LOCUS       NM_001013013            1129 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dehydrogenase/reductase 7C (Dhrs7c), mRNA.
ACCESSION   NM_001013013 XM_126127
VERSION     NM_001013013.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1129)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1129)
  AUTHORS   Ruiz,A., Dror,E., Handschin,C., Furrer,R., Perez-Schindler,J.,
            Bachmann,C., Treves,S. and Zorzato,F.
  TITLE     Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in
            skeletal muscle activates mTORC2, enhances glucose metabolism and
            muscle performance
  JOURNAL   Sci Rep 8 (1), 636 (2018)
   PUBMED   29330505
  REMARK    GeneRIF: Study demonstrates that the skeletal muscle protein
            SRP-35, a retinol dehydrogenase, is directly involved in skeletal
            muscle metabolism, since its over-expression results in higher
            glucose uptake and increased glycogen storage. In addition, SRP-35
            over-expression improves muscle performance in vivo.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1129)
  AUTHORS   Arai,S., Ikeda,M., Ide,T., Matsuo,Y., Fujino,T., Hirano,K.,
            Sunagawa,K. and Tsutsui,H.
  TITLE     Functional loss of DHRS7C induces intracellular Ca2+ overload and
            myotube enlargement in C2C12 cells via calpain activation
  JOURNAL   Am J Physiol Cell Physiol 312 (1), C29-C39 (2017)
   PUBMED   27806939
  REMARK    GeneRIF: Taken together, our findings suggested that DHRS7C
            maintains intracellular Ca(2+) homeostasis involving the ER/SR and
            that functional loss of DHRS7C leads to Ca(2+) overload in the
            cytosol and ER/SR, resulting in enlarged cellular morphology via
            calpain activation
REFERENCE   4  (bases 1 to 1129)
  AUTHORS   Treves,S., Thurnheer,R., Mosca,B., Vukcevic,M., Bergamelli,L.,
            Voltan,R., Oberhauser,V., Ronjat,M., Csernoch,L., Szentesi,P. and
            Zorzato,F.
  TITLE     SRP-35, a newly identified protein of the skeletal muscle
            sarcoplasmic reticulum, is a retinol dehydrogenase
  JOURNAL   Biochem J 441 (2), 731-741 (2012)
   PUBMED   21995425
  REMARK    GeneRIF: skeletal muscle SRP-35 is involved in the generation of
            all-trans-retinaldehyde and may play an important role in the
            generation of intracellular signals linking Ca2+ release (i.e.
            muscle activity) to metabolism.
REFERENCE   5  (bases 1 to 1129)
  AUTHORS   Lu,B., Tigchelaar,W., Ruifrok,W.P., van Gilst,W.H., de Boer,R.A.
            and Sillje,H.H.
  TITLE     DHRS7c, a novel cardiomyocyte-expressed gene that is down-regulated
            by adrenergic stimulation and in heart failure
  JOURNAL   Eur J Heart Fail 14 (1), 5-13 (2012)
   PUBMED   22143674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            W53606.1, AA063835.1, CJ048402.1, AI391290.1 and AI414355.1.
            
            On Sep 28, 2007 this sequence version replaced NM_001013013.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                W53606.1           1-62
            63-474              AA063835.1         40-451
            475-627             CJ048402.1         471-623
            628-1035            AI391290.1         117-524
            1036-1129           AI414355.1         1-94                c
FEATURES             Location/Qualifiers
     source          1..1129
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 41.13 cM"
     gene            1..1129
                     /gene="Dhrs7c"
                     /gene_synonym="1110001P11Rik; SRP-35"
                     /note="dehydrogenase/reductase 7C"
                     /db_xref="GeneID:68460"
                     /db_xref="MGI:MGI:1915710"
     exon            1..133
                     /gene="Dhrs7c"
                     /gene_synonym="1110001P11Rik; SRP-35"
                     /inference="alignment:Splign:2.1.0"
     exon            134..293
                     /gene="Dhrs7c"
                     /gene_synonym="1110001P11Rik; SRP-35"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1075
                     /gene="Dhrs7c"
                     /gene_synonym="1110001P11Rik; SRP-35"
                     /EC_number="1.1.1.105"
                     /note="short-chain dehydrogenase/reductase family 32C
                     member 2; sarcoplasmic reticulum protein of 35 kDa;
                     dehydrogenase/reductase (SDR family) member 7C"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 7C
                     precursor"
                     /protein_id="NP_001013031.2"
                     /db_xref="CCDS:CCDS48822.1"
                     /db_xref="GeneID:68460"
                     /db_xref="MGI:MGI:1915710"
                     /translation="MGLMAVLMLPLLLLGISGLLFIYQEASRLWSKSAVQNKVVVITD
                     AISGLGKECARVFHAGGARLVLCGKNWEGLESLYATLTSVADPSKTFTPKLVLLDLSD
                     ISCVQDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKV
                     LLPNMISRRTGQIVLVNNIQAKFGIPFRTAYAASKHAVMGFFDCLRAEVEEYDVVVST
                     VSPTFIRSYRASPEQRNWETSICKFFCRKLAYGVHPVEVAEEVMRTVRRKKQEVFMAN
                     PVPKAAVFIRTFFPEFFFAVVACGVKEKLNVPEEG"
     exon            294..406
                     /gene="Dhrs7c"
                     /gene_synonym="1110001P11Rik; SRP-35"
                     /inference="alignment:Splign:2.1.0"
     exon            407..617
                     /gene="Dhrs7c"
                     /gene_synonym="1110001P11Rik; SRP-35"
                     /inference="alignment:Splign:2.1.0"
     exon            618..710
                     /gene="Dhrs7c"
                     /gene_synonym="1110001P11Rik; SRP-35"
                     /inference="alignment:Splign:2.1.0"
     exon            711..866
                     /gene="Dhrs7c"
                     /gene_synonym="1110001P11Rik; SRP-35"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1124
                     /gene="Dhrs7c"
                     /gene_synonym="1110001P11Rik; SRP-35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1105..1110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dhrs7c"
                     /gene_synonym="1110001P11Rik; SRP-35"
                     /note="hexamer: AATAAA"
     polyA_site      1124
                     /gene="Dhrs7c"
                     /gene_synonym="1110001P11Rik; SRP-35"
                     /note="major polyA site"
ORIGIN      
        1 taaccattag agcccaagcg agtggcctta acacatggat tttccttcca aaaatgcaga
       61 cccattttaa ttaaatttgt aattaccctt aggggagagc aggacccctg gactccttca
      121 gtgtgaagac gtgagcaaga tggggctcat ggctgtcctg atgctacccc tgctgctgct
      181 gggaatcagc ggcctcctct tcatttacca ggaggcatcc aggctgtggt cgaagtctgc
      241 cgtgcagaac aaagtggtgg tcatcacaga tgccatctca ggactgggaa aggagtgtgc
      301 tcgggtgttc catgcaggtg gggcaaggct ggtgctgtgt ggaaagaact gggagggact
      361 ggagagcctc tatgccacct tgaccagtgt ggctgacccc agcaagacat tcacccccaa
      421 gctggtcctc ctggatctct cagacattag ctgtgttcaa gatgtggcca aagaggtcct
      481 ggactgctac ggctgtgtgg acatcctcat caacaatgcc agcgtgaaag tgaaggggcc
      541 tgcccacaag atttccctgg agcttgacaa aaagatcatg gatgccaact acttcggacc
      601 catcacttta accaaagttc tgcttcccaa catgatctcc aggagaacag gccagattgt
      661 gttagtgaac aacatccaag cgaagtttgg aatcccgttc cgcacagctt atgcagcttc
      721 taagcatgcc gtcatgggct tctttgactg cctccgagcc gaggttgagg aatacgatgt
      781 tgtggtcagc accgtgagcc caactttcat ccgctcctac cgtgcttccc ctgagcaaag
      841 aaactgggag acatccattt gtaaattctt ctgcaggaag ctagcctatg gcgtgcaccc
      901 ggtggaggtg gctgaggaag tgatgcgcac agtacggagg aagaagcaag aggtgttcat
      961 ggccaacccg gtccccaagg ctgccgtgtt catccgcacc ttcttccctg agttcttctt
     1021 cgctgtggtg gcctgtgggg tgaaggagaa gctcaatgtc ccagaagagg gttaacctcg
     1081 tggccaaagg ggtcactcaa ggggaataaa ggctttccta gagaaaaaa
//
