LOCUS       NM_001039514            1332 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus deoxyhypusine synthase (Dhps), mRNA.
ACCESSION   NM_001039514
VERSION     NM_001039514.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1332)
  AUTHORS   Connors,C.T., Villaca,C.B.P., Anderson-Baucum,E.K., Rosario,S.R.,
            Rutan,C.D., Childress,P.J., Padgett,L.R., Robertson,M.A. and
            Mastracci,T.L.
  TITLE     A Translational Regulatory Mechanism Mediated by Hypusinated
            Eukaryotic Initiation Factor 5A Facilitates beta-Cell Identity and
            Function
  JOURNAL   Diabetes 73 (3), 461-473 (2024)
   PUBMED   38055903
REFERENCE   2  (bases 1 to 1332)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1332)
  AUTHORS   Padgett,L.R., Shinkle,M.R., Rosario,S., Stewart,T.M., Foley,J.R.,
            Casero,R.A. Jr., Park,M.H., Chung,W.K. and Mastracci,T.L.
  TITLE     Deoxyhypusine synthase mutations alter the post-translational
            modification of eukaryotic initiation factor 5A resulting in
            impaired human and mouse neural homeostasis
  JOURNAL   HGG Adv 4 (3), 100206 (2023)
   PUBMED   37333770
  REMARK    GeneRIF: Deoxyhypusine synthase mutations alter the
            post-translational modification of eukaryotic initiation factor 5A
            resulting in impaired human and mouse neural homeostasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1332)
  AUTHORS   Kar,R.K., Hanner,A.S., Starost,M.F., Springer,D., Mastracci,T.L.,
            Mirmira,R.G. and Park,M.H.
  TITLE     Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads
            to impairments in growth, viability, neurodevelopment, and
            cognitive functions in mice
  JOURNAL   J Biol Chem 297 (5), 101333 (2021)
   PUBMED   34688659
  REMARK    GeneRIF: Neuron-specific ablation of eIF5A or deoxyhypusine
            synthase leads to impairments in growth, viability,
            neurodevelopment, and cognitive functions in mice.
REFERENCE   5  (bases 1 to 1332)
  AUTHORS   Anderson-Baucum,E., Pineros,A.R., Kulkarni,A., Webb-Robertson,B.J.,
            Maier,B., Anderson,R.M., Wu,W., Tersey,S.A., Mastracci,T.L.,
            Casimiro,I., Scheuner,D., Metz,T.O., Nakayasu,E.S., Evans-Molina,C.
            and Mirmira,R.G.
  TITLE     Deoxyhypusine synthase promotes a pro-inflammatory macrophage
            phenotype
  JOURNAL   Cell Metab 33 (9), 1883-1893 (2021)
   PUBMED   34496231
  REMARK    GeneRIF: Deoxyhypusine synthase promotes a pro-inflammatory
            macrophage phenotype.
REFERENCE   6  (bases 1 to 1332)
  AUTHORS   Templin,A.T., Maier,B., Nishiki,Y., Tersey,S.A. and Mirmira,R.G.
  TITLE     Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine
            signaling
  JOURNAL   Cell Cycle 10 (7), 1043-1049 (2011)
   PUBMED   21389784
  REMARK    GeneRIF: Deoxyhypusine synthase haploinsufficiency attenuates acute
            cytokine signaling.
REFERENCE   7  (bases 1 to 1332)
  AUTHORS   Robbins,R.D., Tersey,S.A., Ogihara,T., Gupta,D., Farb,T.B.,
            Ficorilli,J., Bokvist,K., Maier,B. and Mirmira,R.G.
  TITLE     Inhibition of deoxyhypusine synthase enhances islet {beta} cell
            function and survival in the setting of endoplasmic reticulum
            stress and type 2 diabetes
  JOURNAL   J Biol Chem 285 (51), 39943-39952 (2010)
   PUBMED   20956533
  REMARK    GeneRIF: DHS is required for the ongoing production of proteins,
            particularly CHOP, in response to ER stress in the beta cell.
REFERENCE   8  (bases 1 to 1332)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1332)
  AUTHORS   Chen,Z.P., Yan,Y.P., Ding,Q.J., Knapp,S., Potenza,J.A.,
            Schugar,H.J. and Chen,K.Y.
  TITLE     Effects of inhibitors of deoxyhypusine synthase on the
            differentiation of mouse neuroblastoma and erythroleukemia cells
  JOURNAL   Cancer Lett 105 (2), 233-239 (1996)
   PUBMED   8697449
REFERENCE   10 (bases 1 to 1332)
  AUTHORS   Chen,K.Y. and Dou,Q.P.
  TITLE     NAD+ stimulated the spermidine-dependent hypusine formation on the
            18 kDa protein in cytosolic lysates derived from NB-15 mouse
            neuroblastoma cells
  JOURNAL   FEBS Lett 229 (2), 325-328 (1988)
   PUBMED   3126083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK159104.1 and BB763715.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159104.1, SRR1660815.126644.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1108              AK159104.1         2-1109
            1109-1332           BB763715.1         302-525
FEATURES             Location/Qualifiers
     source          1..1332
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.55 cM"
     gene            1..1332
                     /gene="Dhps"
                     /gene_synonym="Dhs"
                     /note="deoxyhypusine synthase"
                     /db_xref="GeneID:330817"
                     /db_xref="MGI:MGI:2683592"
     exon            1..297
                     /gene="Dhps"
                     /gene_synonym="Dhs"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1200
                     /gene="Dhps"
                     /gene_synonym="Dhs"
                     /EC_number="2.5.1.46"
                     /codon_start=1
                     /product="deoxyhypusine synthase"
                     /protein_id="NP_001034603.1"
                     /db_xref="CCDS:CCDS22492.1"
                     /db_xref="GeneID:330817"
                     /db_xref="MGI:MGI:2683592"
                     /translation="MEGTPPGAAPSSALAAVLKHSSALPPESAQVQGYDFNRGVDYHA
                     LLDAYRTTGFQATNFGRAVQQVNAMIEKKLEPLAVDEDHHADLTQSRRPLTGCTIFLG
                     YTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRE
                     SGINRIGNLLVPNDNYCKFEDWLMPILDQMVLEQNTEGVKWTPSKMISRLGKEINNPD
                     SVYYWAHKNHIPVLSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKRS
                     GMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDA
                     QPVKVYADASLVFPLLVAETFAQKADAFRAEKNED"
     exon            298..462
                     /gene="Dhps"
                     /gene_synonym="Dhs"
                     /inference="alignment:Splign:2.1.0"
     exon            463..584
                     /gene="Dhps"
                     /gene_synonym="Dhs"
                     /inference="alignment:Splign:2.1.0"
     exon            585..681
                     /gene="Dhps"
                     /gene_synonym="Dhs"
                     /inference="alignment:Splign:2.1.0"
     exon            682..768
                     /gene="Dhps"
                     /gene_synonym="Dhs"
                     /inference="alignment:Splign:2.1.0"
     exon            769..874
                     /gene="Dhps"
                     /gene_synonym="Dhs"
                     /inference="alignment:Splign:2.1.0"
     exon            875..978
                     /gene="Dhps"
                     /gene_synonym="Dhs"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1104
                     /gene="Dhps"
                     /gene_synonym="Dhs"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1332
                     /gene="Dhps"
                     /gene_synonym="Dhs"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacttcctg ggctccggcc gacctcgctg agggattttg cgggtctcag ggcgccgagg
       61 ctgctgagac ctgagagcgg ccgcgagcac atggaaggga ccccgccagg ggcggcgccc
      121 tcctcggcgc tggccgccgt gctcaagcac agctcagcgt tgccgcccga gagcgcccag
      181 gtccaaggct acgacttcaa ccgcggcgta gattaccatg cgcttctgga cgcctaccgc
      241 accaccggct tccaggctac caacttcggg cgcgcggtgc agcaagtcaa cgccatgatt
      301 gagaaaaaac tggagccact ggctgtagat gaagatcatc acgcagacct gactcagagc
      361 cgccgcccac ttacaggctg caccattttc ttgggctata cttccaacct catcagttca
      421 ggcatccggg agaccattcg atacctcgtg cagcacaaca tggtggatgt attggtgacc
      481 actgctggag gtgtggaaga agatctcatc aaatgcctgg cgcccacata ccttggcgag
      541 ttcagcctca gggggaagga gctccgggag agtgggatca acaggattgg aaacctgctg
      601 gtgccgaatg acaattactg caagtttgag gactggctca tgcccattct ggaccagatg
      661 gtgctggagc agaacacaga gggtgtgaag tggacacctt ccaagatgat ctcccggctt
      721 gggaaggaga tcaacaaccc agactctgtg tattattggg cccataagaa ccacatccct
      781 gtgctgagtc cagcactcac agatggctca ctgggtgaca tgatcttctt ccattcctat
      841 aaaaacccag gcttggtcct ggacattgtt gaagacctgc gactcatcaa cacgcaggcc
      901 attttcgcca agcgctctgg gatgatcatc ctgggtggag gtgtggtcaa gcaccacatt
      961 gccaacgcta acctcatgag gaatggagca gactacgctg tttatatcaa cacagcccag
     1021 gagtttgatg gctcagactc cggagcccgg ccagatgagg ctgtctcttg gggcaagatc
     1081 cggatggacg cacagccagt aaaggtctat gctgatgctt ctctggtttt ccccttgctg
     1141 gtggctgaga cattcgccca aaaggcagat gccttcagag ctgagaagaa tgaagactaa
     1201 gaagattggt aaagactgag gctttttgcc acacctttat ttattacttt acatgccagc
     1261 ccctccctag gcccactcct tggtcagcag catctctaga ataaatggcc ctttggttgg
     1321 gttttctgag tc
//
