LOCUS       NM_027790               1273 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dehydrogenase/reductase member 2 (Dhrs2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_027790
VERSION     NM_027790.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1273)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1273)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1273)
  AUTHORS   Zhou,Y., Wang,L., Ban,X., Zeng,T., Zhu,Y., Li,M., Guan,X.Y. and
            Li,Y.
  TITLE     DHRS2 inhibits cell growth and motility in esophageal squamous cell
            carcinoma
  JOURNAL   Oncogene 37 (8), 1086-1094 (2018)
   PUBMED   29106393
  REMARK    GeneRIF: Low DHRS2 expression promotes esophageal squamous cell
            carcinoma.
REFERENCE   4  (bases 1 to 1273)
  AUTHORS   Gabrielli,F. and Tofanelli,S.
  TITLE     Molecular and functional evolution of human DHRS2 and DHRS4
            duplicated genes
  JOURNAL   Gene 511 (2), 461-469 (2012)
   PUBMED   23036705
  REMARK    GeneRIF: M. musculus DHRS2 and DHRS4 genes are syntenic outparalogs
            that originated from a duplication of the DHRS4 gene that took
            place before the formation of the mammalian clade. M. musculus
            genes are orthologs of human DHRS2 and DHRS4 genes respectively.
REFERENCE   5  (bases 1 to 1273)
  AUTHORS   Shafqat,N., Shafqat,J., Eissner,G., Marschall,H.U., Tryggvason,K.,
            Eriksson,U., Gabrielli,F., Lardy,H., Jornvall,H. and Oppermann,U.
  TITLE     Hep27, a member of the short-chain dehydrogenase/reductase family,
            is an NADPH-dependent dicarbonyl reductase expressed in vascular
            endothelial tissue
  JOURNAL   Cell Mol Life Sci 63 (10), 1205-1213 (2006)
   PUBMED   16685466
  REMARK    GeneRIF: Functional analysis of the human Dhrs2 ortholog.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK017274.1, AC123533.4, BC117731.2 and AV291604.1.
            
            On Nov 15, 2007 this sequence version replaced NM_027790.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017274.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AK017274.1         3-108
            107-107             AC123533.4         75589-75589         c
            108-1151            BC117731.2         1-1044
            1152-1268           AK017274.1         1154-1270
            1269-1273           AV291604.1         230-234
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.12 cM"
     gene            1..1273
                     /gene="Dhrs2"
                     /gene_synonym="5430405K24Rik; Hep27"
                     /note="dehydrogenase/reductase member 2"
                     /db_xref="GeneID:71412"
                     /db_xref="MGI:MGI:1918662"
     exon            1..62
                     /gene="Dhrs2"
                     /gene_synonym="5430405K24Rik; Hep27"
                     /inference="alignment:Splign:2.1.0"
     exon            63..144
                     /gene="Dhrs2"
                     /gene_synonym="5430405K24Rik; Hep27"
                     /inference="alignment:Splign:2.1.0"
     exon            145..221
                     /gene="Dhrs2"
                     /gene_synonym="5430405K24Rik; Hep27"
                     /inference="alignment:Splign:2.1.0"
     exon            222..375
                     /gene="Dhrs2"
                     /gene_synonym="5430405K24Rik; Hep27"
                     /inference="alignment:Splign:2.1.0"
     exon            376..553
                     /gene="Dhrs2"
                     /gene_synonym="5430405K24Rik; Hep27"
                     /inference="alignment:Splign:2.1.0"
     exon            554..655
                     /gene="Dhrs2"
                     /gene_synonym="5430405K24Rik; Hep27"
                     /inference="alignment:Splign:2.1.0"
     exon            656..726
                     /gene="Dhrs2"
                     /gene_synonym="5430405K24Rik; Hep27"
                     /inference="alignment:Splign:2.1.0"
     exon            727..778
                     /gene="Dhrs2"
                     /gene_synonym="5430405K24Rik; Hep27"
                     /inference="alignment:Splign:2.1.0"
     exon            779..913
                     /gene="Dhrs2"
                     /gene_synonym="5430405K24Rik; Hep27"
                     /inference="alignment:Splign:2.1.0"
     exon            914..969
                     /gene="Dhrs2"
                     /gene_synonym="5430405K24Rik; Hep27"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1273
                     /gene="Dhrs2"
                     /gene_synonym="5430405K24Rik; Hep27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1254..1259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dhrs2"
                     /gene_synonym="5430405K24Rik; Hep27"
                     /note="putative"
ORIGIN      
        1 gtgactgctg cagcttgaga catccctcca ggaatctgag tgcctgagtc cactggcccg
       61 aggacctctg cttgctctgg tcaaccccgc tcactccagt cggcctccgc acgctcagtc
      121 cctgcttgct ccagcccaaa acactcaggg atcgcactca cctcacggca gctccttcgc
      181 agtaatcctc tctggaaaca tcttcataga taagtccaca ggtctttctt caatggctgc
      241 catattcagg cctatcccat gggcctttag gggctctctg tgtctacctc tctcagctcg
      301 aaggttcagc aagacagcgg atgagaatcg ctccctggct gggaaagtgg ctgtgatcac
      361 tggttccacg agagggattg gctttgccat cgccaggcgt ctggcccagg atggggcaca
      421 tgtggtcatc agcagccgga agcaggagaa tgtagatgaa gctgtgacca tattgaagga
      481 ggaggggctg agtgtgactg gcaccatgtg ccacgtgggg aaggctgagg accgccagca
      541 ccttgtgacc acagccctga agcattctgg gggcattgac ttccttgtgt gtgtggccgg
      601 agtcaaccct ctggtgggaa gcaccctggg agccagtgaa cagatctggg acaagatcct
      661 ggatgtaaat gtgaagtctc cagctctgtt gctaagcaag gtgctgccct acatggagaa
      721 cagaagggga ggcagcgttg ttctggtgtc ctccggagtg gcttatgtac cagttccaaa
      781 actgggcgtc tacaacacca gcaagaccgc tctgttgggg ctctgcaagt ctctggctgt
      841 ggagctggct ccaaagggca tcagagtcaa ctgcctagtg ccaggaatta tcaagactga
      901 ctttagccta cgggagaaaa cgatgccaaa catgctgcct gacatgaata aaatcttcgg
      961 agtgaagcgg ttaggggagc cggaagaatg tgccgggctt gtatccttcc tgtgctcctc
     1021 agatgccagc tacatcactg gggagaacat catggtggct ggcttctcct ctaaactgtg
     1081 aagagacagc atgggttaga gactggggtt gaagtcctca agtggaagaa gacacagggc
     1141 ttggtgggaa atatgtaggt gtagagcctt aagatgtgct tgggatccag gtcatatagg
     1201 gatacttact gaaatgttgt gaaggaaagc aggtgtttaa agatttcgtt tggaataaat
     1261 ttgtttggac act
//
