LOCUS       NM_007839               3061 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus DEAH-box helicase 15 (Dhx15), transcript variant 2,
            mRNA.
ACCESSION   NM_007839
VERSION     NM_007839.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3061)
  AUTHORS   Benbarche,S., Pineda,J.M.B., Galvis,L.B., Biswas,J., Liu,B.,
            Wang,E., Zhang,Q., Hogg,S.J., Lyttle,K., Dahi,A., Lewis,A.M.,
            Sarchi,M., Rahman,J., Fox,N., Ai,Y., Mehta,S., Garippa,R.,
            Ortiz-Pacheco,J., Li,Z., Monetti,M., Stanley,R.F., Doulatov,S.,
            Bradley,R.K. and Abdel-Wahab,O.
  TITLE     GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in
            hematologic malignancies
  JOURNAL   Mol Cell 84 (10), 1886-1903 (2024)
   PUBMED   38688280
REFERENCE   2  (bases 1 to 3061)
  AUTHORS   Portoles,I., Ribera,J., Fernandez-Galan,E., Lecue,E., Casals,G.,
            Melgar-Lesmes,P., Fernandez-Varo,G., Boix,L., Sanduzzi,M.,
            Aishwarya,V., Reig,M., Jimenez,W. and Morales-Ruiz,M.
  TITLE     Identification of Dhx15 as a Major Regulator of Liver Development,
            Regeneration, and Tumor Growth in Zebrafish and Mice
  JOURNAL   Int J Mol Sci 25 (7), 3716 (2024)
   PUBMED   38612527
  REMARK    GeneRIF: Identification of Dhx15 as a Major Regulator of Liver
            Development, Regeneration, and Tumor Growth in Zebrafish and Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3061)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3061)
  AUTHORS   Zhu,H., Li,M., Bi,D., Yang,H., Gao,Y., Song,F., Zheng,J., Xie,R.,
            Zhang,Y., Liu,H., Yan,X., Kong,C., Zhu,Y., Xu,Q., Wei,Q. and Qin,H.
  TITLE     Fusobacterium nucleatum promotes tumor progression in KRAS
            p.G12D-mutant colorectal cancer by binding to DHX15
  JOURNAL   Nat Commun 15 (1), 1688 (2024)
   PUBMED   38402201
  REMARK    GeneRIF: Fusobacterium nucleatum promotes tumor progression in KRAS
            p.G12D-mutant colorectal cancer by binding to DHX15.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3061)
  AUTHORS   Wang,G., Xiao,X., Wang,Y., Chu,X., Dou,Y., Minze,L.J.,
            Ghobrial,R.M., Zhang,Z. and Li,X.C.
  TITLE     The RNA helicase DHX15 is a critical regulator of natural
            killer-cell homeostasis and functions
  JOURNAL   Cell Mol Immunol 19 (6), 687-701 (2022)
   PUBMED   35322175
  REMARK    GeneRIF: The RNA helicase DHX15 is a critical regulator of natural
            killer-cell homeostasis and functions.
REFERENCE   6  (bases 1 to 3061)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   7  (bases 1 to 3061)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   8  (bases 1 to 3061)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3061)
  AUTHORS   Lee,C.G., Eki,T., Okumura,K., da Costa Soares,V. and Hurwitz,J.
  TITLE     Molecular analysis of the cDNA and genomic DNA encoding mouse RNA
            helicase A
  JOURNAL   Genomics 47 (3), 365-371 (1998)
   PUBMED   9480750
REFERENCE   10 (bases 1 to 3061)
  AUTHORS   Gee,S., Krauss,S.W., Miller,E., Aoyagi,K., Arenas,J. and
            Conboy,J.G.
  TITLE     Cloning of mDEAH9, a putative RNA helicase and mammalian homologue
            of Saccharomyces cerevisiae splicing factor Prp43
  JOURNAL   Proc Natl Acad Sci U S A 94 (22), 11803-11807 (1997)
   PUBMED   9342318
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY285872.1, AK149869.1, AK145983.1 and BP767627.1.
            
            On Oct 1, 2013 this sequence version replaced NM_007839.2.
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003745.1, AK168835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BY285872.1         1-39
            40-2140             AK149869.1         2-2102
            2141-3036           AK145983.1         2091-2986
            3037-3061           BP767627.1         33-57               c
FEATURES             Location/Qualifiers
     source          1..3061
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 27.51 cM"
     gene            1..3061
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /note="DEAH-box helicase 15"
                     /db_xref="GeneID:13204"
                     /db_xref="MGI:MGI:1099786"
     exon            1..267
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..2584
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /EC_number="3.6.4.13"
                     /note="isoform 2 is encoded by transcript variant 2;
                     putative pre-mRNA-splicing factor ATP-dependent RNA
                     helicase DHX15; DEAH box protein 15; DEAD/H
                     (Asp-Glu-Ala-Asp/His) box polypeptide 15 (RNA helicase A);
                     DEAH (Asp-Glu-Ala-His) box polypeptide 15"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DHX15 isoform 2"
                     /protein_id="NP_031865.2"
                     /db_xref="CCDS:CCDS39085.1"
                     /db_xref="GeneID:13204"
                     /db_xref="MGI:MGI:1099786"
                     /translation="MSKRHRLDLGEDYPSGKKRAGTDGKDRERDRDREDRSKDRDRER
                     DRGDREREREKEKEKELRASTNAMLISAGLPPLKASHSAHSTHSAHSTHSTHSAHSTH
                     TGHTGHTSLPQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVG
                     ETGSGKTTQIPQWCVEYMRSLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVG
                     YSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATDILMGVL
                     KEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEA
                     AIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYSTL
                     PPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPR
                     IRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLG
                     SVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFP
                     LDPQLAKMVIASCDYNCSNEVLSITAMLSVPQCFVRPTEAKKAADEAKMRFAHIDGDH
                     LTLLNVYHAFKQNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDRFNLPRRSTDFTS
                     RDYYINIRKALVTGYFMQVAHLERTGHYLTVKDNQVVQLHPSTVLDHKPEWVLYNEFV
                     LTTKNYIRTCTDIKPEWLVKIAPQYYDMSNFPQCEAKRQLDRIIAKLQSKEYSQY"
     exon            268..703
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /inference="alignment:Splign:2.1.0"
     exon            704..897
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1057
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1276
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1444
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1531
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1681
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1790
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1982
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2105
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2296
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2466
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..3042
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3011..3016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /note="hexamer: AATAAA"
     polyA_site      3031
                     /gene="Dhx15"
                     /gene_synonym="DBP1; Ddx15; DEAH9; HRH2; mDEAH9"
                     /note="major polyA site"
ORIGIN      
        1 ggaggcgcgc acgcaggccc tgccctcgtc gcggccgcca ttttagctcc tggttcgggc
       61 cgcacggagc gggctgtggt ggcgggaggg gtgggggtcc ccgcgagttg agccgcgggc
      121 ctcttgtgcg tggatccggc tgccggagtc tctcttcttc cctccttcct aagcgtccgc
      181 ttctgggagt gcgaggatgt ccaagaggca tcggttggac ctgggggagg attacccctc
      241 cggcaagaag cgtgcgggga ccgatgggaa agaccgggaa cgagatcggg atagagagga
      301 ccgatctaaa gatcgtgacc gagaacgtga tagaggagac agagaacggg agagggaaaa
      361 agaaaaggaa aaagaattga gagcttccac caatgctatg cttatcagtg ctggattgcc
      421 acctttaaaa gcttctcatt cagctcactc aacccactcg gctcattcaa cacattctac
      481 acattctgcc cactcaacac acactggaca cacaggacac acatcacttc cacagtgcat
      541 taatccattc accaacctgc cccatactcc tcgatactat gatattctaa agaaacgact
      601 tcagctccct gtatgggaat acaaggatag atttacagat attcttgtta gacatcagtc
      661 atttgtactt gttggtgaga ctgggtctgg taaaacaaca cagataccac agtggtgtgt
      721 ggagtatatg cgatccttgc caggacccaa aagaggagtc gcctgtacac agcccaggag
      781 agtggctgca atgagtgtgg ctcagagagt tgctgatgag atggacgtga tgttaggcca
      841 ggaagttgga tactccattc gatttgaaga ctgcagtagt gcaaaaacca ttcttaagta
      901 tatgactgac gggatgctac ttcgtgaagc catgaacgat ccccttctgg agcgttatgg
      961 tgtgataatt cttgatgagg cccatgaaag aacattggct acagatattc tcatgggtgt
     1021 tctaaaggaa gttgtaagac agagatcaga tttaaaggtt atagttatga gtgctaccct
     1081 agatgctggg aaattccaga tttactttga taactgtcct ctcttaacta ttcctggccg
     1141 aacacatcct gttgagattt tttatactcc agaaccagag agagattatc ttgaagcagc
     1201 aattcggaca gtgatccaaa tacatatgtg tgaagaggag gaaggagacc ttcttctttt
     1261 cttgactggt caagaggaaa ttgatgaggc ctgtaagaga ataaagcgtg aagttgatga
     1321 tttgggccct gaagttggtg atattaaaat cattccatta tattctacac ttccacccca
     1381 gcagcaacaa cgcatttttg agccaccacc tccaaaaaaa cagaatggag caattggaag
     1441 aaaggtggtg gtgtcaacta atattgcaga gacctctttg acaatagacg gtgtggtgtt
     1501 tgtaattgac cctggatttg caaaacaaaa ggtatataat cctagaatca gagtcgagtc
     1561 tcttctggtg actgccatta gtaaagcttc agctcagcaa agggcgggtc gagctggacg
     1621 gaccagacct gggaaatgct tcaggcttta tacagagaaa gcttataaaa cagaaatgca
     1681 ggacaacacc tatcctgaga tcctgcgctc taacctagga tcggttgtgt tgcagctgaa
     1741 gaagcttggt attgatgact tggtacactt tgattttatg gacccaccag ctcctgaaac
     1801 tctgatgaga gccctagaac ttttgaatta tttggctgct ttaaatgatg atggagatct
     1861 gactgaattg ggatccatga tggcagagtt ccctttagat ccacagctcg ctaaaatggt
     1921 tattgcaagt tgtgactaca actgttctaa tgaggtccta tctattactg ctatgttgtc
     1981 agtcccacag tgttttgttc gccccacgga ggccaagaaa gctgcagatg aggccaagat
     2041 gagatttgcc cacatagatg gagatcatct gacactgctg aatgtctacc acgcttttaa
     2101 acaaaatcat gaatctgttc agtggtgtta tgacaacttc attaactacc ggtccctgat
     2161 gtctgcagac aatgtacgcc agcagctatc aagaattatg gacagattta atttgcctcg
     2221 tcgaagtact gatttcacaa gcagggacta ttatattaat ataagaaaag ctttggttac
     2281 tgggtatttt atgcaagtgg cacatttaga acgaacgggg cattatttaa ctgtgaaaga
     2341 taaccaggtg gtccagttgc atccctctac tgtgcttgat cacaagcctg aatgggtgct
     2401 ttataatgag tttgtgctga cgacaaagaa ttatatccgg acatgtacag atatcaagcc
     2461 agaatggttg gtgaaaattg cccctcaata ttatgacatg agcaatttcc cacagtgtga
     2521 agcaaagaga cagttggacc gcattattgc caaacttcaa tccaaggaat attcacagta
     2581 ctgaattcaa tgcttagaac tgaagttatt cagaggacag ctttaaaaga tgaatgaagt
     2641 caagttcaag ttgtgctctt catgttggtt caataatggc ctttatttga aagcttttta
     2701 atttttcttt acagtaaata ttccattctg atttcataaa ttaaacattt atgcctccct
     2761 tttgtgttga cactgtagct catactggaa aagtcgatca atgttttgca gtttattgaa
     2821 agtagttcta tatataacaa tgttataagc atttctttag aaatggttga aaatgcttct
     2881 aaaatgtgat tatcgaccat ggtatgcatg atcgttgtaa ttgttgacat tccttttaga
     2941 agttgtgaaa tgttacaact tgtgcttctg tagacacaat cttctgtctc catacagagg
     3001 cactgacttc aataaagtct atttatacta atcttggccc aaaaaaaaaa aaaaaaaaaa
     3061 a
//
