LOCUS       NM_001037938            1408 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dehydrogenase/reductase 4 (Dhrs4), transcript variant
            1, mRNA.
ACCESSION   NM_001037938
VERSION     NM_001037938.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1408)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1408)
  AUTHORS   Su,Z., Liu,G., Song,X., Liang,B., Chang,X. and Huang,D.
  TITLE     CpG island evolution in the mammalian DHRS4 gene cluster and its
            role in the regulation of gene transcription
  JOURNAL   Genet Mol Res 15 (2) (2016)
   PUBMED   27323117
  REMARK    GeneRIF: An analysis of the relationship between the promoter
            characteristics and RNA expression of the DHRS4 gene cluster
            indicated that the development of CpG islands, in addition to the
            promoter sequence, during mammalian evolution could modulate the
            dose compensatory regulation of the copy number-varied DHRS4 gene
            cluster
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1408)
  AUTHORS   Gabrielli,F. and Tofanelli,S.
  TITLE     Molecular and functional evolution of human DHRS2 and DHRS4
            duplicated genes
  JOURNAL   Gene 511 (2), 461-469 (2012)
   PUBMED   23036705
  REMARK    GeneRIF: M. musculus DHRS2 and DHRS4 genes are syntenic outparalogs
            that originated from a duplication of the DHRS4 gene that took
            place before the formation of the mammalian clade. M. musculus
            genes are orthologs of human DHRS2 and DHRS4 genes respectively.
REFERENCE   4  (bases 1 to 1408)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   5  (bases 1 to 1408)
  AUTHORS   Keller,B., Volkmann,A., Wilckens,T., Moeller,G. and Adamski,J.
  TITLE     Bioinformatic identification and characterization of new members of
            short-chain dehydrogenase/reductase superfamily
  JOURNAL   Mol Cell Endocrinol 248 (1-2), 56-60 (2006)
   PUBMED   16406282
REFERENCE   6  (bases 1 to 1408)
  AUTHORS   Lei,Z., Chen,W., Zhang,M. and Napoli,J.L.
  TITLE     Reduction of all-trans-retinal in the mouse liver peroxisome
            fraction by the short-chain dehydrogenase/reductase RRD: induction
            by the PPAR alpha ligand clofibrate
  JOURNAL   Biochemistry 42 (14), 4190-4196 (2003)
   PUBMED   12680773
REFERENCE   7  (bases 1 to 1408)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159002.2, BY291911.1, AK146988.1 and BQ032668.1.
            
            On Aug 20, 2009 this sequence version replaced NM_001037938.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054361.1, AB045132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC159002.2         79261-79280         c
            21-122              BY291911.1         1-102
            123-1389            AK146988.1         3-1269
            1390-1408           BQ032668.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1408
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..1408
                     /gene="Dhrs4"
                     /gene_synonym="CR; D14Ucla2; mouNRDR; NDRD; PHCR; PSCD;
                     RRD"
                     /note="dehydrogenase/reductase 4"
                     /db_xref="GeneID:28200"
                     /db_xref="MGI:MGI:90169"
     exon            1..276
                     /gene="Dhrs4"
                     /gene_synonym="CR; D14Ucla2; mouNRDR; NDRD; PHCR; PSCD;
                     RRD"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..985
                     /gene="Dhrs4"
                     /gene_synonym="CR; D14Ucla2; mouNRDR; NDRD; PHCR; PSCD;
                     RRD"
                     /EC_number="1.1.1.184"
                     /EC_number="1.1.1.300"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NADPH-dependent carbonyl reductase/NADP-retinol
                     dehydrogenase; dehydrogenase/reductase (SDR family) member
                     4; peroxisomal short-chain alcohol dehydrogenase;
                     NADPH-dependent retinol dehydrogenase/reductase; short
                     chain dehydrogenase/reductase family 25C member 2"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 4
                     isoform 1"
                     /protein_id="NP_001033027.2"
                     /db_xref="CCDS:CCDS27111.1"
                     /db_xref="GeneID:28200"
                     /db_xref="MGI:MGI:90169"
                     /translation="MQKAGRLLGGWTQAWMSVRMASSGLTRRNPLSNKVALVTASTDG
                     IGFAIARRLAEDGAHVVVSSRKQQNVDRAVATLQGEGLSVTGIVCHVGKAEDREKLIT
                     TALKRHQGIDILVSNAAVNPFFGNLMDVTEEVWDKVLSINVTATAMMIKAVVPEMEKR
                     GGGSVVIVGSVAGFTRFPSLGPYNVSKTALLGLTKNFAAELAPKNIRVNCLAPGLIKT
                     RFSSVLWEEKAREDFIKEAMQIRRLGKPEDCAGIVSFLCSEDASYINGETVVVGGGTP
                     SRL"
     exon            277..454
                     /gene="Dhrs4"
                     /gene_synonym="CR; D14Ucla2; mouNRDR; NDRD; PHCR; PSCD;
                     RRD"
                     /inference="alignment:Splign:2.1.0"
     exon            455..556
                     /gene="Dhrs4"
                     /gene_synonym="CR; D14Ucla2; mouNRDR; NDRD; PHCR; PSCD;
                     RRD"
                     /inference="alignment:Splign:2.1.0"
     exon            557..627
                     /gene="Dhrs4"
                     /gene_synonym="CR; D14Ucla2; mouNRDR; NDRD; PHCR; PSCD;
                     RRD"
                     /inference="alignment:Splign:2.1.0"
     exon            628..679
                     /gene="Dhrs4"
                     /gene_synonym="CR; D14Ucla2; mouNRDR; NDRD; PHCR; PSCD;
                     RRD"
                     /inference="alignment:Splign:2.1.0"
     exon            680..814
                     /gene="Dhrs4"
                     /gene_synonym="CR; D14Ucla2; mouNRDR; NDRD; PHCR; PSCD;
                     RRD"
                     /inference="alignment:Splign:2.1.0"
     exon            815..870
                     /gene="Dhrs4"
                     /gene_synonym="CR; D14Ucla2; mouNRDR; NDRD; PHCR; PSCD;
                     RRD"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1392
                     /gene="Dhrs4"
                     /gene_synonym="CR; D14Ucla2; mouNRDR; NDRD; PHCR; PSCD;
                     RRD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1367..1372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dhrs4"
                     /gene_synonym="CR; D14Ucla2; mouNRDR; NDRD; PHCR; PSCD;
                     RRD"
                     /note="hexamer: AATGAA"
     polyA_site      1392
                     /gene="Dhrs4"
                     /gene_synonym="CR; D14Ucla2; mouNRDR; NDRD; PHCR; PSCD;
                     RRD"
                     /note="major polyA site"
ORIGIN      
        1 gcctagtccc gggccgtcgc agagccggtc ctagaagagg ggcaggcagt ctgggaagtc
       61 agagctctcc cagctagacc agcctcccgc cctttgaaca gtcccctccc ctagcagagt
      121 tcaacccaac cccctggcct gaactatgca gaaagcggga cggctgttag gtggttggac
      181 tcaagcgtgg atgtcggtga ggatggccag ttccgggttg actcgtcgaa accctctctc
      241 caataaggtg gccctggtca cagcctccac cgacgggatc ggctttgcca tcgcccggcg
      301 cctggctgaa gatggggccc acgtggtcgt cagcagccgc aaacagcaga atgtggaccg
      361 tgcagtggcc acactacagg gagagggcct gagtgtgact ggcatcgtgt gccacgtggg
      421 gaaggcagag gatcgagaaa agctgataac cacggctctg aagcgtcacc aggggattga
      481 tatcctggtc tccaatgctg ctgtcaaccc tttctttgga aatctaatgg atgtcacaga
      541 ggaggtgtgg gacaaggttt tgagcattaa tgtgacagct acagccatga tgattaaagc
      601 ggtggtgcca gagatggaaa agcgaggagg cggctcagtg gtgattgtgg gttctgtagc
      661 aggcttcact cggttccctt ctctgggtcc ttacaatgtt agcaaaacag ctttgctggg
      721 tcttactaag aactttgcag cggagttggc cccgaagaac attcgagtga actgcttagc
      781 acctggactc atcaagactc gattcagcag tgtgttgtgg gaggagaaag caagagagga
      841 cttcataaaa gaagccatgc aaatcagaag gctaggcaag ccagaggatt gtgctggcat
      901 agtttccttc ttatgctctg aagacgccag ttacatcaat ggagagaccg tagtagtggg
      961 gggaggaacc ccttctcgcc tctgaggacc cagaaacagc ctaccagggc aggtgtgtgg
     1021 ggcgggctca gtccaccttg cctctgtcgc ccttcgttgc caccacctaa catcttgttc
     1081 acctcacaaa atcagttctg cccagtgata agttcctgct ttccctgtgg tcgaagtgtg
     1141 gtcagatgag catccttgct gttgctatgg ccttgaaaac ggctttgggg agggggcggg
     1201 aagctggggg ataggtagtg ggaaaagggc ttgctgagaa gactgtggct actttagtga
     1261 agatcaaatc cctctcatcc tcgcctctgg acactttgag gagagataga agggacagac
     1321 ctgaacagag atagaaatta acaatttacg tataaggtac aaataaaatg aagatgatcg
     1381 cgttgctctg aaaaaaaaaa aaaaaaaa
//
