LOCUS       NM_178380               4475 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus DEAH-box helicase 38 (Dhx38), transcript variant 1,
            mRNA.
ACCESSION   NM_178380
VERSION     NM_178380.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4475)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4475)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI503007.1, BC046557.1 and AC125162.4.
            
            On Oct 24, 2017 this sequence version replaced NM_178380.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046557.1, AK153917.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AI503007.1         1-260
            261-4450            BC046557.1         1-4190
            4451-4475           AC125162.4         56482-56506         c
FEATURES             Location/Qualifiers
     source          1..4475
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6J x DBA/2J F1"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.09 cM"
     gene            1..4475
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /note="DEAH-box helicase 38"
                     /db_xref="GeneID:64340"
                     /db_xref="MGI:MGI:1927617"
     exon            1..371
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            372..711
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     CDS             389..4075
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /EC_number="3.6.4.13"
                     /note="pre-mRNA splicing factor 16; DEAD/H
                     (Asp-Glu-Ala-Asp/His) box polypeptide 38; DEAH
                     (Asp-Glu-Ala-His) box polypeptide 38"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor ATP-dependent RNA
                     helicase PRP16"
                     /protein_id="NP_848467.1"
                     /db_xref="CCDS:CCDS22652.1"
                     /db_xref="GeneID:64340"
                     /db_xref="MGI:MGI:1927617"
                     /translation="MEDPGEDTSIHRLEGTSLDSQVGGLICKTKSAANEQHVFKAPAP
                     RPSLLGLDLLASLKRREREEKDDGEDKKKSRVSSYKDWEESKDDQKDAEEESEDQAGR
                     SSRRDRHYRSARVETPSHPGGVSEEFWERSRQRERDRREHGVYASSKEEKDRKKERSR
                     DRDYDRKRDRADERDRSRHSSRSDRDGGSERSSRRNEPESPRHRPKDAATPSRSAWEE
                     DDSGYGSSRRSQWETPSPTPSYRDSERGHRPSTRDRDRSIRSKSSDDTPLPTPSYKYN
                     EWADDRRHLGSTPRLSRGRGRREDGEEGIAFDTEEERQQWEDDQRQADRDWYMMDEGY
                     DEFHNPLAYSSEDYVRRREQHLHKQKQKRISAQRRQINEDNERWETNRMLTSGVVHRL
                     EVDEDFEEDNAAKVHLMVHNLVPPFLDGRIVFTKQPEPVIPVKDATSDLAIIARKGSQ
                     TVRKHREQKERRKAQHKHWELAGTKLGDIMGVKKEEEPDKAMTEDGKVDYRTEQKFAD
                     HMKEKSEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNSIVIVVGETGSGKTTQL
                     TQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIRFEDCTSENT
                     LIKYMTDGILLRESLREADLDHYSAVIMDEAHERSLNTDVLFGLLREVVARRSDLKLI
                     VTSATMDAEKFAAFFGNVPIFHIPGRTFPVDILFSKTPQEDYVEAAVKQSLQVHLSGA
                     PGDILIFMPGQEDIEVTSDQIVEHLEELENAPALAVLPIYSQLPSDLQAKIFQKAPDG
                     VRKCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSG
                     RAGRTGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLLKSLGVQDLLQFHFMD
                     PPPEDNMLNSMYQLWILGALDNTGGLTSTGRLMVEFPLDPALSKMLIVSCDMGCSSEI
                     LLIVSMLSVPAIFYRPKGREEESDQIREKFAVPESDHLTYLNVYLQWKNNNYSTIWCN
                     DHFIHAKAMRKVREVRAQLKDIMVQQRMSLASCGTDWDIVRKCICAAYFHQAAKLKGI
                     GEYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHELVMTTKEYMQCVTAVDGEWLAELG
                     PMFYSVKQAGKSRQENRRRAKEEASAMEEEMALAEEQLRARRQEQEKRSPLGSVRSTK
                     IYTPGRKEQGEPMTPRRTPARFGL"
     exon            712..899
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1007
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1155
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1274
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1351
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1507
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1669
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1777
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1890
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2028
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2215
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2401
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2542
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2653
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2770
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2878
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..2991
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            2992..3200
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3355
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3511
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3646
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..3772
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3868
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            3869..3990
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     exon            3991..4475
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4444..4449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /note="hexamer: AATATA"
     polyA_site      4463
                     /gene="Dhx38"
                     /gene_synonym="5730550P09Rik; Ddx38; KIAA0224; Prp16"
                     /note="major polyA site"
ORIGIN      
        1 tcatttccgc ccttagtaaa catggccggt ctcgtgttgt cctcccttgc acacccccga
       61 gccagaggcg gggtgttgac tcttacgcca agcgcgattg gtcgcaagga gactctgaac
      121 ccagaggaag agactgaggc tcggaaggcc tgttcgcggg gttgcactct ggcgtcccgg
      181 aaccctggat ttgtgggctg ctctcgatgg tctttttgga cggatagaag gctccgcgca
      241 gggcattatg ggacgatgat ggccgctttc aaacagcgga atttgcctct ttgagaccct
      301 cggatcgagc ggtggccgcg ctggcgtctc cagatcagga accgaaggcc tcgagagtcg
      361 tgcttggtga gagaaataag agcctgtgat ggaggaccct ggtgaggata cctccatcca
      421 tcgcttggaa ggcaccagtt tggactctca ggttggtggt cttatttgca agaccaaaag
      481 tgcagccaat gagcagcatg tcttcaaagc ccctgctccc cgcccttcac tgctggggct
      541 ggacttactg gcgtccctga aacggaggga gcgagaggag aaggatgatg gggaggacaa
      601 gaaaaagtcc agagtctctt cttacaaaga ctgggaggag agtaaggatg accagaagga
      661 tgccgaggag gagagcgagg accaggctgg ccgaagtagc cggagagaca ggcattaccg
      721 atctgctcgg gtagagactc cgtcccaccc cgggggtgtg agtgaagagt tttgggaacg
      781 cagtaggcag agagagcggg atcggaggga gcacggggtc tatgcctcat ctaaagaaga
      841 aaaggatcgg aagaaggaga gatcccggga tcgagactat gaccgcaaga gagacagagc
      901 agatgagcgg gacagaagta ggcacagcag cagatcagac cgagacggag gctccgagcg
      961 cagcagcaga agaaatgaac ctgagagtcc tcgacatcgg cccaaagatg cagccacccc
     1021 ttcgaggtcc gcctgggagg aggacgacag tggctatggc tcttcaaggc gctctcagtg
     1081 ggaaacaccc tccccaacac cttcctatcg ggactctgag cgaggtcatc ggccgtccac
     1141 tcgggatcga gacaggtcta taaggagcaa gtcttcagat gacacacctc tgccgacccc
     1201 ctcctataag tacaatgaat gggctgatga tagaagacac ttggggtcta ccccacgtct
     1261 gtccaggggc cgaggcagac gtgaggatgg cgaagaaggg attgcgtttg acacagagga
     1321 ggagcggcag cagtgggagg atgaccagag gcaagcagac cgggactggt acatgatgga
     1381 tgagggctac gatgagttcc acaaccctct ggcctactcg tctgaggact acgtgaggcg
     1441 gcgggagcag cacctgcaca aacagaagca gaagcgcatt tcagcgcagc gcaggcaaat
     1501 caacgaggac aatgagcgct gggagacaaa ccgaatgctc accagtgggg tggtccatcg
     1561 gctggaggtg gacgaggact ttgaagagga caatgcggcc aaggtgcatc tgatggtgca
     1621 caacctggtg cctccctttc tggatgggcg catcgttttc accaagcagc cggagcctgt
     1681 gatcccagtg aaggatgcca cctctgacct ggccattatt gctcggaaag gcagccagac
     1741 ggtccgcaag cacagggaac agaaagaacg gagaaaggct cagcacaaac actgggaact
     1801 ggcagggacc aaactaggag acataatggg tgtcaaaaaa gaagaggagc cggataaagc
     1861 tatgacagaa gacgggaaag tggactacag gacggagcag aagtttgcag atcacatgaa
     1921 ggagaaaagc gaggccagca gtgagtttgc caagaagaag tcgatcctgg agcagaggca
     1981 gtacctgccc atctttgccg tgcagcagga gctgctcacc atcatcagag acaacagcat
     2041 tgtgatcgtg gtcggggaga cagggagtgg caagaccact cagctgaccc agtacttgca
     2101 tgaagatggt tacacggact atgggatgat cgggtgtacc cagccccggc gtgtggctgc
     2161 catgtcagtg gccaagagag tcagtgaaga gatggggggc aaccttggag aagaggtggg
     2221 ctatgccatc cgctttgagg actgcacttc ggaaaacacc ttgatcaagt acatgacgga
     2281 tgggatcctg ctgcgcgagt ccctccggga ggctgacctg gaccactaca gcgccgtcat
     2341 catggatgag gcccacgagc gctccctcaa caccgacgtg ctttttgggc tgctccggga
     2401 ggttgtggct cgacgctcag acctgaagct cattgtcacg tcagctacta tggatgcaga
     2461 aaagtttgct gccttctttg ggaatgtacc cattttccac atccctgggc ggacttttcc
     2521 tgttgacatc ctcttcagca agaccccgca ggaagattac gtggaggccg cggtgaagca
     2581 gtccttgcag gtacacctgt ctggggcccc tggggacatc ctgatcttca tgccaggcca
     2641 agaggacatt gaggtgacat ctgaccagat cgtggagcac ctggaggagc tggagaacgc
     2701 gcctgcgctg gcggtactgc ccatctactc ccagctgccg tctgacctgc aggccaagat
     2761 cttccagaag gctccagatg gtgtccggaa gtgcatcgtc gctaccaaca ttgctgagac
     2821 gtctctgact gttgatggca tcatgtttgt catcgactct ggctactgca agttaaaggt
     2881 cttcaacccc aggattggca tggatgccct gcagatttac cccattagcc aggccaatgc
     2941 caaccagagg tcagggagag ctggcaggac gggcccaggt cagtgtttca ggctctacac
     3001 gcagagcgct tacaagaacg aactgctgac caccaccgtg cccgagatcc agaggaccaa
     3061 cctagccaat gtggtgctgc tgctcaagtc cctgggcgtg caggacctgc tgcagttcca
     3121 cttcatggac ccgccccccg aggacaacat gctcaactcc atgtaccagc tctggatcct
     3181 cggagccctg gacaacacag gtggtctcac gtccacaggg cggctgatgg tggagttccc
     3241 actggacccg gccctctcta agatgctcat cgtgtcctgt gacatgggct gcagctccga
     3301 gatcctgctc atcgtctcca tgctctcggt ccccgccatc ttctacaggc ccaagggcag
     3361 agaagaggag agcgatcaaa tccgggagaa gtttgctgtc cccgaaagtg accacctgac
     3421 ctacctgaat gtctacctgc agtggaagaa caacaattac tccaccatct ggtgcaatga
     3481 ccacttcatc cacgccaagg ccatgcggaa ggttcgggag gtacgggccc agcttaagga
     3541 tattatggtg cagcagcgga tgagcctggc ctcatgtggc accgactggg acattgtcag
     3601 gaagtgtatc tgtgctgcct atttccacca ggcagccaag ctcaagggga ttggggaata
     3661 tgtgaacatc cgcacaggga tgccctgcca cttacacccc accagctccc tcttcggcat
     3721 gggctacacc cctgactaca ttgtgtatca cgagctggtc atgaccacca aggagtacat
     3781 gcagtgtgtg accgctgtgg atggagagtg gctggccgag ttaggcccca tgttctacag
     3841 tgtgaagcag gcaggcaaat ctcgccagga gaatcgtcgt cgggctaaag aagaggcctc
     3901 tgccatggaa gaggagatgg ccttggccga ggagcagttg cgtgcccggc gacaggagca
     3961 ggagaagcgc agccccttgg gcagtgtcag gtccacaaag atctacactc caggacggaa
     4021 agagcagggg gagcccatga cgcctcgccg cacgccagcc cgctttggac tgtgagctga
     4081 ggctgtccca ggggaggatg gtggccacgt actaagatct tggctctcca gcccgtgttt
     4141 cctaaggact ccgcagacaa ggctttcacc tgcgtgttca tctgtgggtc atcgaggctg
     4201 gagcagttcc tgctgagtca ggctctgtcc tagagtgggc agtcctgatg cagggctcag
     4261 caggagccta gtgcagggtg aacacgaagc tgcttgagca gcaggaggtg gctggaccat
     4321 cgtacccacg taacctgccc aggacgatgc ctcgctgggg ctgagacttt tttaatcctt
     4381 gtgtaaagaa gcgagatcga ggcagagaaa cgtaatttgt ccatcacatg gggtttggaa
     4441 ataaatatat tatttgtaca atattattgc atttt
//
