LOCUS       NM_177564               1421 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus dehydrogenase/reductase 11 (Dhrs11), mRNA.
ACCESSION   NM_177564
VERSION     NM_177564.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1421)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596083.21.
            
            On Oct 31, 2009 this sequence version replaced NM_177564.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157041.1, BC022224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               AL596083.21        172272-172524       c
            254-463             AL596083.21        168889-169098       c
            464-558             AL596083.21        166593-166687       c
            559-688             AL596083.21        165832-165961       c
            689-781             AL596083.21        165186-165278       c
            782-847             AL596083.21        164924-164989       c
            848-1421            AL596083.21        164249-164822       c
FEATURES             Location/Qualifiers
     source          1..1421
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.34 cM"
     gene            1..1421
                     /gene="Dhrs11"
                     /note="dehydrogenase/reductase 11"
                     /db_xref="GeneID:192970"
                     /db_xref="MGI:MGI:2652816"
     exon            1..253
                     /gene="Dhrs11"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..889
                     /gene="Dhrs11"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.270"
                     /note="short-chain dehydrogenase/reductase family 24C
                     member 1; estradiol 17-beta-dehydrogenase;
                     17-beta-hydroxysteroid dehydrogenase;
                     3-beta-hydroxysteroid 3-dehydrogenase;
                     dehydrogenase/reductase (SDR family) member 11"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 11
                     precursor"
                     /protein_id="NP_808232.2"
                     /db_xref="CCDS:CCDS36261.1"
                     /db_xref="GeneID:192970"
                     /db_xref="MGI:MGI:2652816"
                     /translation="MTRAGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCART
                     VGNIEELAAECKSAGYPGTLIPYRCDLSNEEDILSMFSAVRSQHSGVDICINNAGMAR
                     PDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNIDDGHIININSMCGHRVPPQ
                     SVIHFYSATKYAVTALTEGLRQELLEAQTHIRATCISPGLVETQFAFKLHDKDPGEAA
                     ATYEHIKCLRPEDVAEAVIYVLSTPPHVQVGDIQMRPTEQVT"
     exon            254..463
                     /gene="Dhrs11"
                     /inference="alignment:Splign:2.1.0"
     exon            464..558
                     /gene="Dhrs11"
                     /inference="alignment:Splign:2.1.0"
     exon            559..688
                     /gene="Dhrs11"
                     /inference="alignment:Splign:2.1.0"
     exon            689..781
                     /gene="Dhrs11"
                     /inference="alignment:Splign:2.1.0"
     exon            782..847
                     /gene="Dhrs11"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1421
                     /gene="Dhrs11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccactgca gtgaccaggg agccaccgat cttcagtaac cccagactaa gctccccgct
       61 cccagtgcct ggttcgccga acgaggtggg cagacggctc gggaccatga ctagagctgg
      121 catggagcgg tggcgcgacc ggctggcact ggtgacggga gcctcggggg gcatcggtgc
      181 ggccgtggcc cgggcattag tccagcaggg actgaaggtt gtgggttgtg cccgcaccgt
      241 tggcaacatc gaggagctgg ctgctgaatg taagagtgca ggctaccccg ggactttgat
      301 cccctacaga tgtgacctgt caaatgagga ggacatcctc tccatgttct cagctgtccg
      361 atcccagcac agtggcgtgg atatctgcat caacaatgcc ggcatggccc ggcctgacac
      421 cctgctctcg ggcagcacca gcggatggaa ggacatgttc aatgtgaatg tgctggccct
      481 cagcatctgc actcgggagg cttatcagtc catgaaggag cggaacatag acgacgggca
      541 catcattaac atcaacagca tgtgtggcca ccgagtccca ccccagtctg tgatccattt
      601 ctatagtgcg actaagtatg ccgtcactgc actgacagag ggactcaggc aagagcttct
      661 ggaggcccag acccatatcc gggccacgtg tatctctcca ggcttggtag agacacagtt
      721 cgccttcaaa ctccatgaca aggacccggg ggaagcagct gccacctatg aacacataaa
      781 gtgtctcaga ccagaggacg tggctgaggc tgtcatctac gttcttagca cacccccaca
      841 tgttcaggtt ggtgacatcc agatgaggcc cacagagcag gtgacctagt gttctgtggg
      901 gagatcctac cttctccacc cttcacggct cgcctcctgc ctctggattt taggtgttga
      961 tttctggact ctgcagctta ctttctatgt ccaccccact aagggataga cagcttgtca
     1021 gactattccc attacaaatg tgaaaaactg ggccgggaag agaagacaga atctcgactg
     1081 ttctatctaa cttcttctga gtcctcttgg ggctccgtaa cctttgctct cctgtgcctc
     1141 ttccttttga cctaggaaag ggatgtacct agaaggggca ttgctctatc ctcttacacc
     1201 ctacccccca ccccttaggg ttggagcagc agagacctca tcttttacct gtgtggttgt
     1261 ccagggttcc aggttccctt cccaaccctc ctgcctcccc cccccccagc tctccagcca
     1321 agttttggcc ctcaccctgg ggtccttacc acggctacag agtatcaggg tctgtctcct
     1381 actacatttc actgtaacaa ttaaagagag agattacaac c
//
