LOCUS       NM_007857               4239 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus desert hedgehog (Dhh), mRNA.
ACCESSION   NM_007857
VERSION     NM_007857.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4239)
  AUTHORS   Amano,K., Okuzaki,D., Kitaoka,Y., Kato,S., Fujiwara,M., Tanaka,S.
            and Iida,S.
  TITLE     Pth1r in Neural Crest Cells Regulates Nasal Cartilage
            Differentiation
  JOURNAL   J Dent Res 103 (3), 308-317 (2024)
   PUBMED   38234039
REFERENCE   2  (bases 1 to 4239)
  AUTHORS   Rouault,P., Guimbal,S., Cornuault,L., Bourguignon,C., Foussard,N.,
            Alzieu,P., Choveau,F., Benoist,D., Chapouly,C., Gadeau,A.P.,
            Couffinhal,T. and Renault,M.A.
  TITLE     Thrombosis in the Coronary Microvasculature Impairs Cardiac
            Relaxation and Induces Diastolic Dysfunction
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (1), e1-e18 (2024)
   PUBMED   38031839
REFERENCE   3  (bases 1 to 4239)
  AUTHORS   Souali-Crespo,S., Condrea,D., Vernet,N., Feret,B., Klopfenstein,M.,
            Grandgirard,E., Alunni,V., Cerciat,M., Jung,M., Mayere,C., Nef,S.,
            Mark,M., Chalmel,F. and Ghyselinck,N.B.
  TITLE     Loss of NR5A1 in mouse Sertoli cells after sex determination
            changes cellular identity and induces cell death by anoikis
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38078651
REFERENCE   4  (bases 1 to 4239)
  AUTHORS   Lee,J., Kim,Y., Ataliotis,P., Kim,H.G., Kim,D.W., Bennett,D.C.,
            Brown,N.A., Layman,L.C. and Kim,S.H.
  TITLE     Coordination of canonical and noncanonical Hedgehog signalling
            pathways mediated by WDR11 during primordial germ cell development
  JOURNAL   Sci Rep 13 (1), 12309 (2023)
   PUBMED   37516749
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4239)
  AUTHORS   Norris,A.M., Appu,A.B., Johnson,C.D., Zhou,L.Y., McKellar,D.W.,
            Renault,M.A., Hammers,D., Cosgrove,B.D. and Kopinke,D.
  TITLE     Hedgehog signaling via its ligand DHH acts as cell fate determinant
            during skeletal muscle regeneration
  JOURNAL   Nat Commun 14 (1), 3766 (2023)
   PUBMED   37355632
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4239)
  AUTHORS   Bitgood,M.J., Shen,L. and McMahon,A.P.
  TITLE     Sertoli cell signaling by Desert hedgehog regulates the male
            germline
  JOURNAL   Curr Biol 6 (3), 298-304 (1996)
   PUBMED   8805249
REFERENCE   7  (bases 1 to 4239)
  AUTHORS   Bitgood,M.J. and McMahon,A.P.
  TITLE     Hedgehog and Bmp genes are coexpressed at many diverse sites of
            cell-cell interaction in the mouse embryo
  JOURNAL   Dev Biol 172 (1), 126-138 (1995)
   PUBMED   7589793
REFERENCE   8  (bases 1 to 4239)
  AUTHORS   Marigo,V., Roberts,D.J., Lee,S.M., Tsukurov,O., Levi,T.,
            Gastier,J.M., Epstein,D.J., Gilbert,D.J., Copeland,N.G.,
            Seidman,C.E. et al.
  TITLE     Cloning, expression, and chromosomal location of SHH and IHH: two
            human homologues of the Drosophila segment polarity gene hedgehog
  JOURNAL   Genomics 28 (1), 44-51 (1995)
   PUBMED   7590746
REFERENCE   9  (bases 1 to 4239)
  AUTHORS   Chang,D.T., Lopez,A., von Kessler,D.P., Chiang,C., Simandl,B.K.,
            Zhao,R., Seldin,M.F., Fallon,J.F. and Beachy,P.A.
  TITLE     Products, genetic linkage and limb patterning activity of a murine
            hedgehog gene
  JOURNAL   Development 120 (11), 3339-3353 (1994)
   PUBMED   7720571
REFERENCE   10 (bases 1 to 4239)
  AUTHORS   Echelard,Y., Epstein,D.J., St-Jacques,B., Shen,L., Mohler,J.,
            McMahon,J.A. and McMahon,A.P.
  TITLE     Sonic hedgehog, a member of a family of putative signaling
            molecules, is implicated in the regulation of CNS polarity
  JOURNAL   Cell 75 (7), 1417-1430 (1993)
   PUBMED   7916661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033392.1, AC161165.5 and AK032466.1.
            
            On Mar 27, 2016 this sequence version replaced NM_007857.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032466.1, AK033392.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1709              AK033392.1         2-1710
            1710-2363           AK033392.1         1712-2365
            2364-3495           AC161165.5         101248-102379       c
            3496-4239           AK032466.1         3480-4223
FEATURES             Location/Qualifiers
     source          1..4239
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 55.05 cM"
     gene            1..4239
                     /gene="Dhh"
                     /note="desert hedgehog"
                     /db_xref="GeneID:13363"
                     /db_xref="MGI:MGI:94891"
     exon            1..571
                     /gene="Dhh"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..1459
                     /gene="Dhh"
                     /note="desert hedgehog protein; HHG-3"
                     /codon_start=1
                     /product="desert hedgehog protein preproprotein"
                     /protein_id="NP_031883.1"
                     /db_xref="CCDS:CCDS27810.1"
                     /db_xref="GeneID:13363"
                     /db_xref="MGI:MGI:94891"
                     /translation="MALPASLLPLCCLALLALSAQSCGPGRGPVGRRRYVRKQLVPLL
                     YKQFVPSMPERTLGASGPAEGRVTRGSERFRDLVPNYNPDIIFKDEENSGADRLMTER
                     CKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYG
                     LLARLAVEAGFDWVYYESRNHIHVSVKADNSLAVRAGGCFPGNATVRLRSGERKGLRE
                     LHRGDWVLAADAAGRVVPTPVLLFLDRDLQRRASFVAVETERPPRKLLLTPWHLVFAA
                     RGPAPAPGDFAPVFARRLRAGDSVLAPGGDALQPARVARVAREEAVGVFAPLTAHGTL
                     LVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTGMHWYSRLLYRLAE
                     ELMG"
     exon            572..833
                     /gene="Dhh"
                     /inference="alignment:Splign:2.1.0"
     exon            834..4239
                     /gene="Dhh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2342..2347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dhh"
                     /note="hexamer: AATAAA"
     polyA_site      2367
                     /gene="Dhh"
                     /note="major polyA site"
ORIGIN      
        1 acgggagccg ggcagcagag actggctggg ctggcactca ccctcgaccc acctgctctg
       61 taaatggtag tctatcagta gtaggttcca ggttccccag ggcatgtagg cagagttagc
      121 ggctgccaag tgttcagagc cacagcgctc caggtactct gggaccttct ctatctgcgg
      181 tgctctttag ctcctgcgga gatgcccaat tgacaggaga gccagtgagg acaagaacgc
      241 tcccttccga cccaagtcca cggcacccat ggctctgccg gccagtctgt tgcccctgtg
      301 ctgcttggca ctcttggcac tatctgccca gagctgcggg ccgggccgag gaccggttgg
      361 ccggcggcgt tatgtgcgca agcaacttgt gcctctgcta tacaagcagt ttgtgcccag
      421 tatgcccgag cggaccctgg gcgcgagtgg gccagcggag gggagggtaa caagggggtc
      481 ggagcgcttc cgggacctcg tacccaacta caaccccgac ataatcttca aggatgagga
      541 gaacagcggc gcagaccgcc tgatgacaga gcgttgcaaa gagcgggtga acgctctagc
      601 catcgcggtg atgaacatgt ggcccggagt acgcctacgt gtgactgaag gctgggacga
      661 ggacggccac cacgcacagg attcactcca ctacgaaggc cgtgccttgg acatcaccac
      721 gtctgaccgt gaccgtaata agtatggttt gttggcgcgc ctagctgtgg aagccggatt
      781 cgactgggtc tactacgagt cccgcaacca catccacgta tcggtcaaag ctgataactc
      841 actggcggtc cgagccggag gctgctttcc gggaaatgcc acggtgcgct tgcggagcgg
      901 cgaacggaag gggctgaggg aactacatcg tggtgactgg gtactggccg ctgatgcagc
      961 gggccgagtg gtacccacgc cagtgctgct cttcctggac cgggatctgc agcgccgcgc
     1021 ctcgttcgtg gctgtggaga ccgagcggcc tccgcgcaaa ctgttgctca caccctggca
     1081 tctggtgttc gctgctcgcg ggccagcgcc tgctccaggt gactttgcac cggtgttcgc
     1141 gcgccgctta cgtgctggcg actcggtgct ggctcccggc ggggacgcgc tccagccggc
     1201 gcgcgtagcc cgcgtggcgc gcgaggaagc cgtgggcgtg ttcgcaccgc tcactgcgca
     1261 cgggacgctg ctggtcaacg acgtcctcgc ctcctgctac gcggttctag agagtcacca
     1321 gtgggcccac cgcgccttcg cccctttgcg gctgctgcac gcgctcgggg ctctgctccc
     1381 tgggggtgca gtccagccga ctggcatgca ttggtactct cgcctccttt accgcttggc
     1441 cgaggagtta atgggctgag cttccaagga cagaagtcct ccaagcttca tacgaaatcg
     1501 aaaccgaagc cccaagacct gctggctgag atctggggat gtgagccgca ggtgatgctg
     1561 ataggggagg gggtgagaaa agagagagag agagaaaggt gggctgtact aggaacttct
     1621 tggtttaggc aacttttacc cgagaagagt ggtgtctggt ccttggtaac cgggtttgct
     1681 ggtaggcact ctttaacgag gacttttttg cgtcttcccc agtcgcaccg gataatttta
     1741 ttttctattt ataatttgta atatgatgac ctgcttgccc agcccaccaa ggtgagggcc
     1801 tggagcttgg ctttaacaca gtctgaccca gctagccagc caacctgacg gctcacaccc
     1861 tcacttttcc ctgcaggtga gttaataaag ggaaggcttt attggaaacc accttcactc
     1921 acctccaaag aggaggagaa cccggactaa tccgagtcca caccttactt ccaatttgcc
     1981 cttcttcctc agcacgatct tccaaaccct cttgctgcaa agggtgtccc aacctgtcag
     2041 caatagacca gcaatgtcct gcccctttta aggtactggt tccaccccta gtcaggacca
     2101 gaacttcact tgtgaggatg cataccaact gtgagtgggg tggggctaac caaggcagca
     2161 ggaggagcac ttggagtcct ctattgttag ctattctggc ctatccctgt aggctgtcca
     2221 ttgatcatca gcctagaggt catcctgcct gctaaaacgg tctgattatt ttctgggatt
     2281 ttggtaggcc aactggcgaa ccatgggtgt tccttacaat ccgccacaca tttgtggcca
     2341 aaataaagat tctagagtga tccagaatgg tggtcaaatt ccaggagtac atgcttgtaa
     2401 tcccaacact ttggagatgg cgaaggatag aacagaaaga taatgagttc aaggctaact
     2461 tgggctgtat agtagaacac gcgcttgcgc gcacacacac acacacacac acacacacac
     2521 acagacagag acagatacgg agacacagag atgctggagg gaaaattttc tcatgacctg
     2581 aataatttct caaaacctgt tccaggtttt ggcttgggtg tatctgtggt caagttctag
     2641 tgtggcattg tgagtttcct ccttcggtcc agtggttgtt tctgttggtt ccccatctac
     2701 cgttctttcc cggtctcgtt acaggctggg cttctctagt ttctctgggt gttttggggg
     2761 gaatttttgg actccaacat cgcagaccac tggaatgcag gtagattgat gtctctgagc
     2821 tagggatggg catgtaggac tgccctggaa gtggatatta ccatctgagg gatagttaag
     2881 gtgggtggta cttccaggga ctgggcccaa tcctgctaca attgttgcaa ggaagattgg
     2941 ctctgctctg agcttccaag ccaaccaagt ccatgctgta gatacgttgc cctctggtgg
     3001 cattggagag aattctaagc ttggggacat gtgcttccct ttggttccct ctgtaccaaa
     3061 gggaaatgta ctgcatgctg caccagactt actcatagga actgacccag agggcagaac
     3121 taatgtatgt ggcttgcgtt aacttttagc atggttcggg attctctctc aattcttgga
     3181 tttttttttt ttttcttttt ttacagccct tgtgcctagt tcagctctga ggctctggga
     3241 agcttgaagt gtagataatg gtgcagagtg tccctcactc tggtgaccct caagtcctgt
     3301 ggtcagagat aatagtaaat agagcgtcga acagttcctg ataaaggtcc tctattcacc
     3361 aatgcccaag tctacagacc aaatacccgt tgccaccctg ccttctcctt gcctcagaga
     3421 cacatctcaa acaacagcct ttcctacttt cttaccctac tcttagctgc acctcttaga
     3481 ttctggtacc tttcgtttta tcacccaggt gttgctgggc aatctgttta ctacctcccc
     3541 taagctaagt actactgtgt ctaaactgct gaaactaaag tctttaacca gaaaaccatc
     3601 atggctgact gggaatatac tcaagtagta cagcattagc ctagtgtgcc cagagctcca
     3661 atttcaatcc gcagtaccac tcaaatggct atgcaaaata tttggggaga aaaattcatt
     3721 ggcgttcatt aaatcacatc ctataggtta ctttcagggt ttgaggctca cctctctctc
     3781 caactttgtc ccttgaggcc cctcccctca ttctgtcccc ttgaggctcc tcccctcatt
     3841 ctgttccctt gaggcccctc cctttatctt tgtcctcctg aagcccctcc cagctatgta
     3901 aaaaacacgc gcttcacctg caagcaggta aacgcaccac gtgcttgctg caggtggtcc
     3961 cactaacttg gccgccgagc accttccaac cgcagcaact cttttcaacc caggaactga
     4021 gcagacgtcg ccgcgccgcg taggctttgc attcctgtct cagctgtcta cttcatttct
     4081 actactccgc taaaaggctt gccagcgcgt gcatttcagg gatgagtttt gtttggtttt
     4141 tcaagctggg ggcgcagaga ggaggattgt cttgagttca agggcagcct gggatactta
     4201 gtaaggcccg gccacaaata aatcttatta tttaaaatc
//
