LOCUS       NM_011303               2337 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus dehydrogenase/reductase 3 (Dhrs3), transcript variant
            1, mRNA.
ACCESSION   NM_011303
VERSION     NM_011303.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2337)
  AUTHORS   Klyuyeva AV, Belyaeva OV, Goggans KR, Krezel W, Popov KM and
            Kedishvili NY.
  TITLE     Changes in retinoid metabolism and signaling associated with
            metabolic remodeling during fasting and in type I diabetes
  JOURNAL   J Biol Chem 296, 100323 (2021)
   PUBMED   33485967
  REMARK    GeneRIF: Changes in retinoid metabolism and signaling associated
            with metabolic remodeling during fasting and in type I diabetes.
REFERENCE   2  (bases 1 to 2337)
  AUTHORS   Daniel E, Barlow HR, Sutton GI, Gu X, Htike Y, Cowdin MA and
            Cleaver O.
  TITLE     Cyp26b1 is an essential regulator of distal airway epithelial
            differentiation during lung development
  JOURNAL   Development 147 (4) (2020)
   PUBMED   32001436
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2337)
  AUTHORS   Wu L, Belyaeva OV, Adams MK, Klyuyeva AV, Lee SA, Goggans KR,
            Kesterson RA, Popov KM and Kedishvili NY.
  TITLE     Mice lacking the epidermal retinol dehydrogenases SDR16C5 and
            SDR16C6 display accelerated hair growth and enlarged meibomian
            glands
  JOURNAL   J Biol Chem 294 (45), 17060-17074 (2019)
   PUBMED   31562240
REFERENCE   4  (bases 1 to 2337)
  AUTHORS   Wang S, Huang W, Castillo HA, Kane MA, Xavier-Neto J, Trainor PA
            and Moise AR.
  TITLE     Alterations in retinoic acid signaling affect the development of
            the mouse coronary vasculature
  JOURNAL   Dev Dyn 247 (8), 976-991 (2018)
   PUBMED   29806219
REFERENCE   5  (bases 1 to 2337)
  AUTHORS   Xiao Y, Hill MC, Zhang M, Martin TJ, Morikawa Y, Wang S, Moise AR,
            Wythe JD and Martin JF.
  TITLE     Hippo Signaling Plays an Essential Role in Cell State Transitions
            during Cardiac Fibroblast Development
  JOURNAL   Dev Cell 45 (2), 153-169 (2018)
   PUBMED   29689192
  REMARK    GeneRIF: Epicardial upregulation of DHRS3 gene Results in Defective
            Coronary Vessel Development.
            GeneRIF: Yap targets Dhrs3, to reduce retinoic acid synthesis and
            inhibit cardiac fibroblast differentiation during development.
REFERENCE   6  (bases 1 to 2337)
  AUTHORS   Deisenroth C, Itahana Y, Tollini L, Jin A and Zhang Y.
  TITLE     p53-Inducible DHRS3 is an endoplasmic reticulum protein associated
            with lipid droplet accumulation
  JOURNAL   J Biol Chem 286 (32), 28343-28356 (2011)
   PUBMED   21659514
  REMARK    GeneRIF: p53-Inducible DHRS3 is an endoplasmic reticulum protein
            associated with lipid droplet accumulation.
REFERENCE   7  (bases 1 to 2337)
  AUTHORS   Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M,
            Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice
            DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson
            A, Zambrowicz BP and de Sauvage FJ.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 2337)
  AUTHORS   Abidari JM, Gonzales ET, Inoue K, Lupski JR, Karsenty G and
            Katsanis N.
  TITLE     Identification of novel genes expressed during metanephric
            induction through single-cell library screening
  JOURNAL   Kidney Int 57 (6), 2221-2228 (2000)
   PUBMED   10844592
REFERENCE   9  (bases 1 to 2337)
  AUTHORS   Bachner D, Ahrens M, Schroder D, Hoffmann A, Lauber J, Betat N,
            Steinert P, Flohe L and Gross G.
  TITLE     Bmp-2 downstream targets in mesenchymal development identified by
            subtractive cloning from recombinant mesenchymal progenitors
            (C3H10T1/2)
  JOURNAL   Dev Dyn 213 (4), 398-411 (1998)
   PUBMED   9853961
REFERENCE   10 (bases 1 to 2337)
  AUTHORS   Haeseleer F, Huang J, Lebioda L, Saari JC and Palczewski K.
  TITLE     Molecular characterization of a novel short-chain
            dehydrogenase/reductase that reduces all-trans-retinal
  JOURNAL   J Biol Chem 273 (34), 21790-21799 (1998)
   PUBMED   9705317
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK032958.1, AK151419.1 and AL606909.12.
            
            [WARNING] On Oct 13, 2023 this sequence was replaced by
            NM_011303.8.
            
            On Oct 25, 2017 this sequence version replaced NM_011303.6.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032958.1, AK151419.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AK032958.1         6-65
            61-1759             AK151419.1         2-1700
            1760-1909           AK032958.1         1763-1912
            1910-1910           AL606909.12        13902-13902
            1911-2337           AK032958.1         1913-2339
FEATURES             Location/Qualifiers
     source          1..2337
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.14 cM"
     gene            1..2337
                     /gene="Dhrs3"
                     /gene_synonym="retSDR1; Rsdr1"
                     /note="dehydrogenase/reductase 3"
                     /db_xref="GeneID:20148"
                     /db_xref="MGI:MGI:1315215"
     exon            1..633
                     /gene="Dhrs3"
                     /gene_synonym="retSDR1; Rsdr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..1347
                     /gene="Dhrs3"
                     /gene_synonym="retSDR1; Rsdr1"
                     /EC_number="1.1.1.300"
                     /note="isoform 1 is encoded by transcript variant 1;
                     retinal short-chain dehydrogenase/reductase 1; short-chain
                     dehydrogenase/reductase 3; dehydrogenase/reductase (SDR
                     family) member 3"
                     /codon_start=1
                     /product="short-chain dehydrogenase/reductase 3 isoform 1"
                     /protein_id="NP_035433.1"
                     /db_xref="CCDS:CCDS18912.1"
                     /db_xref="GeneID:20148"
                     /db_xref="MGI:MGI:1315215"
                     /translation="MVWKWLGALVVFPLQMIYLVTKAAVGMVLPPKLRDLSRESVLIT
                     GGGRGIGRHLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREE
                     VYQMAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHVNTLGQFWTTKAFLP
                     RMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVL
                     PFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVDAVQQNQALLLLPWTMNILIILKSI
                     LPQAALEEIHRFSGTYTCMNTFKGRT"
     exon            634..777
                     /gene="Dhrs3"
                     /gene_synonym="retSDR1; Rsdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..897
                     /gene="Dhrs3"
                     /gene_synonym="retSDR1; Rsdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1136
                     /gene="Dhrs3"
                     /gene_synonym="retSDR1; Rsdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1262
                     /gene="Dhrs3"
                     /gene_synonym="retSDR1; Rsdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..2337
                     /gene="Dhrs3"
                     /gene_synonym="retSDR1; Rsdr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttttttt tttttttttc gtccctggcc ttgcctaaac tcttctgtcg gtctgtaaac
       61 attacctgtg aatttcccag ccgaaacggc tgttggggca agaaacttct tgttaaaact
      121 tcccacccct tggactctcc acagcccctc tcaccgtccc aatcttctga gacgcttttt
      181 acctctccgc cagagcagag tttatctttt ttttcttttt cttttttttt tctttttcct
      241 cccatttttc ctcgccctgt cctttacatc tgaaaggaga tcagttcaag agtgaccagg
      301 tgggacgcct ccttttcctt atttagttta ttattgtttg ggggagtttt ctttctatct
      361 ttttttaatt cctgtccggg gagttttgtc caccgcctcc taccacctcc ccctgtaccc
      421 cgctcctccg cgcggaggat ggtgtggaaa tggctgggcg cgctggtagt gttccctctg
      481 caaatgatct atttggtaac caaagcagcc gtgggaatgg tgttgccccc caagcttcgg
      541 gacttgtcgc gggagtcagt cctcatcacc ggcggtggga gaggcatcgg acgccacctc
      601 gctcgggagt tcgcagagcg tggcgccaga aagattgttc tctgggggcg gactgaaaaa
      661 tgcctcaagg agacgacaga ggagattcgg cagatgggca cagagtgcca ctacttcatc
      721 tgtgacgtgg gcaaccggga agaggtgtac cagatggcca aagctgtccg agagaaggtg
      781 ggtgacatca ccatcctggt gaacaatgcc gctgtggtcc atggaaaaag cttgatggac
      841 agtgacgatg atgccctcct caagtcccag catgtcaaca ccctgggcca attctggacc
      901 accaaggcct ttttgccacg tatgctggaa ctccagaacg gccatattgt gtgcctcaat
      961 tccgtgcttg cactgtcagc catccctggc gccatcgact actgcacgtc aaaagcatca
     1021 gccttcgcct tcatggagag cctgaccttg gggctgttgg actgtcctgg tgtcagcgcc
     1081 accaccgttc tgccctttca caccagcacc gagatgttcc agggcatgag agtcaggttt
     1141 cccaacctct tcccgccact gaagccagag acagtagccc ggaggacggt agatgctgtg
     1201 caacaaaacc aggcccttct cttgctcccg tggaccatga atatcctcat tatcttgaaa
     1261 agcatactcc cacaagctgc actggaggag attcacaggt tctcggggac ttacacctgt
     1321 atgaacacct ttaaggggag gacatagagg caggaggaag acacacctga ggagctatgg
     1381 agcctgaggg ggagccacag cagccgggca cacaatcctg tgcctgtgca ttagcacatc
     1441 tgctgggtga acaggactgt tcttgtcccc agggaagatt ttgcagctcc ccaggtcaac
     1501 tccaggacct ttgtgcaaga ctgatgggtt taactctgac ccccatgggg aggcaagaag
     1561 ccggcagcca cccaacaact ttgtacattt ctcattctgt agcgtttgtc atgaaattgc
     1621 ttctccagtc taacccgcct gatgtgcatc tactatttcc aggagagtct gctcccagac
     1681 actctgcctt tccctccaaa accctctcac tcccagctcg tgcaaactgg ttacacagca
     1741 gaaacgcaaa ataaagaggt ggctttcgca gcttccttcg ttcacgtgtt tgggagggag
     1801 gcagctggga aggaacctgc cccaaccaca aagacccatc ttttgagaga gaaggggtct
     1861 gccttggggt ctacaaagag caggagagga actgcagccc agtccaagaa gagagacagg
     1921 agggagggag gtatggccag gcccctccag atacttgtct tccctggtag gatccatgga
     1981 agagttgacc gcatctgtcc ttctttggtc ccactgggcc accaatgtaa aagtaaagtc
     2041 agactccact gagcacctgc ttctgaccct acatggggga accaagatga tactagcaaa
     2101 agatgccatt catctgtgga agaaagaatc atgagtcacc agaaacaatg gcaacgcatc
     2161 acttagggtc agcgctgtgg agtgttacag cacatctggt tgtgggagac ggaaaaccca
     2221 gagaatggaa ggagctggca tggtctcagt caagcaaggg tagaggtgcc catggttctc
     2281 tgccgtgatt ctcatactga gcacattgaa taaatgtcac tgtagtctgt gtggagc
//
