LOCUS       NM_026987               3405 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus DEAH-box helicase 16 (Dhx16), mRNA.
ACCESSION   NM_026987
VERSION     NM_026987.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3405)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3405)
  AUTHORS   Hage,A., Bharaj,P., van Tol,S., Giraldo,M.I., Gonzalez-Orozco,M.,
            Valerdi,K.M., Warren,A.N., Aguilera-Aguirre,L., Xie,X., Widen,S.G.,
            Moulton,H.M., Lee,B., Johnson,J.R., Krogan,N.J., Garcia-Sastre,A.,
            Shi,P.Y., Freiberg,A.N. and Rajsbaum,R.
  TITLE     The RNA helicase DHX16 recognizes specific viral RNA to trigger
            RIG-I-dependent innate antiviral immunity
  JOURNAL   Cell Rep 38 (10), 110434 (2022)
   PUBMED   35263596
REFERENCE   3  (bases 1 to 3405)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3405)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   5  (bases 1 to 3405)
  AUTHORS   Jolly,R.D., Thompson,K.G. and Winchester,B.G.
  TITLE     Bovine mannosidosis--a model lysosomal storage disease
  JOURNAL   Birth Defects Orig Artic Ser 11 (6), 273-278 (1975)
   PUBMED   100
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ141265.1, BC138205.1, BU054791.1, AK010431.1 and AI853344.1.
            
            On Apr 2, 2009 this sequence version replaced NM_026987.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009147.1, BC138204.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                CJ141265.1         2-62
            62-1272             BC138205.1         1-1211
            1273-1273           BU054791.1         106-106
            1274-2960           BC138205.1         1213-2899
            2961-3343           AK010431.1         579-961
            3344-3405           AI853344.1         1-62                c
FEATURES             Location/Qualifiers
     source          1..3405
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.74 cM"
     gene            1..3405
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /note="DEAH-box helicase 16"
                     /db_xref="GeneID:69192"
                     /db_xref="MGI:MGI:1916442"
     exon            1..341
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..3269
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /EC_number="3.6.4.13"
                     /note="DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16;
                     DEAH (Asp-Glu-Ala-His) box polypeptide 16"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor ATP-dependent RNA
                     helicase DHX16"
                     /protein_id="NP_081263.2"
                     /db_xref="CCDS:CCDS28710.1"
                     /db_xref="GeneID:69192"
                     /db_xref="MGI:MGI:1916442"
                     /translation="MATPAGLERWVQEELHSVLGLSERHVAQFLIGTAQRCASAEEFV
                     QRLRDTDTLDLGGPARDFALKLWSKVPRKAVVEKPARAAEREARALLEKNRSYKLLED
                     SESGEEAVGSNGSSLQKKRKRRKHLRKKHQEDEEDEEEEVSESGKRKAGGSKSPTEEK
                     PASEDEWERTERERLQDLEERDAFAERVRQRDKDRTRNVLERSDKKAYEEAQKRLKMA
                     EEDRKAMVPELRKKSRREYLAKREREKLEDLEAELADEEVLFGDVELSRHERRELKYK
                     RRVRDLAREYRAAGEQEKLEATNRYHMPKETRGQPARTVDIVEEESGAPGEEQRRWEE
                     AQLGAASLKFGARDAAAQEAKYQLVLEEDETIEFVRAAQLQGDEEPSGPPLSAQAQQK
                     ESIQAVRRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTKKGMK
                     IACTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREF
                     LSEPDLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATLDTARFSAF
                     FDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEEI
                     EAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAET
                     SLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRL
                     YTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQ
                     LYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSI
                     FYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRA
                     RDVREQLEGLLERVEVGLTSCQGDYVRVRKAITSGYFYHTARLTRSGYRTVKQQQTVF
                     IHPNSSLFEQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYKAKELEDPHAK
                     KMPKKVGKTREELG"
     exon            342..586
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            587..752
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            753..809
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1064
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1268
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1460
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1571
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1687
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1898
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1997
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2150
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2291
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2454
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2573
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2641
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2804
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2966
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3140
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3392
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3329..3334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /note="hexamer: AATAAA"
     regulatory      3346..3351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /note="hexamer: AATGAA"
     polyA_site      3351
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /note="major polyA site"
     polyA_site      3387
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
     polyA_site      3392
                     /gene="Dhx16"
                     /gene_synonym="2410006N22Rik; DBP2; Ddx16; mKIAA0577"
                     /note="major polyA site"
ORIGIN      
        1 ctctttccgg gtttcgcggt ctgtggaatt ggagtctcta cggcagccgg agcgaggcgg
       61 tagtaccgca ggctctgtcc ccgccgcagt cctggccgtt ccgcggttgc gcgcccggag
      121 caggacgcgt cgccatggcg acgccggcgg ggctggagcg gtgggtgcag gaggagctgc
      181 actcggtgct ggggctgagc gagcggcacg tcgcgcagtt cctgatcggc accgcacagc
      241 gctgcgcctc cgccgaggag ttcgtgcagc gcctgcggga caccgacacc ctggacctcg
      301 gggggccggc gcgggacttc gccctgaagc tctggagcaa ggtgccacgg aaggctgtgg
      361 tggaaaagcc agctcgggca gctgagcgag aggcccgagc cctgctagag aaaaaccgtt
      421 cttataagtt gttggaagac agcgagagcg gcgaggaggc agtgggtagt aacgggagca
      481 gcctccagaa gaagcggaag agacggaaac acctcaggaa gaaacaccag gaggacgagg
      541 aggacgagga ggaagaggtt tccgagtcag ggaagaggaa ggcagggggg agtaaatcac
      601 ccacggagga gaagccagcc tcagaggatg aatgggaaag gacggagcgt gagcgtctcc
      661 aggacttgga agaacgggat gcctttgcag agcgggttcg gcaacgggac aaggaccgga
      721 cccggaatgt cctggaacgg tcagataaga aggcctatga agaggctcag aagcgcctca
      781 agatggctga ggaagatcgg aaagccatgg tccctgagct ccgtaagaag tctcgtcggg
      841 aatacctggc gaagcgggag cgagaaaaac tggaggacct ggaggcggaa ctggctgatg
      901 aggaggtcct gtttggggac gtggagctga gtcgccatga gcgcagggag ctcaagtaca
      961 agcgacgtgt gcgggacctg gctcgggagt accgggcagc cggagagcag gagaagctgg
     1021 aggccactaa tcgctaccac atgcccaagg agacccgagg gcagccagct cgaactgtgg
     1081 acatcgttga ggaggaatcg ggtgcgccgg gagaggagca gcggcgctgg gaggaggccc
     1141 agctgggtgc tgcatccctg aagtttggag cccgagatgc tgctgcgcag gaggccaagt
     1201 accagctggt gctggaggag gacgagacca tcgagtttgt ccgtgctgct caactccagg
     1261 gtgacgagga gccgtcaggc ccgcccctgt cagcccaggc ccagcagaag gaatctatcc
     1321 aggctgtgcg ccgcagcctg cccgtgttcc ccttccgaga ggagcttctg gccgccattg
     1381 ccaaccatca ggtcctcatc atcgaaggcg agactggctc tgggaagacc acacagatcc
     1441 cacagtacct ctttgaggag ggttacacaa agaagggcat gaagattgct tgcacccagc
     1501 cccggagagt ggcggctatg agtgtggcag cccgagtggc ccgggagatg ggtgtgaagc
     1561 ttgggaacga ggtgggctac agcatccggt ttgaggactg cacctcagag cgaactgttc
     1621 tccgctacat gacagatgga atgctactcc gagagttcct ctctgagcct gaccttgcaa
     1681 gttacagtgt ggtgatggtg gatgaagctc acgagcggac cttgcacaca gacattctct
     1741 ttggattgat caaagacgtc gctagattcc gacctgagct caaggtcctg gtggcttcag
     1801 ccacactgga tactgcccgg ttttctgcct tcttcgatga cgcccctgtc ttcagaatcc
     1861 ctggacgcag gtttccagtt gacatcttct ataccaaggc cccagaggct gactacctgg
     1921 aagcctgcgt tgtgtctgtg ctgcagatcc acgtgaccca gccccctgga gatatactgg
     1981 tgttcctgac gggacaggag gagattgagg ctgcctgtga gatgctccag gaccgctgcc
     2041 gcaggctggg ctccaagatc cgggagctcc tggtgctgcc catttatgcc aacctgccct
     2101 cagacatgca ggctcgcatc ttccagccca caccccccgg ggcccgaaag gtggttgtgg
     2161 caacaaacat tgcagaaact tccctcacca tcgaaggcat catctatgtg ctggacccag
     2221 ggttctgcaa gcagaagagc tacaaccctc gtacgggaat ggagtcactc acggtcaccc
     2281 cctgcagcaa ggcttcagcc aatcagcggg ctggccgtgc aggtcgagtg gctgccggga
     2341 agtgcttccg cctgtatacg gcctgggcct atcagcatga gctagaggag accacagttc
     2401 ctgagatcca gaggacaagc ctgggcaacg ttgtgctgct gctaaagagc ttagggatcc
     2461 atgacctgat gcactttgac ttcctggacc ctcctccata cgagaccctg ctgctggctt
     2521 tggagcagct ttatgccctt ggcgccctca accaccttgg agaactcacc acgtctggtc
     2581 gaaagatggc agagctgcct gtggatccca tgttgtctaa aatgatcttg gcctccgaga
     2641 agtatagctg ttcagaagag atcctgaccg tggctgctat gctgtctgtc aacaattcca
     2701 tcttctaccg gcccaaggat aaggttgtcc atgccgacaa tgcccgtgtc aacttcttcc
     2761 tccctggtgg agaccacctg gttctgctaa atgtgtacac acagtgggct gagagtggct
     2821 actcttccca atggtgctat gaaaactttg tacagttcag atccatgcgc cgagcccggg
     2881 atgtgcggga acaactggag gggctcttgg agcgtgtgga agttggcttg acttcttgcc
     2941 aaggtgacta cgttcgtgtg agaaaggcca tcacttcggg ttatttttac cacactgcga
     3001 ggctgactcg gagcggctac cgcacagtga agcagcagca gacagtgttt attcatccca
     3061 actcctctct ctttgaacaa cagccacgct ggttgctcta ccatgagctt gtcttgacca
     3121 caaaggaatt catgagacaa gtactggaga ttgaaagcag ctggcttttg gaagtggctc
     3181 cccactacta taaggccaag gagctagaag atccccatgc taagaaaatg cccaaaaaag
     3241 tcggcaagac acgagaagag ctgggctaga gagtgacatg gaccaaacct tgcagctctt
     3301 ttttccttcc atactttaat atctagtaaa taaaattatt tttggaatga agtgcatggg
     3361 aactctggaa cccagagaaa gtgacgtgaa aaaaaaaaaa aaaaa
//
