LOCUS       NM_175512               2817 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus dehydrogenase/reductase 9 (Dhrs9), mRNA.
ACCESSION   NM_175512
VERSION     NM_175512.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2817)
  AUTHORS   Belyaeva,O.V., Wirth,S.E., Boeglin,W.E., Karki,S., Goggans,K.R.,
            Wendell,S.G., Popov,K.M., Brash,A.R. and Kedishvili,N.Y.
  TITLE     Dehydrogenase reductase 9 (SDR9C4) and related homologs recognize a
            broad spectrum of lipid mediator oxylipins as substrates
  JOURNAL   J Biol Chem 298 (1), 101527 (2022)
   PUBMED   34953854
REFERENCE   2  (bases 1 to 2817)
  AUTHORS   Wu,L., Belyaeva,O.V., Adams,M.K., Klyuyeva,A.V., Lee,S.A.,
            Goggans,K.R., Kesterson,R.A., Popov,K.M. and Kedishvili,N.Y.
  TITLE     Mice lacking the epidermal retinol dehydrogenases SDR16C5 and
            SDR16C6 display accelerated hair growth and enlarged meibomian
            glands
  JOURNAL   J Biol Chem 294 (45), 17060-17074 (2019)
   PUBMED   31562240
REFERENCE   3  (bases 1 to 2817)
  AUTHORS   Chen,S., Lu,W., Yueh,M.F., Rettenmeier,E., Liu,M., Paszek,M.,
            Auwerx,J., Yu,R.T., Evans,R.M., Wang,K., Karin,M. and Tukey,R.H.
  TITLE     Intestinal NCoR1, a regulator of epithelial cell maturation,
            controls neonatal hyperbilirubinemia
  JOURNAL   Proc Natl Acad Sci U S A 114 (8), E1432-E1440 (2017)
   PUBMED   28167773
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4115. doi:
            10.1073/pnas.1705671114.. Paszek, Miles [added]. PMID: 28484028]
REFERENCE   4  (bases 1 to 2817)
  AUTHORS   Hu,P., Zhang,M. and Napoli,J.L.
  TITLE     Ontogeny of rdh9 (Crad3) expression: ablation causes changes in
            retinoid and steroid metabolizing enzymes, but RXR and androgen
            signaling seem normal
  JOURNAL   Biochim Biophys Acta 1770 (4), 694-705 (2007)
   PUBMED   17270348
REFERENCE   5  (bases 1 to 2817)
  AUTHORS   Driessen,C., Winkens,H., Haeseleer,F., Palczewski,K. and Janssen,J.
  TITLE     Novel targeting strategy for generating mouse models with defects
            in the retinoid cycle
  JOURNAL   Vision Res 43 (28), 3075-3079 (2003)
   PUBMED   14611944
REFERENCE   6  (bases 1 to 2817)
  AUTHORS   Haeseleer,F. and Palczewski,K.
  TITLE     Short-chain dehydrogenases/reductases in retina
  JOURNAL   Methods Enzymol 316, 372-383 (2000)
   PUBMED   10800688
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK080914.1.
            
            On Jun 3, 2003 this sequence version replaced NM_175512.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080914.1, AK050180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2817
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 40.59 cM"
     gene            1..2817
                     /gene="Dhrs9"
                     /gene_synonym="C730025I08Rik; Rdh15"
                     /note="dehydrogenase/reductase 9"
                     /db_xref="GeneID:241452"
                     /db_xref="MGI:MGI:2442798"
     exon            1..170
                     /gene="Dhrs9"
                     /gene_synonym="C730025I08Rik; Rdh15"
                     /inference="alignment:Splign:2.1.0"
     exon            171..541
                     /gene="Dhrs9"
                     /gene_synonym="C730025I08Rik; Rdh15"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1188
                     /gene="Dhrs9"
                     /gene_synonym="C730025I08Rik; Rdh15"
                     /EC_number="1.1.1.105"
                     /EC_number="1.1.1.209"
                     /EC_number="1.1.1.53"
                     /note="epithelial retinol dehydrogenase; 3alpha-HSD;
                     3-alpha hydroxysteroid dehydrogenase; short-chain
                     dehydrogenase/reductase retSDR8; 3-alpha-HSD;
                     dehydrogenase/reductase (SDR family) member 9"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 9
                     precursor"
                     /protein_id="NP_780721.1"
                     /db_xref="CCDS:CCDS16091.1"
                     /db_xref="GeneID:241452"
                     /db_xref="MGI:MGI:2442798"
                     /translation="MLFWLLALLFLCAFLWNYKGQLKIADIADKYVFITGCDTGFGNL
                     AARTFDKKGFRVIAACLTESGSAALKAKTSERLHTVLLDVTDPENVKKTAQWVKSHVG
                     EKGLWGLINNAGVLGVLAPTDWLTVDDYREPIEVNLFGLINVTLNMLPLVKKARGRVI
                     NVSSIGGRLAFGGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTELADPIK
                     TTEKKLAIWKHLSPDIKQQYGEGYIEKSLHRLKSNTSSVNLDLSLVVGCMDHALTSLF
                     PKTRYIAGKDAKTFWIPLSHMPAVLQDFLLLKQKVELANPKAV"
     exon            542..800
                     /gene="Dhrs9"
                     /gene_synonym="C730025I08Rik; Rdh15"
                     /inference="alignment:Splign:2.1.0"
     exon            801..964
                     /gene="Dhrs9"
                     /gene_synonym="C730025I08Rik; Rdh15"
                     /inference="alignment:Splign:2.1.0"
     exon            965..2817
                     /gene="Dhrs9"
                     /gene_synonym="C730025I08Rik; Rdh15"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2068
                     /gene="Dhrs9"
                     /gene_synonym="C730025I08Rik; Rdh15"
                     /note="major polyA site"
     regulatory      2600..2605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dhrs9"
                     /gene_synonym="C730025I08Rik; Rdh15"
                     /note="hexamer: AATGAA"
     polyA_site      2620
                     /gene="Dhrs9"
                     /gene_synonym="C730025I08Rik; Rdh15"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtcttc acacatgcag gtctcagagc tccgcagacc gcaggcacct tgagaggatc
       61 agcttgacgg agctgcactt ccttcccctg gaccacagca ggaaggtgac aatctgcagc
      121 agcggagcaa gtcgccctca gcttctgcac tgcgagtcat cttcagcgag gacatgatct
      181 tttattgtac gtgaaataag tatccctgtc acacagagaa aaaggaagat gctgttttgg
      241 ttgttggctc tcctgttcct ctgtgctttt ctgtggaatt ataaagggca gttgaagata
      301 gcagacattg ctgacaagta tgtcttcatc accggatgtg acacgggctt tggaaactta
      361 gcagccagaa cttttgataa aaaaggcttc cgtgtcattg ctgcctgcct gactgagtca
      421 ggatcagctg ctttgaaggc caaaacctca gagagactcc acaccgtgct tctggatgtc
      481 actgacccag agaatgtcaa gaagacggcc cagtgggtga agagccatgt aggagaaaag
      541 ggtctctggg gtctgatcaa taatgctggt gttcttggcg tgttggctcc cactgactgg
      601 ttgacagtgg acgactacag agaacccatt gaagttaacc tgtttggact catcaacgtg
      661 acactgaata tgcttccact ggtcaaaaaa gctcgagggc gtgttatcaa tgtctccagc
      721 attggaggcc ggcttgcatt tggtggaggg ggctatactc catccaaata cgcagtggag
      781 ggtttcaatg acagcctaag gcgggatatg aaagcttttg gtgtgcatgt ctcatgcatt
      841 gaaccagggc tgttcaaaac agagctggca gatccaatca agacaactga aaaaaaactg
      901 gccatttgga aacatctgtc tccagatatc aaacaacaat atggagaggg ctacattgaa
      961 aaaagtctac acagactgaa aagcaatacc tcctcggtga acttggacct ctctctagtg
     1021 gtagggtgca tggaccacgc tctaacaagt ctcttcccca agactcggta cattgctggg
     1081 aaagatgcca agacattctg gatacctctg tctcacatgc cagcagtttt acaagacttt
     1141 ttattgctga aacagaaagt agagctggca aatcccaaag ctgtgtgact caactaacca
     1201 caaatgcctg cccccagctt cgagattggc tgatttcaga gacttggcac ctcaatctca
     1261 ttctttacca gacccaactc ggactcactt agaccaggtt tccgttttta aaagaagata
     1321 gtccatagtc tcttcttaag tcttctgtga aaataaggac agagaaggcc tatctcataa
     1381 gccagtcttg ccagatactg aagctttacc tgattggtaa gatgaaagag aaatggaaag
     1441 acttctccat ccaaaatagg tgtgctgcta cctgcccctg actggttcag taatccagat
     1501 tgctaagcat tgtcgcttat tgaaatgtta agtgataaga agtctttaat aagtggatcc
     1561 aatggctctg ttatctggca gagaagaaga ctcaatacat tctgataagc tttgataaga
     1621 acaagaaaga gataaaaggt gttaccacgc agagcactgg tatgaactga gaggcggtta
     1681 gaaacaggga agaaatagaa gggcagaaaa agacaaggaa tgaaaggtgg ggacacgcca
     1741 atacaagcct catactccag agggacacag aggacacact actgctgtta ccgtgaagtc
     1801 actgcatctg gtcctagccc tagaggtacc tcaccagtac cttcatcagt cagctgcatc
     1861 acagcggaag cacaccagtt ctgttggcta cagctgctcc tcattacaag gccaggttct
     1921 tggctccatc tcatggcttc agactctgtg gcttgcttac tgccctttga ctttcccgat
     1981 gtccaaagac taccaagatt tgcagaatcc caagggaatt cctttattga tcttccaatc
     2041 atgctaatcc aatcgctcaa ccttctaatt ctgtctctgt tttgcctcat cctgagatgc
     2101 tttctattat tcttatccct ttaagtagct acaattcgct tactctttct tcccatcaaa
     2161 aactaagtgt catgcagtct accattgagc gcaagcttgc cagctgcagc atctgtgtta
     2221 gcagtgtgcc agctgcactt ctgttaagct ctgagtactt ccttcttagc tgtagctccg
     2281 ccatcagcct tcccacagag aaggctcgct cagcagaaca aggtggctgc tcttcacttg
     2341 ttggttcgga gatactgtga aggagcctgc tgcatatgta aactgtccag acgaaagaga
     2401 atctcttcca tttaaactat cttcaagacc ctaaaccatc tgtgggtagc tcagcctagt
     2461 acataatgaa gaaaattccc aagaagctgc taagaaaaat gttcaagttt tgcctttctc
     2521 tacagtattc atcccagtag ttctcggggg tataagacac cacaggctca tttatgtaga
     2581 aatggccaaa cattcgcaaa atgaaaaact ctgctaccta caggtgattt ctatcgattt
     2641 tactctaagc gatggcctcc tgaatccttg ccaaaggaga cagttctgtt acacttgccc
     2701 ctaactctgg tttctttcac ccttcttttt gtcatggagg ctcaaatcca gaatctcggg
     2761 catgggccca tgctacacca ctgagctaca ccacacccca gttcaggatt tattttt
//
