LOCUS       NM_053272               3984 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus 24-dehydrocholesterol reductase (Dhcr24), mRNA.
ACCESSION   NM_053272
VERSION     NM_053272.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3984)
  AUTHORS   Li,Z., Yu,S., Li,L., Zhou,C., Wang,L., Tang,S., Gu,N., Zhang,Z.,
            Huang,Z., Chen,H., Tang,W., Wang,Y., Yang,X., Sun,X. and Yan,J.
  TITLE     TREM2 alleviates white matter injury after traumatic brain injury
            in mice might be mediated by regulation of DHCR24/LXR pathway in
            microglia
  JOURNAL   Clin Transl Med 14 (4), e1665 (2024)
   PUBMED   38649789
  REMARK    GeneRIF: TREM2 alleviates white matter injury after traumatic brain
            injury in mice might be mediated by regulation of DHCR24/LXR
            pathway in microglia.
REFERENCE   2  (bases 1 to 3984)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3984)
  AUTHORS   Liu,Q., Chen,S., Tian,R., Xue,B., Li,H., Guo,M., Liu,S., Yan,M.,
            You,R., Wang,L., Yang,D., Wan,M. and Zhu,H.
  TITLE     3beta-hydroxysteroid-Delta24 reductase dampens anti-viral innate
            immune responses by targeting K27 ubiquitination of MAVS and STING
  JOURNAL   J Virol 97 (12), e0151323 (2023)
   PUBMED   38032198
  REMARK    GeneRIF: 3beta-hydroxysteroid-Delta24 reductase dampens anti-viral
            innate immune responses by targeting K27 ubiquitination of MAVS and
            STING.
REFERENCE   4  (bases 1 to 3984)
  AUTHORS   Zhang,W.B., Huang,Y., Guo,X.R., Zhang,M.Q., Yuan,X.S. and Zu,H.B.
  TITLE     DHCR24 reverses Alzheimer's disease-related pathology and cognitive
            impairment via increasing hippocampal cholesterol levels in 5xFAD
            mice
  JOURNAL   Acta Neuropathol Commun 11 (1), 102 (2023)
   PUBMED   37344916
  REMARK    GeneRIF: DHCR24 reverses Alzheimer's disease-related pathology and
            cognitive impairment via increasing hippocampal cholesterol levels
            in 5xFAD mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3984)
  AUTHORS   Frutos,M.F., Pardo-Marques,V., Torrecilla-Parra,M., Rada,P.,
            Perez-Garcia,A., Martin-Martin,Y., de la Pena,G., Gomez,A.,
            Toledano-Zaragoza,A., Gomez-Coronado,D., Casarejos,M.J.,
            Solis,J.M., Rotllan,N., Pastor,O., Ledesma,M.D., Valverde,A.M.,
            Busto,R. and Ramirez,C.M.
  TITLE     'MiR-7 controls cholesterol biosynthesis through
            posttranscriptional regulation of DHCR24 expression'
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1866 (2), 194938 (2023)
   PUBMED   37086967
  REMARK    GeneRIF: 'MiR-7 controls cholesterol biosynthesis through
            posttranscriptional regulation of DHCR24 expression'.
REFERENCE   6  (bases 1 to 3984)
  AUTHORS   Ohyama,Y., Meaney,S., Heverin,M., Ekstrom,L., Brafman,A.,
            Shafir,M., Andersson,U., Olin,M., Eggertsen,G., Diczfalusy,U.,
            Feinstein,E. and Bjorkhem,I.
  TITLE     Studies on the transcriptional regulation of cholesterol
            24-hydroxylase (CYP46A1): marked insensitivity toward different
            regulatory axes
  JOURNAL   J Biol Chem 281 (7), 3810-3820 (2006)
   PUBMED   16321981
REFERENCE   7  (bases 1 to 3984)
  AUTHORS   Wechsler,A., Brafman,A., Shafir,M., Heverin,M., Gottlieb,H.,
            Damari,G., Gozlan-Kelner,S., Spivak,I., Moshkin,O., Fridman,E.,
            Becker,Y., Skaliter,R., Einat,P., Faerman,A., Bjorkhem,I. and
            Feinstein,E.
  TITLE     Generation of viable cholesterol-free mice
  JOURNAL   Science 302 (5653), 2087 (2003)
   PUBMED   14684813
REFERENCE   8  (bases 1 to 3984)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3984)
  AUTHORS   Dickinson,R.J., Williams,D.J., Slack,D.N., Williamson,J.,
            Seternes,O.M. and Keyse,S.M.
  TITLE     Characterization of a murine gene encoding a developmentally
            regulated cytoplasmic dual-specificity mitogen-activated protein
            kinase phosphatase
  JOURNAL   Biochem J 364 (Pt 1), 145-155 (2002)
   PUBMED   11988087
REFERENCE   10 (bases 1 to 3984)
  AUTHORS   Waterham,H.R., Koster,J., Romeijn,G.J., Hennekam,R.C., Vreken,P.,
            Andersson,H.C., FitzPatrick,D.R., Kelley,R.I. and Wanders,R.J.
  TITLE     Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause
            desmosterolosis, an autosomal recessive disorder of cholesterol
            biosynthesis
  JOURNAL   Am J Hum Genet 69 (4), 685-694 (2001)
   PUBMED   11519011
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX511043.7 and AL929585.11.
            
            On Sep 7, 2022 this sequence version replaced NM_053272.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1184100.1, AK129036.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-316               BX511043.7         2568-2883
            317-472             AL929585.11        3893-4048
            473-578             AL929585.11        10904-11009
            579-697             AL929585.11        11717-11835
            698-961             AL929585.11        13220-13483
            962-1105            AL929585.11        17682-17825
            1106-1303           AL929585.11        25282-25479
            1304-1482           AL929585.11        25837-26015
            1483-3984           AL929585.11        26104-28605
FEATURES             Location/Qualifiers
     source          1..3984
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 49.67 cM"
     gene            1..3984
                     /gene="Dhcr24"
                     /gene_synonym="2310076D10Rik; 5830417J06Rik; mKIAA0018"
                     /note="24-dehydrocholesterol reductase"
                     /db_xref="GeneID:74754"
                     /db_xref="MGI:MGI:1922004"
     exon            1..316
                     /gene="Dhcr24"
                     /gene_synonym="2310076D10Rik; 5830417J06Rik; mKIAA0018"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1636
                     /gene="Dhcr24"
                     /gene_synonym="2310076D10Rik; 5830417J06Rik; mKIAA0018"
                     /EC_number="1.3.1.72"
                     /note="seladin-1; delta(24)-sterol reductase;
                     3-beta-hydroxysterol delta-24-reductase"
                     /codon_start=1
                     /product="delta(24)-sterol reductase precursor"
                     /protein_id="NP_444502.2"
                     /db_xref="CCDS:CCDS18420.1"
                     /db_xref="GeneID:74754"
                     /db_xref="MGI:MGI:1922004"
                     /translation="MEPAVSLAVCALLFLLWVRVKGLEFVLIHQRWVFVCLFLLPLSL
                     IFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSL
                     RVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVSMGQVTALLNSIGWTLPVLPELD
                     DLTVGGLIMGTGIESSSHKYGLFQHICTAYELILADGSFVRCTPSENSDLFYAVPWSC
                     GTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICEKFTRESQRLENHFVEGLLYSLDE
                     AVIMTGVMTDDVEPSKLNSIGSYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRS
                     IFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMK
                     CMSQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGDEAELYVDIGAYGEPRVKHFEA
                     RSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLRKQLGCQDAFPEVYD
                     KICKAARH"
     exon            317..472
                     /gene="Dhcr24"
                     /gene_synonym="2310076D10Rik; 5830417J06Rik; mKIAA0018"
                     /inference="alignment:Splign:2.1.0"
     exon            473..578
                     /gene="Dhcr24"
                     /gene_synonym="2310076D10Rik; 5830417J06Rik; mKIAA0018"
                     /inference="alignment:Splign:2.1.0"
     exon            579..697
                     /gene="Dhcr24"
                     /gene_synonym="2310076D10Rik; 5830417J06Rik; mKIAA0018"
                     /inference="alignment:Splign:2.1.0"
     exon            698..961
                     /gene="Dhcr24"
                     /gene_synonym="2310076D10Rik; 5830417J06Rik; mKIAA0018"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1105
                     /gene="Dhcr24"
                     /gene_synonym="2310076D10Rik; 5830417J06Rik; mKIAA0018"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1303
                     /gene="Dhcr24"
                     /gene_synonym="2310076D10Rik; 5830417J06Rik; mKIAA0018"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1482
                     /gene="Dhcr24"
                     /gene_synonym="2310076D10Rik; 5830417J06Rik; mKIAA0018"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..3984
                     /gene="Dhcr24"
                     /gene_synonym="2310076D10Rik; 5830417J06Rik; mKIAA0018"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3962..3967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dhcr24"
                     /gene_synonym="2310076D10Rik; 5830417J06Rik; mKIAA0018"
                     /note="hexamer: AATAAA"
     polyA_site      3984
                     /gene="Dhcr24"
                     /gene_synonym="2310076D10Rik; 5830417J06Rik; mKIAA0018"
                     /note="major polyA site"
ORIGIN      
        1 aggcgctgag ccggcggagc gcggagcggg cgaaggagac gggcggcgcg agcccgcacc
       61 cttccgcgcg gtgcgccgcg acaccatgga gcccgccgtg tcgctggccg tgtgcgcgct
      121 gctctttctg ctctgggtgc gagtgaaggg gttggagttc gttctcatcc accagcgctg
      181 ggtgttcgtg tgcctcttct tgctgccgct ctcgctcatc ttcgatatct actactacgt
      241 gcgcgcctgg gtggtgttca agctgagcag tgcgccgcgc ctgcacgagc agcgcgtgcg
      301 ggacatccag aaacaggtcc gggaatggaa ggaacagggc agtaagacct tcatgtgcac
      361 ggggcgccca ggctggctca ctgtctcgct gcgagtcgga aagtacaaga agacccataa
      421 gaacatcatg atcaacctga tggacatcct ggaggtggac accaagaaac agattgttcg
      481 agtggagccc ttggtgtcta tgggtcaggt gacagctttg ctgaactcca ttggctggac
      541 cctgcctgtg ttgcctgagc ttgatgacct cacagtgggg ggcctgatca tgggcacagg
      601 catcgagtca tcgtcccaca agtatggcct gttccaacac atttgcactg cctacgagct
      661 gatcctggca gacggcagct ttgtgcgctg cacaccgtct gaaaactcag acctgttcta
      721 tgccgtgccc tggtcctgtg ggaccctggg cttcctggtg gctgccgaga tccggatcat
      781 cccggccaag aagtatgtca agctgcggtt tgagcctgtt cggggcctgg aggccatctg
      841 tgaaaaattc acccgcgagt cccagcggct ggagaaccac ttcgtggaag ggttgctgta
      901 ctccctggat gaggctgtca tcatgacagg ggtcatgacg gacgacgtag agcccagcaa
      961 gctgaatagc attggcagtt actacaagcc ctggttcttc aagcatgtgg agaactacct
     1021 gaagacaaac cgggagggcc tcgaatacat tcccctgaga cactactacc accgacacac
     1081 gcgcagcatc ttctgggagc tccaggacat catccctttc ggcaacaacc ccatcttccg
     1141 ctacctcttc ggctggatgg tgcctcccaa gatctccctc ctgaagctga cccagggcga
     1201 gacgctacgc aagctgtacg agcagcacca cgtggtgcag gacatgctgg tgcccatgaa
     1261 gtgcatgtca caggccctgc ataccttcca aaatgacatc cacgtctacc ccatctggct
     1321 gtgcccattc atcctgccca gccagccagg actagtgcat cccaagggag atgaagcaga
     1381 gctctacgtg gacatcgggg catacgggga gccacgtgtg aagcacttcg aggccaggtc
     1441 ctgcatgagg cagctggaga agtttgtgcg gagtgtgcac gggttccaaa tgttatacgc
     1501 cgattgctat atgaaccgcg aggaattctg ggagatgttc gatggctcct tgtaccacaa
     1561 gctgcgcaag cagctgggct gccaggacgc cttccctgag gtgtacgaca agatctgcaa
     1621 ggcggcaagg cactgagcag ggcacctggg gagccagctg catggacctg ctctccctcg
     1681 ctcgctccgg cttctctgct ttcccaggtc tcagaaaaga aacccctcca catccccgag
     1741 gcagcccgat ggcttccagg gtggctcggg caagtggaag cacgtggagt cagacagacc
     1801 taagtcccag gcccagatta gccactcgtt agctgtgtga ctgactctgg gctagtcacc
     1861 tggcccctgt gtgccccgtg ttcatctgtg aaaggaggta aaaaaaaaaa aatatctacc
     1921 tgctggatgt caccccacac taagggcttc caccactgct tccatgcaac ctcacgcctg
     1981 gctcctgctt tggatctaac agctgagtcc agacaggctc cccacaggtc acccttgcac
     2041 gggtttggcc aacaccatga aggagttgcc ttggagtttc acctgcatag cttgcatcag
     2101 ccccgagagg gcaaaggagg gtcagccttc cacttggcct cgggggtggg gcagggggca
     2161 tctgattggc aggcaggccc aggatgtgct gtgccaaagc caggtctact ccaaagtcct
     2221 ctctgccatc ttcggaccat cctggcccta cttctgtgtg ctcgagctgc cccagccatc
     2281 actgagccca ctcaggactg ctcctggaag acatctcaag gtgggaagcc tggctttcct
     2341 gggctttgct ttcttaactc ccaccatcca ggcctcctct agagtccact gagtcacaat
     2401 gggggcacat gctcatgact gtgtcactta ggggcggtcc ccacactgag tgagaaaggg
     2461 gcatctgccc tgttgctact gtgaggaccc tccctggggt tagaaagaaa gcatccaggg
     2521 tcactcatct ccccctcccc cattttgttc cctccccccc cctccccccc cccccccccc
     2581 cggctctagt taatttcagt gccttacaaa tcctaagctc agagaaagtt agctccattt
     2641 ccgttcccaa gggaggggcc tctgaggtcc ttctgccttg ttgatgaaga gtggttggtt
     2701 gtagagcccc caccttcaga actgcctggc ccagctggaa acccagagtc tgagggggaa
     2761 tcaggttctg gaaggcaagc cagaactcca gagctgagct ggtcacagtc actcctcccc
     2821 caccacccct gcccctccag aggctgcagt tttctcgcct gtcacttgga acattagagc
     2881 tcctgaagcc tgtctgtctt aagacgttgg gaaagcctcg tgttgaaagc cgggggagct
     2941 taaatgatcc aggtggtagc tagggaccgt ccatcagtgg tccttccctc caccgccacg
     3001 ccagctcctg ggtcgttttc atttatctgg cagagcccag gacccttaga atcatatttt
     3061 agctgaagga tgctcactga tgcggccgag ggcttgggat actgcacagt gctactgtgt
     3121 cctgtgaagg ctggtgcact cagggctgtg ggaaggcaga atcacctcat ccatttggcc
     3181 tgtgaaggaa gtaacctcac tttgctgtct gagcagcatg tattcctggc atgggctctc
     3241 ctagtggtcc atgtgcatcc ttgcgcatgt gcactcgctc gcagactgat gaccctgctt
     3301 gctgcagatg aatggtcaac gcgagctagg ttagttagtg tgatgtataa ggcgccatca
     3361 ttcctcaagt caagcctcca tcccaaagca cctggagctg tggcaatgat gccagcaacc
     3421 tgtgtcaccc aaaatagtca aaatccagcc ctccacagac actccccagg acctggggag
     3481 ggaagggatt ttgagtcaca ttagcctcag gttagtgttt ggctccagta atatcttgcc
     3541 cgaaaagtgg tcgtcttcca agcatggtgt tctgggtccc agccttgtct tatcgcctgt
     3601 cctgtcagtg tccaaccaca cggtggcttg gtggggtcac tcagctgcta tgggacagca
     3661 catgtgggaa gtcaacgcaa gcctctcccc tccgtggctc tggtttcttg gctgcatggt
     3721 tctctgtaaa ttcagttgta gccactgtct ttggctagaa agctgaattg gctgttgctg
     3781 aaaggaagga ggggatgggt gtggcgatgt gtgctgtgtg atttgttgtt tttttttttt
     3841 taatttggtc atggggacca aggagaaggc atgaatccct gtatttggct cttgcagcct
     3901 caggcactgt gcctactctc caggtcatgt ccctgtggtt ctggggccac cacttgtgta
     3961 aaataaagta cagcctggac gcta
//
