LOCUS       NM_028136               4975 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus DEAH-box helicase 36 (Dhx36), mRNA.
ACCESSION   NM_028136
VERSION     NM_028136.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4975)
  AUTHORS   Zhang,K., Zhang,T., Zhang,Y., Yuan,J., Tang,X., Zhang,C., Yin,Q.,
            Zhang,Y. and Tong,M.H.
  TITLE     DNA/RNA helicase DHX36 is required for late stages of
            spermatogenesis
  JOURNAL   J Mol Cell Biol 14 (11) (2023)
   PUBMED   36484653
  REMARK    GeneRIF: DNA/RNA helicase DHX36 is required for late stages of
            spermatogenesis.
REFERENCE   2  (bases 1 to 4975)
  AUTHORS   Chen,X., Xue,G., Zhao,J., Zhang,Y., Zhang,S., Wang,W., Li,Y.,
            Yuan,J., He,L., Chan,C.Y., Liu,Y., Chen,W., Zhao,Y., Hu,P., Sun,H.,
            Kwok,C.K. and Wang,H.
  TITLE     Lockd promotes myoblast proliferation and muscle regeneration via
            binding with DHX36 to facilitate 5' UTR rG4 unwinding and Anp32e
            translation
  JOURNAL   Cell Rep 39 (10), 110927 (2022)
   PUBMED   35675771
  REMARK    GeneRIF: Lockd promotes myoblast proliferation and muscle
            regeneration via binding with DHX36 to facilitate 5' UTR rG4
            unwinding and Anp32e translation.
REFERENCE   3  (bases 1 to 4975)
  AUTHORS   Huang,X., Zhao,K., Jiang,M., Qiu,D., Zhou,J. and Yang,Z.
  TITLE     The G4 resolvase RHAU regulates ventricular trabeculation and
            compaction through transcriptional and post-transcriptional
            mechanisms
  JOURNAL   J Biol Chem 298 (1), 101449 (2022)
   PUBMED   34838591
  REMARK    GeneRIF: The G4 resolvase RHAU regulates ventricular trabeculation
            and compaction through transcriptional and post-transcriptional
            mechanisms.
REFERENCE   4  (bases 1 to 4975)
  AUTHORS   Chen,X., Yuan,J., Xue,G., Campanario,S., Wang,D., Wang,W., Mou,X.,
            Liew,S.W., Umar,M.I., Isern,J., Zhao,Y., He,L., Li,Y., Mann,C.J.,
            Yu,X., Wang,L., Perdiguero,E., Chen,W., Xue,Y., Nagamine,Y.,
            Kwok,C.K., Sun,H., Munoz-Canoves,P. and Wang,H.
  TITLE     Translational control by DHX36 binding to 5'UTR G-quadruplex is
            essential for muscle stem-cell regenerative functions
  JOURNAL   Nat Commun 12 (1), 5043 (2021)
   PUBMED   34413292
  REMARK    GeneRIF: Translational control by DHX36 binding to 5'UTR
            G-quadruplex is essential for muscle stem-cell regenerative
            functions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4975)
  AUTHORS   Jiang,M., Hu,H., Zhao,K., Di,R., Huang,X., Shi,Y., Yue,Y., Nie,J.,
            Yu,S., Wang,W. and Yang,Z.
  TITLE     The G4 resolvase RHAU modulates mRNA translation and stability to
            sustain postnatal heart function and regeneration
  JOURNAL   J Biol Chem 296, 100080 (2021)
   PUBMED   33199370
REFERENCE   6  (bases 1 to 4975)
  AUTHORS   Kim,H.N., Lee,J.H., Bae,S.C., Ryoo,H.M., Kim,H.H., Ha,H. and
            Lee,Z.H.
  TITLE     Histone deacetylase inhibitor MS-275 stimulates bone formation in
            part by enhancing Dhx36-mediated TNAP transcription
  JOURNAL   J Bone Miner Res 26 (9), 2161-2173 (2011)
   PUBMED   21590736
REFERENCE   7  (bases 1 to 4975)
  AUTHORS   Watanabe,A., Tatematsu,M., Saeki,K., Shibata,S., Shime,H.,
            Yoshimura,A., Obuse,C., Seya,T. and Matsumoto,M.
  TITLE     Raftlin is involved in the nucleocapture complex to induce
            poly(I:C)-mediated TLR3 activation
  JOURNAL   J Biol Chem 286 (12), 10702-10711 (2011)
   PUBMED   21266579
REFERENCE   8  (bases 1 to 4975)
  AUTHORS   Mattar,P., Britz,O., Johannes,C., Nieto,M., Ma,L., Rebeyka,A.,
            Klenin,N., Polleux,F., Guillemot,F. and Schuurmans,C.
  TITLE     A screen for downstream effectors of Neurogenin2 in the embryonic
            neocortex
  JOURNAL   Dev Biol 273 (2), 373-389 (2004)
   PUBMED   15328020
REFERENCE   9  (bases 1 to 4975)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 4975)
  AUTHORS   Fu,J.J., Li,L.Y. and Lu,G.X.
  TITLE     Molecular cloning and characterization of human DDX36 and mouse
            Ddx36 genes, new members of the DEAD/H box superfamily
  JOURNAL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34 (5),
            655-661 (2002)
   PUBMED   12198572
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF448804.1 and AC114424.10.
            
            [WARNING] On Apr 10, 2024 this sequence was replaced by
            NM_028136.3.
            
            On Jun 20, 2009 this sequence version replaced NM_028136.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF448804.1, BC138061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2998              AF448804.1         1-2998
            2999-4975           AC114424.10        114337-116313
FEATURES             Location/Qualifiers
     source          1..4975
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 29.97 cM"
     gene            1..4975
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /note="DEAH-box helicase 36"
                     /db_xref="GeneID:72162"
                     /db_xref="MGI:MGI:1919412"
     exon            1..271
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..3055
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /EC_number="3.6.4.13"
                     /note="probable ATP-dependent RNA helicase DHX36; MLE-like
                     protein 1; DEAH box protein 36; DEAH (Asp-Glu-Ala-His) box
                     polypeptide 36; RNA helicase associated with AU-rich
                     element ARE; DEAD/H box polypeptide 36"
                     /codon_start=1
                     /product="ATP-dependent DNA/RNA helicase DHX36"
                     /protein_id="NP_082412.2"
                     /db_xref="CCDS:CCDS17379.1"
                     /db_xref="GeneID:72162"
                     /db_xref="MGI:MGI:1919412"
                     /translation="MSYDYHQSWSRDGGPRGSGQGSSGGGGGGSRGSGGGGGGRGGRG
                     RHPAHLKGREIGLWYAKKQTQKNKEAERQERAVVHMDERREEQIVQLLNSVQAKTDKD
                     SEAQISWFAPEDHGYGTEVSSEKKINSEKKLDNQEKKLLNQEKKTFRITDKSYIDRDS
                     EYLLQENEPNLSLDQHLLEDLQRKKTDPRYIEMQRFRKKLPSYGMQKELVNLINNHQV
                     TVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVATERAES
                     CGNGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNL
                     QSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLE
                     DIIEKIRYVPDQKEHRSQFKRGFMQGHVNRQEKEEKEAIYKERWPAYIKELRTRYSAS
                     TVDVLQMMDDDKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFK
                     SDKFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIK
                     ETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPEI
                     LRTPLEELCLQIKILRLGGIAYFLSRLMDPPSNEAVVLSIKHLMELSALDKQEELTPL
                     GVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKE
                     LAKETRSDHLTVVNAFEGWEEAKRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHL
                     LGAGFVSSRSPKDPKANINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVHTKS
                     DGLVSIHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCLLFFGGDISIQK
                     DKDQEIIAVDEWIVFQSPERIAHLVKGLRKELDSLLQEKIESPHPVDWDDTKSRDCAV
                     LSAILDLIKTQEKATPRNLPPRSQDGYYS"
     exon            272..396
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            397..631
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            632..670
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            671..841
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            842..921
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            922..996
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1163
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1245
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1386
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1489
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1577
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1633
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1698
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1842
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1960
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2059
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2233
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2320
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2404
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2504
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2595
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2716
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2869
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..4975
                     /gene="Dhx36"
                     /gene_synonym="2810407E23Rik; Ddx36; mKIAA1488; RHAU"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccattttca gcggttgagt tttggcagag ctgctagtcg gctccgacaa tgagctacga
       61 ctatcatcag agctggagcc gcgatggggg cccacggggc tccggccagg gctccagcgg
      121 cggcggcggc ggagggagcc ggggctcggg cggcggcgga gggggccgcg gcggccgggg
      181 ccggcatccc gcacacctta agggtcgcga gatcggcctg tggtacgcca agaagcagac
      241 gcagaagaac aaggaggctg agaggcagga gagagctgta gtgcacatgg atgaacgtcg
      301 agaagagcaa attgtgcagc tgctgaattc agtccaagct aagactgaca aagattcaga
      361 agcgcagata tcctggtttg ctcctgagga tcatgggtat ggtactgaag tttcttcaga
      421 gaaaaaaata aactcagaga agaaacttga caaccaggaa aagaaattgc taaaccaaga
      481 aaaaaagaca tttaggatca cagacaaatc atatattgac cgagattctg agtatttatt
      541 gcaagaaaat gagccaaacc taagcttaga tcaacattta ctggaagatt tacaaaggaa
      601 aaaaactgac cctcgatata tagagatgca gcgtttcaga aaaaagctgc cttcatatgg
      661 aatgcagaag gagctggtaa atctaatcaa taaccatcag gtgacagtaa taagtggtga
      721 aactggttgt ggcaaaacca ctcaggttac gcagttcatc ttggataact acatcgaaag
      781 aggaaaaggg tctgcctgca gaatagtgtg tactcagccg agaagaatta gtgccatttc
      841 agtcgctgag agagtggcca cagaaagggc agagtcttgt ggcaatggta atagtactgg
      901 ataccagatt cgtcttcaaa gtcggttgcc aaggaaacaa ggttctatct tatactgcac
      961 aacaggaatc attcttcagt ggctccagtc cgactcacgt ttgtccagtg ttagtcatat
     1021 tgtacttgat gaaattcatg aaaggaatct acagtcggat gttttaatga ctgttattaa
     1081 agatcttctc cattttcgat ctgatctcaa agtaatattg atgagtgcaa ctttgaatgc
     1141 tgagaaattt tcagaatatt ttggtaactg tccaatgata catatacccg ggtttacttt
     1201 tccagttgtg gaatatcttt tggaagatat cattgaaaaa ataagatatg ttccagacca
     1261 aaaagaacat agatcccagt tcaagagggg tttcatgcag ggtcatgtaa atagacaaga
     1321 aaaagaagaa aaagaggcca tctataagga acgctggcca gcgtatataa aggaactgcg
     1381 gacaagatac tctgcaagta ccgtagatgt tttgcaaatg atggatgatg ataaagttga
     1441 tctgaatttg attgctgccc ttattcgata cattgttttg gaagaagagg atggtgcaat
     1501 attggtcttt ctaccaggct gggacaatat cagtactttg catgatctct tgatgtcaca
     1561 agtgatgttt aaatcagata agtttctcat tataccttta cattcactga tgcctaccgt
     1621 caaccagaca caggtattta aaaaaactcc tcccggtgtt cggaaaatag taattgctac
     1681 caacattgca gagactagca tcaccataga tgatgtggtt tatgtaatag atggaggaaa
     1741 aattaaagaa acacactttg acacacagaa caacatcagt accatgtctg ctgagtgggt
     1801 tagtaaagct aatgccaaac agaggaaagg gagagctgga agagttcagc ctggtcattg
     1861 ttatcatctg tataatggtc ttagagcaag tcttctagat gactaccaac taccagaaat
     1921 tttgagaact cctttggaag aactctgttt gcaaataaag atcttgaggc tgggtggaat
     1981 tgcttatttt ctgagtagat taatggatcc accatcaaat gaggcagtgg tgctctccat
     2041 aaaacaccta atggaactga gtgctttgga taagcaagaa gaattaacac ctcttggtgt
     2101 ccatttagcc cgactgcctg ttgagccaca tattggaaaa atgattctct ttggagcttt
     2161 gttctgctgc ttagatccag ttctcaccat tgctgccagt ctcagcttta aagatccctt
     2221 tgtcattcca ttgggaaaag aaaagattgc agatgcaaga agaaaagaac tggcaaagga
     2281 aactagaagt gatcacctga cagttgtgaa tgcatttgag ggctgggaag aagccaaacg
     2341 acgtggtttc aggtatgaaa aggactactg ctgggaatat tttctgtctt cgaacacact
     2401 acagatgctg cataacatga agggacagtt tgctgagcat cttcttggag ctggatttgt
     2461 aagcagtaga agtcccaaag atccaaaagc taatataaat tcagataatg agaagataat
     2521 taaagctgtc atctgtgctg gtttatatcc caaagttgct aaaatccgac taaatttggg
     2581 taaaaagagg aaaatggtaa aagttcacac gaagtctgac ggcctggttt ctattcatcc
     2641 taagtctgtc aacgtggagc agacagactt ccactacaac tggcttatct atcacctgaa
     2701 gatgagaaca agcagtatat acttgtacga ctgtacagaa gtgtcaccat actgcctcct
     2761 gttctttgga ggagatattt ccatccagaa agataaggat caggaaatta ttgctgtaga
     2821 tgagtggatt gtgtttcagt ctccagaaag aattgcccat cttgttaagg gactaagaaa
     2881 ggaactggat agccttctac aagagaagat tgaaagccct catcctgtag actgggacga
     2941 cactaagtca agagactgtg cagtactgtc agctattcta gacttgatca aaactcaaga
     3001 aaaggctact ccaaggaact tgccaccacg gtcacaggac ggatattata gctgacagct
     3061 ttctgtgatg gcctaaaacc tatcctggtg tccataattt ccaatttttt tctttttttt
     3121 agtttttggc aaaatgccaa gccctgggtt atgacttgct tttgtgtgta agttagaaac
     3181 tttcattggg tagtaaagag ttaatgtgca tgactaaaca gtgccatcta gctactataa
     3241 agacattgga aaaagtaata tgctttctga ccttatcctc tgttgtagat atgtccacac
     3301 tttgggagaa ttcccaaagt tgtaacattg agaaattcct ttatgctatt atgcaaaatt
     3361 aattttctgt tcataatgac tgtccagaga caataaaaat agaaagttgg gccaaaaagc
     3421 agtatgaagt aagaatttga atacaaccac attttttaaa aatgaaattc tattattagt
     3481 aaatttgttg taataaagtc cgatatttaa taaaatgtac aatgtataaa tctcagctaa
     3541 cttcttggtt tggtttctag agttctacct atcactgggc tcactcgatt gcttttattt
     3601 gtttgctttt attttttaac tttttaaaag gttcaatacc tacggtcctg ttctgtgtag
     3661 cataatgtag caacagagca tgtgtctgga tgtgatgatg aaggtcctgt ctcagctcat
     3721 caccttttcc ttatttgaaa gacaggtaaa gattgtgagg attaaatatg gtaacatgta
     3781 aaggaccaca gtgtctgatg catatggtct tcacacagtg cttgttacta tttgtccata
     3841 aaatattttt taacctttag taatcaattt taccatttta ttttttgtac taaggacctt
     3901 ggagatggtt aggccaaggg cctcacatac tagatgactg ctatattact gagccacatc
     3961 cccagccctg taaaacacca tttttatgct tctttatgct cttagtggag gtgacaaaca
     4021 aggctgtttt caggcttgtt agctattgtt ttcttcctag ttttggactc ccttcttttt
     4081 ttcctgttgt agtccctacc tctagcttga aggtgttgct tttgttctat ccatgagcca
     4141 gtgattattc tgagataatc aagtttggtc ttctttccct agtaagttgt gagatgacca
     4201 ggacatatgc atagcactgc catggatttg ctgccgatgc tggttcaggt actgctgcca
     4261 tgtctgagta tgtgtcacgt ggcattgtgt acaaagattt ggatgcactg tgtcccttgt
     4321 ttattttttt ggattgtctc accaaaatta tgcttctccc taatcatagt ggtggtgtta
     4381 tggtattgta gcatattagt tttgccccta aagtcaaggt gtgtttacaa gcaagtattt
     4441 agcctccaca gcaaatgcaa aaatgttgtt agaattgttt tttacagaga agcagtacac
     4501 aaaaataagt gatgtcttgc cagcatctgc tgctgtctga catagctaag caagatagag
     4561 ggtggcttgc gggtgctctg aaggttcggc tgcttgttca cagattacga ctcctatctg
     4621 aaaaatgcac tccaagaccc agaatgactt gttctgagtg ctcttaaaaa atagctcatt
     4681 aagaagaaaa agctgtctca catcactctg cacagcacaa aggacaaact ggaaaaaacc
     4741 actgtaacag aaacttatga gatctaccgc tgtttcaaga gcattaggta catgcacatg
     4801 gtaccttcct aattaattga cctggaaaaa gagctgtaat aattttaagt caattaattg
     4861 caaagtgtat ttttctgcat ttgtaaaaca aagtctactc taaaattatt atttggtatc
     4921 tgcacccagg ctaagtaaat ggtggcatat ttccttccat tttcaacact gatct
//
