcta tgcaagaatt
     2161 gtgtgcccaa tccgttatga atgggtgaga gacttactac ccaagttgca tgaacttaat
     2221 gcgcatgatt tgagcagtgt ggctagacgt gaaatgagag aagatgcaag aagaaaatgg
     2281 acaaataagg aaaatgtgaa acagctaaag gatggaatat caaaagaagt tctaaagaaa
     2341 atgcaaagaa gaaatgatga caaatccata tcagatgcac gggctcgctt ccttgagaga
     2401 aagcaacaga gaatccagga ccacagtgac acattaaagg aaactggcta agcagtggac
     2461 tatccaattc aggaagcagg aaagcagcca ggaaatgtgc ttctgttttg ccagttattt
     2521 ccgacagtac tatcagaagg aagtggtcag cagctgttcc tagcctgtga gccgaaagca
     2581 aatcagaatt tataaatcac atctcatcaa tactaacaaa tgacattttg aaaggaaaga
     2641 ttgggttgca tagtcatagt acatgaatcc aatcaaagat gatacaatat ttccctcact
     2701 tctgttttgc tggccttaac tggtatcaaa cagtgtcact gagatatttt caaagaacac
     2761 tgaattgtat ttaatcagcg tgtattccat ttgcattgaa gcattaaaga ttattttcct
     2821 taaatctctt caaggccttc ttattgctgt tagaatagtg ttgtatcagg tatgtgacca
     2881 tttcagaagg ctgaacttac atagaggttt tactcagcaa tacttagatg tctaacagtt
     2941 taattgctcc agagctttat aggtatttaa agactgatta gtaaataaaa ttgcctatgg
     3001 caggactttc ttaaattaat cctactcctt aaagtgattt ttttgggatt atacaaattc
     3061 ctttttatat aaaagtatat tgtttaaaac agtagctata gccattaacc aaaggacaga
     3121 tgtgtatatg tgtgtgtgtg tatgtgtgtg tatgtatatg atacataata tcacacacac
     3181 acaaagttct ttttagctat tcctacatac ttgtgtgtca gcccatgtat gtaggtgtga
     3241 ccgatttcaa gcagcccctc cacctggcct ttctctctct ctctctgtct ctgtctctct
     3301 gtctctgtct ctctctctct ctctcccctc tccctctctc cctctctccc tctctccctc
     3361 tctccctctc tccctctctc cctctctctc tctcctgcac ctgcttgagt aggaccattt
     3421 aaacacctat tatgctattc ttgagatggg atttttcaaa gcggccaaca cttcactaat
     3481 gtttcaaatc aaaaccttga ggctaatatt acactcaggc cacactcagc acttgcctcc
     3541 tcttgtttac tgccttgtat tgtagttatg tgtgtatatg tctgtctttc tcattagatt
     3601 atacgctcct tgtgggcagg gtctgtcttt ttcacctttg tacctttcat ggcatctagc
     3661 atagtgcttt gcacatagtc gtcactcagt gtttgttaat aaagctacta gtgtcattaa
     3721 aact
//
