LOCUS       NM_178367               5179 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DEAH-box helicase 33 (Dhx33), mRNA.
ACCESSION   NM_178367
VERSION     NM_178367.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5179)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5179)
  AUTHORS   Nie,G., Chen,S., Song,Q., Zou,D., Li,M., Tang,X., Deng,Y.,
            Huang,B., Yang,M., Lv,G. and Zhang,Y.
  TITLE     DHX33 mediates p53 to regulate mevalonate pathway gene
            transcription in human cancers
  JOURNAL   Biochim Biophys Acta Gen Subj 1868 (3), 130547 (2024)
   PUBMED   38143011
REFERENCE   3  (bases 1 to 5179)
  AUTHORS   He,X., Zhao,J., Adilijiang,A., Hong,P., Chen,P., Lin,X., Xie,J.,
            Du,Y., Liu,Y., Lin,L., Jin,H.Y., Hong,Y., Liu,W.H. and Xiao,C.
  TITLE     Dhx33 promotes B-cell growth and proliferation by controlling
            activation-induced rRNA upregulation
  JOURNAL   Cell Mol Immunol 20 (3), 277-291 (2023)
   PUBMED   36631557
  REMARK    GeneRIF: Dhx33 promotes B-cell growth and proliferation by
            controlling activation-induced rRNA upregulation.
REFERENCE   4  (bases 1 to 5179)
  AUTHORS   Peng,C., Hou,S.T., Deng,C.X. and Zhang,Y.
  TITLE     Function of DHX33 in promoting Warburg effect via regulation of
            glycolytic genes
  JOURNAL   J Cell Physiol 236 (2), 981-996 (2021)
   PUBMED   32617965
  REMARK    GeneRIF: Function of DHX33 in promoting Warburg effect via
            regulation of glycolytic genes.
REFERENCE   5  (bases 1 to 5179)
  AUTHORS   Wang,X., Feng,W., Peng,C., Chen,S., Ji,H., Zhong,H., Ge,W. and
            Zhang,Y.
  TITLE     Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis
            in vivo
  JOURNAL   Cancer Sci 111 (10), 3564-3575 (2020)
   PUBMED   32767810
  REMARK    GeneRIF: Targeting RNA helicase DHX33 blocks Ras-driven lung
            tumorigenesis in vivo.
REFERENCE   6  (bases 1 to 5179)
  AUTHORS   Liu,Y., Lu,N., Yuan,B., Weng,L., Wang,F., Liu,Y.J. and Zhang,Z.
  TITLE     The interaction between the helicase DHX33 and IPS-1 as a novel
            pathway to sense double-stranded RNA and RNA viruses in myeloid
            dendritic cells
  JOURNAL   Cell Mol Immunol 11 (1), 49-57 (2014)
   PUBMED   24037184
REFERENCE   7  (bases 1 to 5179)
  AUTHORS   Zhang,Y., Saporita,A.J. and Weber,J.D.
  TITLE     P19ARF and RasV(1)(2) offer opposing regulation of DHX33
            translation to dictate tumor cell fate
  JOURNAL   Mol Cell Biol 33 (8), 1594-1607 (2013)
   PUBMED   23401854
  REMARK    GeneRIF: results directly implicate DHX33 as a crucial player in
            establishing rRNA synthesis rates in the face of Ras(V12) or ARF
            signals, adjusting ribosome biogenesis to match the appropriate
            growth or antigrowth signals
REFERENCE   8  (bases 1 to 5179)
  AUTHORS   Zhang,Y., Forys,J.T., Miceli,A.P., Gwinn,A.S. and Weber,J.D.
  TITLE     Identification of DHX33 as a mediator of rRNA synthesis and cell
            growth
  JOURNAL   Mol Cell Biol 31 (23), 4676-4691 (2011)
   PUBMED   21930779
REFERENCE   9  (bases 1 to 5179)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   10 (bases 1 to 5179)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087592.1, BC052172.1 and AL596136.5.
            
            On Jun 23, 2006 this sequence version replaced NM_178367.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027842.1, SRR1660819.69981.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-316               AK087592.1         7-322
            317-2296            BC052172.1         311-2290
            2297-5179           AL596136.5         143308-146190       c
FEATURES             Location/Qualifiers
     source          1..5179
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.21 cM"
     gene            1..5179
                     /gene="Dhx33"
                     /gene_synonym="3110057P17Rik; 9430096J02Rik; Ddx33"
                     /note="DEAH-box helicase 33"
                     /db_xref="GeneID:216877"
                     /db_xref="MGI:MGI:2445102"
     exon            1..316
                     /gene="Dhx33"
                     /gene_synonym="3110057P17Rik; 9430096J02Rik; Ddx33"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2151
                     /gene="Dhx33"
                     /gene_synonym="3110057P17Rik; 9430096J02Rik; Ddx33"
                     /EC_number="3.6.4.13"
                     /note="putative ATP-dependent RNA helicase DHX33; DEAH box
                     protein 33; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide
                     33; DEAH (Asp-Glu-Ala-His) box polypeptide 33"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DHX33"
                     /protein_id="NP_848144.3"
                     /db_xref="CCDS:CCDS24971.1"
                     /db_xref="GeneID:216877"
                     /db_xref="MGI:MGI:2445102"
                     /translation="MPEEASLPPAKRFRPGSCPPGRRVVMLLTAGGGGGAGGGRRQTP
                     PLAQPSASPYREALELQRRSLPIFRARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYL
                     YEGGISRQGIIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFEDVTSEDTRIKF
                     LTDGMLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELGKLPLKV
                     IVMSATMDVDLFSQYFNRAPVLYLEGRQHPIQIFYTKQPQQDYLHAALVSVFQIHQEA
                     PASQDILVFLTGQEEIEAMSKTCRDIARHLPDGCPSMLVLPLYASLPYSQQLRVFQGA
                     PKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQ
                     RTGRAGREDSGICYRLYTEDEFEKFEKMTVPEIQRCNLASVILQLLAMKVPNVLTFDF
                     MSKPSPDHIEAAIAQLDLLGALEHKDDQLTLTPIGRKMAAFPLEPRFAKTILLSSKFH
                     CTEEILTIVSLLSVDSVLYNPPARRDEVQSVRKKFISSEGDHITLLNIYRTFKNIGGN
                     KDWCKENFVNSKNMLLVAEVRAQLREICLKMSMPIMSSRGDMESVRRCMAHSLFMNTA
                     ELQTDGTYATTDTHQPVAIHPSSVLFHCKPACVVYTSLLYTNKCYMRDLCVVDAEWLY
                     EAAPDYFRRKLRTARN"
     exon            317..477
                     /gene="Dhx33"
                     /gene_synonym="3110057P17Rik; 9430096J02Rik; Ddx33"
                     /inference="alignment:Splign:2.1.0"
     exon            478..705
                     /gene="Dhx33"
                     /gene_synonym="3110057P17Rik; 9430096J02Rik; Ddx33"
                     /inference="alignment:Splign:2.1.0"
     exon            706..876
                     /gene="Dhx33"
                     /gene_synonym="3110057P17Rik; 9430096J02Rik; Ddx33"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1062
                     /gene="Dhx33"
                     /gene_synonym="3110057P17Rik; 9430096J02Rik; Ddx33"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1174
                     /gene="Dhx33"
                     /gene_synonym="3110057P17Rik; 9430096J02Rik; Ddx33"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1334
                     /gene="Dhx33"
                     /gene_synonym="3110057P17Rik; 9430096J02Rik; Ddx33"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1423
                     /gene="Dhx33"
                     /gene_synonym="3110057P17Rik; 9430096J02Rik; Ddx33"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1551
                     /gene="Dhx33"
                     /gene_synonym="3110057P17Rik; 9430096J02Rik; Ddx33"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1755
                     /gene="Dhx33"
                     /gene_synonym="3110057P17Rik; 9430096J02Rik; Ddx33"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1842
                     /gene="Dhx33"
                     /gene_synonym="3110057P17Rik; 9430096J02Rik; Ddx33"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..5179
                     /gene="Dhx33"
                     /gene_synonym="3110057P17Rik; 9430096J02Rik; Ddx33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5145..5150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dhx33"
                     /gene_synonym="3110057P17Rik; 9430096J02Rik; Ddx33"
                     /note="hexamer: ATTAAA"
     polyA_site      5167
                     /gene="Dhx33"
                     /gene_synonym="3110057P17Rik; 9430096J02Rik; Ddx33"
                     /note="major polyA site"
ORIGIN      
        1 ccccagccga gcggaactgt ctgcgtccct gcctccggcc gcggtcctcc cgacatgccg
       61 gaggaggcga gcctcccgcc cgctaagaga ttccggccgg gctcctgccc tcccgggaga
      121 cgagtagtga tgctgttgac ggctggcggc ggcggcggag ctggaggagg ccggaggcag
      181 acgccgccgc tggcccagcc ttcggccagt ccctaccgcg aggccctgga gctgcagcgc
      241 cggagtctgc ccatcttccg ggcgcggggg cagctattgg ctcagctccg aaacctggac
      301 aacgcggtcc tcatcgggga aactggctct gggaaaacaa ctcagatccc acagtacctc
      361 tatgaagggg gaattagccg ccagggcatc atcgctgtga cccagccccg tcgagtggct
      421 gccatctctc ttgccaccag agtctcagat gagaagagga cagaactcgg gaagctggtt
      481 ggctatacag tgcgctttga ggatgtcacc tcagaagaca ccaggatcaa gttcctgaca
      541 gatggcatgc ttctgcgtga agcaatttca gactccttgc ttcggaagta cagctgtgtc
      601 attttggacg aggcccatga gcggactatt cacacagatg tgctctttgg agtggtgaag
      661 actgcacaga agaggcgaaa ggagctaggg aaactgcctc tcaaagtgat tgtgatgtca
      721 gctaccatgg atgtcgacct gttttctcag tacttcaata gagcccctgt cctttacctt
      781 gagggtcggc agcatccaat ccagatcttc tataccaaac agcctcagca ggattacctg
      841 catgcagccc ttgtctcagt cttccagatc caccaggaag ctcctgcttc tcaagacatc
      901 ctggtgttcc tcactggtca ggaggagatc gaagcaatga gcaagacctg cagagacatc
      961 gcaaggcacc tcccagatgg ctgcccttca atgctcgtcc ttcctctgta cgcctccctg
     1021 ccctattcgc agcagcttcg agtctttcaa ggggccccaa agggctatcg caaagtgatc
     1081 atttcaacca acatcgctga aacctccata accattacag gaataaaata tgtagttgac
     1141 acgggcatgg ttaaagcaaa gaagtataac cctgacagtg gtcttgaggt actagctgta
     1201 cagagagtat caaagaccca ggcctggcag cgcacaggca gggctgggcg agaggacagt
     1261 ggcatctgct accgactcta cactgaggac gagtttgaga agttcgagaa gatgacggtg
     1321 ccagagatcc agaggtgtaa cctggccagt gtaatacttc agctcctagc aatgaaagtc
     1381 ccaaatgtgc tcacctttga cttcatgtcc aaaccttctc cagatcacat tgaggcggcc
     1441 attgcccagc tggacctgtt aggtgctctt gaacataagg atgaccagct taccctgact
     1501 ccaattggaa gaaagatggc agcattccct ttagagccca gatttgccaa aactatcctc
     1561 ctgtcctcca aattccactg taccgaagag attctgacca tagtctccct gctatctgtg
     1621 gacagtgtcc tttacaaccc tcctgcccgg agagatgagg tgcagagtgt ccggaagaaa
     1681 ttcatatcca gtgaggggga tcacatcacc ctgctcaata tctatcggac cttcaaaaac
     1741 atcggtggga ataaggactg gtgcaaagag aattttgtca acagcaagaa tatgctgcta
     1801 gtagctgaag tcagagcaca gctgagagaa atctgcttaa agatgtcaat gccaatcatg
     1861 tcatctcgag gggacatgga gagtgtccgc cgttgcatgg ctcacagcct ctttatgaat
     1921 actgctgaac tccagacaga tggcacctat gccaccacgg acacacatca gccagtggcc
     1981 atccacccat catctgtcct cttccactgc aagcctgcct gcgtggtcta cacttcactg
     2041 ctctacacca acaaatgcta catgcgtgac ctctgtgtgg tggatgccga gtggctctac
     2101 gaggctgccc ctgactactt caggaggaag ctgagaacgg ccagaaactg aaccgttcca
     2161 ggatgctgcc agcatggctg ggcctggagc ttagatcaca gctgtcttcc aaacataagt
     2221 ttgcagccag acttccagac tccaagagct taaaagaatt gctgaagctt ctcagactca
     2281 cccgtgcaga atgatcctac gtagagcatg agaagctgag cttgtgcctc gggtctcacc
     2341 aggcagtttt ggagactgaa ttaacttctg agcctcagat tcctcatatg ccggagtcgg
     2401 ataagactta cacgttcaga gtaatgaagt ttagagaaaa tgaacagaat gtgacagaga
     2461 cttgcctggt gcaagataag acaatctgtg acttgtgagc cattgtgctt tgtgatacta
     2521 attaggtaca gcacagcccc ttgagctctc atgactgggg gaggagccat aggagactac
     2581 agatccaatt tgttgaaatg tttctccccc cttcttactc cctctcccgt ggatcccaga
     2641 gcctcatgca tgctatgcaa aacactttgc cactgagcca atccccagcc ctcacttcta
     2701 ctttaatgtc tacctgtgtg tattttagat agaaaattaa aaaattgact cccacagaca
     2761 gttccagagt aaggtatatt ctgacctgtt gacccttatg gctcagggtg tagcacattg
     2821 tcttgtctgt ctccaagcag aggccagcaa gtagttcctt ggttggtccc cagtgcctct
     2881 gtggctgcat gtccccaaca gtgctttcag gaaaccagca ggtttcctgg aactaggaag
     2941 ccaacttttc agtgtggtgg ccttctgaag ccccgtggta gttttctctt taactgagca
     3001 cctacaaatg tgtgcctgtg agggaagaga gttcaagtca gagctgctac atggggaaga
     3061 ggaaggaggt acctgacggc tcggaagcca gaggatcagt ttgtcctttc tcctacacct
     3121 agtcttagtt tgggttgttt gttagtttgt tcatttctta aggggtaaac cacttgagac
     3181 agggtttctc tgtgtagccc tgcctgtcct gaaactcgct ctatagacca cactggcctc
     3241 aaacccagag atcagcctgc ctttccctcc caagtgctgg gattgaaggt gtgcaccacc
     3301 acctggccag tctttgtatt tttgatgcta ttaattttca gtggtctgcc tttgcggaaa
     3361 cctggggaca attagctttg ctgcttccta accagtcgcc atctgaaacc ttcgtcgtct
     3421 gcacttgtta gagggaacta gagaagcctc ggcatccttt tcccagttgg aaaagagtca
     3481 tctttgctga tgactaggag caaacattcc ccagtttggt actacttacc tataatcact
     3541 ccccgctgag aagggagggc tgcgagtcct aggccagcct gggctaggcc ttgtatctaa
     3601 gtgaaggaag gggaaggaac acactttcac agagaatgtt tgaagggggg gggagtttta
     3661 gcccttttat tgtgcttaat cggtccaaac acatctgtac tactgggatt ttctcattta
     3721 tacagtgaat tgtatttata agcaacaaat gggccaaact gccttcaagg cacttcgaag
     3781 acagtgggca gtttctttga gtccagcaag ctctttccag agagcctagc ctggctgggc
     3841 acttccattg ccaggatctc attggttcac agctgtgtct gttgagtctg gtctaggctt
     3901 tatctaaccc tagccgtggg caaagctttt agtcagtgct tagggctgtc tgagtactcg
     3961 tgactacttg gatagaaatg gtcacgttat caaccttctg aaaggctctc cggaatgtgc
     4021 tttctttttc agtgtatttt ttgtatttat gcaaggttta tttagccttg cttggtaaga
     4081 ggaacttttg tattttgaaa agaacattca tcgtgctagt taaagaaaac aaggaggcaa
     4141 tatattcccc agcaattaac agtttctgtt ccactgtaaa ctaacagtaa actatcgagg
     4201 tcttttctgg gtcatgggaa cagtagcttg cagtgactgg ctccagggtg aggcctagga
     4261 ccttaccctg gagggactgc tgcagaggac tgggacctcc cagaaaaggg agtgatggat
     4321 acagtttcta aggacccaat gtttctgtat agaaatatgt ttatcattct aacattgtgg
     4381 ggggatttta atagaatatt tagtttttta ttaagctttt ttaaaaatta ctattcaaca
     4441 cagctgctca gggattacat gaggtgggag ccccattctg actccacaga tcactacgaa
     4501 gaaattaatg cttatcttca gccaaaggga cagctctctt caagctttct taagaaagtg
     4561 aaatgttttg tggttttgct gcagtacaac ctgagctact tttcaagttg gcaaactctc
     4621 caacctgaag actccagcct ggacagaata gcctccaaca gacagatgaa cttccacaac
     4681 agccctgcgt gctgcagggg tttatcttct tggtaaccgt ggcctgcgac acccggggca
     4741 ccagttccat taccaggatc cctgtgagaa catttgcatc tcttataaca ggattccaaa
     4801 acagcaaagt atttactgtg gcacaaatcc ttgtgctcca gctaccaggg tctgtttgga
     4861 actgtggccg cgcatctaag atgccattcc ttgagcacat aaactagact ataccggtgg
     4921 ggaaacaatt ctctatagac tgctgtagtg tagaaaactg acaagcggat ttggacatgt
     4981 gctctgttct ctctggtctc aaacataaaa gaacagttct agtatataat gctcgaaatt
     5041 tgcttttgac tatcaaatcc ataaaaactg aatcttgtat aatgatctgt gtggcctctt
     5101 ttgttgggcc tcctttccct tatttaaaga atgctgttta gaatattaaa cattattctt
     5161 actgccattc attcgataa
//
